Interstitial lung diseases comprise a significant part of any respiratory medicine practice. This timely second edition of Diffuse Lung Disease is a practical clinically-oriented resource, covering all the major advances in diagnostic techniques and therapies. Authored by world authorities in the field, this book provides clear and specific recommendations for the management of all forms of interstitial lung diseases. This book is divided into two sections. The first section addresses the general aspects of diagnosis and management, including clinical approach, radiographic approach, physiological changes, and classification. The second section details each individual form of interstitial lung disease. Organized in an easy to follow format, each disease specific chapter includes tables outlining diagnostic approach, differential diagnosis, disease monitoring, and treatment. Illustrative cases, replete with high quality HRCT images, bring an added dimension to this outstanding book.

Specifically focusing on the immediate management and diagnosis of patients in the intensive care unit, this reference contains expert reviews and practical care recommendations for patients with acute respiratory failure. Packed with detailed descriptions of treatment procedures and quality figures throughout each chapter, Practical Pulmonary and Critical Care Medicine will stand as a must-have armamentarium of protocols and guidelines for efficient and effective patient care.

Filling a gap in the literature, this reference provides concise and practical guidelines for the diagnosis and management of sinusitis and furnishes an authoritative outline of our current understanding of the pathophysiology of this condition. Addressing a wide spectrum of issues related to the identification, epidemiology, and etiology of sinusitis, this guide presents detailed illustrations and flowcharts to clarify the interactions between the pathological and physiological processes of sinusitis and illustrate current treatment practices.

The health-related effects of asbestos have long been mired in controversy, with industry and plaintiff attorneys playing a significant role. This comprehensive book provides a balanced and extensive evidence-based critical analysis of the literature concerning asbestos-related diseases, from a scientific and historical perspective. The book presents a carefully referenced review of the medical literature on the health effects of asbestos, and reflects the extensive experience of the author in evaluating patients with asbestos-related disorders.

This addition to the field of pulmonary rehabilitation will be used as a practical resource which demonstrates academic insight into new and emerging aspects of Chronic Obstructive Pulmonary Disease (COPD) rehabilitation. This book provides a European perspective with international experts contributing to the various chapters. There have been significant advances in pulmonary rehabilitation in the last decade and this is reflected in the use of up to date research and clinical opinion.

Comprehensive chapters address pulmonary rehabilitation from the perspective of the patient, nursing, physio, occupational and medical therapists. Recent evaluations concern nutritional implications in COPD, selection criteria and specificity of exercise. The book examines psycho-social influences on COPD and provides practical "best evidence" treatment advice.

An exciting and promising "look to the future" by Professor Calverley concludes the book. Pulmonary Rehabilitation: An Interdisciplinary Approach is an integrated evaluation of the effect of pulmonary rehabilitation on patient care, with critical assessment of outcome tools and the important contribution of an interdisciplinary approach.

Alan B. Weitberg, MD, and a panel of internationally recognized basic scientists and clinicians present a comprehensive discussion of lung cancer, including a practice-oriented review of its diagnosis, evaluation, and treatment. The contributors offer not only an understandable description of its molecular origins-an essential key to developing future therapies and preventive measures-but also rigorously discuss well-tested approaches, as well as those that are currently being evaluated for future use in both the laboratory and clinic. The book also elucidates the creation and effective deployment of treatment guidelines introduced by third party payers to improve clinical outcomes, even while lowering healthcare costs.

Written by world authorities, this reference explores the utilization and advancement of state-of-the-art imaging modalities for the analysis of pulmonary function-providing an up-to-date and global perspective of imaging applications with detailed contributions from experts in Europe, North America, Japan, and Australia.

Providing a solid foundation for specialists in asthma treatment and control, this guide illustrates the importance of asthma monitoring practices for up-to-date assessments of disease levels in specific population groups; the identification of social, geographical, and environmental factors that may influence the development of asthma; and the design of improved and cost-effective prevention and management strategies for optimal patient care.

This timely Second Edition of a landmark reference furnishes in-depth examinations of the latest developments in the physiology, pathophysiology, and clinical relevance of the respiratory muscles and chest wall-reflecting the explosion of information that has occurred since the publication of the previous edition.

The only source to describe the lung surfactant as a complex membranous system, this guide analyzes lung surfactant function from the aspects of molecular biology, biophysics, membrane science, and surface and interface analysis and reviews the latest basic and clinical issues relating to lung disease and (dys)function.

