The successful prophylaxis and treatment of ubiquitous respiratory infections is essential for the enhancement of public health. The chapters provide new insights into the biology of causative pathogens, tackle the epidemiological aspects, and present an update on diagnostics, prevention and therapy of infections. The emerging new pathogens and antibiotic resistance of the old ones are discussed. Novel markers of the severity of community acquired pneumonia, which bears high morbidity and mortality, also are presented.

This book comprehensively summarizes the adverse effects of tobacco smoking on human health. The current second edition has integrated a large set of new data that have been published in numerous scientifc studies and meta-analyses over the past few years. Unfortunately, the harmful sequelae of tobacco smoking are played down by the ind- try and politicians in many industrialized countries. However, about 800,000 people/year in the EU die from the immediate consequences of smoking. The particularly insidious feature of tobacco consumption is that smoking-attributable harmful effects on health do not generally become apparent until three or four decades after smoking initiation. Although some positive changes in the legislative handling of tobacco have appeared in the past fve years, we still need to form a pact, sealed by politicians, the medical prof- sionals, teachers and the media, to target the problem across nations. In this respect, a minority of countries, including the US and the UK, have given positive examples. There are four areas that need to be improved in future: (1) strict bans on tobacco adv- tisement on a global level, (2) better measures to protect against side-stream (passive) smoke exposure, (3) establishment of prevention programs, especially for children and (4) tre- ment of tobacco addiction.

Chapter 1. A Clinical Approach to Rare Lung Diseases Ralph Panos, M.D. Chapter 2. Clinical Trials for Rare Lung Diseases Jeffrey Krischer, Ph.D. Chapter 3. Idiopathic and Familial Pulmonary Arterial Hypertension Jean M. Elwing, M.D., Gail Deutsch, M.D., William C. Nichols, Ph.D., and Timothy LeCras, Ph.D., Chapter 4. Lymphangioleiomyomatosis Francis X. McCormack, M.D, and Elizabeth P. Henske, M.D., Ph.D. Chapter 5. Autoimmune Pulmonary Alveolar Proteinosis Bruce Trapnell, M.D., Koh Nakata, M.D., Ph.D., and Yoshikazu Inoue, M.D., Ph.D. Chapter 6. Mutations in Surfactant Protein C and Interstitial Lung Disease James P. Bridges, Ph. D. and Ralph Panos, M.D. Chapter 7. Hereditary Hemorrhagic Telangiectasia Claire Shovlin, M.D and S. Paul Oh, Ph.D. Chapter 8. Hermansky Pudlak Syndrome Lisa Young, M.D. and Bill Gahl, M.D., Ph.D. Chapter 9. Alpha One Antitrypsin Deficiency Charlie Strange, M.D. and Sabrina Janciauskiene, Ph.D. Chapter 10. The Marfan Syndrome Amaresh Nath, M.D and Enid Neptune, M.D. Chapter 11. Surfactant Deficiency Disorders SP-B and ABCA3 Larry Nogee, M.D. Chapter 12. Pulmonary Capillary Hemangiomatosis Edward D. Chan, M.D., Kathryn Chmura, B.A, and Andrew Sullivan, M.D. Chapter 13. Goodpasture's Syndrome Gangadar Taduri, M.D., D.M., Raghu Kalluri, Ph.D., and Ralph P. Panos, M.D. Chapter 14. Primary Ciliary Diskinesia Michael R. Knowles, M.D., Hilda Morillas, M.D., Margaret W. Leigh, M.D., Maimoona Zariwala, Ph.D. Chapter 15. Pulmonary Alveolar Microlithiasis Koichi Hagiwara, MD, Takeshi Jokoh, M.D., Teruo Tachibana, MD Chapter 16. Cystic Fibrosis Andre Cantin, M.D. Chapter 17. Pulmonary Langerhan's CellHistiocytosis Robert Vassallo, M.D. Chapter 18. Sarcoidosis Ralph Panos, M.D. and Andrew Fontenot, M.D. Chapter 19. Scleroderma Lung Disease Brent Kinder, M.D.

