Vir die vroue wat hy met sy rolprentsterglimlag betower het, was Chris Barnard ’n hartebreker. Vir sy pasiënte ’n harteheler.

Dié nuwe biografie oor Suid-Afrika se beroemdste hartsjirurg vertel nie net van Barnard se kinderjare in Beaufort-Wes, sy prominente huwelike (en egskeidings) en flambojante lewe nie. James Styan ondersoek ook die impak van die historiese eerste hartoorplanting op Barnard se persoonlik lewe en op die Suid-Afrikaanse gemeenskap in die algemeen, waar apartheidswetgewing dikwels die probleme van geneeskunde nog ingewikkelder gemaak het. Die rol van swart mediese personeel soos Hamilton Naki word bespreek, sowel as die intense wedywering wat tussen ander beroemde hartsjirurge en Barnard ontstaan het.

Hoe het Barnard dit reggekry om hulle almal in dié resies om lewe en dood te wen? Hoeveel het sy welbekende sjarme daarmee te doen gehad? En wat is Barnard se nalatenskap vandag, in die lig van sy latere suksesse en aansienlike mislukkings? Styan dek dit alles in dié fassinerende nuwe blik op Chris Barnard wat uitgegee is om saam te val met die 50ste herdenking van die eerste hartoorplanting.

In Death, Dying, and Organ Transplantation: Reconstructing Medical Ethics at the End of Life, Miller and Truog challenge fundamental doctrines of established medical ethics. They argue that the routine practice of stopping life support technology in hospitals causes the death of patients and that donors of vital organs (hearts, lungs, liver, and both kidneys) are not really dead at the time that their organs are removed for life-saving transplantation. These practices are ethically legitimate but are not compatible with traditional rules of medical ethics that doctors must not intentionally cause the death of their patients and that vital organs can be obtained for transplantation only from dead donors.
In this book Miller and Truog undertake an ethical examination that aims to honestly face the reality of medical practices at the end of life. They expose the misconception that stopping life support merely allows patients to die from their medical conditions, and they dispute the accuracy of determining death of hospitalized patients on the basis of a diagnosis of "brain death" prior to vital organ donation. After detailing the factual and conceptual errors surrounding current practices of determining death for the purpose of organ donation, the authors develop a novel ethical account of procuring vital organs. In the context of reasonable plans to withdraw life support, still-living patients are not harmed or wronged by organ donation prior to their death, provided that valid consent has been obtained for stopping treatment and for organ donation.
Recognizing practical difficulties in facing the truth regarding organ donation, the authors also develop a pragmatic alternative account based on the concept of transparent legal fictions. In sum, Miller and Truog argue that in order to preserve the legitimacy of end-of-life practices, we need to reconstruct medical ethics.

Diagnosis of death by neurological criteria (DNC) is a construct which has been part of the British medico-legal landscape for nearly half a century. This book examines the factors behind its emergence, and discusses the various changes that took place in the last few decades that culminated in the current definition and clinical criteria for determining brain-based death. It highlights the continuities and discontinuities in practice, and the impact they have on the issue of withdrawal of mechanical ventilation in intensive care units and on the field of organ transplantation. The book also explores the law's response to the introduction and development of DNC in clinical practice. It demonstrates how the legitimacy of the definition and criteria used by the medical profession were forged in the courtroom rather than in Parliament. It documents why case law were introduced in court, and assesses whether organ donation was a consideration in the deliberations. It will be emphasised that courts have given insufficient consideration to requests made in recent cases to consider a broader range of methods to determine death. Those pleas were made on the grounds that the definition and criteria used in the UK are dissimilar to those used in other jurisdictions that also adopt DNC; and that faith communities have a different understanding of death. By taking a close look at those other approaches before highlighting the inherent limitations of the courtroom as the forum that confers DNC its legitimacy, the book puts forward the argument that the democratic process should be engaged.

