In this new biography of Chris Barnard we not only learn about the life of South Africa’s most famous surgeon, from his Beaufort West childhood through his studies locally and abroad to his prominent marriages – and divorces – but James Styan also examines the impact of the historic heart transplant on Barnard’s personal life and South African society at large, where apartheid legislation often made the difficulties of medicine even more convoluted.

The role of black medical staff like Hamilton Naki is explored, as is the intense rivalry that arose between other famous heart surgeons and Barnard. How did Barnard manage to beat them all in this race of life and death? How much did his famous charisma have to do with it all? And in the light of his later years, his subsequent successes and considerable failures, what is Barnard’s legacy today?

Styan covers it all in this fascinating new account of a real heartbreaker that coincides with the 50th anniversary of the first heart transplant.

Chris Barnard needed the help of exceptional men and women to stay ahead of the fast-developing science of transplantation. One of these exceptional men were Winston Wicomb, the darker brother of the famous Randall.

He had to be hidden as a child to prevent the Apartheid inspectors from discovering his family’s racial identity. He had to endure the rampant racism that existed in South Africa at school and in the army… Winston, who had to fix cars in the backyard to make ends meet, had a curious encounter with Chris Barnard and got appointed in his research laboratory. Winston had to develop an apparatus with which hearts could be kept alive to enable transport.

This is the story of an unlikely hero; a man who changed transplantation forever, and a South African citizen who never got the recognition he deserved.

It’s a story of perseverance. And hope. Even... love.

'Compelling' Christopher Hart, The Sunday Times 'A fascinating book' Daily Mail _______________________________________________________________ We think of transplant surgery as one of the medical wonders of the modern world -- but it's a lot older than you think. As ancient as the pyramids, its history is even more surprising. In Spare Parts, cultural historian Paul Craddock takes us on a fascinating journey and unearths incredible untold stories, from Indian surgeons regrafting lost noses in the sixth century BC, to the seventeenth century architect who helped pioneer blood transfusions, to the French seamstress whose needlework paved the way for kidney transplants in the early 1900s. Expertly weaving together philosophy, science and cultural history, Spare Parts explores how transplant surgery has constantly tested the boundaries between human, animal and machine. It shows us that the history -- and future -- of transplant surgery is tied up with questions not only about who we are, but also what we are, and what we might become. _______________________________________________________________ 'By turns delightful and disturbing . . . A thoroughly engrossing read that I couldn't put down' LINDSEY FITZHARRIS, author of The Facemaker and The Butchering Art 'Spare Parts is a fascinating read filled with adventure, delight and surprise' RAHUL JANDIAL, surgeon and author of Life on a Knife's Edge 'This is a joyful romp through a fascinating slice of medical history' WENDY MOORE, author of The Knife Man

This book summarizes rapid progress and innovation in transplantation and regenerative medicine - the merger of reconstructive plastic surgery and transplantation - called Vascularized Composite Allotransplantation. This merger includes face, hand, uteri, larynx, tongue, penis and trachea translplantations as well as other body part transplants using grafts derived from organ donors. These sorts of transplants are now performed more commonly. Cell therapies for immunomodulation are surrogates for immune responses after transplantation to non-invasive imaging of neuroregeneration for improving functional outcomes after transplant.

Spare Parts examines major developments in the field of organ replacement that occurred in the United States over the course of the 1980s and the beginning of the 1990s. It focuses upon significant medical and social changes in the transplantation of human organs and on the development and clinical testing of the Jarvik-7 artificial heart, with special emphasis on how these biomedical events were related to the political, economic, and social climate of American society.

Part I examines the important biomedical advances and events in organ transplantation and their social and cultural concomitants. In Part II, the focus shifts to the story of the rise and fall of the Jarvik-7 artificial heart in the United States, its relation to American social institutions and cultural patterns, and its bearing on social control issues associated with therapeutic innovation and the patient-oriented clinical research it entails. Part III is a personal conclusion, which explains why the authors left the field of organ transplantation after so many years.

