The present volume on basic physics of ultrasonographic imaging procedures provides clear and concise information on the physics behind ultrasound examinations in diagnostic imaging. It attempts to present the subject from a simple approach that should make it possible for the target groups to comprehend the important concepts which form the physical basis of ultrasonic imaging. The main target group of this manual is radiological technologists and radiographers working with diagnostic ultrasound in developing countries.Clinicians and nurse practitioners may also find the simple presentation appealing. A conscious effort has been made to avoid detailed mathematical treatment of the subject. The emphasis is on simplicity.

The fifth edition of this book presents clinical data, image acquisition, and interpretation of nuclear cardiology procedures through high quality illustrative image examples. It includes up-to-date and comprehensive coverage of advances in instrumentation, radiotracers, protocols, and clinical studies. New content includes indications in imaging cardiac sarcoidosis, amyloidosis, and device infections as well as recent advances in instrumentation (Hybrid PET/MR). It also provides fresh chapters on the history of nuclear cardiology imaging, radionuclide handling techniques and radiation safety, PET-based myocardial perfusion imaging, and vascular imaging. The entire field is presented in pictographic form that is visually pleasing and conforming to current trends of medical education. The fifth edition of the Atlas of Nuclear Cardiology is an essential reference for cardiologists, radiologists, and nuclear medicine physicians interested in the latest approaches to noninvasive diagnostic cardiovascular nuclear imaging techniques. It also serves as a ready reference textbook for medical students and residents as well as nuclear physicists, nuclear medicine technologists, and radiopharmacists.

This book provides a review of image analysis techniques as they are applied in the field of diagnostic and therapeutic nuclear medicine. Driven in part by the remarkable increase in computing power and its ready and inexpensive availability, this is a relatively new yet rapidly expanding field. Likewise, although the use of radionuclides for diagnosis and therapy has origins dating back almost to the discovery of natural radioactivity itself, radionuclide therapy and, in particular, targeted radionuclide therapy has only recently emerged as a promising approach for therapy of cancer and, to a lesser extent, other diseases. As effort has, therefore, been made to place the reviews provided in this book in a broader context. The effort to do this is reflected by the inclusion of introductory chapters that address basic principles of nuclear medicine imaging, followed by overview of issues that are closely related to quantitative nuclear imaging and its potential role in diagnostic and therapeutic applications.

The different chapters discuss the basic principles and various steps required for obtaining quantitatively accurate data from nuclear medicine images including data collection methods and algorithms used to correct them for physical degrading factors (e.g. collimator response, attenuation, scatter, partial volume effect), and image reconstruction algorithms (analytic, iterative) as well as image processing and analysis techniques as their clinical and research applications in neurology, cardiology and oncology. Some algorithms are described and illustrated with some useful features and clinical applications. Other potential applications of quantitative image analysis such asimage-guided radiation therapy are also discussed.

Nuclear medicine plays a crucial role in patient care, and this book is an essential guide for all practitioners to the many techniques that inform clinical management. The first part covers the scientific basis of nuclear medicine, the rest of the book deals with clinical applications. Diagnostic imaging has an increasingly important role in patient management and, despite advances in other modalities (functional MRI and spiral CT), nuclear medicine continues to make its unique contribution by its ability to demonstrate physiological function. This book is also expanded by covering areas of development in nuclear medicine, such as PET, methods of tumor imaging, and data processing. All illustrations for this new edition reflect current standards of image quality.

This practical approach results in a book which is invaluable to the radiologist, physician, physicist, or technologist starting in nuclear medicine but also contains up-to-date advice for the most experienced practitioner.

Essential for students, science and medical graduates who want to understand the basic science of Positron Emission Tomography (PET), this book describes the physics, chemistry, technology and overview of the clinical uses behind the science of PET and the imaging techniques it uses. In recent years, PET has moved from high-end research imaging tool used by the highly specialized to an essential component of clinical evaluation in the clinic, especially in cancer management. Previously being the realm of scientists, this book explains PET instrumentation, radiochemistry, PET data acquisition and image formation, integration of structural and functional images, radiation dosimetry and protection, and applications in dedicated areas such as drug development, oncology, and gene expression imaging. The technologist, the science, engineering or chemistry graduate seeking further detailed information about PET, or the medical advanced trainee wishing to gain insight into the basic science of PET will find this book invaluable.