Produced in association with the American Society of Transplantation, this new edition is full of practical advice for the next generation of transplant professionals. In addition to 5 organ-specific chapters: kidney, pancreas, heart, lung and liver, the book includes essential information on: * immunobiology * pharmacology * donor management * infectious complications * pediatric transplantation * general principles of patient management Fully updated and redesigned to make it even more user-friendly, the book now contains clinical vignettes, key point boxes, and self-assessment multiple choice questions in each chapter. Primer on Transplantation, Third Edition is an invaluable resource for all health professionals in the transplant team including trainees, residents, fellows, physicians, surgeons, nurses and transplant co-ordinators. Purchasing this book entitles you to access to the companion website: www.astprimer.com The website includes: * Interactive Multiple-Choice Questions for each chapter * Figures from the book as Powerpoints for downloading * All chapters online

One: Historical Reflections.- 1. Reflections on the development of organ transplantation.- Two: Immunology of Organ Transplantation.- 2. Cellular and molecular mechanisms of allograft rejection.- 3. What does the alloreactive T cell see?.- 4. HLA matching and organ transplantation.- 5. An effective strategy for transplantation of highly sensitized patients.- 6. Rapid lymphocyte crossmatching for renal transplantation.- Three: Organ Allograft Rejection.- 7. Fifteen-year experience with fine needle aspiration biopsies at the University of Helsinki.- 8. Study of antibody specificity in highly sensitized patients using human monoclonal antibody technology.- 9. Idiotypic-Antiidiotypic antibody interaction and renal transplant survival.- Four: Immunosuppression.- 10. Transplantation and blood transfusion in 1990.- 11. Quadruple-drug immunosuppressive induction treatments for immunological high-risk patients in cadaveric renal transplantation using poly-and monoclonal antibodies.- 12. Sequential combination immunotherapy for cadaveric renal transplantation: OKT3 versus rabbit ATG induction.- 13. Multi-organ transplant experience with OKT3 and strategies for use at the University of Cincinnati Medical Center.- 14. Cyclosporine withdrawal in renal transplant recipients maintained on azathioprine, prednisone and cyclosporine.- 15. Early experience with FK 506 in liver transplantation.- 16. Deoxyspergualin. A novel immunosuppressant: experimental and clinical studies.- 17. Preliminary results with FK 506 in pancreas grafting in a nonhuman primate model.- 18. The effect of DST on graft outcome - the Turkish experience.- 19. Induction of specific unresponsiveness (tolerance) to experimental and clinical allografts using polyclonal antilymphocyte serum and donor-specific bone marrow.- 20. Comparison of cyclosporine assays using radioimmunoassay, fluorescent polarization immunoassay and high-performance liquid chromatography.- Five: Renal Transplantation.- 21. Long-term outcome in renal transplantation.- 22. Ten-year experience with 500 renal transplants.- 23. Long-term results in recipients of cadaveric renal allografts under cyclosporine therapy.- 24. Transplantation of single and double kidneys from pediatric donors.- 25. ABO-incompatible living related donor transplantation.- 26. The use of single pediatric cadaver kidneys for transplantation into adult recipients.- 27. Living unrelated donor renal transplantation.- 28. Renal transplantation in Tunisia - a three-year experience.- 29. Renal transplantation in children.- 30. Kidney donors - long-term follow up.- 31. Current techniques for permanent vascular access surgery - experience with 930 procedures.- 32. Results of 319 consecutive renal transplants from living related and living unrelated donors in Iran.- Six: Liver Transplantation.- 33. Liver transplantation: current status.- 34. An overview of liver transplantation therapy for children.- 35. Current anesthetic management in clinical liver transplantation.- 36. Risk factors in adult liver transplant recipients.- 37. The concept of reduced-size liver transplantation, including split-liver and living related liver transplantation.- 38. Immunological factors contributing to outcome in liver transplantation.- 39. Transplantation for hepatobiliary malignancies.- 40. The diagnosis and management of massive blood loss during liver transplantation.- 41. Early clinical experience with cluster resection and transplantation for right upper quadrant abdominal malignancy.- Seven: Heart/Heart-Lung Transplants.- 42. Lung transplantation: current techniques and outcomes.- 43. Heart-lung transplantation at the University of Minnesota.- 44. Specificity and sensitivity of the cytoimmunological monitoring (CIM): differentiation between cardiac rejection, viral, bacterial, or fungal infection.- Eight: Pancreas Transplantation.- 45. International Pancreas Transplantation Registry report.- 46. Techniques and experience of pancreatic transplantation wit...

This book offers a theoretical and practical overview of the specific ethical and legal issues in pediatric organ transplantation. Written by a team of leading experts, Ethical Issues in Pediatric Organ Transplantation addresses those difficult ethical questions concerning clinical, organizational, legal and policy issues including donor, recipient and allocation issues. Challenging topics, including children as donors, donation after cardiac death, misattributed paternity, familial conflicts of interest, developmental disability as a listing criteria, small bowel transplant, and considerations in navigating the media are discussed. It serves as a fundamental handbook and resource for pediatricians, transplant health care professionals, trainees, graduate students, scholars, practitioners of bioethics and health policy makers.

