The European Collaboration on Boron Neutron Capture Therapy (BNCT), conceived in 1987 and successful in 1989 in gaining financial support as a Concerted Action through the Medical and Health Research Programme of the Commission ofthe European Communities (CEC) in Brussels, considered it an opportune moment to hold its annual Plenary Meeting on 18-20 Septem ber 1991 as an International Workshop entitled "Towards Clinical Trials of Glioma with BNCT". The background to this consideration was influenced by the world-wide resurgence ofinterest in NCT over the last 2 decades and by the exemplifica tions at the Fourth International Symposium on Neutron Capture Therapy for Cancer held in Sydney in December 1990, where it was strongly indicated that within the next 2 years clinical trials would be started both in Europe and the United States. In particular at the High Flux Reactor of the Joint Research Centre of the CEC at Petten in The Netherlands, an epithermal neutron beam designed and installed in the summer of 1990 recently became operable at full reactor power. An extensive series ofexperiments, including the nuclear and radiobiological characterisation of the beam and a healthy tissue tolerance study on canines has started and has the aim to define the preconditions for clinical trials onpatients with Grade III/IV glioma. However, as with any other new therapy modality, it must be demon strated that BNCT is safe for the patient and has a reasonable chance of being an effective therapy.

"More than half of the world's population is at risk of the tropical diseases malaria, leprosy, schistosomiasis, lymphatic filariasis, onchocerciasis, Chagas' disease, African trypanosomiasis and leishmaniasis and half a billion are infected with at least one of these diseases". J. H. F. Remme, World Health Organisation, 1993. "If it is true that science is not limited by frontiers and all research Institutions then belong to mankind, so it is natural for each Institution to be responsible for the problems of those who live in the geographic area under its influence. There are no specific aspects concerning physical, chemical or philosophical concepts and facts, but specificity does exist concerning geology, sociology and pathology. It is the duty of each Institution to study the particular aspects concerning its geographic region, as missing links of the chain of universal knowledge may be found there." H. L. de Oliveira, fonner Rector of the University ofSiio Paulo, 1967. "Nuclear Medicine is cost effective, especially in the developing countries. ( ... ).

Despite 50 years of antibiotics, infection remains a major source of both morbidity and mortality. Immunosuppression, either secondary to drugs in transplant recipients or secondary to HIV, has expanded the number of microorganisms that are known to be pathogenic in man. Imaging of infection has a vital role both in the initial diagnosis and in the continuing management of patients with infection or suspected infection. Functional imaging using nuclear medicine techniques has a unique role to play in identifying sites of infection in a wide range of patients with varying clinical conditions. This book, written by a series of experts not just in the fields of nuclear medicine but also infectious disease and radiology, discusses the role of nuclear medicine in three parts: a review of the pathophysiology of infection; a technical description of those nuclear medicine techniques which can be used in imaging infection; an extensive systematic review including thoracic, abdominal and orthopaedic infection as well as a special section on the acutely ill patient, the immunosuppressed patient and the patient with pyrexia of unknown origin. This book will be of interest to all clinicians looking after patients with infection and who need to use imaging techniques. It will also be of use to radiologists and nuclear medicine physicians who will be using these techniques clinically.

Methods
- Thorough description of the current imaging and functional investigation techniques in nuclear medicine and radiology
- Detailed portrayal of indications and differential diagnoses
Clinical Applications
- Exhaustive description of the features of paediatric urological diseases relevant for diagnostic imaging
- Embryologic and pathophysiologic background
- Clear recommendations on application of diagnostic imaging techniques based on the latest findings and consensus guidelines
Case Studies
- Large number of case reports illustrating standard procedures in diagnostic imaging
- Case descriptions highlighting common diagnostic problems
- Presentation of unusual and rare cases

Bone Tumors: A Practical Guide to Imaging is a concise guide to common tumors encountered by physicians in daily practice. The authors make use of high-yield facts, differential diagnoses, and extensive radiological images to introduce a wide range of bone tumors, focusing on their classic appearance and location in order to provide readers with a solid foundation of knowledge for tumor recognition and evaluation. The book includes explanations of methods for properly evaluating bone lesions, common imaging modalities used for diagnosis, and individual chapters covering different classes of benign and malignant tumors, including cartilage, osseous, fibrous, miscellaneous, and bone metastases. The book concludes with a comprehensive selection of 75 unknown cases, including brief clinical history, description of imaging findings, best differential diagnoses, and short discussion revealing the most likely diagnosis. Bone Tumors is an ideal resource for practicing physicians and residents in radiology, orthopedic surgery, pathology, and primary care. About the Authors Jim S. Wu, MD, is Assistant Professor of Radiology at Beth Israel Deaconess Medical Center, Harvard Medical School. Mary G. Hochman, MD, is Chief of the Section of Musculoskeletal Imaging and Assistant Professor of Radiology at Beth Israel Deaconess Medical Center, Harvard Medical School.

