There is a paradox in hypertension: whereas the pathophysiological
mechanisms of the disease have been related principally to a
constriction of small arteries, most of the complications refer to
damage of the large arteries, particularly at the site of the
brain, the kidney and the heart. In the past, large arteries were
poorly investigated in hypertension mainly in terms of change in
blood flow. Recent studies clearly showed that the large arteries
are largely involved in the mechanisms of hypertension not only
through changes in mean blood flow, but rather through changes in
stiffness of the arterial wall. This aspect may be a key-point for
the development of hypertensive complications. Subsequently, the
goal of treatment may be not only blood pressure reduction but also
improvement of structural and functional abnormalities of the large
vessels. These therapeutic aspects are analyzed in detail in the
present book.
General
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