Written by world authorities, this reference explores the utilization and advancement of state-of-the-art imaging modalities for the analysis of pulmonary function-providing an up-to-date and global perspective of imaging applications with detailed contributions from experts in Europe, North America, Japan, and Australia.

Emphasizing the impact of air toxins and contaminants on human health, this Second Edition examines the latest research from the epidemiology to the cellular mechanisms underlying cardiopulmonary responses to air pollution. This guide offers chapters that address the basic biology, techniques, and clinical practices used to monitor and assess acute and chronic pollutant responses; the effects of specific air toxins and contaminants on various populations chronically exposed to these compounds; and the complex issues associated with translating science to public health policy. This Second Edition offers a current and timely review of the effects of ambient air pollution on the human cardiopulmonary system provides new chapters on particulate matter (PM) air pollution, including particulate dosimetry of the respiratory system, genetic factors in the cardiopulmonary response to PM, PM-induced airway remodeling, and combustion emissions and their relation to cancer furnishes sections by chapter contributors with in-depth expertise in various areas of indoor and outdoor air pollution research maintains a balance between traditional topics and the review of current information showcasing the growing interest in the neuronal and cardiovascular effects that result from the exposure of human populations to PM air pollution crosses several scientific disciplines including epidemiology, toxicology, physiology, and public health presents the evolution of federal legislation and standards for air pollution emissions including the scientific rationale for these regulations

This timely Second Edition of a landmark reference furnishes in-depth examinations of the latest developments in the physiology, pathophysiology, and clinical relevance of the respiratory muscles and chest wall-reflecting the explosion of information that has occurred since the publication of the previous edition.

The first reports of the successful use of mechanical ventilation to treat respiratory disorders in the neonate were published in the 1960s. Subsequent decades have seen the widespread use of ventilation technology, the development of high-frequency ventilation and extracorporeal support, and, most recently, the use of surfactant replacement therapy and synchronized ventilation. Neonatal and pulmonary clinicians now have a wide range of diagnostic and therapeutic tools from which to select a customized management strategy. As a result, the modern neonatal intensive care unit has become a technological wonder, and an occasional source of confusion.

Divided into twenty main sections, this book offers a wealth of information to those providing intensive respiratory care to the newborn. Eighty-three separate chapters, written by leaders in their respective fields, cover a comprehensive range of material, including lung development and function, the principles of mechanical ventilation, available diagnostic and therapeutic equipment, strategies for treating various respiratory disorders, alternative treatments, outcomes, and ethical considerations pertaining to the care of newborns. The outline-style presentation is clinically focused, ensuring that all subjects are described in a manner that is easily understood and easily applied to bedside treatment.

This manual will be of immense value to all those who come in contact with a neonatal intensive care unit, including pediatricians, neonatologists, pulmonary specialists, respiratory therapists, neonatal nurses and nurse practitioners, fellows, residents, interns, and medical students.

The book presents a comprehensive overview of the various disease processes affecting the chest and related abnormalities. It discusses biopsy and bronchography, as well as a variety of imaging techniques including radiography, fluoroscopy, tomography, and ultrasound.

Key Features Comprehensive coverage of all aspects of work-related asthma, including historical aspects, epidemiology and risk factors, mechanisms and genetics, other types of work-related asthma conditions and variants, hypersensitivity pneumonitis, occupational urticaria and dermatitis Assessment of the worker and workplace along with management of the worker, prevention and medicolegal aspects Of interest not only to pulmonologists, but also for industrial hygienists, researchers, lawyers and other health professionals in the field of work-related conditions Detailed information about specific agents, including a variety of high- and low-molecular weight agents

J. Willis Hurst, MD, a pioneer in the development of cardiology, and his colleague, Douglas C. Morris, M.D., both of Emory University, have edited this book and chose its unusual title for very specific reasons. Patients sometimes have an odd view as to anatomic landmarks that identify the location of the chest, and may assign terms other than pain to their discomfort. Hence the quotation marks around "chest pain." The arrow (-->) after "chest pain" indicates that the physician initially may not know the cause of the symptom, so a differential diagnosis must be established.

This book was written to reintroduce in the modern clinical setting the knowledge and skills needed to analyze symptoms, physical findings, and ECG and x-ray abnormalities in order to accurately diagnose more than 50 different conditions that may bring about a complaint of "chest pain." Experts in the fields of cardiology, pulmonology, dermatology, orthopedics, thoracic surgery, and psychiatry contribute a unique perspective on this common but compelling medical problem. Each chapter concentrates on one causative syndrome or malady, from its initial presentation to its etiology, to differential diagnosis and treatment, while an abundance of well-designed figures serve to illustrate the location of the "chest pain."

Any cardiologist, primary care, or emergency care physician who may encounter a patient complaining of "chest pain" will benefit from this book''s clear, concise and thorough approach to the problem.