This book is primarily repackaged content from the Basic Science section of the 'big' Valk book on PET. It contains new, completely revised and unchanged chapters covering the "basic sciences" section of the main book - total 18 chapters:

• 2 new (chapters 1, 16)
• 8 completely revised (chapters 4, 5, 8, 13, 14, 15, 17, 18)
• 3 minor corrections (chapters 2, 6, 11)
• 5 unchanged (chapters 3, 7, 9, 10, 12)

The Sentinel Lymph Node Concept is evaluated from the points of view of pathology, radiodiagnosis and nuclear medicine diagnostics, surgical treatment and clinical oncology. The concept and its practical applications are analyzed for breast cancer, malignant melanoma, tumors of the face, oropharynx, lung, gastrointestinal and urogenital tracts. The first part of the book describes the function and use of the nuclear medicine equipment, the tracers used, colloid solutions and modern developments in histological and immunohistochemical lymph node investigations, as well as possible pitfalls. The consequences of false-negative results are clearly delineated. In the second part, specific tumor-related problems are described.

In the development of many medical technologies the beginning is characterised by an emphasis on the basic scientific principles of the technology and the optimisa tion of the functional aspects of the technology. As a technology matures there is a tendency for the underlying principles to be forgotten as the dinical applications begin to develop and the focus moves to an understanding of the dinical applica tion. This maturity brings with it new challenges for those involved in the use of the technology. An acceptance of the methodology may lead to a scaling back of the ba sic training of staff into the fundamentals of the techniques and lead to a lack of questioning as to those issues which lead to the optimisation in dinical applications. This lack of basic training may ultimately lead to a stifling of research and develop ment of the technology as a whole as trained staff becomes a scarce commodity. Nudear medicine is no exception to this development cyde. As a medical special ty the discipline has matured. The basic imaging technology has become more reli able in everyday use requiring less input from scientific staff. Clinical procedures have become protocols which are often followed without due understanding of the basic principles underlying the imaging procedure. This is clearly demonstrated when new radiopharmaceuticals are introduced into the market place.

Methods involving nuclear physics are today finding applications in many disciplines, including important areas of medicine. This book intends to bridge the gap between the many applications in medicine and the underlying basic nuclear physics which needs to be understood by those applying the methods. In addition, those active in nuclear science will gain insight into the manifold applications of their subject. The main topics of the book are: physical foundations, instrumentation, diagnostics (imaging), therapies and radiation safety. The book will appeal to medical doctors active in nuclear medicine as well as to medical physicists.

Nuclear Medicine in Psychiatry showcases the combined expertise of renowned authors whose dedication to the investigation of psychiatric disease through nuclear medicine technology has achieved international recognition. Psychiatric disorders are discussed both from categorical and functional psychopathological viewpoint and the latest results in functional neuroimaging are detailed. Most chapters are written jointly by a psychiatrist and a nuclear medicine expert, and each contains a section "Clinical Aspects," to link research data with clinical routine. This state-of-the-art compendium will be valuable to anybody in the field of neuroscience, from the psychiatrist and the radiologist/nuclear medicine specialist to the interested general practitioner and cognitive psychologist.

A comprehensive and contemporary reference work covering the basic science and clinical applications of positron emission tomography. This book reflects the tremendous increase in interest in PET as both a clinical and research imaging modality in the past 10 years. Written by experts in the field and edited by those involved in PET development, and training of scientists and medical specialists. Positron Emission Tomography - basic science and clinical practice thoroughly explains the principles, clinical applications and economic aspects of PET today. Chapters go into detail on PET applications in oncology, the central nervous system, cardio-respiratory systems, infectious diseases and pediatrics. Discussions are also found on technology design and evaluation, PET in drug discovery and development in imaging gene expression and therapy. Peter E. Valk MB BS FRACP is based in the Northern California PET Imaging Center, Sacramento, CA USA, Dale L. Bailey PhD FIPEM ARCP is based in the Department of Nuclear Medicine, Guy's Hospital, London UK, David W. Townsend PhD is based in the Department of Radiology, University of Pittsburgh, Pittsburgh, PA USA, Michael N. Maisey MD FRCP FRCR is Professor at the Department of Radiological Sciences, Guy's Hospital, London UK.