Magnetic Resonance Imaging (MRI) is a rapidly evolving technique which is having a significant impact on medical imaging. Only a few years ago, al though Nuclear Magnetic Resonance (NMR) was well known as an important analytical technique in the field of chemical analysis, it was effectively un known in medical circles. Following the initial work of PAUL LAUTERBUR and RAYMOND DAMADIAN in the early 1970s demonstrating that it was possible to use NMR to produce im ages, progress in the medical fields was relatively slow. Recently, however, with the availability of commercial systems, progress has been very rapid, with increasing acceptance of MRI as a basic imaging technique, and the develop ment of exciting new applications. MRI is a relatively complex technique. First, the image depends on many more intrinsic and extrinsic parameters than it does of in techniques like X-ra diography and computed tomography, and secondly, the intrinsic parameters such as T1 and T2 are conceptually complex, involving ideas not usually de scribed in traditional medical imaging courses. In order to produce good MR images efficiently, and to obtain the maximum information from them, it is necessary to appreciate, if not to fully understand, these parameters. Further more, knowledge of how the image is produced helps in appreciating the ori gin of the artifacts sometimes found in MRI due to effects like patient motion and fluid flow."

are new to this edition. The authors provide not only the The second edition of Thyroid Cancer: A Comp- most current review of their respective areas, but also their hensive Guide to Clinical Management marks the pub- own recommendations and approach. The reader is fo- cation of a markedly updated and expanded volume that warned that in many cases these approaches, albeit rooted covers all aspects of the etiology, pathogenesis, diag- sis, initial treatment, and long-term management of all in available data, may be empiric rather than based varieties of thyroid cancer. Like the first edition, it will upon clear-cut results of well-controlled clinical t- als. Nevertheless, controversial issues are examined serve as a valuable reference source for pathologists, and evidence-based recommendations are presented endocrine surgeons, endocrinologists, nuclear medicine when available. physicians, and oncologists. However, the biggest There are updated chapters on our current state change is that the second edition is significantly enlarged and expanded to encompass important and extensive of knowledge of the molecular changes in thyroid treatments of more topics related to nuclear medicine. cancer, molecular markers, and how targeted the- pies are being developed. New therapeutic trials of Nuclear medicine physicians and procedures play a key redifferentiation agents to restore the sodium iodide role in the management of thyroid cancer patients and in symporter when lacking and more traditional che- retrospect, a comprehensive discussion of topics related therapies are discussed, with referral sources listed for to that field was somewhat lacking in the first edition.

Nuclear Medicine Technology Study Guide presents a comprehensive review of nuclear medicine principles and concepts necessary for technologists to pass board examinations. The practice questions and content follow the guidelines of the Nuclear Medicine Technology Certification Board (NMTCB) and American Registry of Radiological Technologists (ARRT), allowing test takers to maximize their success in passing the examinations. The book is organized by sections of increasing difficulty, with over 600 multiple-choice questions covering all areas of nuclear medicine, including radiation safety; radionuclides and radiopharmaceuticals; instrumentation and quality control; patient care; and diagnostic and therapeutic procedures. Detailed answers and explanations to the practice questions follow. Supplementary chapters will include nuclear medicine formulas, numbers, and a glossary of terms for easy access by readers. Additionally, test-taking strategies are covered.

This is a book about scholarship in the broadest sense. The writing of this book has shown how through scholarship we can bring together academics, practitioners, scientists, radio logists, and administrators from around the world to begin the kinds of conversations that promise to move us to a new way of thinking about and enacting radiology education. Over the past century, we have witnessed tremendous change in biomedical science and the scope of this change has demanded new approaches to medical education. The most significant of the changes in medical education has been a fundamental paradigm shift from a teacher-centered approach to a student-centered approach. This shift, c- bined with the explosion of knowledge, has pressed medical schools to undertake major curricular and institutional reform. At the same time, progress in medical education research methods has led to innovative approaches to support the improvement of learning methods and evaluation. Over the past several years there has also been a shift toward thinking about and planning for medical education beyond the undergraduate level to include postgraduate and continuing medical education, but also to consider learning within the professional environment and the development of professional continuous education. Viewing medical education as a continuum that spans from the first year of medical school until retirement introduces new ways to conceptualize the teaching and learning needs that address lifelong learning demands that extend over 30 or 40 years.

