-Presents a practical, case-based approach -Includes real clinical problems and examples, with worked through solutions -Written in an accessible and student friendly manner

This book provides a comprehensive introduction to current state-of-the-art auto-segmentation approaches used in radiation oncology for auto-delineation of organs-of-risk for thoracic radiation treatment planning. Containing the latest, cutting edge technologies and treatments, it explores deep-learning methods, multi-atlas-based methods, and model-based methods that are currently being developed for clinical radiation oncology applications. Each chapter focuses on a specific aspect of algorithm choices and discusses the impact of the different algorithm modules to the algorithm performance as well as the implementation issues for clinical use (including data curation challenges and auto-contour evaluations). This book is an ideal guide for radiation oncology centers looking to learn more about potential auto-segmentation tools for their clinic in addition to medical physicists commissioning auto-segmentation for clinical use. Features: Up-to-date with the latest technologies in the field Edited by leading authorities in the area, with chapter contributions from subject area specialists All approaches presented in this book are validated using a standard benchmark dataset established by the Thoracic Auto-segmentation Challenge held as an event of the 2017 Annual Meeting of American Association of Physicists in Medicine

This book is designed to give the reader a solid understanding of the

physics and instrumentation aspects of PET, including how PET data are collected and formed into an image. Topics include basic physics, detector technology used in modern PET scanners, data acquisition, and 3D reconstruction. A variety of modern PET imaging systems are also discussed, including those designed for clinical services and research, as well as small-animal imaging. Methods for evaluating the performance of these systems are also outlined. The book will interest nuclear medicine students, nuclear medicine physicians, and technologists.

Experimental microdosimetry deals with the measurement of charged particle energy deposition in tissue equivalent volumes, ranging in size from nanometres to micrometres. Microdosimetry is employed to improve our understanding of the relationship between radiation energy deposition, the resulting biological effects, and the appropriate quantities to be used in characterizing and quantifying radiation quality. Although many reviews and contributions to the field have been published over the past fifty years, this new book is the first to provide a single, up to date, and easily accessible account of experimental microdosimetry. This book is designed to be used in medical, radiation, and health physics courses and by Master’s and PhD students. In addition to serving as an introductory text to the field for graduate students, this book will also be of interest as a teaching and reference resource for graduate supervisors and established researchers. Drs. Lennart Lindborg and Anthony Waker have spent a life-time career in experimental microdosimetry research in academic, industrial and regulatory environments and have observed the development of the field from its early days as a recognized discipline; they bring to this book particular knowledge and experience in the design, construction, operation and use of tissue equivalent gas ionization counters and chambers.

This book explains clearly and in detail all aspects of radiation protection in nuclear medicine, including measurement quantities and units, detectors and dosimeters, and radiation biology. Discussion of radiation doses to patients and to embryos, fetuses, and children forms a central part of the book. Phantom models, biokinetic models, calculations, and software solutions are all considered, and a further chapter is devoted to quality assurance and reference levels. Occupational exposure also receives detailed attention. Exposure resulting from the production, labeling, and injection of radiopharmaceuticals and from contact with patients is discussed and shielding calculations are explained. The book closes by considering exposure of the public and summarizing the "rules of thumb" for radiation protection in nuclear medicine. This is an ideal textbook for students and a ready source of useful information for nuclear medicine specialists and medical physics experts.

Written by one of the world's leading experts in the field of nuclear medicine dosimetry, this text describes in detail the use of internal dose calculations in the practice of nuclear medicine. While radiation therapy with external sources of radiation always employs calculations of dose to optimize therapy for each patient, this is not routinely conducted in nuclear medicine therapy. As the trend towards an increasing role of dosimetry in therapy planning increases, this book reviews the available methods and technologies available to make this a more common practice. The book begins by covering the mathematical fundamentals of internal dose calculations, and uses sample calculations to demonstrate key principles. The book then moves forward to describe anthropomorphic models, dosimetric models, and types and uses of diagnostic and therapeutic radiopharmaceuticals. The depth of coverage makes it useful reference and guide for researchers performing dose calculations and for physicians considering incorporating dose calculations into the treatment of their cancer patients.

