Distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, and stroke. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included.

No one argues the need for transplants. The debate centers on how to satisfy the great need for healthy organs. Advances in medical technology and science have made organ procurement, or the search and transfer of organs and tissue from one body to another, a very important issue. Since the demand for healthy organs far exceeds the supply, many questions enter this debate, blending medicine with politics, ethics, research, religion, and other concerns. How are we to meet the need? Can we do so and still respect personal ethics and religious convictions? Can organs be obtained without turning medical emergencies into free-market enterprise? Should people be permitted to sell their organs? Should animals be sacrificed to save the lives of humans? Could cloning be considered as a future source of organs?
With more than thirty of the most important, influential, and up-to-date articles from leaders in ethics, medicine, philosophy, law, and politics, The Ethics of Organ Transplants examines the numerous and tangled issues that surround organ procurement and distribution.
Co-edited by Dr. Arthur L. Caplan, a world recognized scholar in bioethics and health policy, this volume divides the issue into five related areas: (1) sources of organs for transplantation and various methods of transplants, including living donations, fetal tissue use, defining brain death, and nonhuman organ transfer; (2) policy, including presumed consent, required requests, and mandated choice to relieve the shortage problem; (3) the ethics of selling organs, the effect on supply and use of organs, making organ procurement a global effort; (4) case histories and questions on who should (not) receive transplants; and (5) the value

Die vorliegende Habilitationsschrift untersucht die Hypothese, dass die Pumpstorung des Herzens bei Herzinsuffizienz, extrakorporaler Zirkulation und fruh nach Herztransplantation eine gemeinsame immunologische Komponente umfasst. Die direkten Beziehungen zwischen dem Immunsystem und den klassischen Determinanten der kardialen Pumpfunktion, d.h. der Vorlast, Nachlast, Kontraktilitat und Herzfrequenz, werden kritisch diskutiert. Sie werden als mogliche gemeinsame biologische Endstrecke verschiedener pathophysiologischer Konstellationen, von der asymptomatischen linksventrikularen Dysfunktion bis hin zum Sepsis-Syndrom und Multi-Organ-Versagen, interpretiert. Die vorliegende Arbeit, die im interdisziplinaren Konzept des Herzzentrums Munster entstand, stellt einen originellen fachubergreifenden Denkansatz dar. Dieser ist fur Kardiologen, Herzchirurgen, Anasthesiologen und Intensivmediziner gleichermassen von Bedeutung. Er wird in Zukunft im arztlichen Alltag zu einem verbesserten Verstandnis der kardialen Pumpstorung unterschiedlicher Genese sowie zur Entwicklung von neuen Moglichkeiten der Erkennung und Behandlung beitragen.

In der Abdominal- und Transplantationschirurgie konnten in den letzten Jahren beim therapeutischen Vorgehen und bei den erreichten Ergebnissen entscheidende Fortschritte erzielt werden. Die Weiterentwicklungen in der Behandlung endokriner Organe und verschiedener Tumorentit{ten sowohl des Gastrointestinaltraktes als auch des hepatopankreobili{ren Systems -vor allem bei multimodalen Therapieans{tzen - erfordern eine differenzierte pr{operative Diagnostik, Operationsstrategie und postoperative Nachsorge. Dies gilt auch f}r die Nieren-, Leber- oder Prankreastransplantation. Die bei Ausnutzen der vorhandenen therapeutischen M-glichkeiten erreichten Fortschritte wie auch m-gliche Perspektiven, besonders im interdisziplin{ren Behandlungskonzept, werden am Beispiel einer Chirurgenschule (Medizinische Hochschule Hannover) dargestellt.

