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Books > Medicine > Surgery > Transplant surgery
Vir die vroue wat hy met sy rolprentsterglimlag betower het, was Chris Barnard ’n hartebreker. Vir sy pasiënte ’n harteheler.
Dié nuwe biografie oor Suid-Afrika se beroemdste hartsjirurg vertel nie net van Barnard se kinderjare in Beaufort-Wes, sy prominente huwelike (en egskeidings) en flambojante lewe nie. James Styan ondersoek ook die impak van die historiese eerste hartoorplanting op Barnard se persoonlik lewe en op die Suid-Afrikaanse gemeenskap in die algemeen, waar apartheidswetgewing dikwels die probleme van geneeskunde nog ingewikkelder gemaak het. Die rol van swart mediese personeel soos Hamilton Naki word bespreek, sowel as die intense wedywering wat tussen ander beroemde hartsjirurge en Barnard ontstaan het.
Hoe het Barnard dit reggekry om hulle almal in dié resies om lewe en dood te wen? Hoeveel het sy welbekende sjarme daarmee te doen gehad? En wat is Barnard se nalatenskap vandag, in die lig van sy latere suksesse en aansienlike mislukkings? Styan dek dit alles in dié fassinerende nuwe blik op Chris Barnard wat uitgegee is om saam te val met die 50ste herdenking van die eerste hartoorplanting.
Techniques in Revision Hip and Knee Arthroplasty is the one
authoritative volume that gives you an efficient, problem-based
approach to revision arthroplasty of both the hip and knee. Dr.
Giles Scuderi and other leading experts from North America and
Western Europe present their favored surgical procedures and
post-surgical management strategies in this straightforward,
heavily illustrated, video-intensive reference. It's your one-stop,
go-to guide for successful revision surgery for a myriad of
complications, such as implant loosening, polyethylene wear,
osteolysis, or infection of the hip and knee. Get expert guidance
on implant choice, management of complications (including infection
and wound healing), and failure of mechanisms, as well as
step-by-step surgical techniques. Quickly find the exact
information you need with a straightforward "just what you need to
know" approach, including surgical tips and pearls. Stay up to date
with new insights regarding anatomic landmarks, recommended
reconstruction options in revision surgery, including management of
bone defects and instability. Access the fully searchable contents
of the book and an abundance of surgical videos online at Expert
Consult.
In the late 1980s, a promising new treatment for breast cancer
emerged: high-dose chemotherapy with autologous bone marrow
transplantation or HDC/ABMT. By the 1990s, it had burst upon the
oncology scene and disseminated rapidly before having been
carefully evaluated. By the time published studies showed that the
procedure was ineffective, more than 30,000 women had received the
treatment, shortening their lives and adding to their suffering.
This book tells of the rise and demise of HDC/ABMT for metastatic
and early stage breast cancer, and fully explores the story's
implications, which go well beyond the immediate procedure, and
beyond breast cancer, to how we in the United States evaluate other
medical procedures, especially life-saving ones.
It details how the factors that drove clinical use--patient
demand, physician enthusiasm, media reporting, litigation, economic
exploitation, and legislative and administrative
mandates--converged to propel the procedure forward despite a lack
of proven clinical effectiveness. It also analyzes the limited
effect of technology assessments before randomized clinical trials
evaluated decisively the procedure and the ramifications of this
system on healthcare today.
Sections of the book consider the initial conditions surrounding
the emergence of the new breast cancer treatment, the drivers of
clinical use, and the struggle for evidence-based medicine. A
concluding section considers the significance of the story for our
healthcare system.
In Death, Dying, and Organ Transplantation: Reconstructing Medical
Ethics at the End of Life, Miller and Truog challenge fundamental
doctrines of established medical ethics. They argue that the
routine practice of stopping life support technology in hospitals
causes the death of patients and that donors of vital organs
(hearts, lungs, liver, and both kidneys) are not really dead at the
time that their organs are removed for life-saving transplantation.
