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SPECT/CT cameras have considerably improved diagnostic accuracy in recent years. Such cameras allow direct correlation of anatomic and functional information, resulting in better localization and definition of scintigraphic findings. In addition to this anatomic referencing, CT coregistration provides superior quantification of radiotracer uptake based on the attenuation correction capabilities of CT. Useful applications of SPECT/CT have been identified not only in oncology but also in other specialties such as orthopedics and cardiology. This book covers the full spectrum of clinical applications of SPECT/CT in diagnosis and therapy planning of benign and malignant diseases. Opening chapters discuss the technology and physics of SPECT/CT and its use for dosimetry. The role of SPECT/CT in the imaging of a range of pathologic conditions is then addressed in detail. Applications covered include, among others, imaging of the thyroid, bone, and lungs, imaging of neuroendocrine tumors, cardiac scintigraphy, and sentinel node scintigraphy. Individual chapters are also devoted to therapy planning in selective internal radiation therapy of liver tumors and bremsstrahlung SPECT/CT. Readers will find this book to be an essential and up-to-date source of information on this invaluable hybrid imaging technique.
Drawing on an extensive series of cases, this book describes and illustrates in detail the FDG-PET/CT appearances of the most common lymphomas in both adults and children, covering presentations at various anatomic sites. In addition, all other aspects of the current application of FDG-PET/CT in the evaluation and management of patients with malignant lymphomas are described. Full explanations are provided of the potential benefits and limitations of advanced PET/CT techniques and technologies that support novel chemotherapy and radiotherapy approaches in the treatment of lymphoma, and particular attention is paid to the major challenge of incorporating progress in quantitative imaging technology into radiotherapy treatment planning, guidance, and monitoring. This clinical case-based atlas will be an invaluable tool for radiologists, hematologists, and clinical oncologists.
This book introduces molecular imaging and Target Therapy in various cancers. The first part is the subjects and primary focused on the basics of nuclear physics, radiation dosimetry, nuclear medicine equipment and small animal imaging equipment. The second part is about the radiopharmaceutical and commonly used clinical radiopharmaceuticals, including positron emission imaging agent, single photon emission imaging agent, and radionuclide therapy agents as well as their radioactive preparation, quality control, and a brief clinical application were included. Also, this part introduces a number of new imaging agents which were potential value of clinical applications. In the third part, the clinical application of the conventional imaging agent 18F-FDG in different tumors and neurodegenerative diseases and 18F-Dopa imaging in the nervous system are discussed. Besides the clinical applications of 99mTc labeled radiopharmaceuticals in parathyroid disease, coronary heart disease, myocardial infarction, sentinel lymph node, metastatic bone tumors, liver and gallbladder disease in children are introduced. Finally, the applications of radionuclide 131I on treatments of Graves' disease and differentiated thyroid cancer and metastases are investigated respectively. This book is a useful reference for professionals engaged in nuclear medicine and clinical research, including clinical nuclear medicine physicians, nuclear medicine engineers and nuclear medicine pharmacists.
An excellent introduction to the basic concepts of nuclear medicine physics
This "Third Edition" of" Essentials of Nuclear Medicine Physics and Instrumentation" expands the finely developed illustrated review and introductory guide to nuclear medicine physics and instrumentation. Along with simple, progressive, highly illustrated topics, the authors present nuclear medicine-related physics and engineering concepts clearly and concisely. Included in the text are introductory chapters on relevant atomic structure, methods of radionuclide production, and the interaction of radiation with matter. Further, the text discusses the basic function of the components of scintillation and non-scintillation detector systems. An information technology section discusses PACs and DICOM. There is extensive coverage of quality control procedures, followed by updated chapters on radiation safety practices, radiation biology, and management of radiation accident victims.
Clear and concise, this new edition of "Essentials of Nuclear Medicine Physics and Instrumentation" offers readers: Four new chaptersUpdated coverage of CT and hybrid scanning systems: PET/CT and SPECT/CTFresh discussions of the latest technology based on solid state detectors and new scanner designs optimized for dedicated cardiac imagingNew coverage of PACs and DICOM systemsExpanded coverage of image reconstruction and processing techniquesNew material on methods of image display
Logically structured and clearly written, this is the book of choice for anyone entering the field of nuclear medicine, including nuclear medicine residents and fellows, cardiac nuclear medicine fellows, and nuclear medicine technology students. It is also a handy quick-reference guide for those already working in the field of nuclear physics.