The developments that have occurred in the field of organ transplantation during the 1980s and early 1990s, and the simultaneous rise and fall of the Jarvik-7 artificial heart are the subject of this vividly written and absorbing new volume. In Spare Parts, fascinating, interconnected stories of organ transplantation and the artificial heart are recounted in an interpretive framework that explores the vision of the "replaceable body." Themes of uncertainty, gift exchange, and the allocation of scarce material and non-material resources underscore a discussion that openly examines the escalating ardor about the goodness of repairing and remaking people with transplanted organs. Likewise, the stories open questions of life and death, identity, and solidarity. This important book offers insights into the symbolic and anthropomorphic meanings associated with the human body and its organs, and into the ways that medical professionals come to terms with the concomitant aspects of transferring vital body parts. Both artificial and donor organs, as well as the process of transplantation, are the subject of a thoughtful discussion which touches on the medical myths and rituals that they generate. Chronologically, Spare Parts begins where the authors' previous book, The Courage to Fail, leaves off. More than a sequel, however, this work reflects their increasingly troubled and critical reactions to the expansion of organ replacement. Likely to be controversial, this book is must reading for bioethicists, medical sociologists and anthropologists, health-care lawyers, planners and administrators, nurses and physicians, medical journalists and science writers, and concerned lay readers.

As a major transplantation center, the University of Pittsburgh has conducted more than 300 liver transplants. Because the problems faced by an institution contemplating the initiation of such an organ transplantation program are many, unique, and often unexpected, the university has been beseiged by requests from other physicians and hospitals for training and advice. This book represents much of the accumulated experience on hepatic transplantation to date.

Th is book takes an integrated, evidence-based approach the psychiatricaspects of organ transplantation. Unlike any other text currently on the market, this title presents the core principles of transplant psychiatry through an organ-based structure that includes the heart, lungs, liver, GI organs, kidney, composite tissue, and other key areas of transplantation. Each section is divided into chapters discussing psychosocial, medical, and surgical considerations prior to and post-transplant, such as indications leading to a particular type of transplantation, medical course and complications aft er transplantation, psychiatric and psychosocial considerations before and aft er transplantation, history of each type of organ transplant, and any other special considerations. Th e text ends with special topics in care, including psychopharmacology, substance abuse, psychosocial evaluation of recipients and donors, ethical considerations, cross-cultural aspects, and building the transplant psychiatry practice. It includes excellent learning tools, including over 140 tables and figures for ease of use. Written by interdisciplinary experts, Psychosocial Care of End-Stage Disease and Transplant Patients is a valuable resource for students and medical professionals interested in psychiatry, psychology, psychosomatic medicine, transplant surgery, internists, hospital administrators, pharmacists, nurses, and social workers.

This book provides an evidence based guide to the management of common kidney conditions. Concise and highly structured chapters outline a diagnosis and treatment framework for kidney diseases encountered within daily practice. Particular attention is given to the management of chronic kidney disease, genetic kidney diseases, cardiovascular complications, haemodialysis, kidney cancer, peritoneal dialysis, and kidney transplantation. Management of Kidney Disease aims to improve outcomes for patients with kidney diseases and is relevant to trainee and practising nephrologists, as well as healthcare professional treating kidney diseases. Additional questions and answers via app: Download the Springer Nature Flashcards app free of charge and use exclusive additional material to test your knowledge.

