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Diabetes and Cardiovascular Disease (Hardcover, 2nd ed. 2005)
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Diabetes and Cardiovascular Disease (Hardcover, 2nd ed. 2005)
Series: Contemporary Cardiology
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The cause of diabetes mellitus is metabolic in origin. However, its
major clinical manifestations, which result in most of the
morbidity and mortality, are a result of its vascular pathology. In
fact, the American Heart Association has recently stated that,
"from the point of view of cardiovascular medicine, it may be
appropriate to say, diabetes is a cardiovascular disease" (1). But
diabetic vascular disease is not limited to just the
macrovasculature. Diabetes mellitus also affects the
microcirculation with devastating results, including nephropathy,
neuropathy, and retinopathy. Diabetic nephropathy is the leading
cause of end-stage renal disease in the United States, while
diabetic retinopathy is the leading cause of new-onset blindness in
working-age Americans. The importance of this text on Diabetes and
Cardiovascular Disease is evident by the magnitude of the
population affected by diabetes mellitus. Over 10 million Americans
have been diagnosed with diabetes mellitus, while another 5 million
remain undiagnosed. The impact from a public health perspective is
huge and increasing. As the population of the United States grows
older, more sedentary, and obese, the risk of developing diabetes
and its complications will increase. Epidemiological studies have
identified diabetes mellitus as a major independent risk factor for
cardiovascular disease. Over 65% of patients with diabetes mellitus
die from a cardiovascular cause. The prognosis of patients with
diabetes mellitus who develop overt clinical cardiovascular disease
is much worse than those cardiovascular patients free of diabetes
mellitus.
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