After decades of research in clinical transplantation, new techniques have been developed that permit a further understanding of the immune mechanisms underlying immune recognition of allografts and a more accurate and thorough evaluation of compatibility between donors and recipients. The second edition of Transplantation Immunology: Methods and Protocols expands upon the previous edition with current, detailed methods in transplantation immunology. The new methods chapters cover four major areas that are being applied in compatibility evaluations and ongoing transplantation immunology research. Seven overview chapters provide reviews of the molecular basis for alloreactivity, current understanding of humoral and cellular mechanisms, as well as new developments in thoracic organ transplantation, composite tissue transplantation and in the transplantation of sensitized patients. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transplantation Immunology: Methods and Protocol, Second Edition is devoted to transplantation immunology, both in the practice of compatibility testing and in transplantation research.

A DAILY MAIL BOOK OF THE WEEK 'Spare Parts is a fascinating read filled with adventure, delight and surprise' RAHUL JANDIAL, surgeon author of 'Life on a Knife's Edge' 'This is a joyful romp through a fascinating slice of medical history' WENDY MOORE, author of 'The Knife Man' _______________________________________________________________ How did an architect help pioneer blood transfusion in the 1660s? Why did eighteenth-century dentists buy the live teeth of poor children? And what role did a sausage skin and an enamel bath play in making kidney transplants a reality? We think of transplant surgery as one of the medical wonders of the modern world. But transplant surgery is as ancient as the pyramids, with a history more surprising than we might expect. Paul Craddock takes us on a journey - from sixteenth-century skin grafting to contemporary stem cell transplants - uncovering stories of operations performed by unexpected people in unexpected places. Bringing together philosophy, science and cultural history, Spare Parts explores how transplant surgery constantly tested the boundaries between human, animal and machine, and continues to do so today. Witty, entertaining and at times delightfully macabre, Spare Parts shows us that the history - and future - of transplant surgery is tied up with questions about not only who we are, but also what we are, and what we might become. . .

This issue of "Progress in Brain Research" is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.
Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.
Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

This issue of Critical Care Nursing Clinics, Guest Edited by Darlene Lovasik, RN, MN, CCRN, CNRN, will feature such article topics as: Evaluation and Work-up for Transplant; Basic Immunology; Pharmacology; Liver, Pancreas, Kidney Transplants; Living Donor Kideny, Liver Transplants; Heart, Lung, Intestinal and Multivisceral Transplants; Complications After Transplant; Patient Education; Psychosocial Concerns; Ethical Issue; Financial/Operational Considerations; Organ Donation.

The History and Evolution of Hand Transplantation, World Experience After More Than a Decade of Clinical Hand Transplantation, How to Establish a Hand Transplant Program, Recipient Selection - Who is the Right Candidate for Hand Transplantation? Donor-related Issues in Hand Transplantation, Surgical and Technical Aspects of Hand Transplantation - Is it Just Another Replant? Functional Outcome After Hand Transplantation - What can be Achieved? Strategies to Enhance Nerve Regeneration, Immunosuppressive Protocols and Immunological Challenges Related to Hand Transplantation, Acute and Chronic Rejection in Hand Transplantation - What have we Learned? Favoring the Risk Benefit Balance for Hand Transplantation - The Pittsburgh Approach Ethical, Financial and Policy Considerations of Hand Transplantation

The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential. Because of their pluripotency, these cells have been used in various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. The formation of embryoid bodies, which are three-dimensional aggregates of embryonic stem cells, is explained as this is the first step in cell differentiation. Such embryoid body culture has been widely used as a trigger for the in vitro differentiation of embryonic stem cells. The basic capacity of self-renewal of human embryogenic stem cells is explained. The role of TGF-beta in the propagation of human embryonic stem cells is discussed. The differentiation of human embryonic stem cells into neurons, hepatocytes, cardiomyocytes, and retinal cells is fully explained. Donor policies for hematopoietic stem cells are also explained.

World-renown expert, Dr. Paul Martin, has assembled an impressive list of authors to update the important topic of orthotopic liver transplantation. The issue provides comprehensive clinical coverage on this topics as articles are focused from the care of the pre-transplant patient to the care of the post-transplant patient. Content also covers the following topics: Transplantation for Hepatocellular Carcinoma;
Transplantation for Cholangiocarcinoma; Management of Renal Dysfunction in Liver Transplant Patients; Expanded Donors in Liver Transplantation; Current Status of Liver Transplantation for HBV; MELD: End of the First Decade; and Management of Recurrent HCV Infection.