Drs. Vitola and Delbeke assembled a group of standout contributors in order to create a resource that advances the knowledge and skills of experienced nuclear cardiologists and radiologists while also preparing residents for the cutting-edge field of nuclear cardiology. Diagnostic tools, physics and instrumentation, and radiopharmaceuticals and protocols central to the field are examined. The comprehensive text covers key applications of myocardial perfusion imaging, including applications in special populations and in emergency departments. Risk assessment, pitfalls, and artefacts are addressed. Additional chapters detail the value of cardiac MRI, multislice computed tomography, stress echocardiography, and PET and PET/CT to nuclear cardiology. Practical case presentations and a wealth of illustrations reinforce instruction on diagnostic guidelines and methods.

PET in Clinical Oncology describes the use of Positron Emission Tomography (PET) in the diagnosis and management of malignant tumors. Experts from Germany and the United States present basics, technical details, and clinical aspects for both standard and new PET techniques. The book illustrates the importance of PET in comparison to other imaging techniques.
Generously supplemented with charts, tables, and illustrations, each chapter provides the reader with well-delineated descriptions, from the basic technical situation through the clinical use of PET. This book is helpful to all those dealing with the diagnosis and therapy of cancer.

This book is a comprehensive guide to PET and PET CT and serves as a valuable resource for practicing physicians and residents. The text covers topics ranging from the basic principles of physics, molecular assays, preparation of molecular imaging probes, and biochemistry relevant for PET. Additionally, clinical applications in cancer, cardiovascular diseases, and neurological disorders are thoroughly discussed. U.C.L.A. School of Medicine is recognized as one of the leading PET centers in the world. All of the contributors are U.C.L.A. School of Medicine faculty members and they combined their areas of expertise in order to create the premier reference book on PET. Each chapter provides a complete overview of the topic material and guides the reader through the subject matter. Figures, tables, and solved example problems are integrated into the text. Readers also benefit from the extensive references and suggested reading material.

This book contains the original manuscripts, with summaries and diagnostic flow-charts, of speakers of the EANM 2001 post-congress meeting held in Capri, Italy, which examined management issues of patients with inflammatory bowel diseases, orthopaedic infections, vascular prosthesis infection, FUO and endocarditis, rheumatoid arthritis, and neurological infections. Nuclear medicine doctors attended together with radiologists and clinical specialists from different fields (gastroenterologists, orthopaedics, vascular surgeons, internal medicine doctors, rheumatologists, neurologists). The topics discussed in the book are of great importance for clinicians, nuclear medicine doctors and radiologists. At the end of each chapter, the commonly agreed diagnostic flow-charts for the management of patients with inflammation/infection are published.

"More than half of the world's population is at risk of the tropical diseases malaria, leprosy, schistosomiasis, lymphatic filariasis, onchocerciasis, Chagas' disease, African trypanosomiasis and leishmaniasis and half a billion are infected with at least one of these diseases." J. H. F. Remme, World Health Organisation, 1993. "If it is true that science is not limited by frontiers and all research Institutions then belong to mankind, so it is natural for each Institution to be responsible for the problems of those who live in the geographic area under its influence. There are no specific aspects concerning physical, chemical or philosophical concepts and facts, but specificity does exist concerning geology, sociology and pathology. It is the duty of each Institution to study the particular aspects concerning its geographic region, as missing links of the chain of universal knowledge may be found there." H. L. de Oliveira, fonner Rector of the University ofSiio Paulo, 1967. "Nuclear Medicine is cost effective, especially in the developing countries. ( ... ).

A highly practical, case-based approach to neurovascular anatomy in interventional neuroradiology This case-based book presents detailed information on neurovascular anatomy in concise, easily digestible chapters that focus on the importance of understanding anatomy when performing neurointerventional procedures. The case discussions include modern examples of invasive and non-invasive angiographic techniques that are relevant for general radiologists and diagnostic neuroradiologists as well as interventionalists. This book gives readers the detailed knowledge of neurovascular anatomy that allows them to anticipate and avoid potential complications. Key Features: Cases are enhanced by more than 1,000 high-quality radiographs covering the full range of neurovascular anatomy Content focuses on the practical relevance of the anatomical features encountered while performing everyday neurovascular procedures Anatomy and embryology are explained together, enabling readers to fully comprehend the vascular anatomy and its many variants Pearls and pitfalls are provided at the end of each chapter, highlighting the critical anatomy points presented All neuroradiologists, interventionalists, general radiologists, and diagnostic neuroradiologists, as well as residents and fellows in these specialties, will read this book cover to cover and frequently consult it for a quick review before performing procedures.