These practices are ethically legitimate but are not compatible
with traditional rules of medical ethics that doctors must not
intentionally cause the death of their patients and that vital
organs can be obtained for transplantation only from dead donors.
In this book Miller and Truog undertake an ethical examination that
aims to honestly face the reality of medical practices at the end
of life. They expose the misconception that stopping life support
merely allows patients to die from their medical conditions, and
they dispute the accuracy of determining death of hospitalized
patients on the basis of a diagnosis of "brain death" prior to
vital organ donation. After detailing the factual and conceptual
errors surrounding current practices of determining death for the
purpose of organ donation, the authors develop a novel ethical
account of procuring vital organs. In the context of reasonable
plans to withdraw life support, still-living patients are not
harmed or wronged by organ donation prior to their death, provided
that valid consent has been obtained for stopping treatment and for
organ donation.
Recognizing practical difficulties in facing the truth regarding
organ donation, the authors also develop a pragmatic alternative
account based on the concept of transparent legal fictions. In sum,
Miller and Truog argue that in order to preserve the legitimacy of
end-of-life practices, we need to reconstruct medical ethics.
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Tragedy to Triumph
(Hardcover)
Janet Mauk; Contributions by Peter Radigan; As told to Jim McGrath
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R516
Discovery Miles 5 160
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Ships in 18 - 22 working days
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In collaboration with Consulting Editor, Dr. Helen Boucher, Dr.
Jo-Ann Young has put together a state-of the-art issue of the
Infectious Disease Clinics of North America devoted to Management
of Infectious Diseases in Stem Cell Transplantation and Hematologic
Malignancy. Clinical review articles from expert authors are
specifically devoted to the following topics, addressing both the
stem cell transplant recipient and the hematologic malignancy
patient: Chemotherapy Regimens for Hematologic Malignancies and
Issues That Affect Infection; Stem Cell Transplantation Technical
Issues That Affect Infection in The Recipient; Complications of
Stem Cell Transplantation That Cause Infections; Antimicrobial
Prophylaxis and Preemptive Agents and Regimens for the Prevention
of Infection; Workup for Fever During Neutropenia; Herpesvirus
Infections; Cytomegalovirus Infections; Respiratory Virus
Infections; Other DNA Virus Infections; Bacterial Infections;
Fungal Infections; Parasitic Infections; Vaccination; and
Immunoglobulin Replacement. Readers will come away with the latest
information they need to manage infections and improve outcomes in
these patients.
The use of human tissue for transplantation is becoming a billion-dollar business. This book is the first comprehensive exploration of the American tissue transplantation industry. It traces the chain of distribution of musculoskeletal tissue (e.g. bones and ligaments) and skin from the generous donation of grieving families to its transplantation into hundreds of thousands of persons each year. Commodification, commercialization, and the occasional use of tissue for "cosmetic" surgery have raised ethical questions about the acceptability of "markets" in human body parts that have been altruistically donated by families. Inevitably, questions about the informed consent and the need for responsible stewardship by the industry have been raised, often in the Press. The book provides a comprehensive background to these ethical problems by explaining the historical development, breadth, and organization of the tissue industry, including the technical developments that have made it simultaneously clinically relevant and an attractive market for investment capital. It explores the similarities and differences in how government regulates other tissues and solid organs (such as hearts and kidneys). Contributions to the book come from an interdisciplinary group of scholars, industry representatives, government regulators, and, not least, families who have donated tissue from their dead loved ones.
