Techniques in Revision Hip and Knee Arthroplasty is the one authoritative volume that gives you an efficient, problem-based approach to revision arthroplasty of both the hip and knee. Dr. Giles Scuderi and other leading experts from North America and Western Europe present their favored surgical procedures and post-surgical management strategies in this straightforward, heavily illustrated, video-intensive reference. It's your one-stop, go-to guide for successful revision surgery for a myriad of complications, such as implant loosening, polyethylene wear, osteolysis, or infection of the hip and knee. Get expert guidance on implant choice, management of complications (including infection and wound healing), and failure of mechanisms, as well as step-by-step surgical techniques. Quickly find the exact information you need with a straightforward "just what you need to know" approach, including surgical tips and pearls. Stay up to date with new insights regarding anatomic landmarks, recommended reconstruction options in revision surgery, including management of bone defects and instability. Access the fully searchable contents of the book and an abundance of surgical videos online at Expert Consult.

In Death, Dying, and Organ Transplantation: Reconstructing Medical Ethics at the End of Life, Miller and Truog challenge fundamental doctrines of established medical ethics. They argue that the routine practice of stopping life support technology in hospitals causes the death of patients and that donors of vital organs (hearts, lungs, liver, and both kidneys) are not really dead at the time that their organs are removed for life-saving transplantation. These practices are ethically legitimate but are not compatible with traditional rules of medical ethics that doctors must not intentionally cause the death of their patients and that vital organs can be obtained for transplantation only from dead donors.
In this book Miller and Truog undertake an ethical examination that aims to honestly face the reality of medical practices at the end of life. They expose the misconception that stopping life support merely allows patients to die from their medical conditions, and they dispute the accuracy of determining death of hospitalized patients on the basis of a diagnosis of "brain death" prior to vital organ donation. After detailing the factual and conceptual errors surrounding current practices of determining death for the purpose of organ donation, the authors develop a novel ethical account of procuring vital organs. In the context of reasonable plans to withdraw life support, still-living patients are not harmed or wronged by organ donation prior to their death, provided that valid consent has been obtained for stopping treatment and for organ donation.
Recognizing practical difficulties in facing the truth regarding organ donation, the authors also develop a pragmatic alternative account based on the concept of transparent legal fictions. In sum, Miller and Truog argue that in order to preserve the legitimacy of end-of-life practices, we need to reconstruct medical ethics.

In this issue of Thoracic Surgery Clinics, guest editors Drs. Jasleen Kukreja and Aida Venado bring their considerable expertise to the topic of Lung Transplantation. Top experts in the field cover key topics such as inpatient management of the acutely decompensating lung transplant candidate, lung allograft rejection, management of the potential lung donor, postoperative management of lung transplant recipients, and more. Contains a variety of relevant, practice-oriented topics including donation after circulatory death; lung transplant for ARDS; centralized organ recovery and reconditioning centers; infectious complications in lung transplantation; anesthetic management during lung transplantation; and more. Provides in-depth clinical reviews on lung transplantation, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Diagnosis of death by neurological criteria (DNC) is a construct which has been part of the British medico-legal landscape for nearly half a century. This book examines the factors behind its emergence, and discusses the various changes that took place in the last few decades that culminated in the current definition and clinical criteria for determining brain-based death. It highlights the continuities and discontinuities in practice, and the impact they have on the issue of withdrawal of mechanical ventilation in intensive care units and on the field of organ transplantation. The book also explores the law's response to the introduction and development of DNC in clinical practice. It demonstrates how the legitimacy of the definition and criteria used by the medical profession were forged in the courtroom rather than in Parliament. It documents why case law were introduced in court, and assesses whether organ donation was a consideration in the deliberations. It will be emphasised that courts have given insufficient consideration to requests made in recent cases to consider a broader range of methods to determine death. Those pleas were made on the grounds that the definition and criteria used in the UK are dissimilar to those used in other jurisdictions that also adopt DNC; and that faith communities have a different understanding of death. By taking a close look at those other approaches before highlighting the inherent limitations of the courtroom as the forum that confers DNC its legitimacy, the book puts forward the argument that the democratic process should be engaged.

A DAILY MAIL BOOK OF THE WEEK 'Spare Parts is a fascinating read filled with adventure, delight and surprise' RAHUL JANDIAL, surgeon author of 'Life on a Knife's Edge' 'This is a joyful romp through a fascinating slice of medical history' WENDY MOORE, author of 'The Knife Man' _______________________________________________________________ How did an architect help pioneer blood transfusion in the 1660s? Why did eighteenth-century dentists buy the live teeth of poor children? And what role did a sausage skin and an enamel bath play in making kidney transplants a reality? We think of transplant surgery as one of the medical wonders of the modern world. But transplant surgery is as ancient as the pyramids, with a history more surprising than we might expect. Paul Craddock takes us on a journey - from sixteenth-century skin grafting to contemporary stem cell transplants - uncovering stories of operations performed by unexpected people in unexpected places. Bringing together philosophy, science and cultural history, Spare Parts explores how transplant surgery constantly tested the boundaries between human, animal and machine, and continues to do so today. Witty, entertaining and at times delightfully macabre, Spare Parts shows us that the history - and future - of transplant surgery is tied up with questions about not only who we are, but also what we are, and what we might become. . .

