Protein Folding and Misfolding - Shining Light by Infrared Spectroscopy (Hardcover, 2012)

Infrared spectroscopy is a new and innovative technology to study protein folding/misfolding events in the broad arsenal of techniques conventionally used in this field. The progress in understanding protein folding and misfolding is primarily due to the development of biophysical methods which permit to probe conformational changes with high kinetic and structural resolution. The most commonly used approaches rely on rapid mixing methods to initiate the folding event via a sudden change in solvent conditions. Traditionally, techniques such as fluorescence, circular dichroism or visible absorption are applied to probe the process. In contrast to these techniques, infrared spectroscopy came into play only very recently, and the progress made in this field up to date which now permits to probe folding events over the time scale from picoseconds to minutes has not yet been discussed in a book. The aim of this book is to provide an overview of the developments as seen by some of the main contributors to the field. The chapters are not intended to give exhaustive reviews of the literature but, instead to illustrate examples demonstrating the sort of information, which infrared techniques can provide and how this information can be extracted from the experimental data. By discussing the strengths and limitations of the infrared approaches for the investigation of folding and misfolding mechanisms this book helps the reader to evaluate whether a particular system is appropriate for studies by infrared spectroscopy and which specific advantages the techniques offer to solve specific problems.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Biological and Medical Physics, Biomedical Engineering
Release date:	September 2011
First published:	2012
Editors:	Heinz Fabian • Dieter Naumann
Dimensions:	235 x 155 x 19mm (L x W x T)
Format:	Hardcover
Pages:	244
Edition:	2012
ISBN-13:	978-3-642-22229-0
Categories:	Books > Science & Mathematics > Physics > Nuclear structure physics Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins Books > Professional & Technical > Mechanical engineering & materials > Materials science > General Promotions
LSN:	3-642-22229-3
Barcode:	9783642222290

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