Vir die vroue wat hy met sy rolprentsterglimlag betower het, was Chris Barnard ’n hartebreker. Vir sy pasiënte ’n harteheler.

Dié nuwe biografie oor Suid-Afrika se beroemdste hartsjirurg vertel nie net van Barnard se kinderjare in Beaufort-Wes, sy prominente huwelike (en egskeidings) en flambojante lewe nie. James Styan ondersoek ook die impak van die historiese eerste hartoorplanting op Barnard se persoonlik lewe en op die Suid-Afrikaanse gemeenskap in die algemeen, waar apartheidswetgewing dikwels die probleme van geneeskunde nog ingewikkelder gemaak het. Die rol van swart mediese personeel soos Hamilton Naki word bespreek, sowel as die intense wedywering wat tussen ander beroemde hartsjirurge en Barnard ontstaan het.

Hoe het Barnard dit reggekry om hulle almal in dié resies om lewe en dood te wen? Hoeveel het sy welbekende sjarme daarmee te doen gehad? En wat is Barnard se nalatenskap vandag, in die lig van sy latere suksesse en aansienlike mislukkings? Styan dek dit alles in dié fassinerende nuwe blik op Chris Barnard wat uitgegee is om saam te val met die 50ste herdenking van die eerste hartoorplanting.

Techniques in Revision Hip and Knee Arthroplasty is the one authoritative volume that gives you an efficient, problem-based approach to revision arthroplasty of both the hip and knee. Dr. Giles Scuderi and other leading experts from North America and Western Europe present their favored surgical procedures and post-surgical management strategies in this straightforward, heavily illustrated, video-intensive reference. It's your one-stop, go-to guide for successful revision surgery for a myriad of complications, such as implant loosening, polyethylene wear, osteolysis, or infection of the hip and knee. Get expert guidance on implant choice, management of complications (including infection and wound healing), and failure of mechanisms, as well as step-by-step surgical techniques. Quickly find the exact information you need with a straightforward "just what you need to know" approach, including surgical tips and pearls. Stay up to date with new insights regarding anatomic landmarks, recommended reconstruction options in revision surgery, including management of bone defects and instability. Access the fully searchable contents of the book and an abundance of surgical videos online at Expert Consult.

In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we in the United States evaluate other medical procedures, especially life-saving ones.
It details how the factors that drove clinical use--patient demand, physician enthusiasm, media reporting, litigation, economic exploitation, and legislative and administrative mandates--converged to propel the procedure forward despite a lack of proven clinical effectiveness. It also analyzes the limited effect of technology assessments before randomized clinical trials evaluated decisively the procedure and the ramifications of this system on healthcare today.
Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section considers the significance of the story for our healthcare system.

In Death, Dying, and Organ Transplantation: Reconstructing Medical Ethics at the End of Life, Miller and Truog challenge fundamental doctrines of established medical ethics. They argue that the routine practice of stopping life support technology in hospitals causes the death of patients and that donors of vital organs (hearts, lungs, liver, and both kidneys) are not really dead at the time that their organs are removed for life-saving transplantation. These practices are ethically legitimate but are not compatible with traditional rules of medical ethics that doctors must not intentionally cause the death of their patients and that vital organs can be obtained for transplantation only from dead donors.
In this book Miller and Truog undertake an ethical examination that aims to honestly face the reality of medical practices at the end of life. They expose the misconception that stopping life support merely allows patients to die from their medical conditions, and they dispute the accuracy of determining death of hospitalized patients on the basis of a diagnosis of "brain death" prior to vital organ donation. After detailing the factual and conceptual errors surrounding current practices of determining death for the purpose of organ donation, the authors develop a novel ethical account of procuring vital organs. In the context of reasonable plans to withdraw life support, still-living patients are not harmed or wronged by organ donation prior to their death, provided that valid consent has been obtained for stopping treatment and for organ donation.
Recognizing practical difficulties in facing the truth regarding organ donation, the authors also develop a pragmatic alternative account based on the concept of transparent legal fictions. In sum, Miller and Truog argue that in order to preserve the legitimacy of end-of-life practices, we need to reconstruct medical ethics.

