In about 5% of all organ (kidney, liver) transplant recipients, malignancies occur as a late complication of the massive immunosuppression. The malignancies are mainly skin cancers, lymphomas and renal carcinomas. The present book discusses the possible mechanisms of this type of tumorigenesis and inquires into possibilities of prevention. In particular, the described malignancies might be of viral origin. The book informs about a completely new type of carcinogenesis. Apart from the scientific aspects, it is of great practical value.

Provides transplant professionals with a step-wise approach to abdominal organ retrieval and bench surgery, illustrating complex anatomical situations and providing practice points and decision algorithms. A go-to reference for transplant surgeons, trainees and fellows, as well as for other professionals involved in abdominal organ transplantation.

In man and some of the apes, the thumb has the function of a contra finger. This function is made possible by a great freedom of movement of the first metacarpal and a highly developed and differentiated thumb musculature. The grasp function of the hand is dependent on the oppositional capacity and adductive power of the thumb, and is severely limited by a paralysis or dysfunction of the intrinsic thumb muscles. Whereas loss of the function of the adductor pollicis can be partially compensated for by the adductive action of the extensor pollicis longus, in paralysis or dysfunction of the radial thenar muscles compensation can only be provided by surgery. Since 1918, many methods of tendon transfer have been described for the restoration of thumb opposition, all of which bring about an improvement of the grasp function, albeit to different degrees. These methods vary in the selection of the motor, the direction of pull of the tendon, the use of a fulcrum, and the mode of insertion. The highly effective method of Bunnell (1938) is often used as the standard procedure. With this method, the flexor superficialis tendon of the ring finger is looped around the tendon of the flexor carpi ulnaris and passed subcutaneously across the thenar eminence, after which it is fixed on the thumb at the level of the metacarpo-phalangeal joint."

Whether you need to manage a post-transplant infection or reduce the possibility of infection, you will find effective guidance in this handbook. The work of the American Society of Transplantation Infectious Diseases Community of Practice, this reference exclusively uses tables and flowcharts to speed up decision making. This distinguished group of investigators and teachers provide point of care information on optimum management of infection in adult and pediatric organ and stem cell transplant patients. The unique tables and flowcharts are devised by the authors, backed up with extensive references, making the book a fully researched yet easy to use guide. The fast growing specialty of transplantation will be well served by this book as increasing numbers of successful procedures mean transplant teams have to be ever more alert to the possibility of and need for action in the event of ensuing infection.

Produced in association with the American Society of Transplantation, this new edition is full of practical advice for the next generation of transplant professionals. In addition to 5 organ-specific chapters: kidney, pancreas, heart, lung and liver, the book includes essential information on: * immunobiology * pharmacology * donor management * infectious complications * pediatric transplantation * general principles of patient management Fully updated and redesigned to make it even more user-friendly, the book now contains clinical vignettes, key point boxes, and self-assessment multiple choice questions in each chapter. Primer on Transplantation, Third Edition is an invaluable resource for all health professionals in the transplant team including trainees, residents, fellows, physicians, surgeons, nurses and transplant co-ordinators. Purchasing this book entitles you to access to the companion website: www.astprimer.com The website includes: * Interactive Multiple-Choice Questions for each chapter * Figures from the book as Powerpoints for downloading * All chapters online

A history of the little-known or forgotten academic origins of modern organ transplant surgery. This book investigates a crucial -- but forgotten -- episode in the history of medicine. In it, Thomas Schlich systematically documents and analyzes the earliest clinical and experimental organ transplant surgeries. In so doing helays open the historical origins of modern transplantation, offering a new and original analysis of its conceptual basis within a broader historical context. This first comprehensive account of the birth of modern transplantmedicine examines how doctors and scientists between 1880 and 1930 developed the technology and rationale for performing surgical organ replacement within the epistemological and social context of experimental university medicine. The clinical application of organ replacement, however, met with formidable obstacles even as the procedure became more widely recognized. Schlich highlights various attempts to overcome these obstacles, including immunologicalexplanations and new technologies of immune suppression, and documents the changes in surgical technique and research standards that led to the temporary abandonment of organ transplantation by the 1930s. Thomas Schlichis Professor and Canada Research Chair in the History of Medicine at McGill University.

