This book provides a comprehensive review of ethical issues in clinical nephrology. With the advent of dialysis and kidney transplantation midway through the 20 Century, clinical nephrology was one of the first areas of medicine to deal with complex ethical issues such as rationing of health care and discontinuation of life-sustaining therapy. In the first section of the book this historical perspective is reviewed, followed by a consideration of legal issues. Specific ethical issues in nephrology are discussed in detail in the next section. These include problems in the allocation of chronic dialysis and in termination of that treatment. Also reviewed are issues in kidney transplantation, such as proposals for enhanced acquisition of kidneys, including a number of controversial proposals such as payment to donors and xenotransplantation; and equity in allocation of the supply of kidneys. Other chapters consider ethical issues in genetics; special problems in the care of children with kidney disease; and broad societal issues such as allocation of national resources for expensive therapies and economic issues in clinical practice. In the final part of the book ethical issues in the care of patients with kidney disease are discussed from an Asian and African perspective.

As the number and types of pediatric transplants increase and the complexity of chemotherapy regimens continues to evolve, there is a greater need for authoritative guidance, clinically actionable strategies, and easy-to-find information in the challenging area of immunocompromised pediatric patients. Pediatric Transplant and Oncology Infectious Diseases offers up-to-date, targeted coverage of this complex field, compiled by world-renowned editors and authors into one convenient volume. Covers the must-know principles for diagnosing and managing opportunistic infections in immunocompromised populations and detailed aspects of their care - information not specifically covered in pediatric infectious disease textbooks or pediatric oncology books. Features algorithms in every chapter that provide visual, accessible overviews of treatment protocols. Discusses key topics such as microbiome implications in transplantation and oncology, antimicrobial resistant Gram-negative bacteria, EBV-associated post-transplant lymphoproliferative disorders, and many others. Offers well-referenced, evidence-based content throughout, with targeted suggested readings provided. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Comprehensively addressing the topic of the compartment syndrome, this book covers all aspects of this painful and complex condition, ranging from the history to the pathophysiology and treatment in the various body compartments affected by the syndrome, as well as the short- and long-term outcomes. With an up-to-date literature review and the innovative content written by international opinion leaders, it offers all involved in the management of such complicated patients a much-needed source of reference. Discussing compartment syndrome in everyday practice, this book is of interest to surgeons, practicing physicians, anesthesiologists and nurses.

This title includes proceedings of the International Congress held in Chamrousse (France), 1-2 February 1991.

This concise, accessible book covers anesthesia for hepatico-pancreatic-biliary (HPB) surgery and transplantation, based on randomized clinical trials, meta-analyses, case series, reports, and hands-on experience. The anatomy, physiology, pathophysiology and clinical consequences are discussed, and the close ties between HPB resection and transplant anesthesia are explored. The content reflects current real-world practice, as liver and pancreatic transplant surgeries have substantially improved in terms of blood-loss reduction, fast tracking and reduced risk. The book also addresses anesthetic aspects in connection with the recently introduced and rapidly expanding practice of laparoscopic surgery; with enhanced recovery; and with pancreatic surgery. Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation is intended for aspiring HPB and transplant anesthetists, anesthesia trainees, and consultants with experience in HPB anesthesia who want to see whether or not they're up to date on the current standards.

This book presents the first comprehensive review of all facets of liver transplantation using DCD donors. Each of the 19 chapters are written by leading experts in the field, representing some of the most experienced DCD liver transplant programs in the world. Several topics have overlapping coverage in different chapters, providing the reader with the perspective of multiple experts on crucial topics. Chapters also highlight the steps towards building a DCD liver transplant program, the importance of donor and recipient selection, as well as state-of-the-art developments and future directions in the utilization of these organs. Donation after Circulatory Death (DCD) Liver Transplantation serves as a valuable resource for all those involved in liver transplantation using DCD donors.

This updated volume gives a clear description of transplantation surgery and covers the recent developments and innovations that have occurred within the field. New chapters on the management of graft dysfunction, organ preservation, new immunosuppressive drugs, molecular medicine and transplantation, robotics in transplantation, and organ bio-engineering are included. The book aims to be an authoritative guide to transplantation surgery that will help improve the likeliness of procedures being successful. This book will be relevant to transplant surgeons, physicians, and nephrologists.