Spare Parts is written in a narrative, ethnographic style, with thickly descriptive, verbatim, and atmospheric detail. The primary data it is based upon includes qualitative materials, collected via participant observation, interviews in a variety of medical milieu, and content analysis of medical journals, newspapers, and magazine articles, and a number of television transcripts. The new introduction provides an overview of some of the recent developments in transplantation and also underscores how tenacious many of the patterns associated with organ replacement have been. Spare Parts should be read by all medical professionals, sociologists, and historians.

Because of the progress in diagnostic transplantation pathology interpretation of transplant biopsies is increasingly becoming an attractive field for general surgical pathologists. The book focuses on the pathology of transplantation in the following organs: kidney, liver, lungs, heart, pancreas and small intestine. An introductory section addresses common entities that may complicate all transplant recipients such as infections, post-transplant lymphoproliferative disease and graft versus host disease, followed by 6 sections with detailed manifestations of rejection in each organ. This comprehensive, well-illustrated book serves the needs and meets the requirements of pathologists in training and those practicing in centers with limited volume of transplant biopsies in daily practice.

'Gripping ... so powerfully emotional that at times I had to put it down to wipe my eyes' Mail on Sunday 'How do you say thank you to someone for giving you their heart? It is the greatest gift a person can ever give.' Marc is a promising young footballers of 15, growing up in Scotland. A few hundred miles away in England, Martin is a fun-loving 16-year-old. Both are enjoying their summers when they are suddenly struck down by debilitating illnesses. Within days, the boys are close to death. Although their paths have never crossed, their fortunes are about to be bound in the most extraordinary, intimate way. One of them will die and in doing so, he will save the other's life. This is a deeply powerful and dramatic story. It is extremely rare for the family of a donor to have any personal contact with the recipient of their loved one's organ. Yet remarkably, the mothers of these two boys meet and become friends, enabling the extraordinary, bittersweet moment in which a mother who has lost her son meets the boy he saved. Reaching out and placing her palm flat against his chest, she feels the heart of her son beating away inside another. Her boy, the boy who gave his heart away.

International illicit trade in human organs is on the increase, fueled by growing demand and unscrupulous traffickers. In order to truly understand the problem of organ trafficking, an analysis should take into account the various perspectives that come into play in this multifaceted issue. With contributions from international scholars and experts, The International Trafficking of Human Organs: A Multidisciplinary Perspective provides a broad-based exploration of this controversial phenomenon. Divided into four parts, the book examines the issue of human organ trafficking from the perspectives of criminal justice, business, medicine, ethics, philosophy, and theology. The book begins by presenting case studies of the trafficking of body parts occurring in the U.S. and Mexico. It examines the increase in organ harvesting from Chinese prisoners and describes widespread instances of trafficking in Europe. Diverse perspectives Next, it examines the economic ramifications of possible legislation of the sale of body parts and discusses other proposals for increasing the supply of kidneys and other organs. It explores ethical issues surrounding the kidney shortage and incentives to promote donation. It also offers arguments for and against compensation for transplant organs from Kantian, Dworkinian, and other perspectives. Lastly, theologians discuss opposing Catholic and Protestant perspectives on the sale of human organs. Learning tools Each chapter provides discussion questions to provoke vigorous debate and references to facilitate further study. The wide-ranging analysis provided by this volume is certain to enhance further inquiry into a disturbing and increasingly prevalent issue.

With color illustrations throughout, this book analyzes the implications that transplantation and immunosuppression can hold for patients. Discussing the many complications that may occur after kidney transplantation, this source is a must for anyone caring for patients recovering from this type of procedure.

Modernize your approach to graft biopsies, diagnosis and pathogenesis in transplantation pathology, with the second edition of this specialized textbook. Reach the latest classification schemes, combining both anatomic and clinical pathology, and gain a comprehensive understanding of detailed pathological processes, affecting both host and graft. Following publication of the first edition in 2009, technological advances in understanding of transplant immunology and physiology have enhanced many aspects of pathological diagnoses. This edition bridges key knowledge gaps in pathophysiologic mechanisms and constantly evolving clinical protocols, facilitating strong support for the pathologist, clinician, and student. Authored by leading experts in transplantation medicine, this multimedia guide boasts richly illustrated images, underscoring vital diagnostic features for busy readers. Addressing topics such as the immunopathology of graft rejection, laboratory medicine and dermatological complications in transplantation, this textbook engages with a variety of underlying pathogeneses, taking into account current laboratory and clinical findings, worldwide.

