Advanced Imaging of the Abdomen is invaluable to the practising radiologist, and the more senior radiology resident and fellow, who is looking for a background reference source when discussing a suggested imaging approach with the referring physician. The book includes extensive lists, tables, line drawings and illustrations - ultrasonography, computed tomography, magnetic resonance images, scintigraphy. It bridges the interface between the referring clinician and radiologist when faced with a patient suspected of having a complex or more unusual abdominal condition.

The book provides a detailed, up-to-date account of the basics, the technology, and the clinical use of ion beams for radiation therapy. Theoretical background, technical components, and patient treatment schemes are delineated by the leading experts that helped to develop this field from a research niche to its current highly sophisticated and powerful clinical treatment level used to the benefit of cancer patients worldwide. Rather than being a side-by-side collection of articles, this book consists of related chapters. It is a common achievement by 76 experts from around the world. Their expertise reflects the diversity of the field with radiation therapy, medical and accelerator physics, radiobiology, computer science, engineering, and health economics. The book addresses a similarly broad audience ranging from professionals that need to know more about this novel treatment modality or consider to enter the field of ion beam therapy as a researcher. However, it is also written for the interested public and for patients who might want to learn about this treatment option.

The purpose and subject of this book is to provide a comprehensive overview of all types of phantoms used in medical imaging, therapy, nuclear medicine and health physics. For ionizing radiation, dosimetry with respect to issues of material composition, shape, and motion/position effects are all highlighted. For medical imaging, each type of technology will need specific materials and designs, and the physics and indications will be explored for each type. Health physics phantoms are concerned with some of the same issues such as material heterogeneity, but also unique issues such as organ-specific radiation dose from sources distributed in other organs. Readers will be able to use this book to select the appropriate phantom from a vendor at a clinic, to learn from as a student, to choose materials for custom phantom design, to design dynamic features, and as a reference for a variety of applications. Some of the information enclosed is found in other sources, divided especially along the three categories of imaging, therapy, and health physics. To our knowledge, even though professionally, many medical physicists need to bridge the three catagories described above.

Respiratory motion causes an important uncertainty in radiotherapy planning of the thorax and upper abdomen. The main objective of radiation therapy is to eradicate or shrink tumor cells without damaging the surrounding tissue by delivering a high radiation dose to the tumor region and a dose as low as possible to healthy organ tissues. Meeting this demand remains a challenge especially in case of lung tumors due to breathing-induced tumor and organ motion where motion amplitudes can measure up to several centimeters. Therefore, modeling of respiratory motion has become increasingly important in radiation therapy. With 4D imaging techniques spatiotemporal image sequences can be acquired to investigate dynamic processes in the patient's body. Furthermore, image registration enables the estimation of the breathing-induced motion and the description of the temporal change in position and shape of the structures of interest by establishing the correspondence between images acquired at different phases of the breathing cycle. In radiation therapy these motion estimations are used to define accurate treatment margins, e.g. to calculate dose distributions and to develop prediction models for gated or robotic radiotherapy. In this book, the increasing role of image registration and motion estimation algorithms for the interpretation of complex 4D medical image sequences is illustrated. Different 4D CT image acquisition techniques and conceptually different motion estimation algorithms are presented. The clinical relevance is demonstrated by means of example applications which are related to the radiation therapy of thoracic and abdominal tumors. The state of the art and perspectives are shown by an insight into the current field of research. The book is addressed to biomedical engineers, medical physicists, researchers and physicians working in the fields of medical image analysis, radiology and radiation therapy.

This volume addresses a wide range of issues in the field of nuclear medicine imaging, with an emphasis on the latest research findings. Initial chapters set the scene by considering the role of imaging in nuclear medicine from the medical perspective and discussing the implications of novel agents and applications for imaging. The physics at the basis of the most modern imaging systems is described, and the reader is introduced to the latest advances in image reconstruction and noise correction. Various novel concepts are then discussed, including those developed within the framework of the EURATOM FP7 MADEIRA research project on the optimization of imaging procedures in order to permit a reduction in the radiation dose to healthy tissues. Advances in quality control and quality assurance are covered, and the book concludes by listing rules of thumb for imaging that will be of use to both beginners and experienced researchers.