Emphasizing the impact of air toxins and contaminants on human health, this Second Edition examines the latest research from the epidemiology to the cellular mechanisms underlying cardiopulmonary responses to air pollution. This guide offers chapters that address the basic biology, techniques, and clinical practices used to monitor and assess acute and chronic pollutant responses; the effects of specific air toxins and contaminants on various populations chronically exposed to these compounds; and the complex issues associated with translating science to public health policy. This Second Edition offers a current and timely review of the effects of ambient air pollution on the human cardiopulmonary system provides new chapters on particulate matter (PM) air pollution, including particulate dosimetry of the respiratory system, genetic factors in the cardiopulmonary response to PM, PM-induced airway remodeling, and combustion emissions and their relation to cancer furnishes sections by chapter contributors with in-depth expertise in various areas of indoor and outdoor air pollution research maintains a balance between traditional topics and the review of current information showcasing the growing interest in the neuronal and cardiovascular effects that result from the exposure of human populations to PM air pollution crosses several scientific disciplines including epidemiology, toxicology, physiology, and public health presents the evolution of federal legislation and standards for air pollution emissions including the scientific rationale for these regulations

This volume is dedicated to multidisciplinary research at the interface between basic biomedicine and clinical practice. This book guides best practice in the diagnosis and therapy while dealing with difficult-to-treat disorders of yet unclear etiology. Chapters address such disorders as granulomatosis with polyangiitis causing autoimmune-related multiorgan inflammation of blood vessels, increasingly widespread allergy to peanuts, occupational exposure to zinc oxide, and immunogenic responses to pneumococcal and influenza vaccination underlying their preventive effectiveness. Other hot issues deal with the proper use of fluid therapy in the perioperative period and a cognitive decline in lung transplant patients. A new physiotherapeutic approach of treating key myofascial trigger points in low-back pain appears highly beneficial in reducing patients' disability, advancing physiotherapy of this overwhelming condition. Finally, other chapters consider ways to streamline medical management to increase the number of physicians and their availability for patients, a particularly sensitive issue in the current COVID-19 pandemic. The dissemination of clinical knowledge about high-risk and hardly controllable conditions is an inalienable part of progress in medical practice. The book is a resource for clinical specialists, general practitioners, and allied healthcare professionals.

The first reports of the successful use of mechanical ventilation to treat respiratory disorders in the neonate were published in the 1960s. Subsequent decades have seen the widespread use of ventilation technology, the development of high-frequency ventilation and extracorporeal support, and, most recently, the use of surfactant replacement therapy and synchronized ventilation. Neonatal and pulmonary clinicians now have a wide range of diagnostic and therapeutic tools from which to select a customized management strategy. As a result, the modern neonatal intensive care unit has become a technological wonder, and an occasional source of confusion.

Divided into twenty main sections, this book offers a wealth of information to those providing intensive respiratory care to the newborn. Eighty-three separate chapters, written by leaders in their respective fields, cover a comprehensive range of material, including lung development and function, the principles of mechanical ventilation, available diagnostic and therapeutic equipment, strategies for treating various respiratory disorders, alternative treatments, outcomes, and ethical considerations pertaining to the care of newborns. The outline-style presentation is clinically focused, ensuring that all subjects are described in a manner that is easily understood and easily applied to bedside treatment.

This manual will be of immense value to all those who come in contact with a neonatal intensive care unit, including pediatricians, neonatologists, pulmonary specialists, respiratory therapists, neonatal nurses and nurse practitioners, fellows, residents, interns, and medical students.

Respiratory infections constitute a major public health concern. The goal of this book is to share knowledge on the best advances in influenza and influenza-like viral infections, and new molecular-based diagnostic methods that discern the antigenic shift enabling viruses to constantly evolve and elude the host immune response. Co-infections, co-morbidities, persistently meager anti-flu vaccination coverage, and infection complications are dealt with. The chapters also further insight into such topics as the effects of sex hormones, and socioeconomic and anthropometric measures on respiratory and immune functions underlying the severity of asthma and respiratory allergy. Psychological functioning in respiratory disorders, taking into account quality of life, illness acceptance, and depressive symptoms is also reviewed as it is all too often underestimated by healthcare providers. The book is intended for clinicians, researchers, students, and all other actors in health-related issues.

J. Willis Hurst, MD, a pioneer in the development of cardiology, and his colleague, Douglas C. Morris, M.D., both of Emory University, have edited this book and chose its unusual title for very specific reasons. Patients sometimes have an odd view as to anatomic landmarks that identify the location of the chest, and may assign terms other than pain to their discomfort. Hence the quotation marks around "chest pain." The arrow (-->) after "chest pain" indicates that the physician initially may not know the cause of the symptom, so a differential diagnosis must be established.

