Bone is a dynamic tissue that undergoes continual adaptations
during a vertebrates lifespan to attain and preserve skeletal size,
shape, and structural integrity, and plays a pivotal role in
regulating mineral homeostasis in a living body. Bone homeostasis,
which maintains bone mass, is artfully regulated through
osteoclasts, osteoblasts and osteocytes in bone tissues. This
mechanism is regulated through many hormones, cytokines and immune
systems in the bone marrow microenvironment. Aging leads to a
reduction in bone mass, which is reduced by a suppression of
osteoblastic bone formation and an enhancement in osteoclastic bone
resorption. A decrease in bone mass leads to osteoporosis and bone
fracture. Osteoporosis is widely recognized as a major public
health problem. Moreover, bone loss is shown to stimulate in
various pathophysiological states, including inflammation, obesity,
diabetes, and cancer cell bone metastasis. Disease associated with
bone loss is strongly related to osteoclastic bone resorption. This
book focuses recent research topics implicated in
osteoclastogenesis and clinical challenges to prevent and treat
bone loss.
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