This book will serve as the definitive source of detailed information on radiation, ionization, and detection in nuclear medicine. It opens by considering fundamental aspects of nuclear radiation, including dose and energy, sources, and shielding. Subsequent chapters cover the full range of relevant topics, including the detection and measurement of radiation exposure (with detailed information on mathematical modelling); medical imaging; the different types of radiation detector and their working principles; basic principles of and experimental techniques for deposition of scintillating materials; device fabrication; the optical and electrical behaviors of radiation detectors; and the instrumentation used in nuclear medicine and its application. The book will be an invaluable source of information for academia, industry, practitioners, and researchers.

The field of nuclear medicine is expanding rapidly, with the development of exciting new diagnostic methods and treatments. This growth is closely associated with significant advances in radiation physics. In this book, acknowledged experts explain the basic principles of radiation physics in relation to nuclear medicine and examine important novel approaches in the field. The first section is devoted to what might be termed the "building blocks" of nuclear medicine, including the mechanisms of interaction between radiation and matter and Monte Carlo codes. In subsequent sections, radiation sources for medical applications, radiopharmaceutical development and production, and radiation detectors are discussed in detail. New frontiers are then explored, including improved algorithms for image reconstruction, biokinetic models, and voxel phantoms for internal dosimetry. Both trainees and experienced practitioners and researchers will find this book to be an invaluable source of up-to-date information.

Established as a classic text on nuclear chemistry and pharmacy, Fundamentals of Nuclear Pharmacy has been thoroughly revised with new information added covering innovations in imaging technology and clinical applications in the field. The Sixth Edition also eliminates outdated information from previous editions on radiopharmaceuticals now discontinued from the market. Dr. Gopal B. Saha's books have continually been praised for their clarity and accuracy while setting new standards for making complex theoretical concepts readily understandable to the reader. Like past editions, this book is intended to be used as a textbook on nuclear chemistry and pharmacy for nuclear medicine residents and students and as a reference book for nuclear medicine physicians and radiologists. New sections in the Sixth Edition include: * PET/CT and SPECT/CT * Digital Imaging * Exploratory IND * Nanoparticle Imaging * Treatment of liver cancer with 90Y-TheraSpheres and 90Y-SIR-Spheres * Treatment of Non-Hodgkin's lymphoma with 131I-Bexxar

The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing steadily. Many innovative molecular imaging probes have already entered clinical practice, and there is no doubt that the future emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation. This handbook addresses all aspects of molecular imaging in oncology, from basic research to clinical applications. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.

In 194 cases featuring over 450, high-quality images, Nuclear Medicine and PET/CT Cases provides a succinct review of clinically relevant cases covering the full range of nuclear medicine. Cases are grouped into sections including: Nuclear CNS Imaging, Nuclear Inflammation/Infection Imaging, Ventilation/Perfusion Lung Scintigraphy, Pediatric Nuclear Medicine, Cardiac Imaging, Bone Scintigraphy, PET/CT in Oncology, General Oncologic Imaging, Thyroid and Parathyroid, Radionuclide Therapy and Pre-Therapy Evaluation, Liver, Spleen and Biliary Tract, Gastrointestinal Tract, Renal Scintigraphy. Part of the Cases in Radiology series, this book follows the easy-to-use format of question and answer in which the patient history is provided on the first page of the case, and radiologic findings, differential diagnosis, teaching points, next steps in management, and suggestions for furthering reading are revealed on the following page. This casebook is an essential resource for radiology residents and practicing radiologists alike.

