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Amyotrophic Lateral Sclerosis, Second Edition (Hardcover, 2nd edition)
Loot Price: R5,547
Discovery Miles 55 470
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Amyotrophic Lateral Sclerosis, Second Edition (Hardcover, 2nd edition)
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Amyotrophic lateral sclerosis (ALS), a slowly progressive disease
of variable presentation and rate of progress, has come into the
limelight after a century of neglect. Recently, the pace of
research has rapidly accelerated, stemming from several parallel
lines of research: epidemiology and genetics, neurotrophic factors,
excitotoxicity and its integral relation to energy metabolism, free
radical homeostasis and its relation to apoptotic cell death,
calcium metabolism and cytoskeletal proteins within the motor
neuron. Moreover, striking advances in technology for biomedical
research are also contributing. From these investigations,
reclassification of ALS and motor neuron diseases syndromes is
beginning. The introduction of an anti-excitotoxic drug, with an
effect in slowing progression of the disease, has made the process
of diagnosis and clinical management more important. All these
factors have led to a surge in interest and understanding regarding
therapy, the maintenance of quality of life in the disease and the
ethical issues surrounding the progression of this disease. This
book will be of great interest to clinical neurologists and
trainees, and to all those concerned in the care of people with
ALS.
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