The title of this profound work conveys the bold, uncertain, and often dangerous adventure in which medical professionals and their organ transplant and dialysis patients are engaged. Built around a series of case studies developed through years of first-hand ethnographic research, The Courage to Fail is the product of collaborative first-hand research concerned with various social phenomena generated by transplantation and dialysis and also by the development and deployment of an artificial heart. The authors examine the individuals involved and the workings and atmosphere of some of the medical centers in which these forms of therapy have been developed. They examine "gift-exchange" dimensions of transplantation: the transcendent and tyrannical aspects of the "gift of life" that transplants entail for donors and recipients -- and for medical professionals as well. They also analyze the dilemma of uncertainty inherent in medicine, which occurs with particular force in the development of such experimental techniques.

Since publication of the original edition, the authors have continued to follow social and medical developments surrounding organ transplants and dialysis. In their new introduction, they discuss transplantation as a gift of life, how death is defined and when it occurs, efforts to procure more organs, and organ allocation and issues of equity. This book will be of interest to physicians, medical students, medical sociologists, and anyone interested in the history of and issues surrounding organ replacement.

Enter the world of organ transplantation and develop a new understanding of processes and techniques for working effectively with patients in this increasing medical population. This multidisciplinary overview of organ transplantation contains chapters by major figures in the medical arena, internationally known bioethics writers, and experienced chaplains from the clinical setting of transplantation, as well as respected pastoral theologians. The authors, who include Art Caplan, Donald Capps, and Jack Copeland, explain transplantation completely for the nonmedical person and delve into the myriad ethical and religious issues and controversies surrounding organ donation and transplantation. Enlightening chapters clarify issues and help readers better understand the transplantation process, making them more effective in their work with transplant patients. Organ Transplantation in Religious, Ethical and Social Context is divided into three sections. The first emphasizes transplantation as a team effort. Chapters focus on the various roles of chaplains and other team members.Section two addresses ethical questions which arise from transplantation and organ donation and includes interfaith perspectives. The third section is dedicated to theological and pastoral views concerning transplantation. Some specific topics discussed in this book include: a surgeon's perspective of the role of the chaplain influence of psychosocial factors in the heart transplantation decision process ministry to organ recipients and their families the special relationship between the transplant coordinator and the transplant patient Catholic and interfaith perspectives on organ donation using the Psalms as a pastoral resource with transplant patients Hospital chaplains, transplant social workers, transplant coordinators, and other professionals interested or involved in the process of organ transplantation will find this book to be full of interesting and thought-provoking insights and information.

Transplantation Surgery uniquely covers all aspects of this rapidly expanding field in one volume. The book gives a clear description of the current status of transplant surgery for trainees sitting surgery exit examinations. The book will also be of interest to transplant surgeons, physicians and nephrologists who have an interest in this field. It opens with an introductory chapter on the history of transplantation and the basic science of immunobiology, and then examines the practice of transplantation in each major system. No other book covers the breadth of this topic in a single volume. Each contributor to Transplantation Surgery is an internationally recognised expert. Nadey S Hakim is Consultant Surgeon and Surgical Director of the Transplant Unit based at St Mary's Hospital, London, UK. Gabriel M Danovitch is Medical Director of the Kidney Transplant Program, Center for the Health Sciences, Los Angeles, California, USA. Both have been personally involved in many of the major developments in transplantation.

Hematopoietic stem cell transplantation (HSCT) is currently utilized as a treatment option for a variety of life-threatening conditions affecting children and young adults including leukemia, lymphoma, neuroblastoma, brain tumors, inherited immune deficiency syndromes, blood disorders, and inherited metabolic diseases. This expertly written reference provides current information on methods and outcomes in a wide range of pediatric diseases, using a variety of HSCT approaches. It guides the pediatric professional in the proper execution and understanding of HSCT, and provides illustrative discussions of the hematopoietic and immune systems, clear outlines of current chemotherapy regimens, and expert guidance on each phase of stem cell transplantation and management, including patient evaluation and recovery.