Produced in association with the American Society of
Transplantation, this new edition is full of practical advice for
the next generation of transplant professionals. In addition to 5
organ-specific chapters: kidney, pancreas, heart, lung and liver,
the book includes essential information on: * immunobiology *
pharmacology * donor management * infectious complications *
pediatric transplantation * general principles of patient
management Fully updated and redesigned to make it even more
user-friendly, the book now contains clinical vignettes, key point
boxes, and self-assessment multiple choice questions in each
chapter. Primer on Transplantation, Third Edition is an invaluable
resource for all health professionals in the transplant team
including trainees, residents, fellows, physicians, surgeons,
nurses and transplant co-ordinators. Purchasing this book entitles
you to access to the companion website: www.astprimer.com The
website includes: * Interactive Multiple-Choice Questions for each
chapter * Figures from the book as Powerpoints for downloading *
All chapters online
This issue of Medical Clinics of North America, guest edited by
Drs. David A. Sass and Alden M. Doyl, is devoted to Care of the
Liver and Kidney Transplant Recipient. Articles in this issue
include: Liver and kidney transplantation: a half-century
historical perspective; From Child's-Pugh to MELD: Deciding who
really needs a liver transplant; When to consider renal
transplantation in your advanced CKD patients; Management of the
liver transplant recipient: approach to allograft dysfunction;
Acute and chronic allograft dysfunction in renal transplant
recipients; The ABC's of Immunosuppression: a primer for the
primary care physician; Managing cardiovascular risk in the post
solid organ transplant recipient; Diabetes care after transplant:
definitions, risk factors, and clinical management; De novo
malignancies after transplantation: risk and surveillance
strategies; Metabolic bone disease in the post-transplant
population: preventative and therapeutic measures; Infectious
complications and vaccinations in the post-transplant population;
Selection and post-operative care of the living donor; and
Long-term functional recovery, quality of life and pregnancy
following solid organ transplantation.
Personalized Immunosuppression in Transplantation: Role of
Biomarker Monitoring and Therapeutic Drug Monitoring provides
coverage of the various approaches to monitoring immunosuppressants
in transplant patients, including the most recently developed
biomarker monitoring methods, pharmacogenomics approaches, and
traditional therapeutic drug monitoring. The book is written for
pathologists, toxicologists, and transplant surgeons who are
involved in the management of transplant patients, offering them
in-depth coverage of the management of immunosuppressant therapy in
transplant patients with the goal of maximum benefit from drug
therapy and minimal risk of drug toxicity. This book also provides
practical guidelines for managing immunosuppressant therapy,
including the therapeutic ranges of various immunosuppressants, the
pitfalls of methodologies used for determination of these
immunosuppressants in whole blood or plasma, appropriate
pharmacogenomics testing for organ transplant recipients, and when
biomarker monitoring could be helpful.
This book offers a theoretical and practical overview of the
specific ethical and legal issues in pediatric organ
transplantation. Written by a team of leading experts, Ethical
Issues in Pediatric Organ Transplantation addresses those difficult
ethical questions concerning clinical, organizational, legal and
policy issues including donor, recipient and allocation issues.
Challenging topics, including children as donors, donation after
cardiac death, misattributed paternity, familial conflicts of
interest, developmental disability as a listing criteria, small
bowel transplant, and considerations in navigating the media are
discussed. It serves as a fundamental handbook and resource for
pediatricians, transplant health care professionals, trainees,
graduate students, scholars, practitioners of bioethics and health
policy makers.
Lung Transplantation is covered in detail in this important issue
of the Thoracic Surgery Clinics. Articles include: Candidacy for
Lung Transplant and Lung Allocation; ECMO as Bridge to Lung
Transplant; Single Versus Double Lung Transplant: Do Guidelines
Exist?; Extending the Donor Pool: Donation After Cardiac Death;
Extending the Donor Pool: Rehabilitation of Poor Organs; Bronchial
Artery Revascularization; Anastomotic Airway Complications
Following Lung Transplantation: Implications and Interventions;
Pleural Space Complications Associated with Lung Transplantation;
Reflux and Allograft Dysfunction, Is there a Connection?;
Artificial Lungs: Are We There Yet?; and more.
