Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
|
Your cart is empty |
|||
Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
In Bilayer Lipid Membranes. Structure and Mechanical Properties the authors use new methods of measurement, which they have themselves developed, to present an analysis of the relation between membrane structure and viscoelastic properties, in particular in the transversal direction. Hianik and Passechnik's approach is fundamentally different from the usual one, in that they analyze lipid bilayer dynamics during various modes of deformation, arriving at a new, three-layer' model that accounts for the great heterogeneity of biomembranes. The macroscopic parameters of membranes have been measured using a wide variety of methods, leading to a discussion of the correlations between the parameters. There is also an extensive discussion of the dynamic changes in mechanical properties of lipid bilayers in the course of conformational transition of integral proteins. During the conformational changes of proteins, the structure of a bilayer undergoes a transition, reaching a new, stable membrane state. The book is the first to present a comprehensive analysis of long-distance interaction in lipid bilayers and of molecular mechanisms of mechanoreception. Audience: Scientists and graduate students working in biophysics, membranology, physiology, medicine, pharmacology, bioelectronics, electrochemistry, and colloid chemistry.
This book demonstrates the usefulness of tools from statistical mechanics for biology. It includes the new tendencies in topics like membranes, vesicles, microtubules, molecular motors, DNA, protein folding, phase transitions in biological systems, evolution, population dynamics, neural systems and biological oscillators, with special emphasis on the importance of statistical mechanics in their development. The book addresses researchers and graduate students.
The most up to date book on the topic Suitable for use as a textbook Contains a systematic description of each technique it describes Covers a broad readership, including nanotechnology, biotechnology, biophysics, analytical chemistry, and chemical biology Provides a highly simplified tutorial protocol at the end of each chapter to help readers obtain hands-on experience
"Dynamics of Soft Matter: Neutron Applications" provides an overview of neutron scattering techniques that measure temporal and spatial correlations simultaneously, at the microscopic and/or mesoscopic scale. These techniques offer answers to new questions arising at the interface of physics, chemistry, and biology. Knowledge of the dynamics at these levels is crucial to understanding the soft matter field, which includes colloids, polymers, membranes, biological macromolecules, foams, emulsions towards biological & biomimetic systems, and phenomena involving wetting, friction, adhesion, or microfluidics. Emphasizing the complementarities of scattering techniques with other spectroscopic ones, this volume also highlights the potential gain in combining techniques such as rheology, NMR, light scattering, dielectric spectroscopy, as well as synchrotron radiation experiments. Key areas covered include polymer science, biological materials, complex fluids and surface science.
This book offers an overview of state-of-the-art in non amplified DNA detection methods and provides chemists, biochemists, biotechnologists and material scientists with an introduction to these methods. In fact all these fields have dedicated resources to the problem of nucleic acid detection, each contributing with their own specific methods and concepts. This book will explain the basic principles of the different non amplified DNA detection methods available, highlighting their respective advantages and limitations. Non-amplified DNA detection can be achieved by adopting different techniques. Such techniques have allowed the commercialization of innovative platforms for DNA detection that are expected to break into the DNA diagnostics market. The enhanced sensitivity required for the detection of non amplified genomic DNA has prompted new strategies that can achieve ultrasensitivity by combining specific materials with specific detection tools. Advanced materials play multiple roles in ultrasensitive detection. Optical and electrochemical detection tools are among the most widely investigated to analyze non amplified nucleic acids. Biosensors based on piezoelectric crystal have been also used to detect unamplified genomic DNA. The main scientific topics related to DNA diagnostics are discussed by an outstanding set of authors with proven experience in this field.
Continuum Mechanics of Anisotropic Materials(CMAM) presents an entirely new and unique development of material anisotropy in the context of an appropriate selection and organization of continuum mechanics topics. These features will distinguish this continuum mechanics book from other books on this subject. Textbooks on continuum mechanics are widely employed in engineering education, however, none of them deal specifically with anisotropy in materials. For the audience of Biomedical, Chemical and Civil Engineering students, these materials will be dealt with more frequently and greater accuracy in their analysis will be desired. Continuum Mechanics of Anisotropic Materials' author has been a leader in the field of developing new approaches for the understanding of anisotropic materials.