This monograph evaluates the evidence for carcinogenicity of ionizing radiation from internally deposited radionuclides. The radionuclides considered in this monograph belong to two broad categories: those that emit a-particles (helium nuclei) and those that emit b-particles (electrons) during their primary radioactive decay. For purposes of this monograph 'internally deposited' refers to radionuclides in dispersed forms (e.g. dusts suspensions solutions or gases) that enter the body through inhalation ingestion by some form of injection or in some cases by percutaneous absorption. Radionuclides may also enter tissues within removable objects, such as radioactive beads needles etc. that may be implanted surgically for therapeutic purposes or other kinds of fragments implanted accidentally. These kinds of exposures are not considered in this volume. Also not considered are radionuclides (e.g. iron-55 gallium-67) which undergo radioactive decay through processes that do not include emission of either a or b particles. Radon and its decay products were previously evaluated in "IARC Monographs" Volume 43 (1988) as "carcinogenic to humans" (Group 1). The subsequently published scientific literature on occupational and residential exposures to radon was reviewed and included in this volume as an update but no re-evaluation of radon was considered necessary. Six specific radionuclides of the elements radium thorium plutonium and phosphorus plus mixed radionuclides of iodine were evaluated as "carcinogenic to humans "(Group 1) on the basis of sufficient evidence for increased risk of cancer in exposed individuals. These include radium-224 radium-226 radium-228 thorium-232 (administered in colloidal form as thorium-232 dioxide) plutonium-239 (exposure to which also entails exposure to plutonium-240 and other isotopes of plutonium) radioisotopes of iodine including iodine-131 and phosphorus-32. Evidence for increased cancer risk in exposed humans is from medical usage in the cases of radium-224 thorium-232 and phosphorus-32 and from occupational or accidental/environmental exposures for plutonium-239 radium-226 and radium-228 and the radioiodines. In addition the global evaluations of two broad categories of internally deposited radionuclides were made on the basis of carcinogenicity in experimental animals plus other relevant data: Internally deposited radionuclides that emit a particles are "carcinogenic to humans (Group 1)." Internally deposited radionuclides that emit b particles are "carcinogenic to humans (Group 1). Ionizing Radiation Part 1: X-and Gamma (g) Radiation and Neutrons" Volume 75 of the "Monographs" addressed the carcinogenic potential of external X-rays g-rays and neutrons in exposed populations (see overleaf).

A practical how-to manual on breast elastography This comprehensive reference covers the principles and techniques used in performing breast elastography, an innovative imaging technology that can dramatically reduce the need for biopsies. The book begins with an introduction of the techniques, followed by sections on how to perform each technique and methods of interpretation, and concludes with more than 60 detailed case studies. Key Features: Includes case studies covering a wide range of breast pathologies and illustrating the use of all available elastography techniques to help radiologists obtain the best images for each pathology Covers all methods of breast elastography, including sheer wave and strain wave Contains more than 200 high-quality color images that demonstrate how to perform each technique Breast Elastography is an essential reference for all radiologists, residents and fellows, and sonographers involved in breast imaging and evaluation.

This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, -amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.