This practical guide is a comprehensive reference of cases with FDG images obtained on dedicated PET tomographs and hybrid scintillation gamma cameras. Dr. Dominique Delbeke and her collegues at Vanderbilt University Medical Center, along with recognized international experts, provide the reader with in-depth coverage on all aspects of FDG imaging. Unique to this book is the up-to-date coverage on both the technical and clinical aspects of FDG imaging and its cases of those malignancies practitioners are likey to encounter in their daily practice. The text also presents normal and physiologic interpretation of FDG imaging, related pitfalls in imaging interpretation, and the role of FDG imaging in different types of body tumors. Enhanced with over 300 FDG images, this book will serve as an excellent stand-alone guide for nuclear medicine physicians, radiologists, oncologists, and residents in their practice of clinical PET.

This pioneering book, now in its fourth edition, presents the cutting-edge developments in pediatric nuclear medicine. Thoroughly revised and updated, it retains the fundamentals that anchor the book s distinguished reputation and includes the latest advances in PET/CT, SPECT, hybrid imaging, and molecular imaging. "Pediatric Nuclear Medicine and Molecular Imaging, Fourth Edition," is an excellent resource for nuclear medicine physicians, diagnostic radiologists, pediatricians, and residents and fellows.

The Fourth Edition features:

. 16 new chapters, including PET and PET/CT in Children and Young Adults; Lymphoscintigraphy; Skeletal Scintigraphy; Neuroblastoma; Lymphomas and Lymphoproliferative Disorders; Functional Imaging of Pediatric Musculoskeletal Tumors; Solid Tumors in Childhood; Pediatric Molecular Imaging; Combined PET/MRI in Childhood; Radiation Exposures; Radiation Protection in Pediatric Nuclear Medicine; and Dose Optimization in Pediatric Nuclear Medicine.

. Discussion of the use of image fusion and hybrid imaging in children.

. Strategies for communicating potential radiation risk to patients, families and members of the healthcare team.

. Methods to optimize pediatric radiopharmaceutical administered doses and improve image quality.

S. Ted Treves, MD, is Professor of Radiology at Harvard Medical School, Founder and Former Chief, Division of Nuclear Medicine and Molecular Imaging, Children s Hospital Boston (1970-2011). In 2013, he received the Society of Nuclear Medicine and Molecular Imaging s Georg Charles de Hevesy Nuclear Pioneer Award for outstanding contributions to the field of Nuclear Medicine."

This book is a guide for the constantly growing community of the users of medical thermal imaging. It describes where and how an infrared equipment can be used in a strictly standardised way and how one can ultimately comprehensively report the findings. Due to their insight into the complex mechanisms behind the distribution of surface temperature, future users of medical thermal imaging should be able to provide careful, and cautious, interpretations of infrared thermograms, thus avoiding the pitfalls of the past. The authors are well-known pioneers of the technique of infrared imaging in medicine who have combined strict standard-based evaluation of medical thermal images with their expertise in clinical medicine and related fields of health management.

Drug development is very expensive and a fight against time. PET offers possibilities to speed up this process by adding unique in vivo information on pharmacokinetics/dynamics of a drug at an early stage. This information can help decision makers to move the drug in the drug development process or to decide to stop further developments. This unique and complete book highlights the different ways PET can be used and describes the latest trends in the various disciplines within nuclear medicine to further improve methodologies and increase the number of tools to accelerate drug development. Various topics within tracer development, instrumentation, data analysis and many clinical and preclinical topics are described by leading scientists from industry and academia.

The second in a three-volume set exploring Problems and Solutions in Medical Physics, this volume explores common questions and their solutions in Nuclear Medicine. This invaluable study guide should be used in conjunction with other key textbooks in the field to provide additional learning opportunities. Topics include radioactivity and nuclear transformation, radionuclide production and radiopharmaceuticals, non-imaging detectors and counters, instrumentation for gamma imaging, SPECT and PET/CT, imaging techniques, radionuclide therapy, internal radiation dosimetry, and quality control and radiation protection in nuclear medicine. Each chapter provides examples, notes, and references for further reading to enhance understanding. Features: Consolidates concepts and assists in the understanding and applications of theoretical concepts in medical physics Assists lecturers and instructors in setting assignments and tests Suitable as a revision tool for postgraduate students sitting medical physics, oncology, and radiology sciences examinations

