Remarkable advances have occurred since the Series 3 Fascicle published in 1995 with paradigm shifts in every dimension of our understanding of lung tumors including clinical, radiologic, histopathologic, cytopathologic, immunohistochemical, molecular and therapeutic aspects. The molecular revolution leading to effective targeted therapies and breakthroughs in immunotherapy for lung cancer have led to novel approaches incorporating the concept of personalized medicine for patients who historically had little hope. These advances have strengthened the place of pathologists to play a central role in the multidisciplinary team that is now needed to properly diagnose and manage lung cancer patients.

A comprehensive text that looks at respiratory disorders in general, but concentrates on those that are more prevalent in tropical regions. The text is extremely well-illustrated and provides a comprehensive view of different respiratory diseases. A highlight of the book is the discussion on the threat of pulmonary tuberculosis and its unsolved challenges. The epidemiology, the subtle variation in clinical presentation, and the natural history of respiratory diseases in regional contexts have been clearly emphasized. This second edition has been thoroughly revised and updated. Prevailing concepts in lung cancer, asthma, interstitial lung disease, and several other diseases have been discussed at length. The section on newer diagnostic aids involving genetic and molecular biology, has been extensively revised. Every chapter of every section is illustrated wherever necessary with high-quality images contributing to a better understanding of the text.

This book is an account of a study which provided unique information on trends in growth and respiratory health in British children over 25 years, with methodological discussion and other major findings including risk factors for impaired growth, obesity, respiratory disease and the distribution of coronary heart disease factors. The book provides information on trends in growth, height weight for height and subcutaneous arm tissue, and in respiratory health, asthma attacks and related symptoms, in children aged 5 to 11 years, from 1972 to 1994. It provides information on risk factors for impaired growth, obesity and respiratory disease, and on the distribution of risk factors for coronary heart disease in children. The contribution of the National Health and Growth Study extended to topics such as the effects of changes in welfare policy, under-diagnosis and under-treatment of asthma, nocturnal enuresis, disturbed sleep, the impact of passive smoking on the health of children, and the relation of lung function to the child's intra-uterine environment and to passive smoking. The methodological issues in relation to the conduct of the study and analysis of the data are discussed in non-technical language. Each contribution of the study is discussed in relation to current literature, which is fully referenced throughout.

The Neonatal Resuscitation Program (R) (NRP (R)) course conveys an evidence-based approach to care of the newborn at birth and facilitates effective team-based care for healthcare professionals who care for newborns at the time of delivery. NRP utilizes a blended learning approach, which includes online testing and hands-on case-based simulation/debriefing that focus on critical leadership, communication, and team-work skills. The NRP, 8th Edition, introduces a new educational methodology to better meet the needs of health care professionals who manage the newly born baby. New in the 8th edition: Key Points at the beginning of each lesson. Quick response (QR) codes that enable the reader to view short videos about the topic on their mobile device. Lesson Review Questions grouped together at the end of each lesson. Quality Improvement Opportunities and Frequently Asked Questions in each lesson. New sections in Lesson 10 (Special Considerations) about resuscitation of the newborn with a myelomeningocele or an abdominal wall defect. Three Supplemental Lessons (Improving Resuscitation Team Performance, Resuscitation Outside the Delivery Room, and Bringing Quality Improvement to Your Resuscitation Team) that all NRP users to enhance their resuscitation knowledge and performance.

Pulmonary embolism (PE) has experienced a rapid expansion in available treatments, from hyperacute emergency care to the detailed investigation of persistent breathlessness despite anticoagulation during follow up. Whilst recent clinical practice guidelines provide a robust evidence base for more routine aspects of pulmonary embolism management, clinicians frequently face patient-specific challenges where the evidence for patient management may be less secure.Derived from the personal experience of expert clinicians engaged in all aspects of PE care, this book provides a practical update on contemporary management aspects from life-threatening presentation of pulmonary embolism with failed thrombolysis to the patient presenting with complex comorbidity or during pregnancy. General physicians and clinical specialists interested in contemporary diagnosis and management of acute pulmonary embolism will benefit from this book.