This book was written to reintroduce in the modern clinical setting the knowledge and skills needed to analyze symptoms, physical findings, and ECG and x-ray abnormalities in order to accurately diagnose more than 50 different conditions that may bring about a complaint of "chest pain." Experts in the fields of cardiology, pulmonology, dermatology, orthopedics, thoracic surgery, and psychiatry contribute a unique perspective on this common but compelling medical problem. Each chapter concentrates on one causative syndrome or malady, from its initial presentation to its etiology, to differential diagnosis and treatment, while an abundance of well-designed figures serve to illustrate the location of the "chest pain."

Any cardiologist, primary care, or emergency care physician who may encounter a patient complaining of "chest pain" will benefit from this book''s clear, concise and thorough approach to the problem.

Many international experts collaborated in creating this groundbreaking work, a principal-coding system, and in developing reference films and imaging parameters for the" "International Classification of HRCT for Occupational and Environmental Respiratory Diseases. The book is an authoritative guide to the recognition of dust diseases of the lung, using radiological imaging techniques, with special emphasis on high-resolution computerized tomography (CT). The classification is a powerful, essential tool for recording patient data on CT in a globally standardized semiquantitative way. The system is also applicable to surveillance and screening for occupational and environmental respiratory diseases. The book is a valuable resource not only for radiologists but for all who work in occupational medicine and public health.

This text analyses the pathophysiology, diagnosis, treatment and control of respiratory disorders in the newborn infant. It explores the mechanisms, patterns and factors influencing respiratory activity and dysfunction, as well as the aetiology, management and evaluation of conditions such as respiratory distress syndrome, bronchopulmonary dysplasia, airway disorders, and congenital hypoventilation syndromes.

This third edition of Gershwin and Halpern's classic text, Bronchial Asthma, has been completely rewritten and expanded to include, from a variety of disciplines, the latest techniques and developments in the clinical diagnosis and treatment of asthma. With its new patient-oriented chapters on living with asthma, the book will empower the internist, the family practitioner, and the specialist in their struggle to reverse the current trend of increasing asthma mortality and to improve the quality of life of their patients and their families. The editors have selected authoritative contributors to Bronchial Asthma, organizing it into four comprehensive parts: I. Definitions and Host Responses to Bronchospasm defines asthma by analyzing its epidemiology, pathogenesis, and genetic roots, and illuminates the roles of mast cells and eosinophils. Chapters also cover the use of the pulmonary function laboratory and the differential diagnosis of asthma in children and adults. II. Patient Management introduces the latest thinking and techniques about treatment and management of patients, including allergic evaluation, radiological treatment, the role of immunotherapy, the differential management of status asthmaticus, the management of pregnant asthmatics, and an evaluation of unconventional therapies. III. Special Clinical Problems explores respiratory tract infections, the roles of anti-inflammatory agents, food additives, air pollution, aspergillosis, and occupational asthma. Four new chapters analyze exercise-induced asthma, asthma's relationship with chronic sinus disease, and the cross-cultural treatment of asthma in Europe and Japan. IV. Living with Asthma, an entirely new section, examines asthma in school children, athletes and asthma, legal issues for asthmatics, the psychology of asthma, and the use of prospective disease management.

The book presents a comprehensive overview of the various disease processes affecting the chest and related abnormalities. It discusses biopsy and bronchography, as well as a variety of imaging techniques including radiography, fluoroscopy, tomography, and ultrasound.

Starting with patient assessment, the authors explain the physiological basis of all major cardiopulmonary problems before describing the physiotherapy interventions possible - this ensures the reader understands why the problems occur and not just how to treat them. The book concludes with a detailed glossary, an appendix describing all the treatment methods required, and a final section provides case studies to enhance problem-based learning. The unique combination of physiology, the latest evidence, and detailed methodologies and case studies, ensures that Cardiopulmonary Physiotherapy is an essential purchase for all undergraduates. Postgraduate students in their first years of training will also benefit from quick access to the core information they need on a daily basis.

An intensive-care doctor reveals the long-term problems caused by ICUs, and how these can be prevented. Thousands of people are admitted to intensive-care units (ICUs) every day, and this is only increasing with the Covid-19 pandemic. Most of these admissions will be sudden, unexpected, and harrowing - an experience that can alter patients and their families in physical, emotional, and spiritual ways, with effects that endure for years. But there is hope. Dr Ely is a leading ICU doctor. His unconventional methods minimise patients being harmed by the cutting-edge technologies that are saving their lives; post-intensive care syndrome (PICS) is a well-established complication that millions of ICU survivors battle, which Dr Ely aims to eradicate. His cutting-edge studies have convinced doctors around the world to change their ICU practices for the better. Through captivating stories, Dr Ely shows how he and colleagues from around the world have re-introduced humanity into the ICU, creating pathways that bring hope and healing to healthcare. This is the future of medicine, and is a must-read for healthcare professionals, patients, and their families.