In collaboration with Consulting Editor, Dr. Helen Boucher, Dr. Jo-Ann Young has put together a state-of the-art issue of the Infectious Disease Clinics of North America devoted to Management of Infectious Diseases in Stem Cell Transplantation and Hematologic Malignancy. Clinical review articles from expert authors are specifically devoted to the following topics, addressing both the stem cell transplant recipient and the hematologic malignancy patient: Chemotherapy Regimens for Hematologic Malignancies and Issues That Affect Infection; Stem Cell Transplantation Technical Issues That Affect Infection in The Recipient; Complications of Stem Cell Transplantation That Cause Infections; Antimicrobial Prophylaxis and Preemptive Agents and Regimens for the Prevention of Infection; Workup for Fever During Neutropenia; Herpesvirus Infections; Cytomegalovirus Infections; Respiratory Virus Infections; Other DNA Virus Infections; Bacterial Infections; Fungal Infections; Parasitic Infections; Vaccination; and Immunoglobulin Replacement. Readers will come away with the latest information they need to manage infections and improve outcomes in these patients.

This issue of Medical Clinics of North America, guest edited by Drs. David A. Sass and Alden M. Doyl, is devoted to Care of the Liver and Kidney Transplant Recipient. Articles in this issue include: Liver and kidney transplantation: a half-century historical perspective; From Child's-Pugh to MELD: Deciding who really needs a liver transplant; When to consider renal transplantation in your advanced CKD patients; Management of the liver transplant recipient: approach to allograft dysfunction; Acute and chronic allograft dysfunction in renal transplant recipients; The ABC's of Immunosuppression: a primer for the primary care physician; Managing cardiovascular risk in the post solid organ transplant recipient; Diabetes care after transplant: definitions, risk factors, and clinical management; De novo malignancies after transplantation: risk and surveillance strategies; Metabolic bone disease in the post-transplant population: preventative and therapeutic measures; Infectious complications and vaccinations in the post-transplant population; Selection and post-operative care of the living donor; and Long-term functional recovery, quality of life and pregnancy following solid organ transplantation.

One: Historical Reflections.- 1. Reflections on the development of organ transplantation.- Two: Immunology of Organ Transplantation.- 2. Cellular and molecular mechanisms of allograft rejection.- 3. What does the alloreactive T cell see?.- 4. HLA matching and organ transplantation.- 5. An effective strategy for transplantation of highly sensitized patients.- 6. Rapid lymphocyte crossmatching for renal transplantation.- Three: Organ Allograft Rejection.- 7. Fifteen-year experience with fine needle aspiration biopsies at the University of Helsinki.- 8. Study of antibody specificity in highly sensitized patients using human monoclonal antibody technology.- 9. Idiotypic-Antiidiotypic antibody interaction and renal transplant survival.- Four: Immunosuppression.- 10. Transplantation and blood transfusion in 1990.- 11. Quadruple-drug immunosuppressive induction treatments for immunological high-risk patients in cadaveric renal transplantation using poly-and monoclonal antibodies.- 12. Sequential combination immunotherapy for cadaveric renal transplantation: OKT3 versus rabbit ATG induction.- 13. Multi-organ transplant experience with OKT3 and strategies for use at the University of Cincinnati Medical Center.- 14. Cyclosporine withdrawal in renal transplant recipients maintained on azathioprine, prednisone and cyclosporine.- 15. Early experience with FK 506 in liver transplantation.- 16. Deoxyspergualin. A novel immunosuppressant: experimental and clinical studies.- 17. Preliminary results with FK 506 in pancreas grafting in a nonhuman primate model.- 18. The effect of DST on graft outcome - the Turkish experience.- 19. Induction of specific unresponsiveness (tolerance) to experimental and clinical allografts using polyclonal antilymphocyte serum and donor-specific bone marrow.- 20. Comparison of cyclosporine assays using radioimmunoassay, fluorescent polarization immunoassay and high-performance liquid chromatography.- Five: Renal Transplantation.- 21. Long-term outcome in renal transplantation.- 22. Ten-year experience with 500 renal transplants.- 23. Long-term results in recipients of cadaveric renal allografts under cyclosporine therapy.- 24. Transplantation of single and double kidneys from pediatric donors.- 25. ABO-incompatible living related donor transplantation.- 26. The use of single pediatric cadaver kidneys for transplantation into adult recipients.- 27. Living unrelated donor renal transplantation.- 28. Renal transplantation in Tunisia - a three-year experience.- 29. Renal transplantation in children.- 30. Kidney donors - long-term follow up.- 31. Current techniques for permanent vascular access surgery - experience with 930 procedures.- 32. Results of 319 consecutive renal transplants from living related and living unrelated donors in Iran.- Six: Liver Transplantation.- 33. Liver transplantation: current status.- 34. An overview of liver transplantation therapy for children.- 35. Current anesthetic management in clinical liver transplantation.- 36. Risk factors in adult liver transplant recipients.- 37. The concept of reduced-size liver transplantation, including split-liver and living related liver transplantation.- 38. Immunological factors contributing to outcome in liver transplantation.- 39. Transplantation for hepatobiliary malignancies.- 40. The diagnosis and management of massive blood loss during liver transplantation.- 41. Early clinical experience with cluster resection and transplantation for right upper quadrant abdominal malignancy.- Seven: Heart/Heart-Lung Transplants.- 42. Lung transplantation: current techniques and outcomes.- 43. Heart-lung transplantation at the University of Minnesota.- 44. Specificity and sensitivity of the cytoimmunological monitoring (CIM): differentiation between cardiac rejection, viral, bacterial, or fungal infection.- Eight: Pancreas Transplantation.- 45. International Pancreas Transplantation Registry report.- 46. Techniques and experience of pancreatic transplantation wit...