The Badgastein Lecture.- The Challenge of the 21st Century.- Neurology, Psychiatry.- First Evaluation in Humans of [123I]PE21: A Selective Radioligand for Visualization of the Striatal Dopamine Transporter Density.- Comparison of Iodine-123 labelled Nor-ss-Cit and ss-Cit as Potential Radioligands for Serotonin Transporter Imaging.- Brain Serotonin and Dopamine Transporters in Depressive Children.- Prognostic Potential of Tc-99m-ECD-SPET within 6 Hours after Onset of Stroke Symptoms.- Brain Perfusion in Patients with Severe Sleep Apnea Syndrome (SAS) before and after n-CPAP-Therapy.- Therapy.- Radioimmunotherapy of Colorectal Cancer in Small Volume Disease: Preclinical Evaluation in Comparison To Equitoxic Chemotherapy and Preliminary Results of an Ongoing Phase-I/II Clinical Trial.- Radioimmunotherapy of Glioblastoma by Using I-131 and Y-90 Labeled Anti-tenascin Monoclonal Antibodies.- I-131-Lipiodol Therapy in Liver Neoplasms.- Individualized Dose Estimation for Sr-89 with the Use of Diagnostic Tc-99m MDP Bone Scintigraphy.- Rhenium-186-HEDP and Strontium-89-Chloride in Treatment of Metastatic Bone Pain.- The Development of Chromatographic 188W/188Re Generators for Therapy.- Radiopharmacology.- Evaluation of mRNA Targeting by Labeled Oligonucleotides for Tumor-Diagnosis.- Synthesis and Evaluation of [123I]-Iodoaminoglutethimide, a Ligand for Visualization of the Aromatase Enzyme by SPECT.- Comparative Analysis of Kinetic Models to Study Glucose Metabolism of the Brain.- Bone Scintigraphy and Palliative Therapy with Multibone Kit.- Pharmaosintigraphic Study of Localization in the G.I. Tract of Controlled Release Tablets Using 153Sm as Marker.- Endocrinology, Thyroid.- On the Use of Routine Preoperative Scintigraphy in Thyroid Carcinoma Patients.- The Value of HMPAO SPECT Scanning in Patients with Congenital Hypothyreosis.- Advanced Stage Thyroid Cancer - Treatment with Isotretinoin.- Is SPECT-Technique Necessary for Preoperative Diagnosis of Parathyroid Adenoma ?.- Oncology, Haematology.- Comparison of Interlesionally and Systemically Administered Radiolabelled Monoclonal Antibodies in Implanted Tumours.- Comparison of MRI and Somatostatin Receptor Scintigraphy (SRS) in Post-surgical Follow-up of Meningioma.- Comparison of Contrast Enhanced MRI, Tc-99m Hydroxymethylene Diphosphonate and Tc-99m Tetrofosmin Scintimammography in Patients with Suspicious Breast Lesions.- Neoadjuvant Treatment of Patients with Breast Cancer under Surveillance of 99mTc-Tetrofosmin Scintigraphy.- 99Tc-Furifosmin Uptake by Melanoma Cells.- Lymphoscintigraphy in Tumors of the Head and Neck Using a Double Tracer Technique.- Clinical PET.- Clinical Application of 18FDG-PET in the Assessment of Head and Neck Tumors.- The Role of FDG-PET and MIBI Investigations in the Restaging of Treated Patients with Malignant Lymphomas.- Assessment of Pulmonary Nodules and Colorectal Cancer Recurrences by FDG Scan on an"Ordinary" Coincidence Gamma Camera (CDET).- Clinical Utility of 18FDG-PET with Molecular Coincidence Detection (MCD) and a Modified SPECT-Camera.- Deoxyglucose Uptake by Apoptosing and Proliferating Colonic Tumour Cells.- Cardiology.- Relation Between Viability, Improvement of LVEF and Heart Failure Symptoms after Revascularization.- Attenuation Corrected Tl-201 SPECT Using a Gd-153 Moving Line Source: Clinical Value and the Impact of Attenuation Correction on the Extent and Severity of Perfusion Abnormalities.- Correlation of EBCT and Tl-201-SPECT Scintigraphy in Patients with Coronary Heart Disease.- Influence of Right Ventricular Stimulation Site on Left Ventricular Function in a Trial Synchronous Pacing.- Varia.- 153Sm-EDTMP for Pain Relief in Malignant and Benign Bone and Joint Diseases.- Tc-99m-Tetrofosmin SPECT Scintigraphy in the Post-operative Follow-up of Microvascular Anastomosed Flaps in Facial Reconstruction.- Long-Term Follow-up Study of Gastric Emptying and Helicobacter Pylori Eradication among Patients with Functional Dyspepsia.- The Valu

