This volume is a compendium of cutting-edge molecular methods for
the successful transplantation of hematopoietic stem cells. The
availability of genetic profiles for committed and uncommitted stem
cells combined with the determination of molecular steps involved
in hematopoietic stem cell activation and self-renewal hold
tremendous promise for future success in the clinic. Currently,
stem cells can be quantified and sorted successfully, but
transduction, labeling, and in vivo tracking of stem cells are
difficult techniques with traditionally low efficiency levels. The
contributors to this volume describe promising tools for stem cell
transplant research models, such as in vivo bioluminescence
imaging.
Topics included in this volume are molecular profiling of
hematopoietic stell cells, methods for imaging cell fates in
hematopoiesis, PCR-SSP typing of HLA Class I and Class II alleles,
sequence-based HLA typing, and typing minor HLA antigens. Also
discussed in this volume are the roles of natural killer cells and
killer inhibitor receptor polymorphisms, polymorphisms within
epithelial receptors, molecular methods used for the detection of
autologous graft contamination in lymphoid disorders, and the
application of proteomics to posttransplantation follow-up. With
the recent trend moving from gene expression to the protein
expression profiles, the application of proteomics to the
posttransplant follow-up of patients is becoming routine. As a
result, this volume will become an invaluable source for
biochemists, molecular biologists, and clinicians.
General
| Imprint: |
HumanaPress
|
| Country of origin: |
United States |
| Series: |
Methods in Molecular Medicine, 134 |
| Release date: |
May 2007 |
| First published: |
2007 |
| Editors: |
Meral Beksac
|
| Dimensions: |
229 x 152 x 20mm (L x W x T) |
| Format: |
Hardcover
|
| Pages: |
234 |
| Edition: |
2007 ed. |
| ISBN-13: |
978-1-58829-595-8 |
| Categories: |
Books >
Medicine >
Surgery >
Transplant surgery
|
| LSN: |
1-58829-595-8 |
| Barcode: |
9781588295958 |
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