Chronic obstructive pulmonary disease (COPD) affects millions of people across the world. COPD is not only a major burden to patients but is also costly and results in billions of dollars of direct and indirect costs annually. In recent years and with advancement of science, the understanding of COPD has improved significantly. Fortunately, current management guidelines consider COPD a preventable and treatable condition, and recent studies clearly indicate that available pharmacological and non-pharmacological interventions may improve various clinical outcomes. COPD: A Guide to Diagnosis and Clinical Management offers an exciting, evidence-based assessment of the field and will be of significant interest to clinicians who care for patients with COPD, including primary care providers and specialists. Comprehensive and state-of-the-art, this title is authored by experts who took the task of developing a resource that focuses on the essential issues in caring for patients with COPD. The first four chapters of the book cover major points about the systemic nature of COPD, the clinical and physiological assessments, and the outcome measures and prognostic markers. In the following section, various pharmacologic and non-pharmacological management strategies are reviewed based on the available evidence. The final sections outline the non-pulmonary effects of COPD and their management. COPD: A Guide to Diagnosis and Clinical Management is a vital, evidence-based text that will prove invaluable for all clinicians who care for patients with this debilitating disorder.

Endoscopic Therapy is emerging as the preferred therapy for early neoplasia in Barrett's Esophagus. This volume provides the key decision making factors in determining endoscopic therapy for an individual patient. All current techniques and complications of ET are provided including, photodynamic therapy (PDT), APC, multipolar electrocoagulation (MPEC), RF, ER, and cryotherapy. Each technique includes "how to highlights", high quality color endoscopic images, line drawings and diagrams. Endoscopic imaging modalities to detect dysplasia, decision making in the clinical arena and cost-effectiveness of ablation are some of the additional topics discussed in this highly practical volume. Written by experts in the field of endoscopic therapy, this text educates GI practitioners and researchers about this under-utilized approach to the treatment of Barrett's Esophagus.

An understanding of virus infection and the underlying role of the immune system in protection against these diseases is vital in today's medical climate. Previously, only symptoms could be treated, as there were no antiviral therapies. The increasing amounts of research and the huge number of discoveries of immunologic agents and pathways has led to the opportunity to look to the basic physiology of the various disease process as never before. This book is designed to provide the clinician with a thorough and yet approachable textbook describing the relationships between immunology, virology and the disease process.

This comprehensive resource brings together the most current theories, evidence and best practice parameters for the use of nocturnal non-invasive ventilation (nNIV). Chapters focus on the application of acute and chronic nNIV in patients with cardio-respiratory disorders over a range of major medical settings. Updates on past and recent research in this field are highlighted. Authored by leading clinicians and investigators, Nocturnal Non-Invasive Ventilation provides practical and cutting-edge knowledge to physicians, researchers and allied health professionals on the front lines of treating cardio-respiratory and sleep disorders.

This volume provides a modern look on the age-old influenza infection and the preventive role of anti-influenza shots. Influenza pandemic outbreaks are unrelenting despite the growing understanding of the molecular basis of viral infection and its spreads. A leap in medical technologies has revolutionized the design of new influenza vaccines. The chapters cover vaccination strategies in various age-groups of people and provide the extensive amount of knowledge on the immune response to influenza vaccination in a spectrum of disease conditions.

Offers a comprehensive approach to modern imaging of environmental and occupational diseases of the chest Pays particular attention to the role of computed tomography in the detection of early subclinical abnormalities Considers new groups of workers at risk of exposure to agents that may cause pneumoconiosis Written by internationally acclaimed experts

Inadequate humidification of inspired gases can cause a variety of serious problems, and humidification has accordingly become an important aspect of modern intensive care medicine. This book is designed to serve as a practical guide for clinicians, providing information on the theoretical background of humidification, the equipment, and its optimal use. The book starts by examining the physiological basis of humidification. Current devices are then discussed, with careful attention to factors influencing their performance and methods to evaluate their effectiveness. The two scenarios of mechanical and non-mechanical ventilation are considered, and the issue of ventilator-associated pneumonia is addressed in detail. Further chapters focus on such topics as humidification following tracheostomy, humidification of the artificial airway during secretion management, measurement of inspired gas temperature in the ventilated neonate, and humidification in the home care setting.

Incidence of invasive fungal sinusitis has been increasing over the years. The understanding of its pathophysiology has improved with newer serological tests and diagnostic methods helping in earlier diagnosis and reducing patient morbidity. It was believed earlier that invasive fungal sinusitis is seen only in immune compromised patients but clinical reports suggest otherwise. More anti-fungal drugs are being added to improve incidence of patient survival. This book aims to compile all practical information about invasive fungal sinusitis into a single volume. Therefore, busy clinicians would not have to perform exhaustive literature studies to diagnose invasive fungal sinusitis. The book aims to provide an overview of diseases which could be mistaken for invasive fungal sinusitis and discuss how the management is different. Book sections consist of clinical, microbiological, serological, pathological, radiological and pharmacological features of the disease and its management. Each section is important in today's context as it dynamically alters the management of the patient. Early clinical suspicion and rapid microbiological, pathological and radiological diagnosis with aggressive treatment with surgical debridement and medical therapy leads to favorable outcomes.