Organ transplantation is one of the most dramatic interventions in modern medicine. Since the 1950s thousands of people have lived with 'new' hearts, kidneys, lungs, corneas, and other organs and tissues transplanted into their bodies. From the beginning, though, there was simply a problem: surgeons often encountered shortages of people willing and able to give their organs and tissues. To overcome this problem, they often brokered financial arrangements. Yet an ethic of gift exchange coexisted with the 'commodification of the body'. The same duality characterized the field of blood transfusion, which was essential to the development of modern surgery.
This book will be the first to bring together the histories of blood transfusion and organ transplantation. It will show how these two fields redrew the lines between self and non-self, the living and the dead, and humans and animals. Drawing on newspapers, magazines, legal cases, films and the papers and correspondence of physicians and surgeons, Lederer will challenge the assumptions of some bioethicists and policymakers that popular fears about organ transplantation necessarily reflect timeless human concerns and preoccupations with the body. She will show how notions of the body- intact, in parts, living and dead- are shaped by the particular culture in which they are embedded.

This issue of Clinics in Chest Medicine, guest edited by Robert Kotloff, focuses on the topics of Lung Transplantation. Articles include: Candidate Selection, Timing of Listing, and Choice of Procedure for Lung Transplantation; Lung Allocation in the United States, Selection and Management of the Lung Donor; Novel Approaches to Expanding the Lung Donor Pool: Donation After Cardiac Death and Ex Vivo Conditioning; Extracorporeal Life Support as a Bridge to Lung Transplantation; Survival and Quality of Life of Patients Undergoing Lung Transplant; Primary Graft Dysfunction; Acute Allograft Rejection: Cellular and Humoral Processes, and more!

Transplant and oncology patients present a challenge to the infectious disease specialist because many of the entities that infect them are hard to diagnose.? Chemotherapy may further complicate the situation, since it may contraindicate a biopsy or interfere with antibiotic therapy. This issue of Infectious Disease Clinics provides specific information on several entities with the purpose of helping physicians to best treat these difficult infections.

Optimization of Outcomes for Children After Solid Organ Transplantation is reviewed in this issue of Pediatric Clinics, guest edited by Drs. Vicky Lee Ng and Sandy Feng. Authorities in the field have come together to pen articles addressing Renal, Liver, Heart, Lung, and Small Bowel Transplantation in Children; Immunosuppression Armamentarium in 2010: Mechanistic and Clinical Considerations; Tolerance: Is it achievable in Pediatric Solid Organ Transplantation?; Optimizing Growth, Rehabilitation, and Neurodevelopmental Outcomes in Children after Solid Organ Transplantation; Prevention and Treatment of Infectious Issues after Solid Organ Transplantation in Children; Post-Transplantation Lymphoproliferative Disease; Non-Immune Complications Post-Transplantation?; Health-Related Quality of Life after Pediatric Transplantation; Adolescence and Adherence Issues of the Pediatric Solid Organ Recipient; Transition of Care of the Pediatric Solid Organ Recipient to Adult Care Teams; And Most Commonly Asked Questions from Parents of Transplant Families.

The subject of Pediatric Bone Marrow Transplantation is reviewed in this issue of Pediatric Clinics. Guest Editors Drs. Max Coppes, Terry Fry, and Crystal Mackall have assembled a panel of experts who offer reviews on topics including Allogeneic BMT for leukemia, GVL in pediatric leukemia, Stem cell source and outcome following BMT in children, Acute GVHD in children, Chronic GVHD in children, BMT for Hemoglobinopathies, BMT for immunodeficiency, BMT for rheumatologic disorders and other benign diseases, Autologous and Allogeneic BMT for solid tumors, Late effects following BMT, Cell therapies/vaccines for malignancy and infections, BMT for metabolic disorders, BMT for bone marrow failure syndromes, and Immunotherapy in the context of SCT.

Liver Transplantation: Challenging Controversies and Topics grew out of a need I perceived within the fields of transplant hepatology and liver transplantation. Liver transplantation has rightly gained recognition as an established therapy for end-stage liver disease. Few would argue that liver transplantation is one of the few truly lifesaving and life-altering treatments within medicine and surgery. Not many realize that 20 years passed from the time of the first human liver transplantation in 1963 to its acceptance as therapy by the 1983 NIH Consensus Conference on Liver Transplantation. In 2008, 25 years will have passed since the 1983 NIH conference-a mere 25 years for a field that has provided patients hope, doctors options, and to some the "gift of life. " Many issues in liver transplantation involve indications, patient selection, and outcomes after transplantation-these are standard topics, covered by textbooks of hepatology and transplantation. In contrast, the field of liver tra- plantation is young, evolving, dynamic, and issues and decisions are often controversial. Thus, Dr. Trotter and I, as well as our colleagues at the University of Colorado, felt that a text with a different focus was required, one that highlighted controversy and challenged dogma. Out of this perceived need emerged Liver Transplantation: Challenging Controversies and Topics. To meet the transplant community's need for emerging information about liver transplantation, Dr. Larry Chan, Dr. Igal Kam, and I initiated the Controversies in Transplantation Conference.

A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team. An up to date guide to best practice in the use of stem cell transplantation, covering current status in the treatment of malignant and non-malignant conditions, practical aspects and problems such as infection and graft versus host disease. Has a practical, accessible approach with free use of algorithms, list tables. Aimed at the whole transplant team - this is an interdisciplinary field. International contributor team with editors in the UK and USA. Illustrated in colour throughout.