Given the tensions and demands of medicine, highly successful physicians and surgeons rarely achieve equal success as prose writers. It is truly extraordinary that a major, international pioneer in the controversial field of transplant surgery should have written a spellbinding, and heart-wrenching, autobiography. Thomas Starzl grew up in LeMars, Iowa, the son of a newspaper publisher and a nurse. His father also wrote science fiction and was acquainted with the writer Ray Bradbury. Starzl left the family business to enter Northwestern University Medical School where he earned both and M.D. and a PhD. While he was a student, and later during his surgical internship at the Johns Hopkins Hospital, he began the series of animal experiments that led eventually to the world\u2019s first transplantation of the human liver in 1963. Throughout his career, first at the University of Colorado and then at the University of Pittsburgh, he has aroused both worldwide admiration and controversy. His technical innovations and medical genius have revolutionized the field, but Starzl has not hesitated to address the moral and ethical issues raised by transplantation. In this book he clearly states his position on many hotly debated issues including brain death, randomized trials for experimental drugs, the costs of transplant operations, and the system for selecting organ recipients from among scores of desperately ill patients. There are many heroes in the story of transplantation, and many \u201cpuzzle people,\u201d the patients who, as one journalist suggested, might one day be made entirely of various transplanted parts. They are old and young, obscure and world famous. Some have been taken into the hearts of America, like Stormie Jones, the brave and beautiful child from Texas. Every patient who receives someone else\u2019s organ - and Starzl remembers each one - is a puzzle. \u201cIt was not just the acquisition of a new part,\u201d he writes. \u201cThe rest of the body had to change in many ways before the gift could be accepted. It was necessary for the mind to see the world in a different way.\u201d The surgeons and physicians who pioneered transplantation were also changed: they too became puzzle people. \u201cSome were corroded or destroyed by the experience, some were sublimated, and none remained the same.\u201d

This concise, accessible book covers anesthesia for hepatico-pancreatic-biliary (HPB) surgery and transplantation, based on randomized clinical trials, meta-analyses, case series, reports, and hands-on experience. The anatomy, physiology, pathophysiology and clinical consequences are discussed, and the close ties between HPB resection and transplant anesthesia are explored. The content reflects current real-world practice, as liver and pancreatic transplant surgeries have substantially improved in terms of blood-loss reduction, fast tracking and reduced risk. The book also addresses anesthetic aspects in connection with the recently introduced and rapidly expanding practice of laparoscopic surgery; with enhanced recovery; and with pancreatic surgery. Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation is intended for aspiring HPB and transplant anesthetists, anesthesia trainees, and consultants with experience in HPB anesthesia who want to see whether or not they're up to date on the current standards.

On December 2, 1982, the fully mechanical Jarvik-7 heart was placed inside Barney Clark's chest, culminating years of painstaking research and making medical history by successfully pumping Clark's blood for 112 days. True Valor takes an in-depth look at this significant event, telling the stories of the doctors and researchers involved, of Barney Clark, and of the evolution of the artificial heart before and after Clark's transplant. Author Don Olsen is well positioned to tell this story, having worked on the artificial heart project under Dr. William Kolff, the man who designed the Jarvik-7. His narrative conveys the concerns and emotions of those who were part of Clark's story while offering the insights of one who knows that research does not happen overnight but takes time, resources, and the efforts of many people. Olsen's account shares the human sides of this story along with the embedded politics and technical details of medical research in clear, readable language.

As a female surgeon, Dr. Kellee Slater works in one of the most demanding areas of medical operations, liver transplantation. In this inspiring, heartbreaking, and darkly humorous memoir, she opens up the fast-paced world of donor surgery. She takes readers with her as she flies across the Rocky Mountains in winter to collect transplant organs, rushes out of a department store change room to save the life of a toddler who is choking to death, and, horrifyingly, tells the wrong father in a hospital waiting room that there is no hope for his daughter. An ideal read for anyone with an interest in modern medicine, this inspirational memoir portrays both the joyous and difficult experiences of one of the most demanding jobs in the world.

This title provides a comprehensive and state-of-the-art summary of current and future immunosuppressive strategies in transplantation, with emphasis on the basic science mechanisms and clinical applicability of these strategies. The uniqueness of this book is the inclusion of up-to-date information on the basic mechanisms of actions of the immunosuppressive drugs as well as a summary of the clinical trials data and the potential use of these drugs in clinical organ transplantation. In addition to describing the various immunosuppressive strategies, the book has three special features, including immunosuppression in xenotransplantation, gene therapy approaches, and transplantation tolerance. A group of outstanding investigators have been assembled to write the chapters. The book is intended for the transplant professional and the specialist who wants to stay abreast of the current status of immunosuppression in organ transplantation. The book is also useful for basic scientists who work in the field of transplantation immunology.