Answering the demand for acomprehensive, all-purpose volume focusing on the challenging needs of pediatric patients, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients summarizes a wealth of knowledge on the mechanical devices, clinical management, alternative applications, and future directions in the specialized field of pediatric critical care. Condensed advice from experts on the shelf offers guidance in critical intensive care settings! Combining clinical aspects with the latest experimental results, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients -examines current modalities and the best uses of mechanical support, including step-by-step techniques for extracorporeal membrane oxygenation (ECMO), ventricular assist devices (VAD), and intra-aortic balloon pumps -highlights the use of mechanical support in nonsurgical diseases such as myocarditis and cardiomyopathy, with implanted ventricular devices and in long-term follow-up care -discusses the optimal management for perioperative support in cardiac and pulmonary transplantations in children -reviews successful cases of mechanical support, including resuscitation after cardiac arrest, pediatric patients with myocarditis, and circulatory support of patients without cardiac disease -explores anticipated improvements and uses of the Berlin Heart, the Nimbus Rotary Pump, and applications of the Medos-HIA VAD in young patients -and much more! Authored by nearly 40 internationally recognized experts and containing over 500 literature references, drawings, photographs, and tables, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients is an invaluable referencefor cardiologists and pediatric cardiologists, intensivists, cardiac surgeons, pulmonologists, anesthesiologists, general pediatricians, nursing personnel, perfusionists, and medical school students in these disciplines.

Performing a thorough and detailed study of one of the most common yet less accurately understood causes of human illness, this all-inclusive reference examines the epidemiology, pathophysiology, and future treatment options for asthma and respiratory infections.
Contains up-to-date results from clinical trials of antiviral agents that explore new avenues of therapy-including interferons, ICAM-1 receptor blockades, vaccines, and mediator antagonists!

We proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system. The first chapters introduce basic notions of purinergic pharmacology and metabolism, which allows readers from all scientific backgrounds to fully grasp the importance of these signaling networks for airway defenses, including mucociliary clearance and inflammatory responses. Then, chapters are devoted to the groundbreaking discovery that chronic respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD), present specific aberrances in purinergic signaling which essentially drive lung complications. The last chapters describe the animal models used to investigate purinergic signaling in respiratory diseases, and the therapeutic applications developed by the pharmaceutical industry based on receptor agonists/antagonists and metabolic correctors. This highly comprehensive manuscript constitutes an invaluable tool for beginners and experts to follow the rapidly evolving research field of purinergic signaling. Furthermore, the critical analysis of past clinical protocols should facilitate the identification of potent therapeutic targets, and provide a better understanding of the data acquired in current clinical trials.

Discusses three major classes of asthma therapies-bronchodilators, antiinflammatories, and antiallergics-as well as potential new therapeutic approaches
This comprehensive volume addresses the latest treatment strategies for asthma, keying in on the genetics and molecular biology of asthma and pointing the way toward new, commercially viable therapies.
Presents the most up-to-date information available on the genetics, epidemiology, pathology, pharmacology, and pulmonology of asthma.
Written by more than 20 leading international experts, New and Exploratory Therapeutic Agents for Asthma
explores asthma both as incidence of dysfunctional airway smooth muscle and as a disorder of the immune system
examines the role of monoclonal antibodies in allergy and asthma
describes functions and pharmacokinetic profiles of bronchodilator 2 agonists, anticholinergics, and inhaled glucocorticosteroids
investigates the controversy of different types of asthma
illustrates the connections between clinical symptoms and the immunopathology of eosinophilic inflammation
assesses prospects for the development of a successful oral anti-inflammatory therapy, an immunomodulator that lowers antigen-specific IgE, an anticytokine compound, and an agent that safely combines bronchospasmolytic and anti-inflammatory properties
reviews the impact of the recent introduction of antileukotriene agents, clinical findings with PAF antagonists, and selective antimuscarinics
evaluates the relationship between improvements in laboratory results and clinical effectiveness
and more
Containing over 2000 bibliographic citations and a concise introduction for each chapter, New and Exploratory Therapeutic Agents for Asthma is indispensable for pulmonologists, pediatricians, physiologists, immunologists, allergists, pharmaceutical industry scientists, primary care physicians, and medical school students in these disciplines.