Hypoxia, i.e. insufficient availability of oxygen within the tissue, is a more serious problem than realized in clinical routine work, although a large variety of theoretical and experimental data give clearly proven indications. During incidences and progress of many types of diseases hypoxia may enhance development and progress of the disease and, furthermore, decrease chances of efficient treatment of, e.g., tumors. Hypoxic tumor cells are up to three times more resistant towards radiation therapy than normoxic cells. With a diagnostic tool such as provided by hypoxia tracers suitable for PET and SPECT imaging, the particular tissue situation becomes detectable and, thus, treatable. Although the clinical importance of hypoxia imaging is obviously great, to date neither the clinical nor the scientific community at an international level has focused many research activities on the hypoxia problem. As the result of a workshop held by the Section for Radiopharmacy in TA1/4bingen, this book collects observations and findings in order to stimulate the on-going research resulting in important clinical applications. Hypoxia imaging is needed in areas of cardiology, neurology and oncology. Additional applications are to be expected in the field of diabetes, infections and organ transplantation. Therefore, the book addresses those who are basically involved in research in radiochemistry and radiopharmacy as well as those dealing with all biological aspects and facing direct clinical applications.

In 1997, after more than a decade of research, the National Cancer Institute (NCI) released a report which provided their assessment of radiation exposures that Americans may have received from radioactive iodine released from the atomic bomb tests conducted in Nevada during the 1950s and early 1960s. This book provides an evaluation of the soundness of the methodology used by the NCI study to estimate: Past radiation doses. Possible health consequences of exposure to iodine-131. Implications for clinical practice. Possible public health strategies?such as systematic screening for thyroid cancer?to respond to the exposures. In addition, the book provides an evaluation of the NCI estimates of the number of thyroid cancers that might result from the nuclear testing program and provides guidance on approaches the U.S. government might use to communicate with the public about Iodine-131 exposures and health risks. Table of Contents Front Matter Executive Summary 1 Introduction 2 Review of the NCI Radiation Dose Reconstruction 3 Health Risks of I-131 Exposure 4 Implications for Clinical Practice and Public Health Policy 5 Communicating with the Public about Exposure to I-131 6 Research Needs References Glossary Appendix A. Study Activities Appendix B. Copy of the Memorandum from Dr. Charles Land to Dr. Richard Klausner Appendix C. Calculation of Collective Thyroid Dose to the U.S. Population from the Release of I-131 from the Nuclear Weapons Tests in Nevada Appendix D. Thyroid Cancer in Idaho, 1970-1996 Appendix E. Applicable Radiation Exposure Standards and Guides: Past and Present Appendix F. Screening for Thyroid Cancer: Background Paper Committee Biographies

The instrument Lumi-Imager was developed for the detection and accurate quantification of chemiluminescent signals on blots and in microtiter plates. It contains a cooled CCD camera, a specially developed lens system and software. In addition to luminescence, Lumi-Imager F1 can also detect and quantify UV-excited fluorescent signals in gels. Here we describe the components and features of this instrument as well as some of its applications.

This is a comprehensive account of the nature of the hazards presented by ionizing radiation and the methods of protection. It takes the reader through the general background of the subject, the underlying principles applied to the control of radiation hazards (including chapters on human physiology, the biological effects of radiation and radiation detection and measurement), before moving to specialized topics such as medical applications and waste disposal.;This edition has been revised and updated to reflect the significant changes that have occurred in this area in recent years. The most recent ICRP recommendations are included, the section on legislation has been expanded to emphasize the European and International requirements in addition to those of the UK, while the chapter on radiological emergencies has been rewritten to highlight international developments arising from the Chernobyl disaster.

The application of 3D methodology has recently been receiving increasing attention at many PET centres, and this monograph is an attempt to provide a state-of-the-art review of this methodology, covering 3D reconstruction methods, quantitative procedures, current tomography performance, and clinical and research applications. No such review has been available until now to assist PET researchers in understanding and implementing 3D methodology, and in evaluating the performance of the available imaging technology. In all the chapters, the subject matter is treated in sufficient depth to appeal equally to the physicist or engineer who wishes to establish the methodology, and to PET investigators with experience in 2D PET who wish to familiarize themselves with the concepts and advantages of 3D, and to be made aware of the pitfalls.