Living donor kidney (LDK) transplantation has become the definitive approach to the treatment of end-stage renal failure, providing a better quality of life and the best opportunity for survival when compared with dialysis or transplantation from a deceased donor. A timely compendium of the modern day practice of LDK transplantation from a group of outstanding international experts, this text explores a number of controversial aspects of this innovative new technique. Discussing in detail the current situation, the authors also focus on the responsibility of the medical community to the live kidney donor as a patient, and the potential for complacency regarding donor risk. Emphasizing the ethical principles that must dictate medical practice in LDK transplantation for the foreseeable future - voluntarism, informed consent and medical follow-up - this book comprehensively records the best practices currently available.

A DAILY MAIL BOOK OF THE WEEK 'Spare Parts is a fascinating read filled with adventure, delight and surprise' RAHUL JANDIAL, surgeon author of 'Life on a Knife's Edge' 'This is a joyful romp through a fascinating slice of medical history' WENDY MOORE, author of 'The Knife Man' _______________________________________________________________ How did an architect help pioneer blood transfusion in the 1660s? Why did eighteenth-century dentists buy the live teeth of poor children? And what role did a sausage skin and an enamel bath play in making kidney transplants a reality? We think of transplant surgery as one of the medical wonders of the modern world. But transplant surgery is as ancient as the pyramids, with a history more surprising than we might expect. Paul Craddock takes us on a journey - from sixteenth-century skin grafting to contemporary stem cell transplants - uncovering stories of operations performed by unexpected people in unexpected places. Bringing together philosophy, science and cultural history, Spare Parts explores how transplant surgery constantly tested the boundaries between human, animal and machine, and continues to do so today. Witty, entertaining and at times delightfully macabre, Spare Parts shows us that the history - and future - of transplant surgery is tied up with questions about not only who we are, but also what we are, and what we might become. . .

This new book, edited by internationally renowned specialists Jean-Michel Dubernard, Marwan Dawahra and Paul McMaster, also pools the experience of consultants from both Europe and the US. It is divided into three main sections: Organ Preservation, Organ Harvesting and Surgical Techniques. Many different organs are covered including heart, kidneys, lungs, pancreas, intestine and bowel. The various aspects of preservation are discussed including cooling, and preservation solutions, the composition of which are currently being actively explored. Longer term preservation of the heart is still an unsolved problem and this is considered, as well as the pros and cons of organ donation from live or cadaveric donors.

Fully referenced and illustrated with over 50 line drawings, Organ Preservation and Transplant Surgery will be of particular interest to those involved in the often complex surgery of organ harvesting or trainees in transplantation surgery. It gives clear accounts of the techniques involved and a detailed update in the underlying science that determines and currently limits organ storage. It will also prove invaluable to the younger researcher who needs a clearer understanding of the scientific basis of organ preservation and the clinical need for better organ preservation.

Providing the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. * Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questions * Covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program * Contains concise chapters written with a focus on tables, algorithms and figures to aid rapid referral * Benefits from expert contributions from an international authorship

Bile duct injuries (BDI) are considered the most serious surgical complication associated with cholecystectomy. According to different reports, its incidence has remained constant over the years, ranging from 0.1% to 0.9%. BDI is associated with a greater risk of perioperative morbidity and mortality, a reduction in the quality of life, and a decrease in long-term survival. Also, this complication is a concern to surgeons since its progression is uncertain and may lead to demands on professional responsibility ("malpractice") and emotional and physical consequences ("second victim"). Given that injuries in a high percentage of patients are initially unsuspected, the postoperative recovery may be prolonged, and the possibility of a successful repair reduced. Several surgical, endoscopic, and percutaneous procedures may be necessary to manage the lesions and to treat coexisting complications. BDI patients often undergo several repair attempts before successful resolution. This affects their quality of life and has a high psychological, physical, and mental impact due to the prolonged, complex, and unexpected nature of the injury. This currently represents a frequent problem in specialized referral centers or hepatobilopancreatic surgery units, where patients arrive with the sequelae of previous inadequate treatments. Usually, these patients require more elaborate procedures such as reoperations, liver resections and liver transplantation. The prevention, early diagnosis, and adequate treatment in the first approach is of crucial importance to ensure good long-term results. Therefore, this book is an essential resource for surgeons who perform cholecystectomy or treat BDI patients. It provides practical information and a comprehensive review on prevention and proper management, including complex cases. Readers will find contributions by experienced authors from a multidisciplinary and reference team in the management of BDI patients.