Oxygen therapy is a treatment that provides a patient with extra oxygen to breathe in. It is also called supplemental oxygen. It is only available through a prescription from a health care provider. Patients may receive it in hospital, another medical setting, or at home. Some people only need it for a short period of time. Others will need long-term oxygen therapy. There are different types of devices that can provide oxygen. Some use tanks of liquid or gas oxygen. Others use an oxygen concentrator, which pulls oxygen out of the air. The oxygen is administered through a nose tube (cannula), a mask, or a tent. The extra oxygen is breathed in along with normal air. This book is a concise guide to oxygen therapy for clinicians and trainees. Divided into four sections the text begins with an overview of the basic facts of oxygen, describing the different types and their individual uses in clinical therapy. Section two discusses the physiology and monitoring of oxygen therapy, and section three covers different devices and delivery systems, and oxygen toxicity (lung damage from breathing in too much extra oxygen). The final section examines oxygen targets in disease specifics, how the therapy works, and the effects of hypoxia (low oxygen levels in body tissues) and hypoxemia (low oxygen levels in the blood).

A realistic look at treating respiratory diseases! Clinical Manifestations and Assessment of Respiratory Disease, 9th Edition gives you the fundamental knowledge and understanding required to successfully assess and treat patients with respiratory diseases. This foundation helps you learn how to systematically gather relevant clinical data; make an objective evaluation; identify the desired outcome and formulate an assessment; design a safe, appropriate, and effective treatment plan; and document all the steps involved. With this knowledge, you will understand the effectiveness of performing therapies and when to adjust therapy to a desired outcome. UNIQUE! Emphasis on clinical scenarios and critical thinking skills prepares you for real-world practice. UNIQUE! Focus on assessment and Therapist Driven Protocols (TDPs). UNIQUE! Overview boxes highlight the clinical manifestations for each disease. Logically organized content is written at a user-friendly, approachable reading level for ease of use and understanding. Case studies provide realistic examples of the respiratory therapy practitioner's role in successful patient care. End-of-chapter self-assessment questions and answer key are available on the companion Evolve website. NEW! Clinical Connection boxes provide real-world clinical case studies in relevant chapters. NEW! An updated design and additional tables, boxes, and figures draw attention to key information. UPDATED! Content includes the latest developments related to SARS and COVID-19. UPDATED! Information on ventilators, usage, and protocols reflects current practice. NEW! QR codes in most chapters direct to additional outside content to enhance the chapter, including audio sounds and animations.

- Coming Soon - The long-awaited update of The Netter Collection of Medical Illustrations is now becoming a reality! Master artist-physician, Carlos Machado, and other top medical illustrators have teamed-up with medical experts to make the classic Netter "green books" a reliable effective current-day reference. The first three volumes to be released will be: The Reproductive System The Endocrine System The Respiratory System See www.NetterReference.com/greenbooks for more information. Pre-order your copies today! Access rare illustrations in one convenient source from the only Netter work devoted specifically to the respiratory system. Get a complete overview of the respiratory system through multidisciplinary coverage from physiology and biochemistry to adult and pediatric medicine and surgery. Gain a quick understanding of complex topics from a concise text-atlas format that provides a context bridge between primary and specialized medicine. Grasp the nuances of the pathophysiology of today's major respiratory conditions-including pulmonary hypertension, COPD, asthma, environmental lung disease, sleep disorders, infections of the immunocompromised, neonatal breathing disorders, and drug-resistant TB, and modern endoscopic and surgical techniques-through advances in molecular biology and radiologic imaging. Benefit from the expertise of the new editor, David Kaminsky, MD, who contributes significant experience in asthma and general pulmonary and critical care medicine, and his team of world class contributors. Clearly see the connection between basic and clinical sciences with an integrated overview of normal structure and function as it relates to pathologic conditions. Apply a visual approach-with the classic Netter art, updated illustrations, and modern imaging-to normal and abnormal body function and the clinical presentation of the patient. Tap into the perspectives of an international advisory board for content that reflects the current global consensus. A reliable and effective reference on the respiratory system with the visual support of Netter

Pulmonary hypertension is a life-threatening disease with no known cure. Here we provide a concise yet comprehensive review of the current knowledge about the pathophysiology of pulmonary hypertension (PH). The underlying signaling mechanisms involved in pulmonary vascular remodeling and the exaggerated vascular contractility, two characteristic features of pulmonary hypertension, are discussed in depth. The roles of inflammation, immunity, and right ventricular function in the pathobiology of pulmonary hypertension are discussed. The epidemiology of the five groups of pulmonary hypertension (World Health Organization classification; Nice, 2013) is also briefly described. A clear understanding of our current knowledge about the pathogenesis of PH is essential for further exploration of the underlying mechanisms involved in this disease and for the development of new therapeutic modalities. This book should be of interest to researchers and graduate students, both in basic research and in clinical settings, in the fields of pulmonary vascular biology and pulmonary hypertension.