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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies (Hardcover, 1st ed. 2018)
Loot Price: R3,020
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Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies (Hardcover, 1st ed. 2018)
Series: Springer Theses
Expected to ship within 10 - 15 working days
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This thesis describes the use of biophysical and biochemical
methods to prove that calcium has a positive feedback effect on
amplifying and sustaining CD3 phosphorylation and should enhance
T-cell sensitivity to foreign antigens. The study presented shows
that calcium can regulate the signal pathway in cells not only as a
secondary messenger but also through direct interactions with the
phospholipid bilayer. The approach used in the thesis also
represents an important advance, as it couples the use of nuclear
magnetic resonance (NMR) to the analysis of signaling phenomena in
living cells. Moreover, the thesis optimizes the Nanodisc assembly
protocol, which can broaden its range of applications in membrane
protein studies. A preliminary study on the structure of dengue
virus NS2B-NS3p in complex with aprotinin, which may help to
develop new drugs against the dengue virus, is also included.
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