This book depicts the basic aspects of all surgeries for kidney transplantation in both adults and children, including procurement of kidney, preparation of the kidney graft, vessel reconstruction, kidney implantation in various conditions and the diagnosis and management of surgical complications post-transplant. This book also describes the surgery for kidney transplant with abnormal lower urinary tract; the surgery for third or subsequent kidney transplant and the surgery for transplant nephrectomy by the extra capsule or intra capsule technique. Furthermore, it has been emphasized that early recognition of vascular complications is critical in order to avoid the kidney graft loss. This book provides numerous images to illustrate the abnormal findings during the investigation of kidney graft, in order to facilitate prompt diagnosis and management of post-transplant complications. Moreover, the different techniques in management of urological complications are discussed such as Boari flap urinary tract reconstruction. This book also introduces advanced laparoscopic surgery for kidney implantation. The authors share their experiences in developing the large animal training model and early clinical experience. Importantly, editors invited Professor Modi to contribute to the chapters on laparoscopic kidney transplant and robotic kidney transplant. Professor Modi is a well-known pioneer in advanced laparoscopic kidney transplant and robotic kidney transplant. Last but not least, the assessment of live kidney donor has been thoroughly discussed based on the review of the guidelines from a few societies. The surgery for donor nephrectomy by either transperitoneal or retroperitoneal approach has been well illustrated in details with pictures. This book is written based on the authors' 20 years' experience in kidney transplantation. It is hoped to be helpful for transplant fellows and junior transplant surgeons.

‘Jauhar weaves his own personal and family story into his history of the heart…very effectively… This gives a certain dramatic tension to the book, as it tells the fascinating and rather wonderful history of cardiology.’ –Henry Marsh, New Statesman

A Mail on Sunday Book of the Year

The heart lies at the centre of life. For cardiologist Sandeep Jauhar it is an obsession.

In this fascinating history he interweaves gripping scenes from the operating theatre with the moving tale of his family’s history of heart problems – from the death of his grandfather to the ominous signs of how he himself might die.

Jauhar looks at the pioneers who risked patients’ lives and their own careers, and confronts the limits of medical technology, arguing that how we live is more important than any device or drug we may invent. Heart is the all-encompassing story of the engine of life.

When Joseph Murray performed the first successful living kidney donor transplant in 1954, he thought this would be a temporary stopgap. Today, we are no closer to the goal of adequate organ supply without living donors-if anything, the supply-demand ratio is worse. While most research on the ethics of organ transplantation focuses on how to allocate organs as a scarce medical resource, the ethical treatment of organ donors themselves has been relatively neglected. In The Living Organ Donor as Patient: Theory and Practice, Lainie Friedman Ross and J. Richard Thistlethwaite, Jr. argue that living donor organ transplantation can be ethical provided that we treat living solid organ donors as patients in their own right. Ross and Thistlethwaite develop a five-principle framework to examine some of the attempts to increase living donation. It uses the three principles of the Belmont Report: respect for persons, beneficence, and justice modified to organ transplantation, as well as the principles of vulnerability and special relationships creating special obligations. Their approach requires that the transplant community fully embrace current and prospective living organ donors as patients to whom we have special obligations. Only when living organ donors are regarded as patients in their own right and have a living donor advocate team dedicated to their well-being can the moral limits of living solid organ donation be realized and living donors be given the full respect and care they deserve.