This issue of Hematology/Oncology Clinics of North America, guest
edited by Drs. Bipin Savani and Mohamad Mohty, is devoted to Bone
Marrow Transplantation. Articles in this issue include: Acute
Myeloid Leukemia (AML); Acute Lymphoid Leukemia (ALL);
Myelodysplastic Syndrome (AML); Myeloproliferative disorders (MPD);
Chronic Lymphoid Leukemia; Chronic Myeloid Leukemia (CML); Multiple
Myeloma and Amyloidosis; Non-Hodgkin Lymphoma (NHL); Hodgkin
Lymphoma (HL); Severe Aplastic Anemia (SAA) and Paroxysmal
Nocturnal Hemoglobinuria (PNH); Sickle Cell Anemia; Thalassemia;
Benign immunodeficiency diseases; and Referral to transplant
centers.
Cardiac transplantation has had a major impact on the quality of
life and longevity of an ever-increasing number of patients. This
benefit is significantly eroded by the development of an
accelerated form of coronary arterial disease which shows some, but
not all, of the characteristics of native coronary artery disease,
and itself is one of the major indications for transplantation. If
cardiac transplantation is to realize its potential, it is
essential to prevent transplant-related coronary disease. This can
only be done by thorough understanding of the basic mechanisms
involved. This could help in the fight against native
atherosclerosis, which has a major impact on the community and in
preventing vascular damage after other solid organ transplantation.
To date, there is no agreement or good guidelines about the
management of chronic rejection. Transplant-associated coronary
disease is a multifactorial disease contributed by genetic factors
in the donor and recipients. It is also linked to events occurring
during brain death, harvesting and implantation, and most
importantly, events after transplantation. The latter events can be
conveniently divided into antigen-dependent and antigen-independent
with immunological causes playing a part in both. Recent work has
resulted in major and significant accumulation of knowledge in this
field, particularly in the molecular mechanisms and to some extent,
management, of the disease. This knowledge is extensively and
methodically reviewed in this volume by a group of experts in the
field.
Organ transplantation is a much-discussed subject, and the
importance of living organ donation is increasing significantly.
Yet despite all efforts, too few donor organs are available to help
all patients in need. This book analyses whether the national legal
regulations are also partly responsible for the organ shortage in
the Member States of the European Union. In addition to a detailed
analysis of the various national regulations, the main arguments in
favour of and against legal restrictions on living organ donation
are considered. Furthermore, the European Union's authority is
investigated, namely, whether it is entitled to establish statutory
provisions for the Member States with respect to a harmonized
regulation of living organ donation. Based on the results of the
analysis, the author establishes a Best Practice Proposal for
living organ donation.
"Regenerative Medicine Applications in Organ Transplantation"
illustrates exactly how these two fields are coming together and
can benefit one another. It discusses technologies being developed,
methods being implemented, and which of these are the most
promising. The text encompasses tissue engineering, biomaterial
sciences, stem cell biology, and developmental biology, all from a
transplant perspective. Organ systems considered include liver,
renal, intestinal, pancreatic, and more. Leaders from both fields
have contributed chapters, clearly illustrating that regenerative
medicine and solid organ transplantation speak the same language
and that both aim for similar medical outcomes. The overall theme
of the book is to provide insight into the synergy between organ
transplantation and regenerative medicine.
Recent groundbreaking achievements in regenerative medicine have
received unprecedented coverage by the media, fueling interest and
enthusiasm in transplant clinicians and researchers. Regenerative
medicine is changing the premise of solid organ transplantation,
requiring transplantation investigators to become familiar with
regenerative medicine investigations that can be extremely relevant
to their work. Similarly, regenerative medicine investigators need
to be aware of the needs of the transplant field to bring these two
fields together for greater results.
Bridges the gap between regenerative medicine and solid organ
transplantation and highlights reasons for collaboration Explains
the importance and future potential of regenerative medicine to the
transplant communityIllustrates to regenerative medicine
investigators the needs of the transplant discipline to drive and
guide investigations in the most promising directions
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