Many international experts collaborated in creating this groundbreaking work, a principal-coding system, and in developing reference films and imaging parameters for the" "International Classification of HRCT for Occupational and Environmental Respiratory Diseases. The book is an authoritative guide to the recognition of dust diseases of the lung, using radiological imaging techniques, with special emphasis on high-resolution computerized tomography (CT). The classification is a powerful, essential tool for recording patient data on CT in a globally standardized semiquantitative way. The system is also applicable to surveillance and screening for occupational and environmental respiratory diseases. The book is a valuable resource not only for radiologists but for all who work in occupational medicine and public health.

This text analyses the pathophysiology, diagnosis, treatment and control of respiratory disorders in the newborn infant. It explores the mechanisms, patterns and factors influencing respiratory activity and dysfunction, as well as the aetiology, management and evaluation of conditions such as respiratory distress syndrome, bronchopulmonary dysplasia, airway disorders, and congenital hypoventilation syndromes.

Starting with patient assessment, the authors explain the physiological basis of all major cardiopulmonary problems before describing the physiotherapy interventions possible - this ensures the reader understands why the problems occur and not just how to treat them. The book concludes with a detailed glossary, an appendix describing all the treatment methods required, and a final section provides case studies to enhance problem-based learning. The unique combination of physiology, the latest evidence, and detailed methodologies and case studies, ensures that Cardiopulmonary Physiotherapy is an essential purchase for all undergraduates. Postgraduate students in their first years of training will also benefit from quick access to the core information they need on a daily basis.

This book provides a unique frame work for examining acute lung syndromes that arise from hematologic disorders or is defined by a hematologic abnormality as a key feature. Acute lung processes arising from hematologic disorders can present as life-threatening conditions, and as such, the pulmonary physician or critical care physician are often directly involved in care or called upon to provide expertise. Chapters are organized into three sections, each with an emphasis on pathogenesis and current understanding of mechanisms. The text begins with the central theme of the lungs as the direct interface between the external environment and blood, description of individual components of the hematopoietic system, their function and relevance to the lungs. The second section outlines both benign and malignant primary hematologic disorders that can lead to acute pulmonary manifestations. The final section focuses on acute lung syndromes stemming from complications of transfusion and treatment. Chapters are presented in an easy-to-access format, providing information on diagnosis, management, and outcomes. This is a valuable resource for pulmonary fellows in training, pulmonologists, critical care physicians, and physicians involved in caring for patients in the ICU.

Answering the demand for acomprehensive, all-purpose volume focusing on the challenging needs of pediatric patients, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients summarizes a wealth of knowledge on the mechanical devices, clinical management, alternative applications, and future directions in the specialized field of pediatric critical care. Condensed advice from experts on the shelf offers guidance in critical intensive care settings! Combining clinical aspects with the latest experimental results, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients -examines current modalities and the best uses of mechanical support, including step-by-step techniques for extracorporeal membrane oxygenation (ECMO), ventricular assist devices (VAD), and intra-aortic balloon pumps -highlights the use of mechanical support in nonsurgical diseases such as myocarditis and cardiomyopathy, with implanted ventricular devices and in long-term follow-up care -discusses the optimal management for perioperative support in cardiac and pulmonary transplantations in children -reviews successful cases of mechanical support, including resuscitation after cardiac arrest, pediatric patients with myocarditis, and circulatory support of patients without cardiac disease -explores anticipated improvements and uses of the Berlin Heart, the Nimbus Rotary Pump, and applications of the Medos-HIA VAD in young patients -and much more! Authored by nearly 40 internationally recognized experts and containing over 500 literature references, drawings, photographs, and tables, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients is an invaluable referencefor cardiologists and pediatric cardiologists, intensivists, cardiac surgeons, pulmonologists, anesthesiologists, general pediatricians, nursing personnel, perfusionists, and medical school students in these disciplines.

Performing a thorough and detailed study of one of the most common yet less accurately understood causes of human illness, this all-inclusive reference examines the epidemiology, pathophysiology, and future treatment options for asthma and respiratory infections.
Contains up-to-date results from clinical trials of antiviral agents that explore new avenues of therapy-including interferons, ICAM-1 receptor blockades, vaccines, and mediator antagonists!

We proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system. The first chapters introduce basic notions of purinergic pharmacology and metabolism, which allows readers from all scientific backgrounds to fully grasp the importance of these signaling networks for airway defenses, including mucociliary clearance and inflammatory responses. Then, chapters are devoted to the groundbreaking discovery that chronic respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD), present specific aberrances in purinergic signaling which essentially drive lung complications. The last chapters describe the animal models used to investigate purinergic signaling in respiratory diseases, and the therapeutic applications developed by the pharmaceutical industry based on receptor agonists/antagonists and metabolic correctors. This highly comprehensive manuscript constitutes an invaluable tool for beginners and experts to follow the rapidly evolving research field of purinergic signaling. Furthermore, the critical analysis of past clinical protocols should facilitate the identification of potent therapeutic targets, and provide a better understanding of the data acquired in current clinical trials.