The first basic overview of all aspects of transplantation with a clarity not to be found in more inaccessible textbooks. This brand new title provides a succinct overview of both the scientific and clinical principles of organ transplantation and the types of organ transplant, featuring highly-illustrated information covering core topics in transplantation including: * Organ donors * Organ preservation * Assessment of transplant recipients * Indications for transplantation * Immunology of transplantation * Immunosuppression and its complications * Overviews of thoracic and abdominal organ transplantation, including the kidneys, liver, heart and lungs Transplantation at a Glance is the ideal introduction for medical students, junior doctors, surgical trainees, immunology students, pharmacists, and nurses on transplant wards.

Whilst activities like transplantation and medical research have typically been considered on a discrete basis, they are also actually part of a broader phenomenon of medical means being employed to make use of human beings. This book is the first ever systematic critique of such medical use of the human being as a whole. It is divided into two parts. The first part considers what constitutes an appropriate normative lens through which to view such medical use and its constraint. It makes a reasoned ethical and human-rights-based case for preferring respect for human worth over any of the main alternative approaches that have been drawn on in specific contexts and outlines what this preference practically implies. The second part uses this respect-based lens to critique use discourse, law and practice. Drawing on three contrasting case study areas of warfare-related medical use, transplantation and human tissue research, this book exposes both the context-specific and thematic nature of shortfalls in respect. Overall this book provides a compelling analysis of how medical use ought to be constrained and a compelling critique of the excesses of discourse, practice and governance. It is recommended to academics, students, policymakers and professionals whose work is focused on or intersects with the medical sector and anyone else with an interest in medicine and its limits.

The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed.

This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, for example xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book presents much new and exciting work in this field and identifies promising new research directions.

A comprehensive text from the leading transplant centres on the medical management of thoracic organ transplantation, covering the assessment of patients for possible transplantation, through to managing patients after transplantation including any possible complications and shared care aspects of long term management

From humble beginnings as a `barefoot boy' in a small town in the heart of South Africa, he learned to mix with presidents and prime ministers, with royalty and popes, and quickly embraced the high-life of the jet-set who surrounded him. Throughout life, he was a serial womanizer, bedding famous European film stars (and their secretaries). He survived three tempestuous marriages and divorces, each wife becoming younger than the last until their age difference reached 40 years. This scientifically-trained surgeon called on the services of a `witchdoctor' (a sangoma)-unsuccessfully-to help punish those who had contributed to the break-up of his second marriage. With no experience himself, he trained his daughter to become the second-ranked water skier in the world, though he was disappointed she never became world champion. Perhaps the immense effort he put into driving her to success accounted for the relative neglect of his oldest son, who, as a young doctor, suffered increasing depression until he died of a drug overdose at an early age. The surgeon pursued his goals in heart surgery despite a lifetime of pain from arthritis and a disability from asthma, which might eventually have killed him. Having established the first major heart surgery programme in Africa, he eventually became distracted by other interests until he was a mere shadow in his own department. Yet he remained in the public eye through his gifts for public speaking and as a writer. He travelled the world, published two autobiographies, wrote popular books on health for the public, particularly relating to heart disease and arthritis, and penned books on such varied subjects as the politics of apartheid in his homeland, and euthanasia. He became a well-regarded and popular columnist for several South African newspapers, and collaborated on the writing of four novels. He branched into the business world and expanded the meagre financial rewards earned from his surgical services to the South African health care system by investing in restaurants in Cape Town, establishing a game reserve in the hinterland of South Africa, and causing controversy by his role in advertising a cream that reputedly prevented wrinkling of the skin. He set up a heart research foundation and a foundation that paid for children from all over the world to travel to Cape Town for corrective open heart surgery. This charismatic and controversial man was Chris Barnard who, by the way, also dared to carry out the world's first human heart transplant in December 1967. Can we summarize Chris Barnard? Not very easily. He was a first-class doctor-skilled, knowledgeable, compassionate, conscientious, concerned, decisive, and wise. He was an inquiring and innovative surgeon-though famously irascible in the operating room-with a vision of the future developments in his chosen field, and the ability, judgment, and courage to play a part in contributing to those developments. He was an informative and highly entertaining speaker and raconteur, a gifted writer, farmer, restaurateur, an unofficial ambassador for his country-and a good friend.

