Sulfurtransferases: Essential Enzymes for Life stands as the first comprehensive resource on this increasingly important class of enzymes. Following an introduction to the field from the Editors, each chapter covers a specific sulfurtransferase, including its basic biology and roles in healthy functioning, disease, drug discovery, and other biotechnological applications. The physiological function for each enzyme is considered in depth, along with regulation mechanisms, pharmacological inhibitors, and pathology and conditions related to altered enzymatic activity. Sulfurtransferases discussed include rhodanese, MST, thiosulfate-thiol sulfurtransferase, tRNA uracil 4-sulfurtransferase, thiosulfate-dithiol sulfurtransferases, biotin synthase, cysteine desulfurase, lipoyl synthase, molybdenum cofactor sulfurtransferase, thiazole synthase, molybdopterin synthase sulfurtransferase, molybdopterin synthase, tRNA-uridine 2-sulfurtransferase, tRNA-5-taurinomethyluridine 2-sulfurtransferase, tRNA-5-methyluridine (54) 2-sulfurtransferase, and L-aspartate semialdehyde sulfurtransferase, among others. Here, researchers will discover key knowledge and recent advances to bring forward new studies on this increasingly relevant class of enzymes, while clinicians may apply new findings in medical practice.

Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers.

Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist. Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism's physiology and survival.

Progress in Molecular Biology and Translational Science, Volume 160 provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series gives in-depth knowledge on the important molecular biological aspects of organismal physiology and function, along with insights on how this knowledge can be applied to understand and ameliorate human disease. This updated release covers Clinical Drugs in the Environment, Group I Intron Trans-Splicing, Adult Stem Cells on Regenerative Therapy, CRISPR in Animals and Animal Models, The Role of 3'-5'Exoribonucleases in RNA Degradation, and more.

High-Density Sequencing Applications in Microbial Molecular Genetics, Volume 612 in the Methods of Enzymology series provides the latest on the high-density sequencing of DNA and cDNA libraries and how they have revolutionized contemporary research in biology. Methods permitting tens of millions of sequence reads in a single experiment have paved the way to genome-wide studies that are contributing to our understanding of the complexity of living systems. Chapters in this updated volume include Characterizing the role of exoribonucleases in the control of microbial gene expression: Differential RNA seq., Conformational studies of bacterial chromosomes by high-throughput sequencing methods, Measuring mRNA degradation, and more. Addition sections cover Global recognition patterns of bacterial RNA-binding proteins, High-resolution profiling of NMD targets, and the Generation of a metagenomic 3C/Hi-C library of human gut microbiota, Genome-wide mapping of yeast retrotransposons integration target sites, Measuring protein synthesis rates, Finding unsuspected partners of small RNAs with new screening approaches, Use of multiplexed transcriptomics to define the relationship between promoter sequence and transcription output, RNA-based control of quorum sensing in Vibrio cholerae, amongst other highly regarded topics.

This volume and its companion Volume 351 will supplement Volume 194 of MIE. The guides are specifically designed to meet the needs of graduate students and postdocs as well as researchers. Whether an established researcher or newcomer to the field, these volumes will contain all the up-to-date methods needed to study "Genes in Yeast." Procedures are included to enable newcomers to set up a yeast laboratory and to master basic manipulations. Relevant background and reference information will be given for proven procedures that can be used as a guide for developing protocols in a number of disciplines.

Energy, water, affordable healthcare and global warming are four major concerns resulting from resource depletion, record high oil prices, clean water shortages, high costs of pharmaceuticals, and changing climate conditions. Among many potential solutions, advance in membrane technology is one of the most direct, effective and feasible approaches to solve these sophisticated issues. This membrane book presents cutting-edge membrane research and development for water reuse and desalination, energy development including biofuels, CO2 capture, pharmaceutical purification and separation, and biomedical applications.

Advances in Microbial Physiology, Volume 83 in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Topics of interest in this update include RidA paradigm, Targeting the cell envelope to overcome antimicrobial resistance, Biosynthesis and function of microbial methylmenaquinones, Antibiotic efficacy, Role of central metabolism/bacterial physiology on tolerance to cell wall-acting antibiotics, and Physiology of diazotrophs.

Advances in Accelerators and Medical Physics provides in-depth, comprehensive coverage of basic concepts in X-ray therapy, electron beam therapy, particle therapy, BNCT, RI diagnosis and therapy. Each section of the book presents the current state of the field, details about safety and education, and future trends in advanced research. This book will serve as a key resource for researchers and students to find all information on cancer radiotherapy techniques and methods. Heavy ion radiotherapy used for cancer treatment involves the acceleration of carbon ions to 70% of the speed of light to deliver radiation to cancer cells and cause cell death. This therapy is also expected to be effective in cancers that are difficult to treat or do not respond to conventional treatments. Furthermore, this therapy is associated with several advantages such as shorter treatment duration and fewer side effects.

Advances in Microbial Physiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Intersection of Iron and Lipid Metabolism, Volume 52 in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics relating to enzymes research.