This book serves as a reference and comprehensive guide for PET/MR neuroimaging. The field of PET/MR is rapidly evolving, however, there is no standard resource summarizing the vast information and its potential applications. This book will guide neurological molecular imaging applications in both clinical practice and the research setting. Experts from multiple disciplines, including radiologists, researchers, and physicists, have collaborated to bring their knowledge and expertise together. Sections begin by covering general considerations, including public health and economic implications, the physics of PET/MR systems, an overview of hot lab and cyclotron, and radiotracers used in neurologic PET/MRI. There is then coverage of each major disease/systemic category, including dementia and neurodegenerative disease, epilepsy localization, brain tumors, inflammatory and infectious CNS disorders, head and neck imaging, as well as vascular hybrid imaging. Together, we have created a thorough, concise and up-to-date textbook in a unique, user-friendly format. This is an ideal guide for neuroradiologists, nuclear medicine specialists, medical physicists, clinical trainees and researchers.

PET in Clinical Oncology describes the use of Positron Emission Tomography (PET) in the diagnosis and management of malignant tumors. Experts from Germany and the United States present basics, technical details, and clinical aspects for both standard and new PET techniques. The book illustrates the importance of PET in comparison to other imaging techniques.
Generously supplemented with charts, tables, and illustrations, each chapter provides the reader with well-delineated descriptions, from the basic technical situation through the clinical use of PET. This book is helpful to all those dealing with the diagnosis and therapy of cancer.

This comprehensive colour atlas provides a state-of-the-art view of Single Photon Emission Computerised Tomography (SPECT) in relation to its application in the fields of nuclear medicine and psychiatry. The broad range of topics covered by experts in the fields of nuclear medicine, neurology and psychiatry from all over the world, reflects the most recent evolution in functional neuroimaging with clinical neuropsychiatric sciences.The book is organised with respect to clinical indication, which implies that whenever possible methodological problems related to clinical indication are categorised under the relevant topic. It is designed to stimulate discussion of some issues of paramount importance for the present and future development of this interdisciplinary modality for the study of patients with diseases of the central nervous system. This textbook is an important tool to all nuclear physicians, neurologists and psychiatrists and will serve as a guide towards the optimal application of SPECT in diagnosis, study of pathophysiology and therapeutic follow-up in neuropsychiatric illnesses.

A Personal History of Nuclear Medicine is an account of how nuclear medicine developed, and its basic philosophy in the past, present and future. The book outlines the history of the development of nuclear medicine as experienced by the author and describes the hurdles that nuclear medicine has had to face, in view of the perception of risk of radiation. It also explains how nuclear medicine solves medical problems in clinical practice and how it has contributed to a new definition of disease. The book concludes with future projections of the likely developments in this area in the next 50 years.

Target market: nuclear medicine professionals as well non-nuclear medicine physicians and the public

High-yield, image-rich study guide presents complex physics concepts in reader-friendly format Physics is a key component of the American Board of Radiology core and certifying exams, therefore it is an essential area of study for radiology residents and young radiologists prepping for these exams. Radiology residents gather their medical physics knowledge from many sources, often beginning with their first encounter of a radiologic image. As such, Radiologic Physics Taught Through Cases by Jonathon A. Nye and esteemed contributors incorporates an image-rich, case-based layout conducive to learning challenging physics concepts. The book encompasses physical diagnostic radiology scenarios commonly encountered during residency in a format that fosters learning and is perfect for board preparation. Seven technology-specific chapters cover fluoroscopy, mammography, computed tomography, magnetic resonance imaging, nuclear medicine, ultrasound imaging, and image processing. Each chapter features 10 succinct case-based topics intended to quickly convey information. Key Highlights Every chapter starts with a general introduction, followed by case background, images, findings, and a brief explanation of the physical factors underlying the image's creation and displayed contrast Schematics detail important radiation safety topics, such as potential occupational or patient hazards related to fluoroscopic-guided procedures End-of-chapter references provide inspiration for further study Review questions with correct answers at the end of each chapter reinforce key concepts This is a must-have resource for residents prepping for the radiology core exam review and early-career radiologists looking for a robust study guide for radiology certification exam review. This book includes complimentary access to a digital copy on https://medone.thieme.com.