This issue of Medical Clinics of North America, guest edited by Drs. David A. Sass and Alden M. Doyl, is devoted to Care of the Liver and Kidney Transplant Recipient. Articles in this issue include: Liver and kidney transplantation: a half-century historical perspective; From Child's-Pugh to MELD: Deciding who really needs a liver transplant; When to consider renal transplantation in your advanced CKD patients; Management of the liver transplant recipient: approach to allograft dysfunction; Acute and chronic allograft dysfunction in renal transplant recipients; The ABC's of Immunosuppression: a primer for the primary care physician; Managing cardiovascular risk in the post solid organ transplant recipient; Diabetes care after transplant: definitions, risk factors, and clinical management; De novo malignancies after transplantation: risk and surveillance strategies; Metabolic bone disease in the post-transplant population: preventative and therapeutic measures; Infectious complications and vaccinations in the post-transplant population; Selection and post-operative care of the living donor; and Long-term functional recovery, quality of life and pregnancy following solid organ transplantation.

Rikki and her sister, Linda, fell out with one another four months ago. They are not speaking when Linda emails that she has lethal abdominal tumors, that her only hope of survival is a total bone marrow replacement. Linda claims Rikki is too old to donate, and explains there's only a slight chance she is a good match anyway-but Rikki refuses to accept that. Despite the wounding between them, Linda's email ignites a wild aspiration in her sister: she will become the perfect donor, the perfect match, with the healthiest, most vigorous cells possible. She rises with intent to heal herself, her sister, and their rootlines, the patterns formed in their family of origin that have quietly shaped their lives. Rikki walks through the science while confronting dogma that limits how mind can transform body. She builds herself into a stem cell factory using Muay Thai kickboxing and vegetarian nutrition. Working through childhood wounds and mental limits with meditation and yoga, she finds her own power, as well as ways to show up for Linda and walk with her from the edge of death to a new life. Together, the two sisters beat the lymphoma-and, as they rediscover the intimacy and love of their innocent childhood, heal the intertwined roots of their family pain.

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.

Intestinal transplantation remains on the cutting edge of solid organ transplantation. Each potential recipient provides a unique case of intestinal failure with individual intricacies requiring the combined efforts of a complex multidisciplinary team in order to achieve success. Contemporary Small Bowel Transplantation covers all aspects of intestinal transplantation in a manner accessible to all providers and provides specific guidance for those that may come in contact with this field and these patients. The text provides an understanding of the critical pre-operative evaluation, thorough descriptions of each surgical procedure and postoperative management. Areas such as infectious disease, nutrition and graft versus host disease will be addressed in detail. Key controversies and administrative issues unique to intestinal transplantation are covered. Contemporary Small Bowel Transplantation provides critical guidance for the new transplant surgeon, gastroenterologist or administrator as they navigate the challenging field of intestinal transplantation.