Most of the specialists working in this interdisciplinary field of physics, biology, biophysics and medicine are associated with "The International Institute of Biophysics" (IIB), in Neuss, Germany, where basic research and possibilities for applications are coordinated. The growth in this field is indicated by the increase in financial support, interest from the scientific community and frequency of publications. Audience: The scientists of IIB have presented the most essential background and applications of biophotonics in these lecture notes in biophysics, based on the summer school lectures by this group. This book is devoted to questions of elementary biophysics, as well as current developments and applications. It will be of interest to graduate and postgraduate students, life scientists, and the responsible officials of industries and governments looking for non-invasive methods of investigating biological tissues.
This new volume in the Poincare Seminar Series, describing recent developments at the interface between physics and biology, is directed towards a broad audience of physicists, biologists, and mathematicians. Both the theoretical and experimental aspects are covered, and particular care is devoted to the pedagogical nature of the presentations. The first survey article, by Jean-Francois Joanny and Jacques Prost, describes the theoretical advances made in the study of "active gels," with applications to liquid crystals and cell motility. Jasper van der Gucht and Cecile Sykes then report on recent advances made with biomimetic model systems in the understanding of cytokinesis. The next article, by Jonathon Howard, presents several molecular models for motor proteins, which are compared with experimental results for kinesin. David Lacoste and Kirone Mallick then show theoretically that similar ratchet models of motor proteins naturally satisfy a fundamental time-reversal symmetry, the Gallavotti-Cohen fluctuation relation. Jean-Francois Allemand, David Bensimon and Vincent Croquette and their coauthors describe the latest advances made in the real-time single molecule study of the enzymes involved in DNA replication. Raymond E. Goldstein addresses the problem of understanding, from a physics perspective, the driving forces behind the biological evolution of multicellularity, using Volvocine algae as model organisms. Stanislas Dehaene finally addresses the major challenge of understanding the neuronal mechanism of consciousness, and speculates on the possible theoretical explanations of MRI experiments.
This book, a selection of the papers presented at the 2nd World Congress for Electricity and Magnetism, provides state-of-the-art information on applications of electricity and electromagnetic fields on living organisms, especially man.
This ASI brought together a diverse group of experts who span virology, biology, biophysics, chemistry, physics and engineering. Prominent lecturers representing world renowned scientists from nine (9) different countries, and students from around the world representing eighteen (18) countries, participated in the ASI organized by Professors Joseph Puglisi (Stanford University, USA) and Alexander Arseniev (Moscow, RU). The central hypothesis underlying this ASI was that interdisciplinary research, merging principles of physics, chemistry and biology, can drive new discovery in detecting and fighting chemical and bioterrorism agents, lead to cleaner environments and improved energy sources, and help propel development in NATO partner countries. At the end of the ASI students had an appreciation of how to apply each technique to their own particular research problem and to demonstrate that multifaceted approaches and new technologies are needed to solve the biological challenges of our time. The course succeeded in training a new generation of biologists and chemists who will probe the molecular basis for life and disease.
This book provides an overview of single-cell isolation, separation, injection, lysis and dynamics analysis as well as a study of their heterogeneity using different miniaturized devices. As an important part of single-cell analysis, different techniques including electroporation, microinjection, optical trapping, optoporation, rapid electrokinetic patterning and optoelectronic tweezers are described in detail. It presents different fluidic systems (e.g. continuous micro/nano-fluidic devices, microfluidic cytometry) and their integration with sensor technology, optical and hydrodynamic stretchers etc., and demonstrates the applications of single-cell analysis in systems biology, proteomics, genomics, epigenomics, cancer transcriptomics, metabolomics, biomedicine and drug delivery systems. It also discusses the future challenges for single-cell analysis, including the advantages and limitations. This book is enjoyable reading material while at the same time providing essential information to scientists in academia and professionals in industry working on different aspects of single-cell analysis. Dr. Fan-Gang Tseng is a Distinguished Professor of Engineering and System Science at the National Tsing Hua University, Taiwan. Dr. Tuhin Subhra Santra is a Research Associate at the California Nano Systems Institute, University of California at Los Angeles, USA.
