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Cystic fibrosis is the most common life-threatening inherited
disease in the UK and Europe. It affects around 1 in 2500 live
births in the UK. There have been enormous advances in the
treatment of CF over the last 40 years, with life expectancy
increasing from just 5 years in 1964 to mid 30s today, and it now
affects as many adults as children. The burden of care for CF
patients is, however, considerable, and with the increase in life
expectancy the impact of CF on respiratory medicine has increased
Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitive source of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures.Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book."
Worldwide, infectious disease remains a major cause of morbidity and mortality. In developing countries, infection accounts for a substantial proportion of all recorded deaths. Likewise, in developed countries, pneumonia alone results in a large number of deaths. Along with bacteria, parasites and rickettsial organisms, viruses are responsible for many of the infections afflicting the human host. In the past decade alone, viruses that primarily target the lung have caused major respiratory illnesses including outbreaks of severe adult respiratory distress syndrome (SARS) and H1N1 influenza. This book is distinctive in that the entire spectrum of viral disease of the lung is conveniently compiled within a single volume. The epidemiologic, ultrastructural, immunologic, clinical and histopathologic features of well-known viral pathogens and newer emergent infectious agents are discussed. The book is organized in a classic fashion, starting with introductory material and sections on lung defenses and the taxonomic classification of pneumotropic viruses. The various acute viral pneumonias are then considered in a standard format in the main body of the book. Subsequent sections are devoted to the human immunodeficiency virus, viral lung disease in children and other viral-linked tumoral and nontumoral lung conditions. A chapter is also included on animal lung diseases caused by viruses. The text is supplemented by numerous color images.
Fully updated for the second edition, these handy pocket-sized study cards remain an innovative and versatile revision solution. Containing vital techniques and tips, the study cards condense revision into short essential bursts. Ideal for revising quickly on the move, students can also use them when carrying out examinations, or as a reminder before ward rounds and teaching sessions. Arranged into clear sections, the cards allow the reader to find and digest topics easily, whilst full colour illustrations aid quick and confident diagnoses. Taking a system-based approach, the set covers all essential diseases and syndromes in just 166 double-sided cards. Each card first describes the clinical examination and symptoms, before covering the need-to-know essentials: aetiology, indications, differential diagnoses, complications and suitable investigations. The final part of each card covers the treatment or management of the disease.
Using illustrative case examples, this book thoroughly reviews similarities and differences between asthma, chronic obstructive pulmonary disease (COPD) and the overlap syndrome. It is important to highlight the distinctions because these commonly encountered conditions in respiratory and primary care share many similarities but have important differences often mistaken for each other. This can have serious implications for treatment, particularly as new treatments are targeted at specific phenotypes of the diseases. This practical guide shows how to distinguish between the diseases on a pathological and clinical basis so that appropriate management and treatment may be pursued.
Learn the clinical skills necessary to treat any emergency airway problem. . .
Written by international experts in a style that's concise, practical and to the point, "Airway Management in Emergencies" covers all the options-both medical and surgical-for managing any patient's airway in an emergency. Here, you'll find the core knowledge and accompanying management protocols necessary to assess, oxygenate, intubate, and monitor patients requiring emergency airway management. . .
In each chapter, this high-yield coverage is supported by evidence-based algorithms, synoptic tips, and real-world case studies that show you how to resolve any difficult airway scenario you would likely encounter in clinical practice. . .
Features . Highlighted key points in each chapter . . Skill-sharpening review of core knowledge . . Over 100 figures that include a combination of original art work, fluoroscopy and Airwaycam images.. . A practical overview of both established and newer emergency airway equipment . . Far-reaching coverage addressing both the anticipated and unanticipated difficult airway, the uncooperative patient, and the 'failed' airway.. . Chapters on treating a range of patient populations and clinical presentations including an approach to the pediatric, the elderly, and the critically ill patient. . Perspectives on when and how to perform both 'awake' and rapid sequence intubations and effectively administer post-intubation care . . A closing chapter on the interrelationship between human performance and patient safety-and how to optimize both in caring for patients requiring acute airway management . .