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.

This book offers a theoretical and practical overview of the specific ethical and legal issues in pediatric organ transplantation. Written by a team of leading experts, Ethical Issues in Pediatric Organ Transplantation addresses those difficult ethical questions concerning clinical, organizational, legal and policy issues including donor, recipient and allocation issues. Challenging topics, including children as donors, donation after cardiac death, misattributed paternity, familial conflicts of interest, developmental disability as a listing criteria, small bowel transplant, and considerations in navigating the media are discussed. It serves as a fundamental handbook and resource for pediatricians, transplant health care professionals, trainees, graduate students, scholars, practitioners of bioethics and health policy makers.

Lung Transplantation is covered in detail in this important issue of the Thoracic Surgery Clinics. Articles include: Candidacy for Lung Transplant and Lung Allocation; ECMO as Bridge to Lung Transplant; Single Versus Double Lung Transplant: Do Guidelines Exist?; Extending the Donor Pool: Donation After Cardiac Death; Extending the Donor Pool: Rehabilitation of Poor Organs; Bronchial Artery Revascularization; Anastomotic Airway Complications Following Lung Transplantation: Implications and Interventions; Pleural Space Complications Associated with Lung Transplantation; Reflux and Allograft Dysfunction, Is there a Connection?; Artificial Lungs: Are We There Yet?; and more.

This issue of Hematology/Oncology Clinics of North America, guest edited by Drs. Bipin Savani and Mohamad Mohty, is devoted to Bone Marrow Transplantation. Articles in this issue include: Acute Myeloid Leukemia (AML); Acute Lymphoid Leukemia (ALL); Myelodysplastic Syndrome (AML); Myeloproliferative disorders (MPD); Chronic Lymphoid Leukemia; Chronic Myeloid Leukemia (CML); Multiple Myeloma and Amyloidosis; Non-Hodgkin Lymphoma (NHL); Hodgkin Lymphoma (HL); Severe Aplastic Anemia (SAA) and Paroxysmal Nocturnal Hemoglobinuria (PNH); Sickle Cell Anemia; Thalassemia; Benign immunodeficiency diseases; and Referral to transplant centers.

Organ transplantation is a much-discussed subject, and the importance of living organ donation is increasing significantly. Yet despite all efforts, too few donor organs are available to help all patients in need. This book analyses whether the national legal regulations are also partly responsible for the organ shortage in the Member States of the European Union. In addition to a detailed analysis of the various national regulations, the main arguments in favour of and against legal restrictions on living organ donation are considered. Furthermore, the European Union's authority is investigated, namely, whether it is entitled to establish statutory provisions for the Member States with respect to a harmonized regulation of living organ donation. Based on the results of the analysis, the author establishes a Best Practice Proposal for living organ donation.

"Regenerative Medicine Applications in Organ Transplantation" illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine.

Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results.
Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant communityIllustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions

An important review on transplantation for the general surgeon! Topics include: kidney transplant, left lobe liver transplants, advances in lung transplantation, stem cell and cellular transplants, pancreatectomy, management of organ failure, transplant immune suppression, antibody mediated rejection, cardiac assist devices, organ perfusion and preservation, weight reduction therapy, organ allocation and distribution, and more!