In collaboration with Consulting Editor, Dr. Helen Boucher, Dr. Jo-Ann Young has put together a state-of the-art issue of the Infectious Disease Clinics of North America devoted to Management of Infectious Diseases in Stem Cell Transplantation and Hematologic Malignancy. Clinical review articles from expert authors are specifically devoted to the following topics, addressing both the stem cell transplant recipient and the hematologic malignancy patient: Chemotherapy Regimens for Hematologic Malignancies and Issues That Affect Infection; Stem Cell Transplantation Technical Issues That Affect Infection in The Recipient; Complications of Stem Cell Transplantation That Cause Infections; Antimicrobial Prophylaxis and Preemptive Agents and Regimens for the Prevention of Infection; Workup for Fever During Neutropenia; Herpesvirus Infections; Cytomegalovirus Infections; Respiratory Virus Infections; Other DNA Virus Infections; Bacterial Infections; Fungal Infections; Parasitic Infections; Vaccination; and Immunoglobulin Replacement. Readers will come away with the latest information they need to manage infections and improve outcomes in these patients.

The use of human tissue for transplantation is becoming a billion-dollar business. This book is the first comprehensive exploration of the American tissue transplantation industry. It traces the chain of distribution of musculoskeletal tissue (e.g. bones and ligaments) and skin from the generous donation of grieving families to its transplantation into hundreds of thousands of persons each year. Commodification, commercialization, and the occasional use of tissue for "cosmetic" surgery have raised ethical questions about the acceptability of "markets" in human body parts that have been altruistically donated by families. Inevitably, questions about the informed consent and the need for responsible stewardship by the industry have been raised, often in the Press.

The book provides a comprehensive background to these ethical problems by explaining the historical development, breadth, and organization of the tissue industry, including the technical developments that have made it simultaneously clinically relevant and an attractive market for investment capital. It explores the similarities and differences in how government regulates other tissues and solid organs (such as hearts and kidneys). Contributions to the book come from an interdisciplinary group of scholars, industry representatives, government regulators, and, not least, families who have donated tissue from their dead loved ones.

Produced in association with the American Society of Transplantation, this new edition is full of practical advice for the next generation of transplant professionals. In addition to 5 organ-specific chapters: kidney, pancreas, heart, lung and liver, the book includes essential information on: * immunobiology * pharmacology * donor management * infectious complications * pediatric transplantation * general principles of patient management Fully updated and redesigned to make it even more user-friendly, the book now contains clinical vignettes, key point boxes, and self-assessment multiple choice questions in each chapter. Primer on Transplantation, Third Edition is an invaluable resource for all health professionals in the transplant team including trainees, residents, fellows, physicians, surgeons, nurses and transplant co-ordinators. Purchasing this book entitles you to access to the companion website: www.astprimer.com The website includes: * Interactive Multiple-Choice Questions for each chapter * Figures from the book as Powerpoints for downloading * All chapters online

This issue of Medical Clinics of North America, guest edited by Drs. David A. Sass and Alden M. Doyl, is devoted to Care of the Liver and Kidney Transplant Recipient. Articles in this issue include: Liver and kidney transplantation: a half-century historical perspective; From Child's-Pugh to MELD: Deciding who really needs a liver transplant; When to consider renal transplantation in your advanced CKD patients; Management of the liver transplant recipient: approach to allograft dysfunction; Acute and chronic allograft dysfunction in renal transplant recipients; The ABC's of Immunosuppression: a primer for the primary care physician; Managing cardiovascular risk in the post solid organ transplant recipient; Diabetes care after transplant: definitions, risk factors, and clinical management; De novo malignancies after transplantation: risk and surveillance strategies; Metabolic bone disease in the post-transplant population: preventative and therapeutic measures; Infectious complications and vaccinations in the post-transplant population; Selection and post-operative care of the living donor; and Long-term functional recovery, quality of life and pregnancy following solid organ transplantation.