A succinct yet comprehensive overview of respiratory medicine, written for students and professionals Essential Respiratory Medicine is an indispensable text offering an understanding of respiratory conditions and their clinical management within evidence-based guidelines. Containing information on taking a medical history, performing examinations and investigations, diagnosis and the management of respiratory conditions, this comprehensive text was put together by a noted expert in the field. Written in an accessible manner, Essential Respiratory Medicine contains the foundational science associated with respiratory medicine, a wide-variety of practical procedures, helpful diagrams, and self-assessments designed to enhance understanding of the material presented. The text covers a variety of conditions as well as providing suggestions for engaging with patients at different stages of care. This important resource: Demonstrates an effective approach to patients presenting with common respiratory symptoms Includes a description of all key practical procedures with diagrams Discusses acute management of important respiratory emergencies Covers both acute and chronic disease Contains a companion website containing a range of learning materials, including downloadable management summaries and algorithms, an image bank, videos of patient examination, example respiratory sounds and multiple-choice questions Essential Respiratory Medicine is an essential resource for anyone on a clinical placement, rotation, or training programme in respiratory medicine.
Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.
There is an increasing need for medical thoracoscopy performed by pulmonologists, which may be video assisted and has the advantage of being very cost-effective. This book is a comprehensive and up-to-date guide to thoracoscopy for pulmonologists that documents the considerable progress in endoscopic telescopes and instrumentation. Clear practical guidance is provided on technique, and diagnostic, therapeutic, and interventional applications of thoracoscopy are all carefully examined with the aid of high-quality illustrations. Although medical thoracoscopy is much less invasive than thoracotomy, complications can occur in a small number of cases; these are discussed and advice on prevention is provided. The concluding section examines the future of the field, covering developments such as mini thoracoscopy, autofluorescence thoracoscopy, and flexi-rigid thoracoscopy.
This book explores the unique aspects involved in the management of ECMO patients such as physiopathology and indications, setting up the device, monitoring ECMO and the patient, troubleshooting, ethical aspects and rehabilitation. For the past eight years, management of acute heart failure and Acute Respiratory Distress Syndrome (ARDS) patients has been improved by the development of short-term assistance devices, with ECMO as a first line treatment. This highly informative book provides essential insights for ICU nurses at ECMO centers around the world, who face the substantial challenges involved in the management of ECMO patients. Above all, it meets their training needs with regard to bedside monitoring for these patients, which has become a major issue. The editors and most of the contributors serve at La Pitie-Salpetriere ICU, France, which, in terms of the number of admissions and major publications produced, is one of the world's leading authorities on ECMO.
The past decade has seen mounting global concern regarding viral outbreaks such as SARS, avian influenza and West Nile virus. In 2004 and 2005, reports of bird-to-human, and possible human-to-human, transmissions of the H5N1 influenza viruses raised fears that these viruses could cause a pandemic on the scale of the Spanish flu pandemic of 1918. Previous to this, a novel coronavirus had been identified as the aetiological agent of the severe acute respiratory syndrome (SARS), a new respiratory viral disease that emerged at the end of 2002 and caused profound disturbances in over 30 countries worldwide in 2003. It is not known whether the SARS coronavirus will re-emerge, especially since its origins and potential reservoir(s) are unresolved. However, these outbreaks have shown that these viruses can emerge in any part of the world at any time.
This book critically evaluates the latest scientific evidence on novel or re-emerging viral diseases and brings together contributions from world experts on this topic, explaining best practice in their area, and discussing lessons learned and how best to collaborate to prevent and control future outbreaks.
Topics covered include: the latest advances in virology, particularly in the area of epidemiology diagnostics animal models for viral infection, and antiviral and vaccine development.
