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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Therapeutic Immunosuppression (Paperback, Softcover reprint of the original 1st ed. 2001)
Loot Price: R1,596
Discovery Miles 15 960
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Therapeutic Immunosuppression (Paperback, Softcover reprint of the original 1st ed. 2001)
Series: Immunology and Medicine, 29
Expected to ship within 10 - 15 working days
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Therapeutic immunosuppression has very broad applications in
clinical medicine, ranging from prevention and treatment of organ
and bone marrow transplant rejection, management of various
autoimmune disorders (e.g., rheumatoid arthritis), skin disease,
and asthma. Whereas traditionally only a small repertoire of
immunosuppressive agents was available for clinical use, recent
discoveries have significantly increased the number of approved
agents, resulting in numerous trials to further evaluate their
potential. In addition, products of the biotechnology industry -
monoclonal antibodies, cytokines, cytokine antagonists, and other
products of genetic engineering that target key molecular pathways
in disease pathogenesis - have either already made, or are on the
verge of making an important impact on treatment. There is also
considerable interest in the potential of cell-based therapies
(particularly hematopoietic stem and dendritic cell therapy) of
allo- and autoimmunity. Important recent advances in the
immunotherapy of allergic diseases are also covered in this book.
Gene therapy offers considerable promise for suppressing pathogenic
processes in either transplantation or autoimmune disorders. The
possibility of combining these important new advances to maximize
benefit to the patient, and to minimize possible untoward effects
(which are also given extensive coverage in this book), is one of
the most exciting challenges of contemporary medicine. This volume
is intended both for practising physicians and surgeons and for
biomedical scientists at the graduate/postdoctoral levels, and is
designed to provide the theory behind these various approaches to
immunosuppression, and to provide state-of-the-art reviews of
current developments in each area. Each chapter is contributed by
one or more experts in the field. There was a need to bring this
information together in a single volume, as much of the key recent
developments have been dispersed throughout the biomedical
literature, largely in specialized journals. Since, as in the past,
important developments in immunosuppressive therapy in one branch
of medicine (i.e. transplantation) are likely to benefit another
(e.g., dermatology, rheumatology, gastroenterology),
cross-disciplinary coverage of the mechanistic basis of the various
therapeutic strategies in a single volume is likely to convey the
potential of advances in therapy in the most coherent manner
possible.
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