In this thesis two variants of the fast variable elimination method are developed. They are intuitive, simple to implement and give results which are in very good agreement with those found from numerical simulations. The relative simplicity of the techniques makes them ideal for applying to problems featuring demographic stochasticity, for experts and non-experts alike. Within the context of mathematical modelling, fast variable elimination is one of the central tools with which one can simplify a multivariate problem. When used in the context of of deterministic systems, the theory is quite standard, but when stochastic effects are present, it becomes less straightforward to apply. While the introductory and background chapters form an excellent primer to the theory of stochastic population dynamics, the techniques developed can be applied to systems exhibiting a separation of timescales in a variety of fields including population genetics, ecology and epidemiology.
Macromolecules in the body form noncovalent associations, such as DNA-protein or protein-protein complexes, that control and regulate numerous cellular functions. Understanding how changes in the concentration and conformation of these macromolecules can trigger physiological responses is essential for researchers developing drug therapies to treat diseases affected by these imbalances. Introduction to Macromolecular Binding Equilibria gives students in medicinal chemistry, pharmaceuticals, and bioengineering the necessary background in biophysical chemistry for research applications in drug discovery and development. Building upon a fundamental knowledge of calculus and physical chemistry, this compact, graduate-level text prepares students for advanced work in solution thermodynamics and binding phenomena and applying methods in this book to their own research. This book describes the underlying theory of binding phenomena and explains how to apply the binding polynomial approach for building models and interpreting data. It also covers practical considerations for setting up binding experiments and describes how to obtain true thermodynamic isotherms unbiased by model assumption via model-free analysis of binding data.
This book describes current advances in the research on membranes and applications in industry, groundwater, and desalination processes. Topics range from synthesis of new polymers to preparation of membranes using new water treatments for effluents, graphite membranes, development of polymeric and ceramic materials for production of membranes intended to separate gases and liquids, and liquid-liquid phases. The authors include materials used to produce catalytic membranes for polymer synthesis. The book also details theoretical approaches and simulation of membrane processes and parameters and design.
This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer's disease and Parkinson's disease to Huntington's disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today's forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
This book deals with the adhesion, friction and contact mechanics of living organisms. Further, it presents the remarkable adhesive abilities of the living organisms which inspired the design of novel micro- and nanostructured adhesives that can be used in various applications, such as climbing robots, reusable tapes, and biomedical bandages. The technologies for both the synthesis and construction of bio-inspired adhesive micro- and nanostructures, as well as their performance, are discussed in detail. Representatives of several animal groups, such as insects, spiders, tree frogs, and lizards, are able to walk on (and therefore attach to) tilted, vertical surfaces, and even ceilings in different environments. Studies have demonstrated that their highly specialized micro- and nanostructures, in combination with particular surface chemistries, are responsible for this impressive and reversible adhesion. These structures can maximize the formation of large effective contact areas on surfaces of varying roughness and chemical composition under different environmental conditions.
Lanthanides have fascinated scientists for more than two centuries now, and since efficient separation techniques were established roughly 50 years ago, they have increasingly found their way into industrial exploitation and our everyday lives. Numerous applications are based on their unique luminescent properties, which are highlighted in this volume. It presents established knowledge about the photophysical basics, relevant lanthanide probes or materials, and describes instrumentation-related aspects including chemical and physical sensors. The uses of lanthanides in bioanalysis and medicine are outlined, such as assays for in vitro diagnostics and research. All chapters were compiled by renowned scientists with a broad audience in mind, providing both beginners in the field and advanced researchers with comprehensive information on on the given subject. "
Conifer Cold Hardiness provides an up-to-date synthesis by leading scientists in the study of the major physiological and environmental factors regulating cold hardiness of conifer tree species. This state-of-the-art reference comprehensively explains current understanding of conifer cold hardiness ranging from the gene to the globe and from the highly applied to the very basic. Topics addressed encompass cold hardiness from the perspectives of ecology, ecophysiology, acclimation and deacclimation, seedling production and reforestation, the impacts of biotic and abiotic factors, and methods for studying and analyzing cold hardiness. The content is relevant to geneticists, ecologists, stress physiologists, environmental and global change scientists, pathologists, advanced nursery and silvicultural practitioners, and graduate students involved in plant biology, plant physiology, horticulture and forestry with an interest in cold hardiness.