The problems a transplant patient faces do not stop once the surgery is over; in addition to problems with the transplant itself, the host body reacts in a number of different ways to the arrival of a new organ and the immuno suppression required to sustain it. This pioneering text from an internationally known expert on the kidney details the problems that a patient faces with a kidney transplant and looks at how the physician can treat these; it will be an essential resource for all those involved in the initial and continuing treatment of kidney transplant patients.

Perhaps no medical breakthrough in the twentieth century is more spectacular, more hope-giving, or more fraught with ethical questions than organ transplantation. Each year some 25,000 Americans are pulled back from the brink of death by receiving vital new organs. Another 5,000 die while waiting for them. And what distinguishes these two groups has become the source of one of our thorniest ethical questions. In Raising the Dead, Ronald Munson offers a vivid, often wrenchingly dramatic account of how transplants are performed, how we decide who receives them, and how we engage the entire range of tough issues that arise because of them. Each chapter begins with a detailed account of a specific case--Mickey Mantle's controversial liver transplant, for example--followed by careful analysis of its surrounding ethical questions (the charges that Mantle received special treatment because he was a celebrity, the larger problems involving how organs are allocated, and whether alcoholics should have an equal claim on donor livers). In approaching transplant ethics through specific cases, Munson reminds us of the complex personal and emotional dimension that underlies such issues. The book also ranges beyond our present capabilities to explore the future possibilities in xenotransplantation (transplanting animal organs into humans) and stem cell technology that would allow doctors to grow new organs from the patient's own cells. Based on extensive scientific research, but written with a novelist's eye for the human condition, Raising the Dead shows readers the reality of organ transplantation now, the possibility of what it may become, and how we might respond to the ethical challenges it forces us to confront.

Fully revised throughout, the second edition of Manual of Stem Cell and Bone Marrow Transplantation is based on the in-house handbook used at the world-renowned Dana-Farber Cancer Institute. It is a practical pocket manual for all members of the stem cell and bone marrow transplant team. Written by experts at Dana-Farber, the contents are handily arranged in outline format for maximum usefulness and convenience. This essential and user-friendly manual covers all aspects of the transplantation process, from stem cell processing through management of transplant-related complications. Topics discussed thoroughly include evaluation and counselling of patients and donors, preventative care, graft-versus-host disease and conditioning regimens. A new extensive chapter on oral health in stem cell transplantation has been added. These features make the Manual of Stem Cell and Bone Marrow Transplantation an ideal resource for the entire transplant team.

This volume is a complete manual of operative techniques for battling a severe liver injury. It provides an easy pre-operative and intra-operative reference with clear illustrations, line drawings as well as actual intra-operative color pictures, supplemented by online video segments. The early sections of the book deal with the fundamentals of surgical anatomy and critical maneuvers in the resuscitation of the patient in extremis. The various technical maneuvers for manual control of hemorrhage, debridement-resection as well as formal lobectomy of the liver, the identification of biliary tract injuries and other miscellaneous techniques, such as balloon tamponade of missile tracts, are discussed in complete detail. The book also sketches the role of liver transplantation surgeons in the acute trauma setting. The final chapters focus on the urgent problem of teaching operative techniques to young trauma surgeons in an era of dwindling surgical experience. Written by authors who are world- renowned experts in trauma management, often termed "master-surgeons", Operative Techniques for Severe Liver Injury is required preparation for all surgeons who are likely to face a massive crush injury of the liver.

The evolution of medicine is one of the outstanding features of the past century. The progress achieved by organ transplants is particularly important in this regard. Transplant medicine has progressed massively, but, due to insufficient social donation responses, waiting patient lists increase and the sad consequences of this reality persist indefinitely. This book provides a thorough analysis of the problems presented by organ transplants and social behaviour. It interprets the evolution of transplantation, and its associated medical, ethical-legal, psychosocial and religious problems, as well as educational proposals that have accompanied this medical practice over time. It will serve to provide, at all societal levels, the possibility of a clear understanding of this serious health crisis.