This book depicts the basic aspects of all surgeries for kidney transplantation in both adults and children, including procurement of kidney, preparation of the kidney graft, vessel reconstruction, kidney implantation in various conditions and the diagnosis and management of surgical complications post-transplant. This book also describes the surgery for kidney transplant with abnormal lower urinary tract; the surgery for third or subsequent kidney transplant and the surgery for transplant nephrectomy by the extra capsule or intra capsule technique. Furthermore, it has been emphasized that early recognition of vascular complications is critical in order to avoid the kidney graft loss. This book provides numerous images to illustrate the abnormal findings during the investigation of kidney graft, in order to facilitate prompt diagnosis and management of post-transplant complications. Moreover, the different techniques in management of urological complications are discussed such as Boari flap urinary tract reconstruction. This book also introduces advanced laparoscopic surgery for kidney implantation. The authors share their experiences in developing the large animal training model and early clinical experience. Importantly, editors invited Professor Modi to contribute to the chapters on laparoscopic kidney transplant and robotic kidney transplant. Professor Modi is a well-known pioneer in advanced laparoscopic kidney transplant and robotic kidney transplant. Last but not least, the assessment of live kidney donor has been thoroughly discussed based on the review of the guidelines from a few societies. The surgery for donor nephrectomy by either transperitoneal or retroperitoneal approach has been well illustrated in details with pictures. This book is written based on the authors' 20 years' experience in kidney transplantation. It is hoped to be helpful for transplant fellows and junior transplant surgeons.

With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area. Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation. Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field. Key chapters include: * Transplant-related complications * Immune responses to transplants * Emerging issues in transplantation * Biomarkers of Allograft rejection and tolerance * T cells and the principles of immune responses In full colour throughout, over 100 outstanding diagrams support the text, all figures being fully downloadable via the book's companion website. The result is an essential tool for all those responsible for managing patients awaiting and undergoing organ transplantation, including transplant surgeons and clinicians, immunologists and researchers.

"Regenerative Medicine Applications in Organ Transplantation" illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine.

Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results.
Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant communityIllustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions

This issue of "Progress in Brain Research" is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.
Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

This book is the first to provide a thorough overview of the experience of pancreas transplantation in Asian countries, including in particular Korea, Taiwan, and Japan. Recent trends are identified and attention drawn to differences in comparison with the United States and Europe. Such differences relate, for example, to the history of pancreas transplantation, the operative procedure, and the organ-sharing system. In addition, the insulin-secreting ability of pancreatic islet cells is thought to vary depending on race. Beyond these aspects, the coverage also encompasses ABO-incompatible living donor pancreas transplantation, which is very rarely performed elsewhere in the world. By introducing the number, technique, and outcomes of pancreas transplantation in Asian countries, the book will hopefully further stimulate the pancreas transplantation program in this region and beyond. It will be of value for all medical professionals in the field and will be informative for diabetic patients receiving insulin treatment in Asia.

This concise, accessible book covers anesthesia for hepatico-pancreatic-biliary (HPB) surgery and transplantation, based on randomized clinical trials, meta-analyses, case series, reports, and hands-on experience. The anatomy, physiology, pathophysiology and clinical consequences are discussed, and the close ties between HPB resection and transplant anesthesia are explored. The content reflects current real-world practice, as liver and pancreatic transplant surgeries have substantially improved in terms of blood-loss reduction, fast tracking and reduced risk. The book also addresses anesthetic aspects in connection with the recently introduced and rapidly expanding practice of laparoscopic surgery; with enhanced recovery; and with pancreatic surgery. Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation is intended for aspiring HPB and transplant anesthetists, anesthesia trainees, and consultants with experience in HPB anesthesia who want to see whether or not they're up to date on the current standards.

There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy.
Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier.
The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices.
- Provides detailed description of clinical trials in cell transplantation
- Review of current therapeutic approaches
- Coverage of the broad range of diseases addressed by cell therapeutics
- Discussion of stem cell biology and its role in transplantation

Over the past decade, there has been rapid growth in bioengineering applications in the field of spine implants. This book explains the technical foundation for understanding and expanding the field of spine implants, reviews the major established technologies related to spine implants, and provides reference material for developing and commercializing new spine implants. The editors, who have a track record of collaboration and editing technical books, provide a unified approach to this topic in the most comprehensive and useful book to date.
-Related website provides the latest information on spine technology including articles and research papers on the latest technology and development.
-Major technologies reviewed include devices used for fusion (screws, plates, rods, and cages), disc repair and augmentation, total disc replacement, and vertebral body repair and augmentation.
-Technology landscape, review of published/public domain data currently available, and safety and efficacy of technology discussed in detail.