Macromolecules in the body form noncovalent associations, such as
DNA-protein or protein-protein complexes, that control and regulate
numerous cellular functions. Understanding how changes in the
concentration and conformation of these macromolecules can trigger
physiological responses is essential for researchers developing
drug therapies to treat diseases affected by these imbalances.
Introduction to Macromolecular Binding Equilibria gives students
in medicinal chemistry, pharmaceuticals, and bioengineering the
necessary background in biophysical chemistry for research
applications in drug discovery and development. Building upon a
fundamental knowledge of calculus and physical chemistry, this
compact, graduate-level text prepares students for advanced work in
solution thermodynamics and binding phenomena and applying methods
in this book to their own research.
This book describes the underlying theory of binding phenomena
and explains how to apply the binding polynomial approach for
building models and interpreting data. It also covers practical
considerations for setting up binding experiments and describes how
to obtain true thermodynamic isotherms unbiased by model assumption
via model-free analysis of binding data.
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