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.

This book offers a theoretical and practical overview of the specific ethical and legal issues in pediatric organ transplantation. Written by a team of leading experts, Ethical Issues in Pediatric Organ Transplantation addresses those difficult ethical questions concerning clinical, organizational, legal and policy issues including donor, recipient and allocation issues. Challenging topics, including children as donors, donation after cardiac death, misattributed paternity, familial conflicts of interest, developmental disability as a listing criteria, small bowel transplant, and considerations in navigating the media are discussed. It serves as a fundamental handbook and resource for pediatricians, transplant health care professionals, trainees, graduate students, scholars, practitioners of bioethics and health policy makers.

Lung Transplantation is covered in detail in this important issue of the Thoracic Surgery Clinics. Articles include: Candidacy for Lung Transplant and Lung Allocation; ECMO as Bridge to Lung Transplant; Single Versus Double Lung Transplant: Do Guidelines Exist?; Extending the Donor Pool: Donation After Cardiac Death; Extending the Donor Pool: Rehabilitation of Poor Organs; Bronchial Artery Revascularization; Anastomotic Airway Complications Following Lung Transplantation: Implications and Interventions; Pleural Space Complications Associated with Lung Transplantation; Reflux and Allograft Dysfunction, Is there a Connection?; Artificial Lungs: Are We There Yet?; and more.

This issue of Hematology/Oncology Clinics of North America, guest edited by Drs. Bipin Savani and Mohamad Mohty, is devoted to Bone Marrow Transplantation. Articles in this issue include: Acute Myeloid Leukemia (AML); Acute Lymphoid Leukemia (ALL); Myelodysplastic Syndrome (AML); Myeloproliferative disorders (MPD); Chronic Lymphoid Leukemia; Chronic Myeloid Leukemia (CML); Multiple Myeloma and Amyloidosis; Non-Hodgkin Lymphoma (NHL); Hodgkin Lymphoma (HL); Severe Aplastic Anemia (SAA) and Paroxysmal Nocturnal Hemoglobinuria (PNH); Sickle Cell Anemia; Thalassemia; Benign immunodeficiency diseases; and Referral to transplant centers.

Cardiac transplantation has had a major impact on the quality of life and longevity of an ever-increasing number of patients. This benefit is significantly eroded by the development of an accelerated form of coronary arterial disease which shows some, but not all, of the characteristics of native coronary artery disease, and itself is one of the major indications for transplantation. If cardiac transplantation is to realize its potential, it is essential to prevent transplant-related coronary disease. This can only be done by thorough understanding of the basic mechanisms involved. This could help in the fight against native atherosclerosis, which has a major impact on the community and in preventing vascular damage after other solid organ transplantation. To date, there is no agreement or good guidelines about the management of chronic rejection. Transplant-associated coronary disease is a multifactorial disease contributed by genetic factors in the donor and recipients. It is also linked to events occurring during brain death, harvesting and implantation, and most importantly, events after transplantation. The latter events can be conveniently divided into antigen-dependent and antigen-independent with immunological causes playing a part in both. Recent work has resulted in major and significant accumulation of knowledge in this field, particularly in the molecular mechanisms and to some extent, management, of the disease. This knowledge is extensively and methodically reviewed in this volume by a group of experts in the field.

Organ transplantation is a much-discussed subject, and the importance of living organ donation is increasing significantly. Yet despite all efforts, too few donor organs are available to help all patients in need. This book analyses whether the national legal regulations are also partly responsible for the organ shortage in the Member States of the European Union. In addition to a detailed analysis of the various national regulations, the main arguments in favour of and against legal restrictions on living organ donation are considered. Furthermore, the European Union's authority is investigated, namely, whether it is entitled to establish statutory provisions for the Member States with respect to a harmonized regulation of living organ donation. Based on the results of the analysis, the author establishes a Best Practice Proposal for living organ donation.

"Regenerative Medicine Applications in Organ Transplantation" illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine.

Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results.
Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant communityIllustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions