Radiochemical methodology constitutes the most important base for the successful functioning of a PET group in the routine production and development of radiopharmaceuticals. Of the several hundred products which have been labelled with positron emitters during the past two decades about 35 are presently considered to be of major interest. The time for a state-of-the-art review is right, since this field has advanced over the past fifteen years to reach a level where guidelines can now be suggested. Chapters of this book deal with each of the main methodological aspects of the chemistry needed to develop an effective radiopharmaceutical, namely radionuclide production, automation and metabolite analysis. A further chapter on QA/QC is written by a broadly-based expert group and is meant to provide a guideline and a base for future monographs and regulations on major PET radiopharmaceuticals of today. This book will help the increasing numbers of scientists who are now entering the field of PET to appreciate the methodological aspects that are normally addressed by chemists in relation to PET radiopharmaceuticals; it provides many useful practical guidelines and will promote early success in their own endeavours, since these will often necessarily begin by establishing chemical methodology of the kind discussed here.

Dr. Peter S. Conti is a Professor of Radiology and the Director of the PET Imaging Science Center at the University of Southern California, and is a Fellow of both the American College of Radiology and American College of Nuclear Physicians. He is a pioneer in the development of the clinical applications of PET and more recently PET-CT. He and one of his fellows, Dr. Daniel Cham, have published this groundbreaking PET-CT case-based book, which reveals how PET-CT can be applied in routine clinical scenarios. Leading authorities in the field examine a wealth of heavily-illustrated original PET-CT cases that showcase both common and uncommon cancers, and the latest PET-CT applications for neurological and cardiovascular disorders. Correlative three-dimensional cross-sectional PET and CT images highlight pathological findings. Each of the clinical applications is accompanied by a concise explanation of the patient history and interpretation of the PET-CT study. Insightful discussions and "pearls and pitfalls" are included to assist in a better understanding of pathology, diagnosis, and imaging approaches. Readers also find important coverage of pathophysiology and technical artifacts. This unique book is ideal for nuclear medicine practitioners, radiologists, and residents, as well as referring clinicians interested in learning more about how this new medical imaging technology can be applied in their patient populations.This unique book is ideal for nuclear medicine practitioners, nuclear medicine residents, and clinicians interested in medical imaging for tumor patients.

Presents an overall analytical treatment of MRI physics and engineering. Special attention is paid to the treatment of intrinsic artefacts of the different sequences which can be described for the different scan methods. The book contains many images, especially showing specific properties of the different scan methods. The methods discussed include RARE, GRASE, EPI and Spiral Scan. The 3rd edition deals with stranger gradient and new RF coil systems, and sequences such as Balanced FFE and q-space diffusion imaging and SENSE.

Special emphasis on teaching the CT technologists getting started in MDCT

This book is designed to give the reader a solid understanding of the

physics and instrumentation aspects of PET, including how PET data are collected and formed into an image. Topics include basic physics, detector technology used in modern PET scanners, data acquisition, and 3D reconstruction. A variety of modern PET imaging systems are also discussed, including those designed for clinical services and research, as well as small-animal imaging. Methods for evaluating the performance of these systems are also outlined. The book will interest nuclear medicine students, nuclear medicine physicians, and technologists.

There can never be enough material in the public domain about cancers, and particularly breast cancer. This book adds much to the literature. It provides general information on breast cancer management and considers all new methods of diagnosis and therapy. It focuses on nuclear medicine modalities by comparing their results with other diagnostic and therapeutic approaches. The coverage provides readers with up-to-date knowledge on breast cancer as well as information on the advances in the field of diagnosis. It also details data on the development of some new modalities and provides a general overview of the available tools for breast cancer treatment.

Skull base anatomy is extremely complex, with vital neurovascular structures passing through multiple channels and foramina. Brain tumors such as pituitary tumors, acoustic neuromas, and meningiomas are challenging to treat due to their close proximity to cranial nerves and blood vessels in the brain, neck, and spinal cord. Medical imaging is an essential tool for identifying lesions and critical adjacent structures. Detecting and precisely mapping out the extent of disease is imperative for appropriate and optimal treatment planning and ultimately patient outcome. Eugene Yu and Reza Forghani have produced an exceptional, imaging-focused guide on various neoplastic diseases affecting the skull base, with contributions from a Who's Who of prominent radiologists, head and neck surgeons, neurosurgeons, and radiation oncologists. The content is presented in a clear and concise fashion with chapters organized anatomically. From the Anterior Cranial Fossa, Nasal Cavity, and Paranasal Sinuses - to the Petroclival and Lateral Skull Base, an overview and detailed analysis is provided for each region. Key Highlights Fundamentals of skull base imaging, including recent developments in diagnostic modalities More than 400 radiographs, color anatomical drawings, and color intraoperative photos elucidate the imaging appearances of a wide spectrum of disease affecting the skull base, as well as important anatomic variants and pathways of disease spread Clinically oriented imaging approach focuses on diagnostic and prognostic features important in the evaluation of skull base abnormalities Atlas of skull base CT and MRI anatomy provides an easy to access, quick reference for identifying important anatomic landmarks Insights on the pathways of tumor growth and the role of clinical imaging in the management of skull base cancers Critical and contrasting viewpoints from multidisciplinary experts provide a well-rounded perspective This invaluable resource chronicles current knowledge in state-of-the-art skull base tumor imaging with clinical pearls on pathophysiology, prognosis, and treatment options. It is a must-have for radiology, neurosurgery, and otolaryngology residents and clinicians who care for patients with head and neck neoplasms.