This issue of PET Clinics focuses on PET/MRI: Clinical Applications, and is edited by Drs. Drew Torigian and Andreas Kjaer. Articles will include: PET/MRI in Prostate Cancer; PET/MRI in Vascular Disease; PET/MRI in Lymphoma; PET/MRI in Head and Neck Cancer; PET/MRI in Brain Disease; PET/MR in Cancers of GI Tract; PET/MRI in Gynecologic Cancer; Clinical PET/MRI Systems and Patient Workflow; PET/MRI in Heart Disease; PET/MR in Breast Cancer and Lung Cancer; PET/MRI in Musculoskeletal Disorders; PET/MRI in Pediatric Oncology; Clinical PET/MRI: Future Perspectives; and more!

Percutaneous Surgery of the Upper Urinary Tract: Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows as well as those teaching in the field.

This state-of-the-art set of handbooks provides medical physicists with a comprehensive overview of the field of nuclear medicine. In addition to describing the underlying, fundamental theories of the field, it includes the latest research and explores the practical procedures, equipment, and regulations that are shaping the field and it's future. This set is split into three volumes, respectively titled: Instrumentation and Imaging Procedures; Modelling, Dosimetry and Radiation Protection; and Radiopharmaceuticals and Clinical Applications. Volume one, Instrumentation and Imaging Procedures, focuses primarily on providing a comprehensive review into the detection of radiation, beginning with an introduction to the history of nuclear medicine to the latest imaging technology. Volume two, Modelling, Dosimetry and Radiation Protection, explores the applications of mathematical modelling, dosimetry, and radiation protection in nuclear medicine. The third and final volume, Radiopharmaceuticals and Clinical Applications, highlights the production and application of radiopharmaceuticals and their role in clinical nuclear medicine practice. These books will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine. The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history

This issue of PET Clinics examines normal variations and benign findings in FDG PET/CT Imaging. Topics include Standardization and quantification in FDG PET /CT imaging for staging and restaging of disease, dynamic changes in FDG update in normal tissues, as well as normal variations in the brain, head and neck, thorax, abdomen, pelvis, and in pediatrics.

This volume presents pedagogical content to understand theoretical and practical aspects of diagnostic imaging techniques. It provides insights to current practices, and also discusses specific practical features like radiation exposure, radiation sensitivity, signal penetration, tissue interaction, and signal confinement with reference to individual imaging techniques. It also covers relatively less common imaging methods in addition to the established ones. It serves as a reference for researchers and students working in the field of medical, biomedical science, physics, and instrumentation. Key Features * Focusses on the clinical applications while ensuring a steady understanding of the underlying science * Follows a bottom-up approach to cover the theory, calculations, and modalities to aid students and researchers in biomedical imaging, radiology and instrumentation * Covers unique concepts of nanoparticle applications along with ethical issues in medical imaging

Contains over 3300 entries with accompanying diagrams, images, formulas, further reading, and examples Covers both the classical and newest elements in medical imaging, radiotherapy, and radiation protection Discusses material at a level accessible to graduate and postgraduate students in medical physics and related disciplines as well as medical specialists and researchers.

The third edition of this critically acclaimed book has updated and expanded the survey of clinical, biological and pathological management of localized and advanced renal cell carcinoma. Internationally renowned editors and contributors explore the latest developments in molecular genetics, focusing on the novel targets that have been discovered in epithelial renal tumors. Comprehensive and authoritative, Renal Cell Carcinoma: Molecular Targets and Clinical Applications, Third Edition is the definitive text on the rapidly evolving landscape of experimental therapeutics, written and edited by leaders of the field.