This text serves as a convenient one-stop resource on the pathogenesis, diagnosis and treatment of kidney diseases in context of advanced heart failure and presence of ventricular assist devices. Advances in managing heart failure, evidence-based practices and therapies are covered, along with the management of this unique and complex subset of patients. The book also provides insights into combined heart and kidney transplantation. Authored by leaders in nephrology, cardiology and transplantation, this book fills a critical knowledge gap in understanding and treating patients with acute or chronic dysfunction of the heart and kidneys and how one induces dysfunction in the other organ.

The author of the New York Times bestseller Broken Open returns with a visceral and profound memoir of two sisters who, in the face of a bone marrow transplant-one the donor and one the recipient-begin a quest for acceptance, authenticity, and most of all, love. A mesmerizing and courageous memoir: the story of two sisters uncovering the depth of their love through the life-and-death experience of a bone marrow transplant. Throughout her life, Elizabeth Lesser has sought understanding about what it means to be true to oneself and, at the same time, truly connected to the ones we love. But when her sister Maggie needs a bone marrow transplant to save her life, and Lesser learns that she is the perfect match, she faces a far more immediate and complex question about what it really means to love-honestly, generously, and authentically. Hoping to give Maggie the best chance possible for a successful transplant, the sisters dig deep into the marrow of their relationship to clear a path to unconditional acceptance. They leave the bone marrow transplant up to the doctors, but take on what Lesser calls a "soul marrow transplant," examining their family history, having difficult conversations, examining old assumptions, and offering forgiveness until all that is left is love for each other's true selves. Their process-before, during, and after the transplant-encourages them to take risks of authenticity in other aspects their lives. But life does not follow the storylines we plan for it. Maggie's body is ultimately too weak to fight the relentless illness. As she and Lesser prepare for the inevitable, they grow ever closer as their shared blood cells become a symbol of the enduring bond they share. Told with suspense and humor, Marrow is joyous and heartbreaking, incandescent and profound. The story reveals how even our most difficult experiences can offer unexpected spiritual growth. Reflecting on the multifaceted nature of love-love of other, love of self, love of the world-Marrow is an unflinching and beautiful memoir about getting to the very center of ourselves.

As there is a high incidence of disease recurrence after liver transplantation, this volume is designed around the need for a reference text dealing exclusively with this problem. The book places special emphasis on pre- and post-transplant predictors of recurrence, severity assessment, prophylaxis, and treatment. Pathobiology of disease recurrence is discussed in detail where applicable. Issues including quality of life and cost burden are also covered in the text. Written by well-known authorities in each field, Disease Recurrence After Liver Transplantation: Natural History, Treatment and Survival serves as a comprehensive reference for physicians and surgeons who take care of liver transplant recipients and a major addition to the literature detailing the current understanding of disease recurrence.

Although cardiac surgery has made an enormous progress during the last decades, the discipline has to cope with essential changes: Patients are increasingly cared for by cardiologists and therefore referred to the surgeon in a later stage of disease. Consequently, they are more often in an increasingly serious state or in advanced age with significant comorbidities. In order to meet the requirements of these different patient groups, cardiosurgical treatments require special protectional strategies for the heart in order to perform the planned operations safely. This book presents the latest knowledge of modern techniques of myocardial protection taking into consideration the different patient groups and current scientific strategies. Furthermore, it discusses present and future scientific approaches in myocardial protection and preservation.

Written by internationally acclaimed specialists, Cardio-Thoracic, Vascular, Renal and Transplant Surgery provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume Cardio-Thoracic, Vascular, Renal and Transplant Surgery provides a valuable resource for all general surgeons and residents in training. Other healthcare providers will also find this a useful resource.

The transplant physicians and surgeons at Cleveland Clinic have collaborated to produce, Kidney and Pancreas Transplantation: A Practical Guide. This volume is devoted to kidney and pancreas transplantation and is well grounded in scientific principles, quantitative clinical reasoning, clinical pharmacology, tested clinical practices and overall clinical applicability. Also addressed are key aspects in the initiation, maintenance and sustained growth of viable clinical programs in kidney and pancreas transplantation. Kidney and Pancreas Transplantation: A Practical Guide will be of great value to transplant physicians as well as medical and surgical fellows who intend to pursue an interest in transplantation.

