Comparative Biology of the Normal Lung, Second Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung.

This issue of Clinics in Chest Medicine, guest-edited by Dr. Gerard Criner and Dr. Bartolome Celli, is focused on Chronic Obstructive Pulmonary Disease. Topics discussed in this issue include but are not limited to: COPD Pathogenesis; Epidemiology of COPD; Host, Gender, and Early Life Factors as Risks for COPD; Alpha One Antitrypsin Deficiency; Lung Function Testing; Assessing Symptom Burden; Chest Imaging in the Diagnosis and Assessment of the Patient with COPD; Biomarkers in the Diagnosis and Assessment of COPD; Asthma/COPD Overlap; Multimorbidity in the Patient with COPD; Definition Causes, Pathogenesis, and Consequences of Exacerbations; Treatment of Acute Exacerbations; Prevention of Exacerbations; Bronchodilators; Benefits and Risks of Inhaled Corticosteroids in COPD; Systemic Medications; Smoking Cessation/Vaccinations; Pulmonary Rehabilitation; Oxygen Therapy/Noninvasive Ventilation; and Interventional and Surgical Therapies for COPD.

This issue of Thoracic Surgery Clinics is devoted to "Advanced Lung Cancer: Radical Surgical Therapy" and is edited by Dr. Raja M. Flores. Articles in this outstanding issue include: Surgical Resection of Lung Cancer in the Elderly; Extended Chest Wall Resection and Reconstruction in the Setting of Lung Cancer; The Management of Non-Small Cell Lung Cancer with Oligometastases; Lung Resection in Patients with Marginal Pulmonary Function; Surgery for Small Cell Lung Cancer; Bronchial and Arterial Sleeve Resection after Induction Therapy for Lung Cancer; Advanced Lung Cancer: Aggressive Surgical Therapy Vertebral Body Involvement; Pulmonary Resection after Pneumonectomy; Superior Vena Caval Resection in Lung Cancer; Surgical Resection of Non-Small Cell Lung Cancer with N2 Disease; Lung Transplantation for Multifocal Lung Adenocarcinoma; Extended Resections of Non-Small Cell Lung Cancers Invading the Aorta, Pulmonary Artery, Left Atrium or Esophagus: Can They Be Justified?; VATS Lobectomy after Induction Therapy; Extrapleural Pneumonectomy for Pleural Disease; Carinal Resection, and more!

Clinics Collections: Asthma draws from Elsevier's robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, pulmonologists, otolaryngologists, allergists, pediatricians, and other healthcare professionals, with practical clinical advice and insights on this highly prevalent disease and its comorbidities. Clinics Collections: Asthma guides readers on how to apply current primary research findings on asthma to everyday practice to help overcome challenges and complications, keep up with new and improved treatment methods, and improve patient outcomes. Areas of focus include pathogenesis, treatment and management of adult asthma, management of pediatric asthma, and special considerations. Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format. Elsevier Clinics Collections provide concise reviews of today's most prevalent conditions and significant medical developments.

The second edition of The Lung: Development, Aging and the Environment provides an understanding of the multi-faceted nature of lung development, aging, and how the environment influences these processes. As an essential resource to respiratory, pulmonary, and thoracic scientists and physicians it provides an interface between the normal and disease cluster of chapters, allowing for a natural complement to each other. The interface between different lung diseases affecting the pediatric lung also adds a useful source for comparing how different lung diseases share key pathophysiological features. This same complementarity comes across in the logical line up of chapters dealing with the normal pediatric lung. New research, including cell-based strategies for infant lung function, epigenetics, and prenatal alcohol exposure on lung development and function are some of the important additions to this edition of this reference work.
Describes the normal processes of lung development, growth and agingConsiders the effects of the environmental contaminants in the air, water, soil, and diet on lung development, growth and healthDescribes genetic factors involved in susceptibility to lung diseaseCovers respiratory health risk in children"

This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments over the past decade. The discoveries of endothelin overexpression as well as prostacyclin and nitric oxide deficiency in association with pulmonary hypertension have led to important therapeutic insights. The new therapies have led to significant improvements in patient function, quality of life and survival. In this book, expert authors describe these new therapies. It will be of interest not only to cardiologists, pulmonary specialists and rheumatologists, but also many nurses and pharmacotherapists.

