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The Mizoroki-Heck Reaction - The Heck Reaction (Hardcover, New)
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The Mizoroki-Heck Reaction - The Heck Reaction (Hardcover, New)
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Exploring the importance of Richard F. Heck's carbon coupling
reaction, this book highlights the subject of the 2010 Nobel Prize
in Chemistry for palladium-catalyzed cross couplings in organic
synthesis, and includes a foreword from Nobel Prize winner Richard
F. Heck. The Mizoroki-Heck reaction is a palladium-catalyzed
carbon-carbon bond forming process which is widely used in organic
and organometallic synthesis. It has seen increasing use in the
past decade as chemists look for strategies enabling the controlled
construction of complex carbon skeletons. The Mizoroki-Heck
Reaction is the first dedicated volume on this important reaction,
including topics on:* mechanisms of the Mizoroki-Heck reaction*
intermolecular Mizoroki-Heck reactions* focus on regioselectivity
and product outcome in organic synthesis* waste-minimized
Mizoroki-Heck reactions* intramolecular Mizoroki-Heck reactions*
formation of heterocycles* chelation-controlled Mizoroki-Heck
reactions* the Mizoroki-Heck reaction in domino processes*
oxidative heck-type reactions (Fujiwara-Moritani reactions)*
Mizoroki-Heck reactions with metals other than palladium* ligand
design for intermolecular asymmetric Mizoroki-Heck reactions*
intramolecular enantioselective Mizoroki-Heck reactions*
desymmetrizing Mizoroki-Heck reactions* applications in
combinatorial and solid phase syntheses, and the development of
modern solvent systems and reaction techniques* the asymmetric
intramolecular Mizoroki-Heck reaction in natural product total
synthesis Several chapters are devoted to asymmetric Heck reactions
with particular focus on the construction of otherwise
difficult-to-obtain sterically congested tertiary and quaternary
carbons. Industrial and academic applications are highlighted in
the final section. The Mizoroki-Heck Reaction will find a place on
the bookshelves of any organic or organometallic chemist. "I am
convinced that this book will rapidly become the most important
reference text for research chemists in academia and industry who
seek orientation in the rapidly growing and - for the layman -
confusing field described as the "'Mizoroki-Heck reaction'."
(Synthesis, March 2010)
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