This unique manual provides comprehensive, yet practical and easily accessed advice on the key issues of asthma management in both adult andpaediatric patients. The second edition will continue to help all those involved with the care of asthmatic patients to apply the recently updated international guidelines. It combines vital information on how to tackle practical, clinical issues, whilstat the same time highlighting essential basic sciences to aid diagnosis, management and treatment.Provides solutions to day-to-day clinical problems in asthma management Clear, concise and practical advice helps the reader to clarify asthma severity and select appropriate treatment plansDiagrams illustrate the stepwise approaches to asthma management Each chapter concludes with a list of summary pointsExpanded sections on acute and chronic asthma in children written by international paediatric respiratory experts Use of icons in margins to highlight the most recent drugs and therapiesNew larger format, with an eye-catching design aids easy access to key information

Discusses three major classes of asthma therapies-bronchodilators, antiinflammatories, and antiallergics-as well as potential new therapeutic approaches
This comprehensive volume addresses the latest treatment strategies for asthma, keying in on the genetics and molecular biology of asthma and pointing the way toward new, commercially viable therapies.
Presents the most up-to-date information available on the genetics, epidemiology, pathology, pharmacology, and pulmonology of asthma.
Written by more than 20 leading international experts, New and Exploratory Therapeutic Agents for Asthma
explores asthma both as incidence of dysfunctional airway smooth muscle and as a disorder of the immune system
examines the role of monoclonal antibodies in allergy and asthma
describes functions and pharmacokinetic profiles of bronchodilator 2 agonists, anticholinergics, and inhaled glucocorticosteroids
investigates the controversy of different types of asthma
illustrates the connections between clinical symptoms and the immunopathology of eosinophilic inflammation
assesses prospects for the development of a successful oral anti-inflammatory therapy, an immunomodulator that lowers antigen-specific IgE, an anticytokine compound, and an agent that safely combines bronchospasmolytic and anti-inflammatory properties
reviews the impact of the recent introduction of antileukotriene agents, clinical findings with PAF antagonists, and selective antimuscarinics
evaluates the relationship between improvements in laboratory results and clinical effectiveness
and more
Containing over 2000 bibliographic citations and a concise introduction for each chapter, New and Exploratory Therapeutic Agents for Asthma is indispensable for pulmonologists, pediatricians, physiologists, immunologists, allergists, pharmaceutical industry scientists, primary care physicians, and medical school students in these disciplines.

An up-to-the-minute reference guide for health professionals confronting pulmonary disorders in children, Pediatric Asthma offers the latest findings on this classification-defying disease and related conditions. Written by more than 20 international experts in the field, the book focuses on drug administration-issues of compliance, aerosol delivery, and pharmacokinetic differences among children-with a view toward developing new and more efficacious therapies.
Provides cutting-edge analysis for more effective diagnosis of children with asthma and improved monitoring and treatment for chronic patients
With a firm theoretical grounding and reflecting the state of the art in pharmacological research and development, Pediatric Asthma
reviews the prevalence, causes, and demographics of childhood asthma worldwide
explores determinants of the disorder in various populations-gender, age and severity of onset, atopic status, family history, and smoking
elucidates physiological factors such as airway remodeling, airway hyperresponsiveness, and persistent inflammation
describes in vivo and in vitro testing for asthma-associated allergy and the pros and cons of allergen immunotherapy
delineates the dynamics of the lung in terms of phenomena such as peak expiratory flow (PEF), forced vital capacity (FVC), and bronchial hyperresponsiveness (BHR)
highlights the importance of patient education and self-management
investigates the role that developmental psychopathologies and neurobehavioral dysfunctions may play in pediatric asthma
discusses inflammatory mediators such as cytokines, chemokines, leukotrienes, and prostaglandins
evaluates intravenous and inhaled 2 agonists for the bronchodilating treatment of acute severe asthma
and more
Featuring over 2100 references, more than 60 user-friendly tables, and a handy Appendix on clinical monitoring of childhood asthma and recommended drug dosages for its treatment, Pediatric Asthma is an indispensable resource for pediatricians, pediatric pulmonologists, and pediatric pharmacists; clinical allergists and immunologists; general and family practitioners; and graduate and medical school students in these disciplines.

