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Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II (Paperback, Softcover reprint of the original 1st ed. 1980)
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Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II (Paperback, Softcover reprint of the original 1st ed. 1980)
Series: Environmental Science Research, 22
Expected to ship within 10 - 15 working days
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More than one hundred short-term bioassays are now available for
detecting the toxicity, mutagenicity, and potential carcinogenicity
of chemicals. These bioassays were developed and validated with
individual compounds, and their principal application was perceived
to be in evaluating the health hazard of such materials. However,
man is rarely exposed to single chemicals; his exposure to
hazardous chemicals is more commonly a multifactorial phenomenon.
Although chemical analysis can be used to detect known hazardous
compounds, it would be a staggering and expensive task to analyze
large numbers of samples for all known or suspected hazardous
constituents. Furthermore, the biological activity of a complex
mixture cannot be reliably predicted from knowledge of its
components. On the other hand, bioassays alone cannot tell us which
components of complex mixtures are responsible for the biological
activity detected. Thus, cost effectiveness and technical
feasibility dictate stepwise and perhaps iterative application -of
both chemical and biological methods in evaluating the health
effects of complex environmental mixtures. Through the coupling of
reliable biological detection systems with methods of chemical
fractionation and analysis, it is frequently possible to isolate
the individual chemical species that show biological activity.
Initially, complex mixtures may be separated and bioassayed in
carefully defined chemical fractions. The results of such
short-term screening bioassays then may be used td guide the course
of further fractionation and to determine the need for more
stringent and comprehensive biological testing.
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