Sincethepublicationofthisbook in2005, thegrowthofpositron emission tomography(PET)andPET/CTmodalityhasbeenphenomenalwiththed- coveryofef?cientdetectorsandtheadditionofsophisticatedscannersand powerfulsoftware. Becauseofthevastadvancementandchangesintechn- ogy, andalso withgreatappreciationofthesuccess ofthe?rst edition, we thoughtasecondeditionofthebookwouldbeappropriate. Thebookisrevisedtoagainful?lltheneedsofnuclearmedicineprof- sionalssuchasphysicians, technologists, andresidents, alongwithstudents fortheirboardexaminationandtraining. Thecontentsofthebookhavebeen keptatthebasiclevelaswasinthe?rstedition. The organization of the book essentially has remained the same. Some chaptershavebeenrevisedvery extensively, while others haveonly minor changes. NochangehasbeenmadeinChap. 1asitisbasedonbasicphysics. Extensive revision has been made in Chaps. 2 and 3 to include up-to-date information on detectors, scanners, and data collection. Chapter 4 in the original edition has been divided into Chaps. 4 and 5 to allow for a se- ratechapteron"Storage,Display,andPACS. "Chapter6hasbeenupdated withnewinformationonNEMAstandardsonacceptancetestsofPETsc- ners. NewPETradionuclidesandthelistofcurrentavailablecyclotronshave beenaddedtoChap. 7. Chapter8includesasectiononCompoundingofPET Radiopharmaceuticals,inadditiontoseveralnewPETradiopharmaceuticals. NewregulationsconcerningtheuseofPETradiopharmaceuticals,thelice- ingofphysiciansandtechnologists,andtheaccreditationofPETfacilitiesto beeligibleforreimbursementforPETproceduresareallincludedinChap. 9. Chapter10hasbeenrevised,focusingontheissuesofcurrentreimbursement issuesforPETstudies. OnlyminorchangeshavebeenmadeinChaps. 11and 12toincludeup-to-dateinformation. Questionshavebeenaddedattheend ofeachchapter,asappropriate,tore?ectthechangesincontents. IthankmycolleaguesattheClevelandClinicFoundationfortheirsupport in manywaysand Mrs. DianeGrif?s for kindly typingand completingthe manuscriptontime. vii viii Preface IsincerelythankAndrewMoyer,editorofradiologyandnuclearmedicine, atSpringerforsupportandencouragement,andS. GeethalakshmiSrinivasan, ProjectManager,atSPiTechnologiesIndiaPvtLtdforexcellentproduction ofthebook. Cleveland,OH GopalB. Saha Contents 1. RadioactiveDecayandInteractionofRadiationwithMatter ...1 AtomicStructure ...1 RadioactiveDecay ...2 ?Decay ...2 ? ? Decay ...3 + Positron(?) Decay ...3 ElectronCapture ...3 IsomericTransition ...4 RadioactiveDecayEquations ...5 GeneralDecayEquations ...5 SuccessiveDecayEquations ...7 UnitsofRadioactivity ...9 UnitsofRadioactivityinSystemInternationale ...9 Calculations ...9 InteractionofRadiationwithMatter ...10 InteractionofChargedParticleswithMatter ...10 Interactionof?RadiationwithMatter ...12 Questions ...15 ReferencesandSuggestedReading ...17 2. PET ScanningSystems ...19 Background ...19 SolidScintillationDetectorsinPET ...20 PhotomultiplierTube ...24 PulseHeightAnalyzer ...25 ArrangementofDetectors ...25 PETScanners ...28 CoincidenceScintillationCameras ...29 PET/CTScanners ...30 SmallAnimalPETScanner ...33 MobilePETorPET/CT ...36 ix x Contents Questions ...38 ReferencesandSuggestedReading ...39 3. DataAcquisition and Corrections ...41 PETDataAcquisition ...41 TimeofFlightMethod ...46 Two-Dimensionalvs. Three-Dimensional DataAcquisition ...47 FactorsAffectingAcquiredPETData ...49 Normalization ...49 PhotonAttenuation ...50 AttenuationCorrectionMethods ...52 RandomCoincidences ...53 ScatterCoincidences ...55 CorrectionforScatterCoincidences ...56 DeadTime ...58 RadialElongation ...59 PET/CTDataAcquisition ...6 0 FactorsAffectingPET/CTData ...62 Questions ...67 ReferencesandSuggestedReading ...68 4. ImageReconstruction ...71 SimpleBackprojection ...71 FilteredBackprojection ...72 TheFourierMethod ...73 TypesofFilters ...75 IterativeReconstruction ...

Offers basic data on more than 3,600 radionuclides. Emphasizes practical application such as basic research, acheo0logy and dating, medical radiology and industrial. Balanced and informative details on the biological effects of radiation and resultant controversy. Trimmed down student version of a product that costs many times the price.