Achieving Quality in Brachytherapy addresses the main issues that often prevent correct delivery of brachytherapy treatment. The book explains how to set up a functional quality assurance program in brachytherapy and covers all the steps needed to undertake particular treatment plans, from the initial planning required to the detailed specification. It highlights the importance of planning as a means of controlling and dealing with errors during the treatment process and advises on what to check and how to check during treatment to ensure effective quality assurance. This comprehensive reference is ideal for professionals working in brachytherapy, physics, and radiation oncology, and serves as an introduction for trainees with an undergraduate degree in medical physics or clinical radiation oncology.

This invaluable little pocketbook takes the reader through the basics of chest X-ray examination and interpretation. It covers the range of conditions clinicians are likely to encounter on the wards, and guides the reader through the diagnostic process based on the appearance of the abnormality shown. Suitable for medical students, junior doctors and other health professionals who interpret chest X-rays, including radiographers, nurses and physiotherapists, this text is the ideal solution to increasing your skills and boosting your confidence in using chest X-rays for diagnosis and management. Chest X-Ray Made Easy has garnered international praise as the ideal quick and simple guide to understanding chest X-rays. Concise and succinct - makes interpretation of chest X-rays as simple as possible Comprehensive but easy to understand Specifically designed for junior doctors and students New chapter on what and when to request, and how to do that New images throughout, including obvious and subtle examples of abnormalities Includes CT images and how they correlate with chest X-rays Sections on radiation doses and indications for chest X-rays Sections on chest X-ray appearances in COVID-19 Updated section on imaging in pregnancy Features interpretation of placement of lines, tubes, and of complications Quiz section to test knowledge Established title that is trusted internationally

The spectrum of systemic rheumatologic disease (often termed connective tissue disease) is characterized by autoimmune-mediated organ dysfunction and the lungs are a frequent target. There are numerous pulmonary manifestations--with varied incidence and prevalence--associated with connective tissue diseases and all patients with rheumatologic disease are at risk of developing associated lung disease. It is not known why specific connective tissue diseases are more likely to be associated with certain types of lung disease and there is still much to learn about the natural history of this connection. Largely due to the interplay concerning the diverse nature of the connective tissue diseases and the frequently heterogeneous forms of lung involvement encountered, the arena of rheumatologic lung disease poses major challenges to practicing clinicians. Moreover, the assessment and management of rheumatologic lung disease requires a multi-disciplinary approach and is optimized by active engagement by rheumatologists working closely with pulmonologists and other specialists.Pulmonary Manifestations of Rheumatic Disease offers a practical and comprehensive overview of lung disease encountered in patients with systemic rheumatic diseases. The book helps practicing clinicians in the ongoing assessment, management, and understanding of rheumatologic lung disease. While providing chapters on the science and pathophysiology underlying rheumatologic lung diseases, the text has a case-based approach and is more significantly weighted towards the clinical aspects and implications of the diseases. The first text of its kind specifically dedicated to describe diverse, commonplace, and challenging aspects of rheumatologic lung diseases, Pulmonary Manifestations of Rheumatic Disease serves as an invaluable tool for the practicing clinician.

Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become "the" reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field.
Key Features
* Comprehensive coverage of both basic science and clinical aspects of asthma
* Extensively referenced throughout

"Analyzes the role of peptides in promoting or suppressing inflammation. Thoroughly examines the therapeutic potential of key peptides, analogs, agonists, and antagonists that influence cell injury and repair."

This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for the further development of safe and efficient gene delivery systems.

This book presents the current trends and state of the art solutions addressing various issues related to pulmonary disorders. Diagnostic and therapeutic challenges are tackled, starting with the noncommunicable diseases of sarcoidosis and granulomatosis with polyangiitis. Pulmonary involvement, practically unavoidable, runs an insidious course, and is often occulted by systemic symptoms. The establishment of a firm diagnosis, with a precision no one could oppugn, is difficult. Other issues pertain to quality of life, disease preventive measures, and the move toward personal health care in chronic sufferers from multiple conditions in later life. There is also an update on the prevalence and diagnostic and treatment challenges of extrapulmonary tuberculosis. In addition, the place of neuroproteomics in modern clinical practice is presented. The practical insights emphasize the role of science in advancing biomedical knowledge and care. The book is addressed to researchers and practitioners, and allied health care professionals engaged in effective patient care and therapy.

Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma is studied; however, the tissue remodelling process is a significant process that should not be overlooked. This valuable reference synthesizes current data and concepts developed to determine the relationship between airway wall remodelling and the pathogenesis of asthma. It discusses evidence for structural changes in asthmatic airway, the relationship between airway thickening and hyperresponsiveness, the relationship between cytokine production and tissue remodelling and inflammation, the significance of epithelial changes and the extracellular matrix, and in vivo and in vitro experimental approaches to the assessment of remodelling. Pharmacological and biochemical mechanisms that control cell proliferation are also examined. The consequences of airway wall remodelling for airway hyperresponsiveness is the unique focus of this volume, offering a fresh perspective of advances in asthma research.