Physics in Nuclear Medicine - by Drs. Simon R. Cherry, James A. Sorenson, and Michael E. Phelps - provides current, comprehensive guidance on the physics underlying modern nuclear medicine and imaging using radioactively labeled tracers. This revised and updated fourth edition features a new full-color layout, as well as the latest information on instrumentation and technology. Stay current on crucial developments in hybrid imaging (PET/CT and SPECT/CT), and small animal imaging, and benefit from the new section on tracer kinetic modeling in neuroreceptor imaging. What's more, you can reinforce your understanding with graphical animations online at www.expertconsult.com, along with the fully searchable text and calculation tools. Master the physics of nuclear medicine with thorough explanations of analytic equations and illustrative graphs to make them accessible. Discover the technologies used in state-of-the-art nuclear medicine imaging systems Fully grasp the process of emission computed tomography with advanced mathematical concepts presented in the appendices. Utilize the extensive data in the day-to-day practice of nuclear medicine practice and research. Tap into the expertise of Dr. Simon Cherry, who contributes his cutting-edge knowledge in nuclear medicine instrumentation. Stay current on the latest developments in nuclear medicine technology and methods New sections to learn about hybrid imaging (PET/CT and SPECT/CT) and small animal imaging. View graphical animations online at www.expertconsult.com, where you can also access the fully searchable text and calculation tools. Get a better view of images and line art and find information more easily thanks to a brand-new, full-color layout. The perfect reference or textbook to comprehensively review physics principles in nuclear medicine.

The second in a three-volume set exploring Problems and Solutions in Medical Physics, this volume explores common questions and their solutions in Nuclear Medicine. This invaluable study guide should be used in conjunction with other key textbooks in the field to provide additional learning opportunities. Topics include radioactivity and nuclear transformation, radionuclide production and radiopharmaceuticals, non-imaging detectors and counters, instrumentation for gamma imaging, SPECT and PET/CT, imaging techniques, radionuclide therapy, internal radiation dosimetry, and quality control and radiation protection in nuclear medicine. Each chapter provides examples, notes, and references for further reading to enhance understanding. Features: Consolidates concepts and assists in the understanding and applications of theoretical concepts in medical physics Assists lecturers and instructors in setting assignments and tests Suitable as a revision tool for postgraduate students sitting medical physics, oncology, and radiology sciences examinations

Nuclear medicine is the bridge between a particular clinical problem and a relevant test using radionuclides. It began as a minor technical tool used in a few branches of medicine, notably endocrinology and nephrology. However, throughout the world it has become established as a clinical discipline in its own right, with specific training programmes, special skills and a particular approach to patient management. Although the practicing nuclear medicine physician must learn a great deal of basic science and technology, a sound medical training and a clinical approach to the subject remains important. It is for this reason that in the text there has been an attempt to approach the subject from a clinical standpoint, including where necessary relevant physiological material.

In the fast-changing age of precision medicine, PET/CT is increasingly important for accurate cancer staging and evaluation of treatment response. Fundamentals of Oncologic PET/CT, by Dr. Gary A. Ulaner, offers an organized, systematic introduction to reading and interpreting PET/CT studies, ideal for radiology and nuclear medicine residents, practicing radiologists, medical oncologists, and radiation oncologists. Synthesizing eight years' worth of cases and lectures from one of the largest cancer centers in the world, this title provides a real-world, practical approach, taking you through the body organ by organ as it explains how to integrate both the FDG PET and CT findings to best interpret each lesion. Based on the Annual Oncologic PET/CT Continuing Education Course founded and directed by Dr. Ulaner. Provides step-by-step guidance on how to interpret PET/CT images for patients with cancer. Uses a unique, highly practical format, presenting common and uncommon findings for each organ system, and then explaining how to best arrive at a diagnosis for those findings. Describes how to integrate PET findings with CT, MR, ultrasound, and radiography, to increase specificity of PET findings. Features more than 1,000 high-quality PET, CT, and correlative radiographic images, with over 600 in full color. Discusses how to avoid common interpretive pitfalls. Demonstrates how to organize an FDG PET/CT report efficiently and concisely. Includes a separate chapter on novel radiotracers - including Sodium Fluoride, DOTATATE, Choline, Fluciclovine, and PSMA targeting agents. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Mankind has evolved in a sea of radiation. We have been bombarded constantly by X rays, y rays, UV rays, and particulate radiations from outer space, and by terrestrial radiations from the ground we walk on, from our building materials, and from our own bodies. Recently, we have become increasingly subjected to man-made radiations, especially from the medical and defense industries. All of these radiations are capable of affecting us biologically, both to our benefit and to our detriment. This book provides a thorough review of the physical and biological dosimetry of these radiations. It is targeted to those health professionals who are concerned with understanding the mechanisms fundamental to the biological action of ionizing radiation or who are involved in the application, measurement, or treatment of the effects of such radiations. The first chapter, on "Bioeffect Dosimetry in Radiation Therapy," should be of special interest to anyone involved in the treatment of cancer by radiation. It includes a brief review of the history of the manipulation of time-dose parameters in order to improve therapeutic benefit, and an up-to-date analysis of time-dose relationships designed for use in fractionated radiotherapy and brachytherapy. This is followed by two chapters reviewing and comparing national and international protocols for the precise measurement of photon and electron radiations in therapy. These chapters should be invaluable to radiation physicists responsible for treatment machine calibrations.