Proceedings of the 3rd Joint International Conference on Hyperfine Interactions and International Symposium on Nuclear Quadrupole Interactions, HFI/NQI 2010 held at CERN, Switzerland, September 13-17, 2010 Reprinted from Hyperfine Interactions Volume. This volume focuses on the most recent studies on all aspects of hyperfine interaction detected by nuclear radiation and nuclear quadrupole interactions detected by resonance methods in the areas of materials, biological and medical science, as well as on contributions on new developments in instrumentation and methods, ab initio calculations and simulations. This volume comprises research papers, reviews, and short communications recording original investigations related to: Theory on Hyperfine Interactions (HFI) and Nuclear Moments; Magnetism and Magnetic Materials (Bulk and Thin Layers); HFI probes in Semiconductors, Metals and Insulators; Lattice Dynamics and Ion-Solid Interactions; Surfaces, Interfaces, Thin Films, and Nano-structures; Resonance Methods; Nuclear Moments, Nuclear Polarization and Spin Dynamics; Investigations in Biology, Chemistry, and Medicine; New Directions and Developments in Methodology. The papers present the latest scientific work of various invited speakers and contributor researchers from the five continents that have brought their perspectives to the meeting.

Clinical studies during the past 10 years have shown that PET is more sensitive than CT and MRI for the detection of many tumors. In many cases, however, for example in head and neck tumors, combination with radiological procedures is necessary. It may be speculated that PET should be the first study in a malignant tumor when metastatic spread is suspected. MRI and CT may then be restricted to those body areas which evince sites of increased glucose metabolism. Thus, a combination of metabolic and morphologic procedures will enhance tumor detection and change the therapeutic strategy. In this light, an atlas including PET, CT, MRI, and histology data seems desirable to combine metabolic and morphologic imaging. This book presents an overview of the available data which should be of great interest not only for specialists in radiology and nuclear medicine, but also for oncologists.

Nuclear Medicine in Psychiatry showcases the combined expertise of renowned authors whose dedication to the investigation of psychiatric disease through nuclear medicine technology has achieved international recognition. Psychiatric disorders are discussed both from categorical and functional psychopathological viewpoint and the latest results in functional neuroimaging are detailed. Most chapters are written jointly by a psychiatrist and a nuclear medicine expert, and each contains a section "Clinical Aspects", to link research data with clinical routine. This state-of-the-art compendium will be valuable to anybody in the field of neuroscience, from the psychiatrist and the radiologist/nuclear medicine specialist to the interested general practitioner and cognitive psychologist.

This invaluable and well-presented text brings together previously fragmented or incompletely elucidated data on the impressive recent advances in orthopedic nuclear medicine. The book begins by acquainting the readers with various anatomic, physiologic, pathologic and technical concepts crucial to understanding orthopedic nuclear medicine and its utilization in clinical practice. Subsequent chapters detail the diagnosis of skeletal infections, trauma, vascular disorders, metabolic and neoplastic bone diseases, soft tissue calcifications and joint disorders. A separate section is devoted to the use of radionuclides in the treatment of bone and joint diseases. A unique feature of this richly illustrated volume is its comprehensive and clinically oriented approach. The book will prove invaluable to all with an interest in diagnostic and therapeutic orthopedics, including radiologists, orthopedists, rheumatologists, pediatricians, other clinicians and nuclear medicine professionals.

This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer's disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences.

This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics - the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy.

The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.

Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?cation of potential responders as well as therapy monitoring for an early bene?t assessment. Molecular imaging (MI) is based on the selective and speci?c interaction of a molecular probe with a biological target which is visualized through nuclear, magnetic resonance, near infrared or other methods. Therefore it is the method of choice for patient selection and therapy monitoring as well as for speci?c e- point monitoring in modern drug development. PET (positron emitting tomography), a nuclear medical imaging modality, is ideally suited to produce three-dimensional images of various targets or processes. The rapidly increasing demand for highly selective probes for MI strongly pushes the development of new PET tracers and PET chemistry. 'PET chemistry' can be de?ned as the study of positron-emitting compounds regarding their synthesis, structure, composition, reactivity, nuclear properties and processes and their properties in natural and - natural environments. In practice PET chemistry is strongly in?uenced by the unique properties of the radioisotopes used (e. g. , half-life, che- cal reactivity, etc. ) and integrates scienti?c aspects of nuclear-, organic-, inorganic- and biochemistry.