This book offers a comprehensive overview of medullary thyroid carcinoma, both in the more common sporadic form and in the familial form, multiple endocrine neoplasia (MEN) types 2A and 2B. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. The role of calcitonin as a highly sensitive and specific tumor marker for the screening, diagnosis, and follow-up of MTC and metastatic disease is described, and the significance of other tumor markers is also considered. With regard to treatment, the use of thyroidectomy is fully discussed, including in children carrying the mutations in the RET proto-oncogene considered causative for MEN 2. Additionally, the value of tyrosine kinase inhibitors as the most effective treatment modality in patients with a large tumor burden or rapid tumor growth, or both, is explained. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.
Using SWOT analysis, this book examines in detail the strengths and weaknesses of the hybrid modalities PET-CT and PET-MRI for imaging of the central nervous system, comparing their merits and evaluating their advantages over the stand-alone modalities. The aim is to employ a truly systematic approach in order to define the potential clinical benefit of these modalities and to identify shortcomings, opportunities, and threats. Clinical application of the modalities is explored in a range of conditions, including dementia and related disorders, movement disorders, psychiatric disorders, cerebrovascular disease, infection/inflammation, brain tumors, and pediatric neurologic disorders. In addition, the basics of hybrid imaging are addressed, covering physics, instrumentation, data analysis and quantitation, radiopharmaceuticals, and contrast media. PET-CT and PET-MRI in Neurology, written by experts from Europe and the United States, will be essential reading for imaging specialists and of value for neurologists, psychiatrists, neurosurgeons, and pediatricians.
This book, now in its third edition, aims to promote a deeper understanding of the scientific and clinical basis of nuclear medicine and the new directions in medical imaging, which will lead to better utilization of nuclear medicine techniques in patient management and to further modifications and innovations in the field. The new edition has been revised and updated to reflect recent changes and to ensure that the contents are in line with likely future directions. The book starts by providing essential basic information on general pathophysiology, cell structure, and cell biology as well as the mechanisms of radiopharmaceutical localization in different tissues and cells. The clinical applications of nuclear medicine are then presented in a series of chapters covering every major organ system. These chapters relate the basic relevant knowledge of anatomy, physiology, and pathology to the clinical utilization of various scintigraphic modalities. The therapeutic applications of nuclear medicine, including recent advances, are discussed in a separate chapter. The final chapter is devoted to the biologic effects of ionizing radiations, including radiation from medical procedures. A glossary at the end of the book has been expanded with clear explanations of certain terms and uncommon disease conditions that will help students and trainees in understanding pertinent concepts. It is hoped that this book will continue to help nuclear medicine practitioners, trainees, students, and researchers, as well as professionals in various other medical fields.
This book is a collection of all pertinent information on radiation safety applicable in nuclear medicine and research using radioactive materials. Radiation exposure causes harm to humans and is strictly controlled by several regulatory authorities (NRC, FDA, EPA, DOT, etc). The practice of nuclear medicine involves the use of radioactive materials in patients and research, and is well regulated by these agencies. However, information on radiation safety practice in nuclear medicine and research areas is scattered throughout the literature and federal registers. For busy nuclear technologists and professionals, it is quite time consuming to look for and acquire specific information and instructions to follow in radiation-related occasions and incidents. This guide provides ready-made, handy information on radiation safety as required in the practice of nuclear medicine, presented in a concise form for easy understanding and quick reference related to a given situation and/or incident. This is an ideal reference for nuclear medicine physicians, nuclear medicine technologists, and researchers using radioactive materials.
