West Nile virus is a neurotropic flavivirus that has emerged
globally as a primary cause of viral encephalitis. Infection of
humans and other vertebrate animals is associated with a febrile
illness that can progress to a lethal encephalitis or flaccid
paralysis syndrome. Its appearance in the Western Hemisphere in
1999 and the corresponding increase in global disease burden over
the last decade have been accompanied by intensive study, including
the entry of many scientists into the field. Breakthroughs have
been made in understanding the unique transmission pattern between
the vector and the multiple avian and mammalian hosts and targets.
Studies in mammalian systems have dissected the viral and host
factors that determine the pathogenesis and outcome of West Nile
virus infection. On the basis of these experiments, progress has
been made on the identification of genetic factors that predispose
to severe human disease. Thus, in a remarkably short period of
time, insight has been gained on a wide variety of disciplines
related to West Nile virus biology. The aim of this book was to
assemble an up-to-date and cutti- edge anthology from the leading
experts in the field. The chapters are balanced by submissions from
newcomers who have made significant recent contributions with those
from established investigators who have dedicated their careers to
the study of West Nile virus.
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