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Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
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4D Modeling and Estimation of Respiratory Motion for Radiation Therapy (Paperback, Softcover reprint of the original 1st ed. 2013)
Loot Price: R3,832
Discovery Miles 38 320
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4D Modeling and Estimation of Respiratory Motion for Radiation Therapy (Paperback, Softcover reprint of the original 1st ed. 2013)
Series: Biological and Medical Physics, Biomedical Engineering
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Respiratory motion causes an important uncertainty in radiotherapy
planning of the thorax and upper abdomen. The main objective of
radiation therapy is to eradicate or shrink tumor cells without
damaging the surrounding tissue by delivering a high radiation dose
to the tumor region and a dose as low as possible to healthy organ
tissues. Meeting this demand remains a challenge especially in case
of lung tumors due to breathing-induced tumor and organ motion
where motion amplitudes can measure up to several centimeters.
Therefore, modeling of respiratory motion has become increasingly
important in radiation therapy. With 4D imaging techniques
spatiotemporal image sequences can be acquired to investigate
dynamic processes in the patient's body. Furthermore, image
registration enables the estimation of the breathing-induced motion
and the description of the temporal change in position and shape of
the structures of interest by establishing the correspondence
between images acquired at different phases of the breathing cycle.
In radiation therapy these motion estimations are used to define
accurate treatment margins, e.g. to calculate dose distributions
and to develop prediction models for gated or robotic radiotherapy.
In this book, the increasing role of image registration and motion
estimation algorithms for the interpretation of complex 4D medical
image sequences is illustrated. Different 4D CT image acquisition
techniques and conceptually different motion estimation algorithms
are presented. The clinical relevance is demonstrated by means of
example applications which are related to the radiation therapy of
thoracic and abdominal tumors. The state of the art and
perspectives are shown by an insight into the current field of
research. The book is addressed to biomedical engineers, medical
physicists, researchers and physicians working in the fields of
medical image analysis, radiology and radiation therapy.
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