Stay on top of recent, significant changes in the areas of nuclear medicine and molecular imaging with this updated and expanded volume in the popular Case Review Series. Nuclear Medicine and Molecular Imaging, 3rd Edition offers highly illustrated, case-based preparation for board review to help residents and recertifying radiologists succeed on exams and provide state-of-the-art patient care. Presents 150 case studies organized by level of difficulty, with all new multiple-choice questions, answers, and rationales that mimic the format of certification exams. Provides more cases on positron emission tomography (PET), including all the latest applications of PET/CT hybrid imaging. Covers new tracers such as Ga68 DOTA, F-18 amyloid, and F-18 prostate cancer imaging agents as well as new indications for Tc99m sestamibi. Reflects recent changes in nuclear medicine including information on patient selection, how therapy affects patients, and if there is evidence of recurring disease. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This work is devoted to understanding the recent advances in nuclear medicine and molecular imaging technologies along with their application to integrated medical therapy and future drug development. This anthology is based on the international symposium in 2015 entitled "Perspective on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. "The symposium provided an opportunity to exchange ideas on how to promote nuclear medicine technology and how to extend the technology to medical therapy and drug development, and was also a good opportunity to discuss the future perspective of nuclear medicine and molecular imaging by worldwide leaders in the field. Molecular imaging technologies have been rapidly developed worldwide in recent years. Among those developments, nuclear medicine has come to play an important role in quantitative analysis of biological process in vivo as well as in wide clinical use. With the current progress of nuclear medicine and molecular imaging, this modality has been applied for treatment monitoring and predicting its outcome with the use of optimal imaging biomarkers and suitable quantitative analysis. Truly, a new era has arrived with clinical use of nuclear medicine and molecular imaging for personalized medicine. This volume will benefit a wide variety of researchers in life science including those working in drug development, molecular imaging, and medical therapy as well as physicians who utilize diagnostic imaging.
The Physics of Three Dimensional Radiation Therapy presents a broad
study of the use of three-dimensional techniques in radiation
therapy. These techniques are used to specify the target volume
precisely and deliver radiation with precision to minimize damage
to surrounding healthy tissue. The book discusses multimodality
computed tomography, complex treatment planning software, advanced
collimation techniques, proton radiotherapy, megavoltage imaging,
and stereotactic radiosurgery. A review of the literature, numerous
questions, and many illustrations make this book suitable for
teaching a course.
This book, written by authors with national and international reputations in the field, covers all aspects of radionuclide and hybrid bone imaging. Introductory sections present the basic science and consider the current status and limitations of conventional radiological techniques. The underlying principles of PET-CT and SPECT-CT are carefully explained, and the value of different PET and SPECT tracers, assessed. The role of single- and dual-modality approaches in the imaging of benign bone diseases and malignancies is then discussed in detail in a series of well-illustrated chapters. The pathologies addressed include metabolic bone disease, arthritis, bone and joint infections, primary bone and soft tissue tumors, and metastases from breast and prostate cancer. A further section considers the role of bone scintigraphy in the pediatric patient, and the closing chapters focus on miscellaneous subjects, including bone densitometry and radionuclide targeted therapy.
Edited by Dominique Delbeke and Ora Israel, two leading authorities in the field of nuclear medicine, this practical guide is a reference source of cases for images obtained on state-of-the-art integrated PET/CT and SPECT/CT imaging systems. The cases are presented in-depth so that they will be of value to residents training in nuclear medicine and radiology and to nuclear medicine physicians and radiologists who need to become familiar with this technology. Internationally recognized contributors provide the reader with in-depth coverage on the technical and clinical aspects of hybrid imaging. Principles of hybrid imaging, physics and instrumentation, normal distribution of radiopharmaceuticals and protocols central to the field are covered. A comprehensive review of nuclear oncology cases found in everyday practice, ranging from simple to complex are also addressed. The full spectrum of clinical applications is covered including head and neck tumors, breast cancer, colorectal cancer, pancreatic cancer, and genitourinary tumors. Additional chapters examine cardiac hybrid imaging, benign bone diseases and infection and inflammation. A wealth of illustrations reinforce the key teaching points discussed throughout the book.