The Fourth Edition of Dr. Gopal B. Saha's Physics and Radiobiology of Nuclear Medicine was prompted by the need to provide up-to-date information to keep pace with the perpetual growth and improvement in the instrumentation and techniques employed in nuclear medicine since the last edition published in 2006. Like previous editions, the book is intended for radiology and nuclear medicine residents to prepare for the American Board of Nuclear Medicine, American Board of Radiology, and American Board of Science in Nuclear Medicine examinations, all of which require a strong physics background. Additionally, the book will serve as a textbook on nuclear medicine physics for nuclear medicine technologists taking the Nuclear Medicine Technology Certification Board examination. The Fourth Edition includes new or expanded sections and information for: * PET/MR, including the attenuation correction method and its quality control tests; * accreditation of nuclear medicine and PET facilities; * solid state digital cameras; * time of flight and scatter correction techniques; * CT scanners and attenuation correction in SPECT/CT; * partial volume effects; * quality control of CT scanners; * ion chamber survey meters, proportional counters, and G-M counters.

Neurological applications of PET include using itto identify Alzheimer's Disease, including differentiating between other forms of Dementia, to show causes of seizures that were otherwise unclear, and to diagnose psychiatric disorders like Schizophrenia. Although other books on PET may have a chapter or section on neurological applications, this is the only comprehensive and up-to-date book on neurological PET. It reviews PET in neuroscience with particular emphasis on findings that indicate its potential for improving diagnosis and treatment in neurology and psychiatry. Improving the transfer of the huge scientific developments in brain PET into clinical carewill produce tangible human benefit. To this end, "NeuroPET" focuses on practical and potentially clinically relevant issues and identify solid ground as well as open questions. In addition, the book includes major chapters on the methodological background, including tracer physiology and kinetic modeling, and a comprehensive literature review."

Nuclear medicine and lung diseases is intended for chest physicians who use nuclear medicine techniques in clinical practice and for nuclear physicians who perform tests in patients with chest disorders. The book is valuable for clinical practice and describes the interrelationship between the two specialities. Chest physicians will be better able to understand the significance of the results of nuclear medicine and nuclear physicians will appreciate more fully the clinical contexts in which nuclear techniques are of value. In the first part the physical and technical principles of nuclear medicine and the physiopathological bases are developed. In the second part the applications of nuclear medicine are presented in separate chapters on chest diseases - diffuse, infiltrative lung diseases, lung tumors, infections, pulmonary embolism, lung function and surgery, AIDS, lung transplantation, chronic obstructive bronchopulmonary diseases and therapy. Nuclear medicine and lung diseases represents the work of 15 French authors led by three main authors.

Echocardiography has now reached its maturity and plays a key role in the clinical assessment of cardiac function. However, its ability to assess myocardial perfusion remains a clinical challenge.

Myocardial contrast echocardiography is a technique that uses microbubbles. These microbubbles remain entirely within the intravascular space and their presence in any myocardial region denotes the status of microvascular perfusion within that region. During the last few years, a large number of research studies have been dedicated to this topic. The latest developments in echocardiographic techniques and second-generation contrast agents allow for the potential assessment of myocardial perfusion and provide an accurate endocardial border delineation.

In the present book, these new echocardiographic techniques dedicated to the assessment of myocardial perfusion are described in detail by experts from both sides of the Atlantic. Tips and tricks are included, explaining the basic concepts that are needed to understand and perform contrast echocardiography.

Nuclear Imaging of the Chest provides up-to-the minute information on the diagnostic nuclear imaging of chest disorders. The authors habe endeavored to integrate and consonsolidate the many different subspecialities in order to enable a holistic understanding of chest diseases from the nuclear medicine standpoint. Highlights of the book include the description of aerosol lung imaging in COPD and the updates on breast and lung cancer imaging. It is required reading not only for nuclear medicine practitioners and researchers but also for all interested radiologists, traumatologists, pulmonologists and cardiologists.