This book is based on the latest comprehensive data about molecular mechanism of acute pancreatitis, chronic pancreatitis and pancreatic cancer. The diagnostic techniques including histology, radiology, sonography etc. are based on the sensitivity and specificity of the respective methods. Special focus is given to the indication and contraindication to surgical techniques. The book contains specific treatment modality and results for the first time after long-term outcome evaluation. There is detailed description of diagnosis and treatment, and the book is abundantly illustrated with approximately 300 color illustrations.

This book discusses the effects of emerging technologies on surgeons and surgical practice. The book opens with an overview of disruptive technologies, and their economic, scientific, ethical and social implications. Next comes a section describing how the Internet, virtual reality and simulation technology will change training and education. A section on Robotics covers computer-guided surgery, robotics and endoluminal therapies. Innovations in surgical instruments, including MEMS and Nanotechnology are outlined, as well. Next, the book reviews tissue engineering and artificial organs, genetic engineering, stem cells, emerging transplantation technologies and the brain-machine interface. A concluding section discusses ways of adapting to future technologies.

This beautifully illustrated monograph provides an up-to-date and comprehensive overview about all fields of liver and biliary tract surgery and liver transplantation. It consists of four sections with 48 chapters: Section I: Anatomy, physiology, imaging and general principles, Section II: Biliary tract surgery, Section III: Liver surgery and Section IV: Liver transplantation. The book includes more than 500 figures and illustrations mostly in color. Some of the topics such as computer assisted surgery planning are treated comprehensively for the first time. The book is written in a concise and well conceived way.

Liver Anesthesiology and Critical Care Medicine emphasizes all aspects of this broad and important area and is the definitive textbook for anybody involved in the perioperative care of liver patients. The book is divided into three sections: Physiology and Pathophysiology, Anesthesiology, and Critical Care Medicine. The anesthesiology section contains information about liver transplantation and other liver surgeries and provides detailed practical direction and concise background information of all aspects of the anesthetic management of these patients based on the most recent evidence. The critical care section describes basic critical care management as it relates to liver surgical patients and addresses specific postoperative issues relevant for liver resection and liver transplant patients. The book combines practical guidance to the perioperative management with extensive background and clinical evidence to allow the reader gain an in -depth understanding of this complex and fascinating topic.

Computer-Assisted Surgery (CAS) is a new tool for performing complex procedures in a predictable and safe way. This book is designed to serve as a comprehensive review of Computer-Assisted Surgery, covering the current status of both research and applications. CAS includes Virtual Preoperative Planning (VPP) and Intraoperative Virtual Navigation (IVN), which are a set of technologies used to measure oncological margins in 3-Dimensions (3D), to locate small intraosseous tumors and apply controlled resections preserving anatomical structures. During VPP, patient acquired multimodal images are processed and an interactive virtual scenario is created. This can then be used as a platform to measure oncological distances and preplan osteotomies in safe areas. IVN is a procedure which allows the execution of the VPP with a mean error of less than 3mm. For the student, medical doctors, research and development scientists or new researchers, the protocols are central to the performance of Computer-Assisted technologies.

This book addresses important biomaterials which are commonly used to fabricate scaffolds and it describes two major protocols employed in scaffold fabrication. Tissue engineering or regenerative medicine aims at restoring ex-novo tissues and organs whose functionality has been compromised as a consequence of diseases or traumatic events. The innovative concept underlying tissue engineering is the use of autologous cells, obtained from a biopsy of the patient. Cells are seeded on a porous scaffold which has the role of supporting and guiding cells towards the development of tissue-like structures as well as providing a platform for the delivery under controlled condition of growth factor release, etc. The successful manufacture of scaffolds for tissue engineering applications is crucial. In this book, these biomaterials are discussed. The book also covers illustrated examples, structure and properties of scaffolds, cellular interactions and drug delivery.