PACS: A Guide to the Digital Revolution, Second Edition, fills an incredible need by explaining the technological advances associated with the transition of radiology departments to filmless environments. The editors are leaders in the field of medical imaging and they provide insight into emerging technologies for physicians, administrators, and other interested groups. Chapters address key topics in current literature with regard to the generation, transfer, interpretation, and distribution of images.

This new edition has been updated to include: 1. An overview of the latest medical imaging standards; 2. A discussion of security issues as they relate to PACS, especially regarding HIPAA; 3. An introduction to current information on PACS workstations, including the impact of new software and hardware on radiologists; 4. An updated explanation of data storage and compression that highlights how advancements are applied; 5. A section on how PACS influences research and education.

This book reports the majority of lectures given during the NATO Advanced Study Institute ASI-982996, which was held at the European Scientific Institute of Archamps (ESI, Archamps - France) from November 15 to November 27, 2007. The ASI course was structured in two parts: the first was dedicated to what is often called "teletherapy", i. e. radiotherapy with external beams, while the second focused on internal radiotherapy, also called "brachytherapy" or "curietherapy" in honour of Madame Curie who initiated the technique about a century ago. This ASI took place after the European School of Medical Physics, which devoted a 3 week period to medical imaging, a subject complementary to the topics of this book. Courses devoted to nuclear medicine and digital imaging techniques are collected in two volumes of the NATO Science Series entitled "Physics for Medical Imaging Applications" (ISBN 978-1-4020-5650-5) and "Molecular imaging: computer reconstruction and practice" (ISBN 978-1-4020- 8751-6). Every year in autumn ESI organises the European School of Medical Physics, which covers a large spectrum of topics ranging from Medical Imaging to Radiotherapy, over a period of 5 weeks. Thanks to the Cooperative Science and Technology sub-programme of the NATO Science Division, weeks four and five were replaced this year by the ASI course dedicated to "Physics of Modern Radiotherapy & Brachytherapy". This allowed the participation of experts and students from 20 different countries, with diverse cultural background and p- fessional experience.

Edited by Dominique Delbeke and Ora Israel, two leading authorities in the field of nuclear medicine, this practical guide is a reference source of cases for images obtained on state-of-the-art integrated PET/CT and SPECT/CT imaging systems. The cases are presented in-depth so that they will be of value to residents training in nuclear medicine and radiology and to nuclear medicine physicians and radiologists who need to become familiar with this technology. Internationally recognized contributors provide the reader with in-depth coverage on the technical and clinical aspects of hybrid imaging. Principles of hybrid imaging, physics and instrumentation, normal distribution of radiopharmaceuticals and protocols central to the field are covered. A comprehensive review of nuclear oncology cases found in everyday practice, ranging from simple to complex are also addressed. The full spectrum of clinical applications is covered including head and neck tumors, breast cancer, colorectal cancer, pancreatic cancer, and genitourinary tumors. Additional chapters examine cardiac hybrid imaging, benign bone diseases and infection and inflammation. A wealth of illustrations reinforce the key teaching points discussed throughout the book.

A century of technical progress, critical analyses, and clinical comparisons have shaped exercise testing in cardiology as we know it today: a simple, noninvasive physiological test that yields irreplaceable information on an individual s physical capacity and ischemic risk. Increasingly prescribed, exercise testing is one of the mostly commonly used medical examinations worldwide. It is both diagnostically and prognostically valuable, and is optimized when combined with myocardial perfusion imaging.. Its indications are broadened every day and there is a good chance that each and every one of us has had, or will one day have, an exercise test. This short and precise book follows a pragmatic and hands-on approach to help physicians who prescribe exercise testing to identify its indications, advantages, and limits. And in interpreting the findings they will find invaluable help in the section entitled: What should be done with exercise test results? As for those who perform exercise tests whether beginners or experts they will find in these pages precious details and facts that can be profitably employed in their everyday practice."

