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Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms (Hardcover)
Loot Price: R3,284
Discovery Miles 32 840
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Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms (Hardcover)
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A microfluidic biochip is an engineered fluidic device that
controls the flow of analytes, thereby enabling a variety of useful
applications. According to recent studies, the fields that are best
set to benefit from the microfluidics technology, also known as
lab-on-chip technology, include forensic identification, clinical
chemistry, point-of-care (PoC) diagnostics, and drug discovery. The
growth in such fields has significantly amplified the impact of
microfluidics technology, whose market value is forecast to grow
from $4 billion in 2017 to $13.2 billion by 2023. The rapid
evolution of lab-on-chip technologies opens up opportunities for
new biological or chemical science areas that can be directly
facilitated by sensor-based microfluidics control. For example, the
digital microfluidics-based ePlex system from GenMarkDx enables
automated disease diagnosis and can bring syndromic testing near
patients everywhere. However, as the applications of molecular
biology grow, the adoption of microfluidics in many applications
has not grown at the same pace, despite the concerted effort of
microfluidic systems engineers. Recent studies suggest that
state-of-the-art design techniques for microfluidics have two major
drawbacks that need to be addressed appropriately: (1) current
lab-on-chip systems were only optimized as auxiliary components and
are only suitable for sample-limited analyses; therefore, their
capabilities may not cope with the requirements of contemporary
molecular biology applications; (2) the integrity of these
automated lab-on-chip systems and their biochemical operations are
still an open question since no protection schemes were developed
against adversarial contamination or result-manipulation attacks.
Optimization of Trustworthy Biomolecular Quantitative Analysis
Using Cyber-Physical Microfluidic Platforms provides solutions to
these challenges by introducing a new design flow based on the
realistic modeling of contemporary molecular biology protocols. It
also presents a microfluidic security flow that provides a
high-level of confidence in the integrity of such protocols. In
summary, this book creates a new research field as it bridges the
technical skills gap between microfluidic systems and molecular
biology protocols but it is viewed from the perspective of an
electronic/systems engineer.
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