This book provides a comprehensive framework for treatment and management of bronchopulmonary dysplasia. In recent years great strides have been made toward understanding the pathogenesis and clinical aspects of BPD, which is the most common chronic lung disease affecting infants. This one-stop resource is written by leading scientists and clinicians in the field, and chapters discuss the most recent developments in the basic scientific, translational, and clinical characteristics of the disease. Topics such as hyperoxia, pre- and post-natal inflammation, and genetics and biomarkers of BPD are included, as well as non-invasive ventilation techniques, nutrition, and radiology applications from pre-term birth to adulthood. The book closes with an in-depth look at emerging therapeutic options for prevention of BPD. Bronchopulmonary Dysplasia is an essential volume for all neonatologists, pediatric pulmonologists, and scientists interested in developmental disorders of the lung.

Collaboratively authored by international experts and innovators, this book serves as a comprehensive introduction to flexible bronchoscopy in children, a guide to normal and abnormal bronchoscopy findings, and as the first pediatric bronchoscopy text to describe the array of innovative technologies now being utilized in advanced diagnostic and interventional bronchoscopy programs. Flexible bronchoscopy is a core clinical service provided by academic pediatric pulmonary medicine programs and a critical skill that trainees are expected to develop. The role of flexible bronchoscopy in the care of children with disorders of the respiratory tract has evolved rapidly over the past decade due to technological advances in diagnostic and therapeutic instruments. While many of these tools were designed for adult patients, pediatric pulmonologists have adapted them to meet the unique needs of children. The book is organized into three sections: the history and fundamentals of flexible bronchoscopy; the role of flexible bronchoscopy in evaluation of pediatric respiratory tract disorders; and advanced diagnostic and interventional bronchoscopy. Throughout, images and videos enhance the text and provide invaluable perspective. This is an ideal guide for practicing pediatric pulmonologists and trainees, and will also prove useful to pediatric anesthesiologists, intensivists, otolaryngologists and respiratory therapists.

This book provides a detailed review of state of the art knowledge on critical care topics as well as the latest research findings. It covers the core aspects in excellent detail, but is not so comprehensive as to make its daily use unfeasible. For each condition considered, discussion of the pathophysiology is integrated with observations on diagnosis and treatment in order to allow a deeper understanding. The book is scientifically based, with extensive references to published research. This will allow readers to investigate their individual interests further and will enable physicians to justify measures by providing a coherent, evidence-based strategy and relevant citations where needed. Core Knowledge in Critical Care Medicine will appeal to experienced practitioners as an aide-memoire, but will also be of great value to a wide range of more junior staff wishing to complement their background knowledge with important facts applicable to everyday practice.

This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. The text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. Updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. This leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. The coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. The book presents insights from experts across disciplines to emphasize the importance of collaborative care. Advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung cancer.

This, the second of two volumes on personalized medicine in lung cancer, touches upon the recent progress in targeted drug development based on genomics; emerging biomarkers and therapeutic targets such as EMT, cancer stem cells, and the tumor microenvironment; current personalized clinical management and radiation therapy for lung cancers; and the promise of epigenetics and next-generation sequencing for the advancements towards personalized therapy of lung cancer patients. With chapters on state-of-the-art therapies and technologies written by leading experts working to develop novel companion diagnosis tools for the personalized treatment of lung cancer patients, this volume brings readers up-to-date by presenting the current knowledge on the efforts to make personalized management of lung cancer patients a reality.

Dispelling the commonly held belief that lung cancer is always self-inflicted, this book guides patients, their loved ones, and caregivers through diagnosis, acceptance, and treatment, and provides support and hope to the tens of thousands of people coping with this illness. Lung cancer is a serious illness-one that is considered among medicine's most dreaded diagnoses. Alone, it's responsible for 29 percent of cancer deaths in the United States and causes more deaths than breast, colon, ovarian, and prostate cancer combined! Additionally, lung cancer isn't typically discovered until it causes symptoms, at which point options are limited and the chances of a cure greatly reduced. But it doesn't have to be this way. In this book, Dr. Eric Presser provides an empowering, comprehensive guide to lung cancer for anyone seeking a deeper understanding of the treatments available, coping with the diagnosis, and dealing with the side effects associated with the disease on both patients and their loved ones. His book offers a complete resource for anyone touched by lung cancer, presenting the latest scientifically tested information to help reduce the rates of illness and infirmity and ultimately make lung cancer a thing of the past. The book first covers the basic information necessary to understand lung cancer, including lung anatomy. Dr. Presser then identifies the six steps that will with help people cope with lung cancer and take charge of their lives. The final section focuses on nutrition and lung cancer in addition to practical concerns such as health insurance, work and disability, and financial challenges. Provides a crucial reference that helps patients, caregivers, and loved ones educate themselves and obtain the best possible treatments Discusses customized chemotherapy; treatment options for early-stage lung cancer, including minimally invasive surgery techniques pioneered by author Dr. Eric Presser; and today's most promising treatments, including multimodality therapy Examines the latest diagnostic tools for the early detection of lung cancer, emphasizes the importance of cancer staging, and evaluates the range of alternative treatments Guides readers concerning emotional matters such as telling family members and dealing with guilt, and with the practical needs of late-stage lung cancer patients