Top Score for the Radiology Boards: Q & A for the Core and Certifying Exams is the ideal diagnostic radiology board prep resource. Written by radiologist Alan Weissman, with contributions from dozens of leading experts at renowned institutions, Top Score has a simple ambition: to improve your test scores. The book covers all exam categories, including non-interpretive skills (NIS), physics, safety, breast, cardiac, diagnostic radiology, gastrointestinal, genitourinary, interventional, musculoskeletal, neuroradiology, nuclear, pediatrics, thoracic, ultrasound/reproductive/endocrinology, vascular, and general radiology. Chapters are composed of four types of test cases of varying focus and complexity, each on a two-page spread. Essentials starts with a patient presentation, followed by board-type multiple-choice questions. Details begins with a case presentation, followed by 10 rapid-fire questions, enabling brisk, high-volume learning. Image Rich presents multiple images that require accurate identification, enabling accelerated, high-volume image assessment practice. More Challenging follows the same format as Essentials but adds a higher degree of difficulty. Key highlights High-quality, board-type Q&A with detailed answer explanations High yield "Top Tips" for each case Special radiology artifacts section Image Rich and Details sections aid in rapid and lasting topic mastery Comprehensive review, covering all sections tested by the American Board of Radiology Written by experienced, expert question writers NIS chapter emphasizes proficiency in vital practice-related skills This quintessential home-study guide will help radiology residents and fellows prep for and ace both the certifying and core exams.

Presented in an interesting, historical and philosophical way, this book describes the current state of play in brain imaging, showing the differences among the different imaging modalities, and reviewing the knowledge about the chemical reactions in the brain, and their relationship to thinking, feeling and acting.

The book reviews all the results of PET and PET/CT imaging of the brain with all radiopharmaceuticals that bind to receptors in all recognized and classified mental diseases, as well as the studies on the localization of those sites that are activated by sensory or motor activity. The book illustrates the parts of the brain activated and deactivated during sensory perception, motion and other mental functions and explains how the process of neurotransmission takes place in chemical terms.

The book is a valuable reference resource for all those in nuclear medicine and radiology as well as the educated general public.

Units of Radiation Protection.- Basic Nuclear Physics.- Interaction of Ionizing Radiation with Matter.- Detectors for Radiation Protection.- International Safety Standards for Radiation Protection.- Organization of Radiation Protection.- Practical Safety Measures1.- Radiation Sources.- X Rays and X-Ray Regulations.- Environmental Radioactivity.- Nuclear Power Plants.- Biological Effects of Ionizing Radiation.- Radiation Accidents.- Non-Ionizing Radiation.- Solutions to the Problems.- Written Test on Radiation Protection.- Radiation-Protection Glossary1.

This book reports the majority of lectures given during the NATO Advanced Study Institute ASI-982996, which was held at the European Scientific Institute of Archamps (ESI, Archamps - France) from November 15 to November 27, 2007. The ASI course was structured in two parts: the first was dedicated to what is often called "teletherapy", i. e. radiotherapy with external beams, while the second focused on internal radiotherapy, also called "brachytherapy" or "curietherapy" in honour of Madame Curie who initiated the technique about a century ago. This ASI took place after the European School of Medical Physics, which devoted a 3 week period to medical imaging, a subject complementary to the topics of this book. Courses devoted to nuclear medicine and digital imaging techniques are collected in two volumes of the NATO Science Series entitled "Physics for Medical Imaging Applications" (ISBN 978-1-4020-5650-5) and "Molecular imaging: computer reconstruction and practice" (ISBN 978-1-4020- 8751-6). Every year in autumn ESI organises the European School of Medical Physics, which covers a large spectrum of topics ranging from Medical Imaging to Radiotherapy, over a period of 5 weeks. Thanks to the Cooperative Science and Technology sub-programme of the NATO Science Division, weeks four and five were replaced this year by the ASI course dedicated to "Physics of Modern Radiotherapy & Brachytherapy". This allowed the participation of experts and students from 20 different countries, with diverse cultural background and p- fessional experience.

In general, image processing texts are intended for students of engineering and computer science, and there is little written at all on the specific requirements of medical image processing. Students of medical radiation science (Diagnostic radiography, Nuclear medicine, Radiation therapy) usually have minimal mathematical and computer science training and find the available texts incomprehensible. A text that explains the principles of image processing in minimally-mathematical language is needed for these students. Contrary to the claims of some textbook authors, the vast majority of technologists that process images do not need to understand the mathematics involved, but would nevertheless benefit from a thorough understanding of the general process.

Compiled from sessions presented at the 2008 AAPM Summer School, which was held June 25-27, 2008 at the Baylor College of Medicine, Texas Medical Center, Houston, TX. Topics include PET and CT basics, diagnostic and clinical alications, PET/CT scanner designs and characteristics, scanner testing, PET ACR accreditation and acceptance testing, PET/CT simulation for therapy alications, shielding calculations and radiation safety, and site planning.