The Year Book of Pulmonary Disease brings you abstracts of the articles that reported the year's breakthrough developments in pulmonary disease carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Asthma and Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Lung Cancer, Community-Acquired Pneumonia, Lung Transplantation, Sleep Disorders, and Critical Care Medicine are represented highlighting the most current and relevant articles in the field.

The 2nd edition of this book describes the recent techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill, defined as those who have acute failure of at least one organ, due to either a pathological condition or a medical intervention, and require intensive care treatment. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as noninvasive mechanical ventilation, protective ventilation, prone positioning, intravenous salbutamol in ARDS, high-frequency oscillatory ventilation, mild hypothermia after cardiac arrest, daily interruption of sedatives, tranexamic acid, diaspirin cross-linked hemoglobin, albumin, growth hormone, glutamine supplementation, tight glucose control, supranormal oxygen delivery, and hydroxyethyl starch in sepsis. The topics selection was performed with the help of hundreds of specialists from dozens of countries; they expressed via web if they agreed or not with these topics and if they used them in their daily clinical practice. The clear text is supported by "how to do" sections and "key point" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in Critically Ill Patients is of interest for a wide variety of specialists, including intensivists, emergency doctors, and anesthesiologists.

Comprehensive Tracheostomy Care is a resource developed by the UK National Tracheostomy Safety Project (NTSP) to help promote and facilitate the safe management of tracheostomies and laryngectomies. The scope includes hospital in-patient specialist areas such as critical care, head & neck units and specialist wards, but it is also applicable to more general wards, outpatient and community settings. The majority of the content is for adult patients, complemented by a dedicated paediatric chapter developed with colleagues from Great Ormond Street Hospital. The manual is a one stop shop covering all aspects of tracheostomy and laryngectomy management. It includes multidisciplinary resources from surgical, anaesthetic, nursing, intensive care and allied health backgrounds, along with guidance from key UK stakeholder organisations. Emergency guidance has been reviewed and endorsed by relevant Royal Colleges, national organisations and patient groups. It takes into account many national and international guidelines, policies and resources. It has been developed by consulting as widely as possible, across traditional professional boundaries using expertise and existing guidance from around the world, including the Global Tracheostomy Collaborative (www.globaltrach.org). Relevant existing resources are brought together coherently, with new resources presented in easy-to-follow text, illustrations, photographs and innovative linked e-learning and interactive resources.

This edition has been extensively rewritten in order to reflect the changes in clinical practice and learning methods which have taken place since the 5th edition was published. The seventeen chapters are divided into three sections: normal voice, descriptions of the various types of voice disorders, and the methods of treating abnormal voice.

A profile summary of each voice disorder is provided for easy reference and comparison, and tables are used throughout the text. New laryngeal images and electroglottographic interpretations have also been included.

The current emphasis on evidence-based practice is addressed in the review and descriptions of intervention strategies used in voice therapy.

The newly introduced Specialty Certificate Examinations are a compulsory component of assessment for all UK medical trainees and represent the final examination barrier before being able to apply for consultant positions. This book provides a unique examination-specific revision guide for the SCE in Respiratory Medcine. Comprising of best of five multiple choice questions, detailed answers and separate revision notes, Revision Notes for the Respiratory Medicine Specialty Certificate Examination is the only book you need to prepare for this important examination. Questions are based around clinical scenarios and supplemented with images of radiological investigations such as x-rays and lung function tests. Each question is structured as in the examination itself. The revision notes cover key areas and difficult concepts assessed in the examination, referencing national and international guidelines in topics including respiratory infection, respiratory malignancy, industrial lung disease, sleep disorders, standard respiratory tests and medical statistics.

Asthma is a very common chronic disease involving the respiratory system in which the airways occasionally constrict, become inflamed, and are lined with excessive amounts of mucus, often in response to one or more triggers. In children, the most common triggers are viral illnesses, such as those that cause the common cold and identifiable allergies. This airway narrowing causes symptoms such as wheezing, shortness of breath, chest tightness, and coughing. While measurement of airway function is possible for adults, most new cases are diagnosed in children who are unable to perform such tests. Diagnosis in children is based on a careful compilation and analysis of the patient's medical history and subsequent improvement with an inhaled bronchodilator medication. This 2nd edition will provide clinicians with an update on the management of asthma, and will include new sections covering paediatric asthma, new treatment strategies, and updated management guidelines (including new British Thoracic Society BTS] guidelines).

