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Books > Medicine > Clinical & internal medicine > Musculoskeletal medicine
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Bone Toxicology (Hardcover, 1st ed. 2017)
Loot Price: R5,888
Discovery Miles 58 880
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Bone Toxicology (Hardcover, 1st ed. 2017)
Series: Molecular and Integrative Toxicology
Expected to ship within 12 - 19 working days
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The content of this book is intended to provide the toxicologist in
drug development in the pharmaceutical and biotechnology industries
with a broad understanding of bone and its interactions with other
organ systems in safety assessments. The book is divided into three
parts. The first part describes our current understanding of bone
biology and its primary regulatory pathways. Additional chapters
address regulatory and study design considerations for
incorporating bone end points in toxicology studies, with special
consideration being given to juvenile toxicology studies. This is
intended to address recent regulatory requirements to evaluate
skeletal development for drugs in development for pediatric
populations. The second part of the book describes the principal
techniques and methods used in bone research; understanding how
these end-points are derived is fundamental to their appropriate
application. These first two parts of the book provide the
background and the means to develop the concepts in part three
which describes bone and its interaction with other organ systems.
The unique series of chapters in part three, contributed to by key
leaders in their respective fields and in bone research, provides a
comprehensive collective work. Although constantly evolving, the
crosstalk and interaction of the skeleton with several organ
systems is now recognized and well documented, such as for the
reproductive system, muscle and kidney, while our understanding of
the interaction with other organ systems, such as the immune system
and CNS, is in its infancy. Recent work highlights the key role of
the skeleton in the regulation of energy metabolism and the impact
this has on research in metabolic diseases such as obesity and
diabetes. The hope is that this book will enlighten many and
encourage more to explore the impact of new compounds on the
skeleton in the development of effective and safe drugs.
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