This book provides an expert view into the current technologies that are revolutionizing the field of solid organ transplantation. This unique book provides insight into progress made in areas spanning robotic surgery to tissue engineering and also gives a glimpse into what may lie ahead for this innovative specialty. Topics covered include nanotherapy, machine perfusion, artificial organ development, robotics in transplant surgery, mobile health technology, stem cell therapy, and ex vivo repair of organs. This is an ideal book for biomedical engineers, physicians and surgeons, general and transplant surgeons, medical students, medical and surgical trainees, and transplant procurement technicians.

There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy.
Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier.
The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices.
- Provides detailed description of clinical trials in cell transplantation
- Review of current therapeutic approaches
- Coverage of the broad range of diseases addressed by cell therapeutics
- Discussion of stem cell biology and its role in transplantation

Over the past decade, there has been rapid growth in bioengineering applications in the field of spine implants. This book explains the technical foundation for understanding and expanding the field of spine implants, reviews the major established technologies related to spine implants, and provides reference material for developing and commercializing new spine implants. The editors, who have a track record of collaboration and editing technical books, provide a unified approach to this topic in the most comprehensive and useful book to date.
-Related website provides the latest information on spine technology including articles and research papers on the latest technology and development.
-Major technologies reviewed include devices used for fusion (screws, plates, rods, and cages), disc repair and augmentation, total disc replacement, and vertebral body repair and augmentation.
-Technology landscape, review of published/public domain data currently available, and safety and efficacy of technology discussed in detail.

Every day, newspapers and television news programs present stories on the latest controversies over healthcare and medical advances, but they do not have the space to provide detailed background on the issues. Websites and weblogs provide information from activists and partisans intent on presenting their side of a story. But where can students - or even ordinary citizens - go to obtain unbiased, detailed background on the medical issues affecting their daily lives? This volume in the Health and Medical Issues Today series provides readers and researchers a balanced, in-depth introduction to the medical, scientific, legal, and cultural issues surrounding organ tranplants and its import in today's world of healthcare. Organ Transplantation is organized to provide readers with easy access to the information they need: BLSection 1 provides overview chapters on the background information needed to intelligently understand the issues and controversies surrounding organ transplants, such as how organs are procured and who determines who gets an organ. BLSection 2 offers capsule examinations of the contemporary issues and debates that provoke the most heated disagreements and misunderstandings, such as controversies over who deserves to get an organ, and the concerns over xenotransplantation BLSection 3 includes reference material on organ transplantation, including primary source documents from important players in the debates, a timeline of important events, and an annotated bibliography of useful print and electronic resources. This volume in the Health and Medicine Today series provides everything a student requires to understand the issues involved in organ transplantation and provides aspringboard for further research into the issue

The developments that have occurred in the field of organ transplantation during the 1980s and early 1990s, and the simultaneous rise and fall of the Jarvik-7 artificial heart are the subject of this vividly written and absorbing new volume. In Spare Parts, fascinating, interconnected stories of organ transplantation and the artificial heart are recounted in an interpretive framework that explores the vision of the "replaceable body." Themes of uncertainty, gift exchange, and the allocation of scarce material and non-material resources underscore a discussion that openly examines the escalating ardor about the goodness of repairing and remaking people with transplanted organs. Likewise, the stories open questions of life and death, identity, and solidarity. This important book offers insights into the symbolic and anthropomorphic meanings associated with the human body and its organs, and into the ways that medical professionals come to terms with the concomitant aspects of transferring vital body parts. Both artificial and donor organs, as well as the process of transplantation, are the subject of a thoughtful discussion which touches on the medical myths and rituals that they generate. Chronologically, Spare Parts begins where the authors' previous book, The Courage to Fail, leaves off. More than a sequel, however, this work reflects their increasingly troubled and critical reactions to the expansion of organ replacement. Likely to be controversial, this book is must reading for bioethicists, medical sociologists and anthropologists, health-care lawyers, planners and administrators, nurses and physicians, medical journalists and science writers, and concerned lay readers.

This book is a comprehensive guide to hair transplantation for dermatologists and hair transplant surgeons. The text begins with an introduction to evaluation, workup and postoperative care, and anaesthesia and pain management. The next chapters guide clinicians step by step through direct hair transplantation, design, and reconstruction, followed by discussion on follicular unit excision (FUE), a technique using grafts. In addition to detailed coverage of hair transplantation on the scalp, the book also explores body hair transplants and eyebrow and eyelash transplantation, concluding with a chapter on setting up a hair transplant centre. The book is further enhanced by nearly 400 descriptive photographs, diagrams and tables. Key points Comprehensive, step by step guide to hair transplantation Includes discussion on follicular unit excision (FUE) and its complications Covers body hair and eyebrow/eyelash transplantation as well as scalp Features nearly 400 clinical photographs, diagrams and tables