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Radioiodination: Theory, Practice, and Biomedical Applications (Hardcover, 1992 ed.)
Loot Price: R9,021
Discovery Miles 90 210
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Radioiodination: Theory, Practice, and Biomedical Applications (Hardcover, 1992 ed.)
Series: Developments in Nuclear Medicine, 21
Expected to ship within 12 - 17 working days
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Among the readily available -emitting radionuclides, the nuclides
of iodine have the greatest versatility in labeling both the
hydrophilic and the lipophilic compounds that are used in biology
and medicine. Biologically important micrmolecules,
semimacromolecules, and macromolecules have been identified which,
after iodination, almost maintain the same molecular configuration
and similar biologic specificity as those of the parent molecules.
The multiple techniques for iodination and the clinical use of
iodinated products have made possible the present status of the
development of diagnostic nuclear medicine. 125r, with a half-life
of 60 days, has a crucial role in competitive protein-binding
studies. 131r is useful for measuring thyroid uptake, for the
diagnosis of thyroid carcinoma and metastasis, and for therapy. 1nr
, with a reasonably shorter half-life, is almost ideal for thyroid
workup and for a few useful labeled radiopharmaceutical. Although
~c is used more widely in diagnostic procedures, the radionuclides
of iodine will always have a major role in biology and medicine. A
considerable amount of information is scattered in the literature
regarding the chemistry of radioiodination and the mechanism of
tracer localization in cells and tissues. Labeled peptides,
proteins, and antibodies are extensively used for protein turnover
studies, receptor binding and tumor imaging studies, and
radioimmunoassay. The general trend in the use of tracers in
clinical nuclear medicine has been an evolution from 3H, 14C, 11C,
and 13 to 125 , 131 and 123r to ~c and 111rn.
General
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