Respiratory tract infections (RTIs) are the most common acute medical problem encountered in primary care. Not only are RTIs very common, the spectrum of disease is wide. Clinical management differs according to the characteristics of the infected host and infecting pathogen. Despite these features, there are currently no pocketbooks that bring together clinically relevant information on this broad and important subject area in an accessible and practical manner. This pocketbook offers a concise companion for health care professionals who manage patients with acute lung infections. The book covers aspects related to the diagnosis and initial management of these patients, with attention to specific infections which are notable for being difficult to manage, common or of particular clinical importance. The book will appeal to a wide variety of professionals in acute medicine, respiratory medicine, infectious diseases, primary care, and other internal medicine specialties.

Respiratory disease is one of the leading causes of both mortality and morbidity, causing a significant burden on healthcare resources, the economy, and on individual patients and their carers. Respiratory conditions are managed in many different settings, from home and residential care through the full range of primary to tertiary care. The multifaceted nature of both diseases affecting respiration and the care options is comprehensively covered in this second edition of the Oxford Handbook of Respiratory Nursing. Offering a systematic description of the main respiratory diseases found in adults, the Handbook covers the assessment, diagnosis, and nursing management of each condition. With a special focus on the role of the multidisciplinary team in meeting the multiple care needs of respiratory patients, including physical and psychosocial concerns, and both pharmacological and non-pharmacological therapies, the Oxford Handbook of Respiratory Nursing is a unique and invaluable companion for all healthcare professionals working within the specialty. Fully updated to reflect changes in new national and international guidance, with additional topics on biologics, antifibrotic therapy, inspiratory flow, and new NICE and UKIG standards and algorithms, the material has been fully overhauled to reflect current best practice and therapeutic options. Concise, didactic, and augmented with further reading and useful online resources, the second edition of the Oxford Handbook of Respiratory Nursing gives nurses working in the field all the information they need at their fingertips.

This issue provides fully updated information on respiratory infections, including healthcare associated pneumonia, new diagnostic tests for pneumonia, epidemic viral pneumonia and other emerging pathogens, biomarkers to optimize antibiotic therapy for pneumonia, pharmacokinetics and pharmacodynamics to improve management of penumonia.? Nosocomial tracheobronchitis and bronchiectasis are also discussed.? Articles on CAP and VAP, including an examination of the impact of guidelines on outcomes, de-escalation therapy, inhaled antibiotic therapy and prevention of VAP are also included.

Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries. Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hoekfelt and V.C. Jordan.

PET imaging has been used for the assessment of lung cancer for several years for diagnosis, staging, and post-treatment follow up.? Expanded applications are now being used and explored in the imaging of the heart, thoracic vascular disease, and chest wall disorders.? This issue provides an up-to-date review of the uses of PET for oncologic and nononcologic diseases of the thorax.

Based around the curriculum for specialist trainees in respiratory medicine and designed for those preparing for exit exams, this book contains 44 well-structured, peer-reviewed cases gathered from the Oxford Hospitals, comprehensively covering the various disorders of the respiratory system. new developments in medical training at junior and registrar levels have created a need for a collection of cases which enable self-assessment, directed at post-graduates. Each case comprises a brief clinical history and relevant examination findings, details of investigations, medical imaging followed by questions on differential diagnosis, and management and detailed answers and discussion.

This textbook comprehensively covers mechanical ventilation in neonates and children integrating the latest knowledge and understanding of developmental biology, age-related and disease-specific physiologic differences in the practice of mechanical ventilation. The physiology associated with ventilation and lung mechanics are described. Guidance is provided on how to carry out a range of clinical assessments appropriately, including those for ventilation, mechanics and breathing control. Available pathophysiology-based management strategies for a range of situations including respiratory failure and ventilatory failure are also provided. Mechanical Ventilation in Neonates and Children: A Pathophysiology Based Management Approach broadly covers a range of topics associated with mechanical ventilation in children and neonates. It is a valuable resource for specific seminars or courses that concentrate on respiratory failure in children and for those preparing for board certification examinations for neonatal/perinatal medicine and pediatric critical care medicine.