Despite years of research world-over, non-toxic and effective radiomodulators remain elusive. In recent years, there has been a shift towards the use of herbals, which are also apparently being viewed as sources of promising radiomodulatory drugs. This book discusses the potential of radiation countermeasure agents and radiosensitizers of herbal origin, their multifaceted mode of action, specifically the use of the former in a nuclear theatre of operations, rescue operations and deep space missions in addition to their application during radiotherapy.

A valuable new reference in the diagnosis and image-guided treatment of congenital heart defects Congenital heart defects represent the most common birth defect and affect millions of children worldwide. Defects of the heart and great vessels span a broad spectrum. Modern medical progress has enabled more than 90% of patients to reach adulthood. In many cases, however, patients remain ill throughout their lives, with significant limits on quality of life and physical capacity. Our ongoing goals are to improve treatment options even further. This book details all important imaging techniques for diagnosing congenital heart defects and assessing their severity. The author is a highly experienced expert in his field, making his clinical experience available to readers who can then implement that knowledge in their own daily routine. Key Features: All key imaging modalities, including 2D and 3D echocardiography, cardiac catheter exams, MRI and MR angiography, CT, and chest X-ray Descriptions of general and technical fundamentals, a structure based on clinical pictures, and current standard values Crucial information emphasized in callout boxes and tabular overviews Supports the professional dialogue between all the involved caretakers Richly illustrated with more than 1,000 stunning images from the newest generation of devices Gutberlet's Diagnostic Imaging of Congenital Heart Defects: Diagnosis and Image-Guided Treatment will be welcomed by pediatric and general radiologists as a comprehensive, multimodality guide to the diagnosis and management of congenital heart defects. This book includes complimentary access to a digital copy on https://medone.thieme.com.

Percutaneous Surgery of the Upper Urinary Tract: Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows as well as those teaching in the field.

This issue of Cardiology Clinics, edited by Sharmila Dorbala and Piotr Slomka, examines Nuclear Cardiology. Topics include Advances in SPECT Hardware and Software; Advances in PET Hardware and Software; Technical Advances and Clinical Applications of Cardiac PET/MR; Translational Coronary Atherosclerosis Imaging (NaF PET, FDG); Quantitative Nuclear Cardiology Using New Generation Equipment; Myocardial Perfusion Flow Tracers; Translational Molecular Nuclear Cardiology; Radionuclide Imaging in Congestive Heart Failure (Sarcoid, Amyloid, Viability); Clinical Applications of Imaging Myocardial Innervation; Gated Radionuclide Imaging Including Dyssynchrony Assessment; Clinical PET Myocardial Perfusion Imaging Including Flow Quantitation; and Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease.

This two-part issue, edited by Dr. Rathan Subramaniam, reviews current clinical information in "PET/CT and Patient Outcomes." In Part II of this issue, articles will include: Hepatobiliary and Pancreatic Cancer; Endometrial, Cervical & Ovarian Cancer; Renal, Bladder and Testicular Cancer; Musculoskeletal and Soft Tissue Tumors; Myocardial Perfusion / Viability; Unknown Primary Cancer; Gastric Cancer; Brain Tumors; Neuroendocrine Tumors, and more!