Organ transplantation is a much-discussed subject, and the importance of living organ donation is increasing significantly. Yet despite all efforts, too few donor organs are available to help all patients in need. This book analyses whether the national legal regulations are also partly responsible for the organ shortage in the Member States of the European Union. In addition to a detailed analysis of the various national regulations, the main arguments in favour of and against legal restrictions on living organ donation are considered. Furthermore, the European Union's authority is investigated, namely, whether it is entitled to establish statutory provisions for the Member States with respect to a harmonized regulation of living organ donation. Based on the results of the analysis, the author establishes a Best Practice Proposal for living organ donation.

After decades of research in clinical transplantation, new techniques have been developed that permit a further understanding of the immune mechanisms underlying immune recognition of allografts and a more accurate and thorough evaluation of compatibility between donors and recipients. The second edition of Transplantation Immunology: Methods and Protocols expands upon the previous edition with current, detailed methods in transplantation immunology. The new methods chapters cover four major areas that are being applied in compatibility evaluations and ongoing transplantation immunology research. Seven overview chapters provide reviews of the molecular basis for alloreactivity, current understanding of humoral and cellular mechanisms, as well as new developments in thoracic organ transplantation, composite tissue transplantation and in the transplantation of sensitized patients. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transplantation Immunology: Methods and Protocol, Second Edition is devoted to transplantation immunology, both in the practice of compatibility testing and in transplantation research.

The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential. Because of their pluripotency, these cells have been used in various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. The formation of embryoid bodies, which are three-dimensional aggregates of embryonic stem cells, is explained as this is the first step in cell differentiation. Such embryoid body culture has been widely used as a trigger for the in vitro differentiation of embryonic stem cells. The basic capacity of self-renewal of human embryogenic stem cells is explained. The role of TGF-beta in the propagation of human embryonic stem cells is discussed. The differentiation of human embryonic stem cells into neurons, hepatocytes, cardiomyocytes, and retinal cells is fully explained. Donor policies for hematopoietic stem cells are also explained.

This book examines the position of children who provide tissue to potentially save the life of another. It questions whether child donors of all ages have been treated appropriately and whether they are sufficiently protected in acting as tissue donors, and ultimately considers whether a new regulatory response is needed to benefit donor children. The book couples a legal exposition of the donor child's position with the medico-ethical reality of clinical practice. In recent years, a growing body of literature concerning the clinical experiences and outcomes for child donors has emerged. This book adds to this by examining another dimension - the regulatory frameworks at play. It examines the ethical arguments for and against children acting as tissue donors and provides an original analysis of the legal and non-legal regulatory frameworks governing children's participation in the United Kingdom, United States and Australia. It combines these doctrinal and theoretical approaches with insights into clinical practice gained from the results of qualitative research conducted with health professionals. The analysis inevitably explores the more general issues of children's right to make medical decisions, the role of parents in decision-making, the value of the best interests test and alternative (legal and ethical) standards, rights of participation of children before the courts, and the role of law and other forms of regulation in a clinical context.

This volume presents a comprehensive overview of the latest advances in basic and translational research in the field of reconstructive transplantation and its potential therapeutic implications. Dr. Thomas E. Starzl and Dr. Raimund Margreiter, both pioneers in the field of transplantation, have written the foreword for the book. The volume spans such topics as skin rejection, immune monitoring, stem cell-based immunomodulatory strategies, costimulatory blockade, tolerance induction, chronic rejection, ischemia reperfusion injury, nerve regeneration, cortical reintegration, and small and large animal models for reconstructive transplantation. The book is intended for biomedical researchers and basic scientists in the field of reconstructive transplantation, transplant immunology and regenerative medicine, as well as clinicians, surgeons and multidisciplinary specialists, who are practicing or interested in this novel and exciting field. Postgraduate fellows and students will also find it a valuable reference.

CARDIAC VALVE ALLOGRAFTS (HOMOGRAFTS) highlights the current controversy about freehand subcoronary aortic valve and root replacement with regard to postoperative morbidity and long term durability. It discusses particular implantation techniques of preference in young patients and in different root pathology. Other chapters address intermediate- and long-term results on cardiac valve and vascular homografts for treating complicating cardiac valve and aortic infections. The chapter on basic science additionally makes this book a highly authoritative reference source for cardiac surgeons, physicians and scientists. This work provides a current survey of the state-of-the-art.