This book comprehensively addresses the use of pulmonary function measurement for the evaluation, screening and timing of noninvasive mechanical ventilation (NIMV) from hospital to home care. To do so, it describes three clinical stages of NIMV support: before NIV, to detect early markers and determine whether NIV is appropriate; during NIV, to evaluate NIV response; and in long-term NIV support. Additionally, it assesses a range of complementary health care organizations (pulmonary function labs, pneumology wards, semi-intensive care units and home mechanical ventilation programs), techniques (chest physiotherapy/airway secretions, etc.) and applications. In closing, the book offers practical recommendations on how noninvasive ventilation and lung function measurement can improve outcomes and quality of life, making it a valuable resource for all specialists, e.g. intensivists and pneumologists, as well as anesthesiologists and therapists.

This authoritative text is written by leaders in pulmonary rehabilitation. It is clearly written, logically organized, well referenced, and emphasizes evidence-based practice and a contemporary multidisciplinary approach. Offering unrivaled depth, this edition updates coverage of the benefits of pulmonary rehabilitation, therapeutic interventions, smoking cessation, exercise training, and much more as well as important research such as the Global Initiative for Chronic Obstructive Lung Disease (GOLD) report. This text prepares students for the Certified Respiratory Therapist (CRT) exam and the written registry and clinical simulations portions of the Registered Respiratory Therapist (RRT) exams. Information on existing techniques and procedures is expanded and updated in chapters on lung transplantation, functional performance assessment and training, and the management of pulmonary rehabilitation services. Illustrations, photographs, tables, and boxes address new and important information, reinforcing and simplifying the material. A hard cover and portable size offer durability and convenience. Reader-friendly features in each chapter include an outline, professional skills objectives, and a summary, allowing easy access to content and highlighting important concepts and ideas. New chapters covering new advances and discoveries in respiratory care: Systemic Effects of Chronic Obstructive Pulmonary Disorders Complementary Alternative Medicine for Patients with Chronic Lung Disease Pulmonary Rehabilitation and Lung Volume Reduction Surgery Management of and Reimbursement for Pulmonary Rehabilitation Services Exercise and Pulmonary Hypertension New and revised illustrations and photographs. Expanded coverage of patients with respiratory diseases other than COPD as well as pediatric pulmonary patients. New and revised pedagogy including chapter outlines and updated objectives Enhanced chapters Addresses the latest research and reports including The Global Initiative for Chronic Obstructive Lung Disease (GOLD) report recommending pulmonary rehabilitation.

Does your heart rate increase when you are paged to the emergency department or ICU for emergency airway management? Would you know how to handle the unexpected arrival of a patient with a gunshot wound to the neck and worsening airway compromise? This guide to critical airway emergencies will prepare you to safely manage these high-pressure situations. Case-based discussions focus on specific scenarios and provide background on the relevant medical issues along with practical guidance and algorithms. This systematic approach gives quick access to vital clinical information. Multidisciplinary in approach and written by experts from a variety of specialties, the content covers both pediatric and adult patients, encompassing many of the challenging airway situations you could be faced with. Every healthcare practitioner involved with emergency airway management will benefit from this book.

Although asbestos was once considered a miracle mineral, today even the word itself has ominous implications for all strata of our society. Incorporated in the past into over 3000 different industrial and consumer products, as well as in building materials and military equipment, opportunities for exposure continue to be ever present in our environment. Of all of us who are potentially exposed, blue collar workers are at greatest risk.
Countless thousands of workers and servicemen in a wide variety of trades were disabled or have died consequent to the health effects of asbestos, and many more can be expected to be affected in years to come. Litigation continues, and financial awards in the billions have bankrupt many Fortune 500 companies and numerous smaller companies.
While one might implicate our forefathers in this widespread, relentless medical catastrophe, it has been only in recent decades that science has appreciated the complexities of the problem and the long latencies before the asbestos-associated diseases appear clinically. After all these years, prevention remains the hallmark of disease control, as modern treatments remain, to a large extent, futile.