This book is a pocket guide to the role of PET/CT in malignancies of the hepatobiliary system and pancreas. Imaging findings characteristic of malignancies are described and illustrated, and attention drawn to normal variants and artifacts. In addition, information is presented on epidemiology, clinical presentation, pathology, staging, and management in order to provide the clinical insight required by the imaging specialist. The book will be of immense value to practicing nuclear physicians as well as hybrid imaging specialists, particularly during reading sessions and multidisciplinary team meetings. It will also serve as a quick reference for residents and fellows in the PET/CT department. The book is published within the series Clinicians' Guides to Radionuclide Hybrid Imaging, which is compiled under the auspices of the British Nuclear Medicine Society. The series is the joint work of professionals worldwide who share a common vision in promoting nuclear medicine as an important imaging specialty for the diagnosis and management of oncological and non-oncological conditions.
The Institute of Nuclear Medicine, founded in 1961, celebrates with this Festschrift, its Golden Jubilee. It has been a remarkable 50 years of progress of the radionuclide tracer methodology. From initial, physiology based experimentation, a full independent medical discipline evolved, and with it, a comprehensive clinical service. Diagnosis and Treatment with radiotracers have established the basis for Nuclear Medicine. Technological advances have permeated the field like none other, its multidisciplinary character and its translational research are embedded in the history of the Institute and its success. Recent and latest advances in the field promise a future as bright as has been witnessed and documented in the last 50 years.
This book offers a comprehensive overview of the state of the art in the practice of radioguided surgery. The opening section is devoted to the basic physics principles for detection and imaging, radiation detection device technology, principles of surgical navigation, radionuclides and radiopharmaceuticals, and radiation safety. A series of chapters then address the clinical application of radioguided surgery for a variety of malignancies, including breast cancer, melanoma and other cutaneous malignancies, gynecologic malignancies, head and neck malignancies, thyroid cancer, urologic malignancies, colon cancer, gastroesophageal cancer, lung cancer, bone tumors, parathyroid adenomas, and neuroendocrine tumors. For each application, the recommended methodological approaches are discussed and the available cumulative clinical experiences of investigators from across the globe are reviewed. A conscious effort is made to highlight recent developments and innovative multidisciplinary approaches within each clinical area. Interesting issues and novel approaches are further explored through a collection of selected case reports at the end of the book. The contributing authors are all experts in their own fields, ensuring that the book will hold wide appeal for surgeons, surgical technologists, nuclear medicine physicians, nuclear medicine technologists, and various trainees.
This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like "The Production of Radionuclides" and "Basics of Radiochemistry". The second section is the main focus of the book. In this section, each chapter's author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a "Best of the Rest" chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including "Bioconjugation Methods," "Click Chemistry in Radiochemistry", and "Radiochemical Instrumentation." This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.
This new atlas, the fourth of a successful series, is a completely revised and updated edition of a previously published FDG PET-CT atlas. In the past few years, considerable progress has been made in the field of PET-CT imaging, and this new edition takes full account of these recent developments. Furthermore, its educational mission has been broadened: beyond serving as a straightforward guide to FDG PET-CT imaging it now encompasses the integrative use of contrast-enhanced CT and MRI. The new edition also includes non-oncological indications for FDG PET-CT. The atlas aims to help imaging practitioners to recognize physiological and benign pathological FDG uptake and illustrates in a case-based, practical manner the PET-CT appearances of all the major tumors and infectious, inflammatory, and neurodegenerative disorders. The main clinical applications are covered, and learning points and pitfalls are clearly articulated. The consistent, user-friendly format facilitates image interpretation and allows rapid review of key information needed for FDG PET-CT imaging.