Atlas of Nuclear Cardiology provides detailed guidance on how to and how not to perform imaging studies so you can get the best image quality and avoid artifacts. Ami E. Iskandrian and the editorial team responsible for Braunwald's Heart Disease bring you the most clinically relevant, case-based, evidence-based, practical, and contemporary atlas of nuclear cardiology. High-quality, full-color images ensure that you get the possible results. Access the fully searchable contents online at www.expertconsult.com, along with a moving image library that demonstrates myocardial perfusion imaging, myocardial tracers, PET, PET-CT, and gated SPECT. Stay current on recent developments in nuclear cardiac imaging such as equilibrium radionuclide angiocardiography (ERNA) and first-pass radionuclide angiography (FPRNA). Master the application of techniques to specific clinical situations with detailed case studies and discussions of challenging issues. Gain a clear visual understanding from numerous, high-quality images in full color. Find information quickly and easily thanks to a practical, consistent format throughout the text. Master nuclear imaging with the practical, case-based information you need, from the Braunwald experts you trust

PET and SPECT imaging has improved to such a level that they are opening up exciting new horizons in medical diagnosis and treatment. This book provides a complete introduction to fundamentals and the latest progress in the field, including an overview of new scintillator materials and innovations in photodetector development, as well as the latest system designs and image reconstruction algorithms. It begins with basics of PET and SPECT physics, followed by technology advances and computing methods, quantitative techniques, multimodality imaging, instrumentation, pre-clinical and clinical imaging applications.

Positron emission tomography (PET) has been approved for the diagnosis and staging of gynecologic malignancies for several years now.? This issue reviews the imaging of cervical, uterine, and endometrial cancers.? There is also an articles on the uses of PET/CT for imaging normal and abnormal anatomy, as well as gynecologic imaging using other modalities.? Lastly this issue contains a review of newer radionuclide tracers currently in development.

This Safety Guide provides recommendations and guidance on fulfilling the requirements of IAEA Safety Standards Series No. GSR Part 3, Radiation Protection and Safety of Radiation Sources: International Basic Safety Standards, for ensuring radiation protection and safety of radiation sources in medical uses of ionizing radiation with regard to patients, workers, carers and comforters, volunteers in biomedical research, and the public. It covers radiological procedures in diagnostic radiology (including dentistry), image guided interventional procedures, nuclear medicine and radiotherapy. Recommendations and guidance are provided on applying a systematic approach to ensure that there is a balance between being able to utilize the benefits from medical uses of ionizing radiation and minimizing the risk of radiation effects to people.

Advances in Blood Cell Labeling; D.A. Goodwin, et al. A New Direct Method of Cell Labeling in Whole Blood by Administration of 111-In Labeled Antisense Oligonucleotide Probe; M.K. Dewanjee, et al. Transchelation of 114mIn from Iga-DTPA to Abscess-Related Proteins; A.J. Carlson, et al. The Antibody Approach of Labeling Blood Cells; S.C. Srivastava. Quality Control of Radiolabeled White Cells; A.M. Peters. Granulocyte Cell Labeling with TcNNOET; A. Moisan, et al. Arteriosclerosis and Monocyte Adhesion In vivo; I. Virgolini, et al. Stabilization of Exametazime for Leukocyte Labeling; C. Solanki, et al. 99mTc Labeling of Interleukin2 for In vivo Targetin of Activated TLymphocytes; M. Chianelli, et al. Nitric Oxide and Prostaglandin I2 for Radiolabeling of Human Platelets; I. Neumann, et al. 111In Labeling of Human IgG Using a DTPASIgG Kit; M. Roca, et al. 46 additional articles. Index.

This book reviews the principal applications of nuclear medicine, specifically from the viewpoint of the mathematical and physical analyses that support the interpretation. In contradistinction to other approaches, the mathematics does not precede the applications in introductory chapters, but is presented in the application chapters with various degrees of granularity.

Magnetic Particle Imaging (MPI) is a novel imaging modality. In MPI superparamagnetic iron oxide nanoparticles are used as tracer materials. The volume is the proceeding of the 2nd international workshop on magnetic particle imaging (IWMPI). The workshop aims at covering the status and recent developments of both, the instrumentation and the tracer material, as each of them is equally important in designing a well performing MPI. For instance, the current state of the art in magnetic coil design for MPI is discussed. With a new symmetrical arrangement of coils, a field-free line (FFL) can be produced that promises a significantly higher sensitivity compared with the standard arrangement for a FFP. Furthermore, the workshop aims at presenting results from phantom and pre-clinical studies.