Written by leaders in the field, the third edition of Common Surgical Diseases: An Algorithmic Approach to Problem Solving, provides surgical residents and medical students with a current, concise and algorithmic approach to frequently encountered clinical challenges. Each chapter details every common surgical disease in the form of a succinct text coupled with step-by-step algorithm. It also walks the reader through the evaluation, diagnosis, treatment and follow-up of the most common surgical problems. Thoroughly updated and revised, the third edition focuses on problems most frequently encountered by general surgeons and their residents and students. More factual information is included in the form of charts and tables for quick and easy reference. The section on critical care is updated and expanded. The section on pre-operative considerations has new chapters on how to best manage patient's medications before surgery (anticoagulants, anti-platelet drugs) and prophylaxis of deep venous thrombosis. Other new chapters include access for hemodialysis, adrenal incidentaloma, esophageal cancer, pancreatic cancer, management of abdominal wall defects, hyperglycemia, necrotizing soft tissue infections and SIRS/sepsis. Especially pertinent in todays' medical environment is an understanding of the genetic component of certain cancers and chapters are devoted to screening and treating patients with genetic predispositions to colorectal and breast cancer.

The 5th International Symposium on Artificial Heart and Assist Devices was held in Tokyo on January 26 - 27, 1995, bringing together leading researchers and specialists from all over the world. The proceedings of the symposium presents the newest ideas and approaches in the field, and will be of special interest and relevance to all who are concerned with artificial organs, cardiovascular surgery, organ transplantation, biomaterials, and related disciplines. Reflecting the content of the symposium, the major topics in this volume include biocompatible material development, clinical use of assist devices, completely implantable devices, and heart transplantation. These are presented in the two main divisions of the book: The first consists of eight lectures by leading researchers, world-renowned in the field of the artificial heart. The second comprises more than 50 papers on such subjects as biomaterials, research and development of ventricular assist systems and the total artificial heart, and their use as a bridge to heart transplantation. An additional, special feature of the book is the inclusion of descriptions of exhibitions at the symposium, with photographs of all artificial heart devices and systems displayed by major laboratories and companies from around the world.

In December, 1966, two patients dying of months after the transplants had been per uremia as a result of diabetic kidney disease formed. This was long enough, however, to were offered a small chance of survival. Ac establish unequivocally in both patients cording to the thinking of the time, it was that an endocrine organ, the pancreas, could inappropriate-and perhaps even unethical function normally and for many days as a to offer them either chronic hemodialysis or human-to-human graft. The patients had kidney transplantation. These were considered become normoglycemic independent of insulin a waste of effort because it was believed that injections. scarce medical resources should not be spent The possible long-term benefits of restoring on patients, uremic or not, whose chances of insulin function were hotly argued then, and surviving for more than a few months were they have not been fully determined 20 years thought to be very small. Reduced to its later. It seems to me now, however, that the essence, the idea was that diabetic patients basic premise is sounder than I realized in were terrible risks and would remain so even if 1966: if one could restore an effective, norm the uremia were corrected."

Nitric Oxide in Transplant Rejection and Anti-Tumor Defense represents a unique combination of three interrelated topics that is unavailable in any other single work: * The detection and visualization of nitric oxide in biological materials using EPR spectroscopy and EPR imaging; * Nitric oxide in immune mechanisms of allograft rejection; and * The involvement of nitric oxide in anti-tumor defense. By bringing together specialists from these three disciplines, the book investigates the common molecular and cellular mechanisms underlying phenomena in transplants and oncology. In addition, the book provides an introduction to biological applications of EPR spectroscopy and imaging. Nitric Oxide in Transplant Rejection and Anti-Tumor Defense will appeal to researchers and graduate-level students investigating transplant rejections and their immune mechanisms, anti-tumor immune defenses, novel types of contrast agents for EPR imaging, and biological applications of EPR spectroscopy and EPR imaging.

This is an essential guide to the data, basic science, outcome studies and decision-making processes involved in blood and marrow stem cell transplantation. Organized according to disease types and procedures, it contains more than 100 tables, figures and algorithms that reflect up-to-date research and give guidance on the choices between different types of chemotherapy, autologous vs. allogeneic transplantation, peripheral blood vs. bone marrow stem cells, and standard vs. experimental treatments. This new edition summarizes the research of the last four years and gives mature data for all established indications, such as acute myeloid leukemia, myelodysplastic syndrome and Hodgkin and non-Hodgkin lymphomas. New chapters discuss global trends in stem cell transplantation, cellular therapies including donor lymphocytes, and pediatric neurologic and metabolic disorders. With an expanded complications section, links to electronic databases and discussion of new drugs and alternative stem cell sources, this text belongs in every transplant unit.