In the never-ending quest for miniaturization, optically controlled particle trapping has opened up new possibilities for handling microscopic matter non-invasively. This thesis presents the application of photorefractive crystals as active substrate materials for optoelectronic tweezers. In these tweezers, flexible optical patterns are transformed into electrical forces by a photoconductive material, making it possible to handle matter with very high forces and high throughput. Potential substrate materials' properties are investigated and ways to tune their figures-of-merit are demonstrated. A large part of the thesis is devoted to potential applications in the field of optofluidics, where photorefractive optoelectronic tweezers are used to trap, sort and guide droplets or particles in microfluidic channels, or to shape liquid polymers into optical elements prior to their solidification. Furthermore, a new surface discharge model is employed to discuss the experimental conditions needed for photorefractive optoelectronic tweezers.
Biological chemistry has changed since the completion of the human genome project. There is a renewed interest and market for individuals trained in biophysical chemistry and molecular biophysics. The Physical Basis of Biochemistry, Second Edition, emphasizes the interdisciplinary nature of biophysical chemistry by incorporating the quantitative perspective of the physical sciences without sacrificing the complexity and diversity of the biological systems, applies physical and chemical principles to the understanding of the biology of cells and explores the explosive developments in the area of genomics, and in turn, proteomics, bioinformatics, and computational and visualization technologies that have occurred in the past seven years. The book features problem sets and examples, clear illustrations, and extensive appendixes that provide additional information on related topics in mathematics, physics and chemistry.
This second edition of a well-received book focuses on rhythmic behaviour in plants, which regulates all developmental and adaptive responses and can thus be regarded as quintessential to life itself. The chapters provide a timely update on recent advances in this field and comprehensively summarize the current state of knowledge concerning the molecular and physiological mechanisms behind circadian and ultradian oscillations in plants, their physiological implications for growth and development and adaptive responses to a dynamic environment. Written by a diverse group of leading researchers, the book will spark the interest of readers from many branches of science: from physicists and chemists wishing to learn about the multi-faceted rhythms in plants, to biologists and ecologists involved in the state-of-the-art modelling of complex rhythmic phenomena.
In "Single Molecule Studies of Proteins," expert researchers discuss the successful application of single-molecule techniques to a wide range of biological events, such as the imaging and mapping of cell surface receptors, the analysis of the unfolding and folding pathways of single proteins, the analysis interaction forces between biomolecules, the study of enzyme catalysis or the visualization of molecular motors in action. The chapters are aimed at established investigators and post-doctoral researchers in the life sciences wanting to pursue research in the various areas in which single-molecule approaches are important; this volume also remains accessible to advanced graduate students seeking similar research goals.
This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.
This book provides a critical, carefully researched, up-to-date summary of membranes for membrane bioreactors. It presents a comprehensive and self-contained outline of the fundamentals of membrane bioreactors, especially their relevance as an advanced water treatment technology. This outline helps to bring the technology to the readers' attention, and positions the critical topic of membrane fouling as one of the key impediments to its more widescale adoption. The target readership includes researchers and industrial practitioners with an interest in membrane bioreactors. |
You may like...
Protein and Peptide-based Microarrays…
Navid Rabiee, Michael R. Hamblin
Paperback
R722
Discovery Miles 7 220
Artificial Intelligence In Radiation…
Seong K. Mun, Sonja Dieterich
Hardcover
R3,722
Discovery Miles 37 220
Modern Applications in Membrane Science…
Isabel Escobar, Bart Van der Bruggen
Hardcover
R5,419
Discovery Miles 54 190
Advances in Nanomaterials for Drug…
Mahdi Karimi, Maryam Rad Mansouri, …
Hardcover
R1,564
Discovery Miles 15 640
|