"Novel and Re-emerging Respiratory Viral Diseases" offers a comprehensive and interdisciplinary account of all aspects of the topic, from basic molecular biology to public health issues, and is therefore essential reading for virologists, infectious disease specialists, public health managers, researchers and epidemiologists, as well as those working invaccine development, pharmaceutical medicine and drug discovery
Learn everything you need to safely and compassionately care for patients requiring ventilator support with Pilbeam's Mechanical Ventilation: Physiological and Clinical Applications, 6th Edition. Known for its simple explanations and in-depth coverage of patient-ventilator management, this evidence-based text walks readers through the most fundamental and advanced concepts surrounding mechanical ventilation and guides them in properly applying these principles to patient care. This new edition features a completely revised chapter on ventilator graphics, additional case studies and clinical scenarios, plus all the reader-friendly features that promote critical thinking and clinical application - like key points, AARC clinical practice guidelines, and critical care concepts - that have helped make this text a household name among respiratory care professionals. UNIQUE! Chapter on ventilator associated pneumonia provides in-depth, comprehensive coverage of this challenging issue. Brief patient case studies list important assessment data and pose a critical thinking question to readers. Critical Care Concepts are presented in short questions to engage readers in applying knowledge to difficult concepts. Clinical scenarios cover patient presentation, assessment data, and treatment options to acquaint readers with different clinical situations. NBRC exam-style assessment questions at the end of each chapter offer practice for the certification exam. Key Point boxes highlight need-to-know information. Logical chapter sequence builds on previously learned concepts and information. Bulleted end-of-chapter summaries help readers to review and assess their comprehension. Excerpts of Clinical Practice Guidelines developed by the AARC (American Association for Respiratory Care) make it easy to access important information regarding indications/contraindications, hazards and complications, assessment of need, assessment of outcome, and monitoring. Chapter outlines show the big picture of each chapter's content. Glossary of mechanical ventilation terminology includes definitions to highlighted key terms in each chapter. NEW! Completely revised chapter on ventilator graphics offers a more practical explanation of ventilator graphics and what readers need to know when looking at abnormal graphics. NEW! Additional case studies and clinical scenarios cover real-life scenarios that highlight the current trends in pathologies in respiratory care.
Pleural diseases are very common and of increasing prevalence. This brand new title in the ABC series covers a wide range of conditions including pneumothorax, pleural effusions, pleural infections, chylothorax and mesothelioma.
Written by a team of specialists this overview of pleural diseases is a practical guide for the management of pleural diseases including general practitioners, junior doctors, specialist nurses, radiologists and all healthcare professionals working within chest medicine.
This book is a concise but detailed treatise on the laryngeal nervous system. It is ideal for researchers starting work in this field in that it provides a quick update on present-day basic neurolaryngology. A brief introduction to the methodology that made recent progress possible is followed by a review of classical basic neuroanatomy and neurophysiology. Additionally, the book provides some of the most recent findings in neurolaryngology. The many illustrative figures and microscopic photographs help readers to achieve a clearer understanding of the text and ample references provide links to further reading in specific areas of the field. The book contains much general material that will be instructive even for researchers not specializing in basic neurolaryngology and will provide an essential grounding for clinicians in laryngology.
The book focuses on the contagion nature of respiratory ailments, the ways a pulmonary disease is spread. Respiratory infections are surrounded by interrelated circumstances that act upon individual and community and eventually underlie morbidity. Patient's age, vulnerability to infections, immune function and responses, comorbidities, but also medical care and the agility in coping with stress, are just a few basic determinants of a diseased state. Modern medication, like newfangled antibiotics and their unrestrained use, may not guarantee the best solution to patient's condition. A valuable asset of this book is a blend of personal experience and expertise of contributors in pursuit of finding new solutions to old clinical problems. The book will be of interest to clinicians, researchers, health care providers, and other health care professionals, particularly those dealing with contagious diseases.
Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel's Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases. Included with your print purchase is the Expert Consult eBook version, which offers content updates, videos, review questions, and Thoracic Imaging Cases (TICs), all of which are easily navigable on any device for access on rounds or in the clinic. The embedded videos cover thoracoscopy, therapeutic bronchoscopy, volumetric chest CT scans, and more, while brand-new audio files highlight normal and abnormal breath sounds and the separate components of cough. Full-color design enhances teaching points and highlights challenging concepts. Understand clinical applications and the scientific principles of respiratory medicine. Detailed explanations of each disease entity allow you to work through differential diagnoses. Expert Consult eBook version included with purchase. This enhanced eBook experience offers content updates, videos, review questions, and Thoracic Imaging Cases (TICs), all of which are easily navigable on any device for access on rounds or in the clinic. Includes more than 1,000 figures and over 200 videos and audio files. Key Points and Key Reading sections highlight the most useful references and resources for each chapter. An expanded sleep section now covers four chapters and includes control of breathing, consequences of sleep disruption, as well as obstructive and central apnea. New chapters in the Critical Care section cover Noninvasive Ventilation (NIV) and Extracorporeal Support of Gas Exchange (ECMO). New chapters focusing on diagnostic techniques now include Invasive Diagnostic Imaging and Image-Guided Interventions and Positron Emission Tomography, and a new chapter on Therapeutic Bronchoscopy highlights the interventional role of pulmonologists. Embedded videos feature thoracoscopy, therapeutic bronchoscopy, volumetric chest CT scans, and more. Brand-new audio files highlight normal and abnormal breath sounds and the separate components of cough.
Roitt's Essential Immunology - the textbook of choice for students and instructors of immunology worldwide Roitt s Essential Immunology clearly explains the key principles needed by medical and health sciences students, from the basis of immunity to clinical applications. A brand new introduction sets the scene to section 1, Fundamentals of Immunology, introducing the microbial world and the strategies the body employs to defend itself. Each chapter then guides the reader through a different part of the immune system, and explains the role of each cell or molecule individually, and then as a whole. Section 2, Applied Immunology, discusses what happens when things go wrong, and the role the immune system plays alongside the damaging effects of a disease, including cancer, immunodeficiency, allergies and transplantation and the beneficial effects of vaccines. The 13th edition continues to be a user-friendly and engaging introduction to the workings of the immune system, whilst supporting those who require a slightly more detailed understanding of the key developments in immunology. The content has been fully updated throughout and includes: * An expansion on key clinical topics, including: innate immunity, autoimmune conditions, asthma, primary immunodeficiency, and HIV/AIDS * Beautifully presented with improved artwork and new illustrations * A range of learning features, including introduction re-cap boxes, end of chapter and section summaries to aid revision, as well as further reading suggestions, and a glossary to explain the most important immunology terms. Roitt's Essential Immunology is also supported by a companion website at www.roitt.com including: * An additional online only chapter on immunological methods and applications * Further interactive multiple choice and single best answer questions for each chapter * Animations and videos showing key concepts * Fully downloadable figures and illustrations, further reading and useful links * Updated extracts from the Encyclopaedia of Life Sciences * Podcasts to reinforce the key principles explained in the text
The Pulmonology pocket contains information invaluable to healthcare professionals in the management of pulmonary conditions. The pocket covers a variety of topics including arterial blood gases, pulmonary function tests, COPD and asthma, pulmonary infections and vascular conditions like pneumonia, pulmonary embolism and PAH. Important formulas, conversions, and drugs commonly used to treat pulmonary conditions are included as well. * Assessment, monitoring, and latest treatment algorithms for all major pulmonary disorders * Widely used guidelines and statements from major medical organizations and journals * Chapters: Anatomy/Physiology, Assessment and Monitoring, Obstructive Lung Diseases, Pulmonary Infections, Interstitial Lung Diseases, Pulmonary Vascular Diseases, Pleural Diseases, Lung Cancer, Other Lung Diseases, Therapy (drugs and gas therapy) For physicians, nurses, residents, students, respiratory therapists, and all other healthcare professionals.