A tactical guide for radiologists and nuclear medicine physicians, Diagnostic Imaging: Nuclear Medicine, Second Edition is practical, easy-to-use, and in-touch with the realities of multimodality diagnostic imaging. This comprehensive yet accessible reference addresses the most appropriate nuclear medicine options available to answer specific clinical questions within the framework of all imaging modalities. Sweeping updates include a complete reorganization, new differential diagnoses based on findings, and new chapters on physics and Nuclear Regulatory Commission guidelines. User-friendly bulleted text and a uniform chapter layout allow fast and effortless access to the crucial knowledge you need! Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, 2,000 full-color annotated images, and an extensive index Expanded coverage of the most important topics and trends in nuclear medicine including Recently revised radioactive iodine therapy guidelines for hyperthyroidism and thyroid cancer New bone tumor therapy radium-223 (currently indicated for treatment of painful bone metastases in prostate cancer) New I-123 ioflupane dopamine transporter imaging for diagnosis of parkinsonian syndromes F-18 PET/CT bone scan (particularly its indication for nonaccidental trauma in children) Meticulous updates throughout reflect the latest advances as well as all study guide topics listed for the new American Board of Radiology exam, including physics and Nuclear Regulatory Commission guidelines Expert Consult eBook version included with purchase allows you to search all of the text, figures, and references from the book on a variety of devices
Positron Emission Tomography with Computed Tomography (PET/CT) is a nuclear medicine imaging modality using positron-emitting radiotracers and a combined PET and CT scanner in order to detect and localize high radiotracer signal abnormalities. Although PET has evolved into a diagnostic modality of prime importance in oncology (with the radiotracer (F18-FDG) it was originally envisioned to image and diagnose diseases of the brain and the heart. Lack or limited experience in PET may result in an erroneous interpretation of the findings in this sensitive imaging modality.The existence of various rare cancers has resulted in scanty if not a lack of knowledge about the usefulness of PET in these interesting albeit uncommon maladies. The author, drawing from more than ten years of experience as the chairman/director of the only PET Center in the Philippines, aims to present the most interesting cases he has encountered which may be educational to those beginning their practice or even helpful to veterans of the field whose scope of practice has been limited to the most common and reimbursable indications of an FDG-PET scan."
Written by one of the world's leading experts in the field of nuclear medicine dosimetry, this text describes in detail the use of internal dose calculations in the practice of nuclear medicine. While radiation therapy with external sources of radiation always employs calculations of dose to optimize therapy for each patient, this is not routinely conducted in nuclear medicine therapy. As the trend towards an increasing role of dosimetry in therapy planning increases, this book reviews the available methods and technologies available to make this a more common practice. The book begins by covering the mathematical fundamentals of internal dose calculations, and uses sample calculations to demonstrate key principles. The book then moves forward to describe anthropomorphic models, dosimetric models, and types and uses of diagnostic and therapeutic radiopharmaceuticals. The depth of coverage makes it useful reference and guide for researchers performing dose calculations and for physicians considering incorporating dose calculations into the treatment of their cancer patients.
Imaging is crucial in the multidisciplinary approach to head and neck cancer management. The rapid technological development of recent years makes it necessary for all members of the multidisciplinary team to understand the potential applications, limitations, and advantages of existing and evolving imaging technologies. It is equally important that the radiologist has sufficient clinical background knowledge to understand the clinical significance of imaging findings. This book provides an overview of the findings obtained using different imaging techniques during the evaluation of head and neck neoplasms, both before and after therapy. All anatomic areas in the head and neck are covered, and the impact of imaging on patient management is discussed in detail. The authors are recognized experts in the field, and numerous high-quality images are included. This second edition provides information on the latest imaging developments in this area, including the application of PET-CT and diffusion-weighted magnetic resonance imaging.
The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing steadily. Many innovative molecular imaging probes have already entered clinical practice, and there is no doubt that the future emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation. This handbook addresses all aspects of molecular imaging in oncology, from basic research to clinical applications. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.
This volume focuses on cytological, biochemical, and molecular biological methods to identify and examine the function of each nuclear body, with an emphasis on the analysis of long non-coding RNAs. Chapters focus on exploring recent studies that reveal how certain long non protein-coding RNAs accumulate in specific nuclear bodies and regulate the function of the bodies by serving as architectural components or controlling the dynamics of associating protein components. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Nuclear Bodies and Noncoding RNAs: Methods and Protocols serves as a guideline for further study into the sophisticated regulation of gene expression.
This publication is a compendium of physical principles, system descriptions, instrument quality assurance, and clinical applications of extant tomographic methods in nuclear medicine. Written by an expert in this pertinent field, each chapter deals with the topics in a comprehensive fashion to provide a ready reference of all the work done on the subject and an estimate of the future utilization. Descriptions of methods available to nuclear medicine for tomographic viewing include positron emission, single photon emission, and planar tomography. This is an excellent resource volume of general applicability for nuclear medicine physicians, nuclear medicine scientists, and researchers in organ imaging and processing techniques.
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