This book provides an informative update on scientific advances relating to transplant dermatology that may be applicable to clinical practice. Commentary is provided on the emerging role of viruses in transplant dermatology, the management of skin disease secondary to transplant medication, sunscreen use in transplant recipients, the role of revision of immunosuppression, and advances in photodynamic therapy. The latest staging and management criteria for high-risk squamous cell carcinoma and the implications for clinical practice are then analyzed. Finally, the management of other cutaneous malignancies is discussed, covering malignant melanoma, Merkel cell carcinoma, and rarer tumors that also behave aggressively and require special consideration in solid organ transplant patients. Each particular advance is addressed in an individual chapter by leaders in the field. The book both expands current knowledge and complements previous textbooks on the subject.

This reference work provides a comprehensive review of the most crucial and provocative aspects of pancreas transplantation. It represents a unique source of information and guidance for the current generation of transplant surgeons that evolved from being pure clinicians into savvy administrators knowledgeable in every regulatory aspect governing transplantation. The book contains 15 chapters covering every single aspect of the surgical operation in the donors as well as the recipients of pancreas transplants. The pre-operative workup, as well as the post-operative immunosuppression management, and the treatment of recurrent diseases are addressed in detail. In addition, the book further expands the role of islet cell transplant with its ever increasing prominence, which includes the role of autologous islet cell transplant. The impact of increasing regulatory burdens from the federal government coupled with the economic and health burden of Diabetes mellitus is discussed.

This work provides a one-of- a-kind volume that includes all aspects of heart transplantation from its historic beginning to its current day standards which now make the procedure a long-term treatment option for heart failure patients. The subjects covered include technical aspects of the procurement and implant procedures, as well as the medical nuances of pre-operative preparation and post-transplant immunosuppression management; the current day multi-disciplinary make up of the transplant team along with information on the keys to building and running a successful transplant program; regulatory standards and listing policies and the impact of the growing mechanical circulatory support technologies on the transplant field; and emerging technologies and future possibilities. All chapters are written by experts in the field and include the most up-to-date peer reviewed studies and clinical guidelines. This book gives an ever-changing reference that will become the text of choice for those beginning or continuing their transplant careers.

Organ transplantation is in many cases the only available treatment for end-organ failure. The transplantation of tissues and cells offers major therapeutic benefits and improvement of the quality of life, but raises a number of questions of principle. The Council of Europe is the leading standard-setting institution in the field. It approaches organ transplantation from an ethical and human rights perspective, taking compliance with the principles of non-commercialization and voluntary donation of substances of human origin as the basis for all ethical concerns in this respect. Its work includes assuring the safety and quality of organs, tissues and cells, meeting the organ shortage, living donation and preventing and minimizing organ trafficking. This is the 3rd edition of the guide, which applies to the transplantation of organs, tissues and cells of human origin for therapeutic purposes. Its aim is to provide guidance for all those involved in order to maxim

This handbook is the most authoritative and up-to-date reference on spine technology written for practitioners, researchers, and students in bioengineering and clinical medicine. It is the first resource to provide a road map of both the history of the field and its future by documenting the poor clinical outcomes and failed spinal implants that contributed to problematic patient outcomes, as well as the technologies that are currently leading the way towards positive clinical outcomes. The contributors are leading authorities in the fields of engineering and clinical medicine and represent academia, industry, and international government and regulatory agencies. The chapters are split into five sections, with the first addressing clinical issues such as anatomy, pathology, oncology, trauma, diagnosis, and imaging studies. The second section, on biomechanics, delves into fixation devices, the bone implant interface, total disc replacements, injury mechanics, and more. The last three sections, on technology, are divided into materials, commercialized products, and surgery. All appropriate chapters will be continually updated and available on the publisher's website, in order to keep this important reference as up-to-date as possible in a fast-moving field.