Sleep-related abnormalities occurring as a result of allergic disorders can impact an affected individual's health and overall well-being in a myriad of ways. This comprehensive book thoroughly covers the management of allergic and sleep disorders, providing a detailed discussion on how these co-occurring, often overlapping conditions can be treated in a personalized and patient-oriented manner. Allergy and Sleep: Basic Principles and Clinical Practice takes care to include a wide range of multidisciplinary perspectives required to effectively assess and manage allergy and sleep disorders, from allergists, sleep medicine specialists, otolaryngologists, and dermatologists, to primary care physicians, pharmacists, psychologists, and other researchers. Allergy and Sleep begins with a thorough grounding on the science of sleep, allergy, immunology, circadian rhythms and circadian immunology. Part II addresses assessment and treatment of common allergic diseases with comorbid sleep components, in a practical, easy-to-use case-based format. Later sections closely examine sleep-related disturbances commonly associated with asthma, allergic rhinitis, and atopic disease; providing treatment guidelines, and detail various approaches to management throughout the patient's lifespan. This resource concludes with a review of disease, sleep and circadian-specific therapeutics. Written by experts in their respective fields, Allergy and Sleep: Basic Principles and Clinical Practice is an ideal resource and important reference for any clinician working with patients suffering from sleep-related abnormalities due to allergic disorders.
Most postgraduate examinations now include radiographic interpretation. This may be presented as a slide show of as a film-viewing session. Radiographs and other imaging modalities are also used ubiquitously in the viva section of most such examinations including those of the American Boards and professional societies and universities worldwide. This series of Clinical Film Viewing will assist candidates to prepare for this process. Each book examines a particular system or technique followed by profusely illustrated cases typical of those presented in postgraduate examinations.
Pulmonary diseases are the major cause of human morbidity, taxing the health care system due to disease prevalence, chronicity, and social and fiscal costs. This book concentrates on the inflammatory and immunogenic settings of pulmonary disorders and related medical areas. Excessive inflammation causes lung injury and forms a conducive background for pathogenic infections, particularly in immuno-compromised hosts. Bacterial immuno-evasive strategies develop, leading to self-perpetuating pathologies. Inflammation also is an essential component of non-communicable lung diseases, including asthma and respiratory allergies, and smoking-related or granulomatous diseases. The chapters combine a strong grounding in basic science with extensive clinical knowledge and experience. Advances in diagnostics, as well as preventive and therapeutic aspects also are tackled. The book provides useful information to clinicians, researchers, health care and other medical professionals.
Respiratory Medicine Lecture Notes covers everything from the basics of anatomy and physiology, through to the aetiology, epidemiology, symptoms and management of a full range of respiratory diseases, providing a comprehensive yet easy-to-read overview of all the essentials of respiratory medicine. Key features of this new, full-colour edition include: Updated and expanded material on chest X-rays and radiology Self-assessment exercises for each chapter A range of clinical images and scans showing the key features of each disease Fully supported by a companion website at www.lecturenoteseries.com/respiratory featuring figures, key points, web links, and interactive self-assessment questions Ideal for learning the basics of the respiratory system, starting a placement, or as a quick-reference revision guide, Respiratory Medicine Lecture Notes is an invaluable resource for medical students, respiratory nurses and junior doctors.
Fully rewritten and updated for the cutting-edge sixth edition, Spencer's Pathology of the Lung follows in its predecessors' footsteps as the gold-standard textbook of pulmonary diseases. All recognized diseases of the lungs are discussed and illustrated with extensive, high-quality color images. Each chapter includes practical, clear and concise diagnostic features, including immunohistochemistry, molecular tests and differential diagnoses, while rare entities are discussed and illustrated in detail. This thoroughly reworked edition includes new classification schemes and the latest understanding of the pathophysiology and molecular aspects of a wide range of diseases. Non-neoplastic diseases are presented according to epidemiology, genetics, clinical manifestations, radiographic findings, pathology, cytology, laboratory findings, pathogenesis, differential diagnosis, prognosis and natural history. Neoplasms are discussed according to cell or origin with sections devoted to genetics, molecular findings and clinicopathologic correlations. Downloadable versions of all images are available on a CD-ROM packaged with the print book. Written and edited by leading experts in the field, this is an essential resource for practising and trainee pathologists.
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