Cyclotrons are used for preparation of a wide variety of radionuclides that find application in single photon emission computed tomography (SPECT) as well as in positron emission tomography (PET). This publication gives comprehensive guidelines for the planning and decision making processes and design and implementation of a cyclotron based radionuclide production facility. It will enable Member States to plan such facilities in a cost effective manner.

A state-of-the-art guide on the interventional management of venous disease from renowned experts! The diagnosis and management of venous disorders is a core competency of interventional radiology, comprising up to 75% of an interventional radiologist's caseload in some institutions. Venous Interventional Radiology by prominent interventional radiologist Laura Findeiss and an impressive group of contributors is a highly practical vascular interventional radiology reference that covers a full spectrum of venous disease. The richly illustrated book starts with an opening chapter on venous anatomy, physiology, and epidemiology. Disease-specific chapters cover common to complex disorders, from varicose veins and venous ulceration, to thromboembolic disease and pulmonary embolism. Each chapter presents the latest minimally invasive image-guided interventions for the diagnosis and management of a specific disease. Clinical cases provide discussion of patient presentation/symptoms, clinical evaluation, procedural and non-invasive management strategies, and follow-up, all of which are key to delivering comprehensive patient care. Key Highlights Angiographic and cross-sectional imaging findings enhance knowledge of disease processes A chapter dedicated to vascular/venous access provides guidance on this basic yet critical component of patient care The classification, evaluation, and treatment of venous anomalies and syndromes The authors discuss pitfalls and complications, including their own pearls of wisdom and unanswered questions This highly practical guide is a must-have resource for trainee and veteran interventional radiologists and vascular surgeons. This book includes complimentary access to a digital copy on https://medone.thieme.com.

Written by a leading international authority in the field, this book is ideal for physicians and residents in nuclear medicine who want to improve their knowledge in internal dosimetry. The text is a practical introduction that guides the reader through fundamental concepts in the calculation of radiation dose, including discussions of standardized models, methods of calculations, and available software applications. This comprehensive guide discusses too the biological effects of radiation on living systems. The book also includes an overview of regulatory aspects related to the radiation dosimetry of new radiopharmaceuticals.

This book provides an up-to-date summary of the latest scientific developments on the use of PET-CT imaging in Non-Hodgkin Lymphoma (NHL). It encompasses the entire spectrum of NHL - from pathology to radiological and PET-CT imaging and to the management of NHL. The highlight of the book is the excellent pictorial depiction of normal variants, pitfalls and artifacts while exploring the different types of NHL and its manifestations. Each chapter, written by well-known and experienced oncologists and physicians, is enriched by a wide range of images to ensure a clear concept of PET-CT imaging in NHL and will definitely keep the readers interested. This book will be a useful tool for nuclear physicians, radiologists, referring clinicians and oncologists, as well as para-medical staff working in this field.

The purpose of this book is to provide the outline for the "nuts and bolts" establishment and operation of a nuclear cardiology laboratory. In so doing, the authors have attempted to deal with the relevant issues that a laboratory director must address in either setting up the laboratory or maintaining its competitive edge and clinical competence over time. The authors primarily attempted to identify issues related to outpatient imaging facilities. However, where appropriate issues related to inpatients in hospital-based laboratories are also discussed.

In this new edition, the authors have kept the basic format established in the first edition. In addition to reviewing, modifying and updating each chapter in the first edition, they have added entirely new chapters on PET imaging, hybrid imaging and the clinical appropriateness of nuclear cardiology procedures.

This book is designed to give the reader a solid understanding of the

physics and instrumentation aspects of PET, including how PET data are collected and formed into an image. Topics include basic physics, detector technology used in modern PET scanners, data acquisition, and 3D reconstruction. A variety of modern PET imaging systems are also discussed, including those designed for clinical services and research, as well as small-animal imaging. Methods for evaluating the performance of these systems are also outlined. The book will interest nuclear medicine students, nuclear medicine physicians, and technologists.

This compendium describes the major production routes of the six most relevant iodine radio isotopes and the various methods of labeling molecules of biological, diagnostic or pharmaceutical interest with them. The chapters describe the basic reaction mechanisms, and the influence of iodine introduction on physical/chemical and pharmacological properties. They include examples of important reaction pathways for the preparation of radio-iodine compounds.

The present volume on basic physics of ultrasonographic imaging procedures provides clear and concise information on the physics behind ultrasound examinations in diagnostic imaging. It attempts to present the subject from a simple approach that should make it possible for the target groups to comprehend the important concepts which form the physical basis of ultrasonic imaging. The main target group of this manual is radiological technologists and radiographers working with diagnostic ultrasound in developing countries.Clinicians and nurse practitioners may also find the simple presentation appealing. A conscious effort has been made to avoid detailed mathematical treatment of the subject. The emphasis is on simplicity.