Advances in Quantum Chemistry, Volume 86 highlights new advances in the field, with this new volume presenting topics covering Can orbital basis sets compete with explicitly correlated ones for few-electron systems?, Converging high-level equation-of-motion coupled-cluster energetics with the help of Monte Carlo and selected configuration interaction, Coupled cluster downfolding techniques: a review of existing applications in classical and quantum computing for chemical systems, Multi-reference methods for the description of dynamic and nondynamic electron correlation effects in atoms and molecules, Exploring the attosecond laser-driven electron dynamics in the hydrogen molecule with different TD-CI approaches, and much more. Additional sections cover Molecular systems in spatial confinement: variation of linear and nonlinear electrical response of molecules in the bond dissociation processes, Relativistic Infinite-order two-component methods for heavy elements, Second quantized approach to exchange energy revised - beyond the S^2 approximation, Calculating atomic states without the Born-Oppenheimer approximation, Convergence of the Correlated Optimized Effective Potential Method, and more.

DNA Damage and Double Strand Breaks, Volume 51 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters that provide an update on female and male genital schistosomiasis and a call to integrate efforts to escalate diagnosis, treatment and awareness in endemic and non-endemic settings, vertebrates as uninfected disseminators of helminth eggs and larvae, and combatting anthelmintic resistance in ruminants.

Breast MRI: State of the Art and Future Directions provides a comprehensive overview of the current applications of breast MRI, including abbreviated MRI, as well as presenting technical recommendations, practical implementation and associated challenges in clinical routine. In addition, the book introduces novel MRI techniques, multimodality imaging, and advanced image processing coupled with AI, reviewing their potential for impeding and future clinical implementation. This book is a complete reference on state-of-the-art breast MRI methods suitable for MRI researchers, radiographers and clinicians. Breast cancer is one of the leading causes of death among women with early detection being the key to improved prognosis and survival. Magnetic resonance imaging (MRI) of the breast is undisputedly the most sensitive imaging method to detect cancer, with a higher detection rate than mammography, digital breast tomosynthesis, and ultrasound.

Jack Sabin, Scientist and Friend, Volume 85 in the Advances in Quantum Chemistry series, highlights new advances in the field, with chapters in this new release including: Elastic scattering of electrons and positrons from alkali atoms, Dissipative dynamics in many-atom systems, Shape sensitive Raman scattering from Nano-particles, Experience in E-learning and Artificial Intelligence, Structure and Correlation of Charges in a Harmonic Trap, Simulation of Molecular Spectroscopy in Binary Solvents, Approach for Orbital and Total Mean Excitation Energies of Atoms, and A New Generation of Quasiparticle Self-Energies. Additional sections cover: The stopping power of relativistic targets, Density functional methods for extended helical systems, Inspecting nlm-distributions due to charge exchange collisions of bare ions with hydrogen, Long-lived molecular dications: a selected probe for double ionization, and much more.

Advances in Microbial Physiology, Volume 81 highlights new advances in the field with this new release presenting interesting chapters written by an international board of authors. Updates in this release include sections on Antibiotic tolerance, Lanthanides in bacterial proteins, Bacterial toxins and host-microbe interactions, and Nitric oxide.

Advances in Microbial Physiology, Volume 150 in this important serial, highlights new advances in the field with this new volume including content by an international board of authors. Chapters in this new release include Organization of respiratory chains in the bacterial cell, Anaerobic methane oxidizing archaea, Dawn of the DedA: the structure and function of the DedA family of integral membrane proteins associated with bacterial viability and antimicrobial resistance, Nickel, an essential virulence determinant of Helicobacter pylori: trafficking pathways and their targeting by bismuth, Dissimilatory sulfur compounds oxidation in thermophilic and chemolithoautotrophic bacteria belonging to the Aquificales order, and much more.

Advances in Quantum Chemistry presents surveys of current topics in this rapidly developing field, one that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry and biology. The book features detailed reviews written by leading international researchers. In this volume, the readers are presented with an exciting combination of themes.

Viral Replication Enzymes and their Inhibitors, Part B, Volume 50 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics surrounding enzymes.

Advances in Microbial Physiology, Volume 79, the latest release in this serial that highlights new advances in the field, presents interesting and timely chapters authored by an international board of subject matter experts.

Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics.

Advances in Quantum Chemistry presents surveys of current topics in this rapidly developing field one that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry, and biology. It features detailed reviews written by leading international researchers. In this volume the readers are presented with an exciting combination of themes.

Biological Experiments in Space: 30 Years Investigating Life in Space Orbit covers investigations of plant, algae, animals, fish, microorganisms and tissue cultures on space flights, beginning with the first orbital space station on Salyut 1. The book includes results on the influence of the entire complex of physical factors associated with spaceflight on biological systems, including analysis of the impact of microgravity on organisms, as well as the effects of electric and magnetic fields. This book offers important insights for researchers of space biology and astrobiology, as well as space agency and industry specialists developing future space stations and missions. Lack of gravity, temperature and chemical gradients, magnetic and electrical fields, spectral composition and intensity of light, and high-energy cosmic radiation influence many important metabolic and physiological processes in animals, plants, and microorganisms, as well as transfer phenomena in and around them. Success of future space exploration depends on understanding the effects of these factors on biological organisms and developing appropriate countermeasures, aimed at improving growth, development, and reproduction in microgravity.