Prepare for success on respiratory therapy credentialing exams! Updated to reflect the 2009 National Board of Respiratory Care (NBRC) content outlines, Sills' The Comprehensive Respiratory Therapist's Exam Review, 5th Edition helps you review for both entry and advanced level credentialing exams. It covers every testable subject, providing content review, self-assessment questions, and study hints. The new Evolve website contains electronic testing offering realistic practice for the entry-level credentialing exam and the advanced-level credentialing Written Registry Exam (WRE) and Clinical Simulation Exam (CSE). Self-study questions at the end of each chapter include an answer key with rationales to help you analyze your strengths and weaknesses in content learned. UNIQUE! Exam Hint boxes point out point out subjects that are frequently tested, helping you study, plan your time, and improve your test-taking skills. Rationales for each question provide feedback for correct and incorrect answers so you understand why an answer is correct or incorrect and retain information better. Difficulty level codes (recall, application, analysis) for each question on Evolve help you prepare for questions in the way that is most appropriate (e.g., memorization for recall or synthesis for analysis). Special NBRC coding of topics corresponds to every topic covered in the NBRC Detailed Content Outline (DCO) so you can easily review each of the testable topics. Secure Evolve website lets you experience the actual NBRC testing environment in a computerized format. NEW! Therapist Multiple Choice Exam (TM-CE) practice test aligns with the new 2015 NBRC Written Exam. UPDATED! Revised content reflects the 2015 NBRC Detailed Content Outline and examination matrix so you know exactly what to expect on the exams - and can review each of the areas covered on the matrix. NEW! More analysis-type questions added to the end-of-chapter self-study questions reflect changes in the matrix content outlines. NEW! Greater consistency in formulas, abbreviations, and equations achieved through aligning the text and Evolve site to comprehensive Abbreviation and Equation Glossaries. EXPANDED! 22 clinical simulations feature shortened sections and align with the new 2015 NBRC Clinical Simulation Exam in both study mode and exam mode, giving you the opportunity to practice this difficult portion of the Registry Exam on Evolve. NEW! Standard Normal Range Guide features reference tables with normal values of various parameters used in respiratory care assessment. EXPANDED! New practice exams on Evolve, including one 140-question TM-CE with automatic scoring to delineate entry and advanced credentialing levels, let you assess your understanding in both study (untimed) and exam (timed) modes.

This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.

This comprehensive volume on the blood-gas barrier (BGB) among vertebrates covers its structure and composition along with aspects of evolution, bioengineering, and morphometry. The book also discusses the embryological development of the BGB, including chronology of events and molecular control in vertebrates; modulation of the barrier function, including cyclic stretch-induced increases in alveolar epithelial permeability; mechanisms of lung vascular/epithelial permeability; transport mechanisms of the BGB, including sodium transport channels; factors affecting trans-barrier traffic of fluids, such as chronic elevation of pulmonary microvascular pressure; stress failure; regulation and repair in acute lung injury; chronic lung disease; and lung transportation. Ten authoritative chapters approach the blood-gas barrier holistically, from basic structure and development to pathology and treatment. Properties of the BGB are discussed in the earlier chapters, followed by prenatal and post-natal development and mechanisms of the healthy BGB. The latter half of the book delves into the pathology of the BGB, analyzing common afflictions and exploring options for treatment, including its alterations during lung transplantation. Intuitively structured and comprehensive, The Vertebrate Blood-Gas Barrier in Health and Disease is ideal for researchers and clinicians interested in pneumology and angiology.

This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer-statistics and epidemiology of lung cancer-along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer-immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.

This volume presents the most recent developments in diagnosis and treatment of patients with gastroesophageal reflux disease (GERD) and those who continue to be refractory to conventional GERD therapies. The book delineates the role of newly developed endoscopic therapies in GERD and outlines the best candidates for surgical fundoplication. Topics as the risks associated with GERD, lifestyle modification in GERD and the role of H2RA and proton pump inhibitor therapy in treating reflux disease are also explored. Written by authorities in the field, Diagnosis and Treatment of Gastroesophageal Reflux Disease is a concise yet comprehensive resource that is useful for primary care providers, gastroenterologists, pulmonologists, surgeons and ENT specialists.