This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. The book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.

Extracorporeal membrane oxygenation (ECMO) has been in clinical use for some 40 years, but it is only in the past decade that its application in the treatment of life-threatening circulatory and respiratory failure has truly flourished. This book presents a comprehensive overview of both pathophysiological and practical aspects of circulatory and respiratory extracorporeal support. The basics of ECMO, including its history, the "ECMO team", cannulation, materials, and blood-surface interactions, are first discussed. The various indications for and particular characteristics of circulatory and respiratory extracorporeal life support are then described in detail in the main part of the book. Patient care during ECMO and monitoring of the ECMO patient are also carefully covered, with explanation of the management of technical and clinical complications and transport-related problems. Further topics include long-term therapy options beyond ECMO, such as ventricular assist devices and transplants, outcome, the new frontiers of ECMO for organ procurement and future challenges. The authors are well-known experts in the field whose authoritative contributions and attention to practical aspects will be invaluable for novices and experienced practitioners alike.

Principles and Practice of Interventional Pulmonology provides a comprehensive text covering all aspects of Interventional Pulmonology. Providing both pathophysiologic background as well as illustrated and clear instruction on how procedures ought to be performed, this text will be of great value to interventional pulmonologists, thoracic surgeons, surgical oncologists, and interventional radiologists.

During the past decades, "Dynamics of the singing voice" has successfully been established as a reference text for teachers of singing, singers, choral conductors and organists, speech and voice therapists, laryngologists and other health professionals, psychologists and those in linguistics. It discusses the physiological, psychological, musical and emotional aspects of the voice, particularly as they relate to singing but also to speaking. The book provides a greater understanding of how the voice works and the many factors involved in singing as well as an objective discussion of singing without reference to specific techniques.

In this fifth edition, the author has now updated and rearranged the content. Furthermore she has added a new chapter on vocal pedagogic aspects in order to meet the requirements of the art of singing of the 21st century. Thus this new book provides the reader with the established concepts in combination with the latest knowledge about modern approaches to the singing voice.

The common cold is unlike any other human disease because of two f- tors: firstly, it is arguably the most common human disease and, secondly, it is one of the most complex diseases because of the number of viruses that cause the familiar syndrome of sneezing, sore throat, runny nose and nasal congestion. These two factors have made a 'cure' for the common cold one of the most difficult scientific and clinical endeavours (a topic often d- cussed in the popular media, where comparisons are made with the ease of putting a man on the moon). The present book brings together a wide range of experts from epidemiologists to virologists and pharmacologists to look at recent advances in our knowledge of the common cold. In some respects the book is unique, as it focuses on the common cold, a syndrome so familiar to the layperson but one that receives little attention from the scientist and clinician. The common cold can be viewed from many different aspects as illustrated in Figure 1. The core knowledge for understanding the common cold must first come from virology and this is discussed in several chapters of the book. There have been major advances in this field because of the use of new methods of detecting viruses such as polymerase chain reaction techniques that have greatly aided our understanding of the epidemiology of viruses associated with common cold.

This book consists of 23 essays about prominent people and events in the history of respiratory physiology. It provides a first-hand chronicle of the advancements made in respiratory physiology starting with Galen and the beginnings of Western physiology. The volume covers every aspect of the evolution of this important area of knowledge: pulmonary circulation, Boyle's Law, pulmonary capillaries and alveoli, morphology, gas exchange and blood flow, mechanics, control of ventilation, and comparative physiology. The book emphasizes societal and philosophical aspects of the history of science. Although it concentrates on physiology, it also describes how cultural movements, such as The Enlightenment, shaped the researchers discussed. This book is published on behalf of the American Physiological Society by Springer. Access to APS books published with Springer is free to APS members.

Nutrition in Pediatric Pulmonary Disease is a much needed resource for practitioners that provides a basic understanding of nutrition and nutritional supplements; their impact on physiologic function and how this can be applied for general health maintenance as well as a supplemental treatment for pulmonary diseases. This book provides information on (1) basics of nutrition, supplements and herbs and how they influence physiology (2) their application and potential use for various pulmonary diseases along with evidence regarding efficacy and safety. Also examined are (3) how diet, dietary supplements and herbs are integrated together for treatment and prevention of pulmonary disease. Finally (4) several health promoting diets and their potential benefits to patients with pulmonary diseases will be discussed. Nutrition in Pediatric Pulmonary Disease is an excellent new resource for practicing physicians who are interested in incorporating more nutritional approaches to treating their patients.

Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach is an excellent resource for clinicians who care for individuals affected by alcohol use disorders in diverse settings. Although alcohol abuse alone does not cause acute lung injury, it renders the lung susceptible to dysfunction in response to the inflammatory stresses of sepsis, trauma, and other clinical conditions recognized to cause acute lung injury. In parallel, these same pathophysiological effects of alcohol abuse significantly increase the risk of a wide range of serious lung infections. Many clinicians involved in the primary treatment of alcohol use disorders, such as addiction psychiatrists, will find this text of interest as it will expand their understanding of the health consequences of alcohol use disorders. In parallel, clinicians who specialize in pulmonary and/or critical care medicine will have a unique resource that provides a comprehensive review of the pathophysiology of alcohol-related lung disorders and insights into evolving therapeutic options in these vulnerable individuals. Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach fills a gap in the literature and presents the evolving clinical research that may soon lead to novel therapies that can improve lung health in individuals with alcohol use disorders and co-existing conditions such as HIV infection.

The field of interventional bronchoscopy is rapidly expanding and has emerged as a new and exciting subspecialty in pulmonary medicine. To date, the impact of interventional bronchoscopy procedures has been felt in diagnosis, staging, and management of lung cancer, the most lethal cancer worldwide. Interventional Bronchoscopy: A Clinical Guide provides a state-of-the art description of interventional bronchoscopy procedures, addressing the scientific basis, indications, techniques, results, complications, and cost issues. Chapters address the current status, the advantages of new techniques and, most importantly, when to choose new techniques over the existing techniques. Each chapter will discuss the future of these procedures. Interventional Bronchoscopy: A Clinical Guide is an essential resource for a successful interventional pulmonology service and will be useful for the bronchoscopist, anesthesiologist, radiologist, thoracic surgeon and oncologist as well as practicing pulmonologists who do not perform these procedures but have to make decisions regarding appropriate referral of their patients to advanced airway centers.

The dynamics of body metabolism are changed in the disease process and interact with physical activity. The alteration of metabolism and its consequences raise the need for simple and reliable methods for assessment of body composition. The chapters aim to investigate various interacting components converging on metabolic changes in lung and muscle tissues taking into consideration the drug effects. The effects of exercise and nutritional status are dealt with at a great extent.

Diagnostic imaging is an essential component in the evaluation of the patient with known or suspected respiratory tract disease. While chest radiography continues to serve as the primary tool for imaging the chest, advances in computed tomography (CT) have led to a variety of applications such as high-resolution CT (HRCT), advanced 3-D airway imaging, and image-guided procedures. The aim of this book is to deliver a clinically-oriented approach to pulmonary imaging. Each chapter of the book will provide an organized approach to the different facets of imaging of specific clinical scenarios, focusing on strengths and weaknesses of available imaging tests. High quality examples of typical imaging findings of specific conditions will supplement the text. The target readers include practicing internists, pulmonologists, thoracic surgeons, and primary care practitioners. Other readers will include respiratory care therapists and medical students. The proposed cohort of authors represents experts in the field of thoracic radiology. These authors have experience in thoracic radiology and medical writing, each will deliver a high-quality chapter meeting the aims and scope of this book while addressing the target audience. Aside from the first three chapters, which are introductory materials, each author will be invited to select a clinician with whom they work closely to serve as a co-author in order to provide a chapter that maintains the clinical orientation of this book.

This book presents a concise, evidence-based review of extracorporeal life support (ECLS) for adult diseases. It describes the use of ECLS with patients who are experiencing severe hypoxemic respiratory failure (ARDS and pneumonia), ventilatory failure (status asthmaticus and COPD), cardiogenic shock and circulatory or gas exchange failure following complications in cardiothoracic surgery, as well as its use as a bridge to lung transplant. Historically, clinicians have used ECLS as a last resort; however, this text details the technological improvements, evidence of improved outcomes and adverse consequences of alternative treatments that are causing this modality to be more commonly adopted. Topics include a description of the complex physiology and technology underlying ECLS; the evidence base for its use in specific clinical conditions; vascular access techniques; daily management of the circuit and patient; guidance regarding the weaning and decannulation process and recommendations for crisis management and rehabilitation related to ECLS. Extracorporeal Life Support for Adults is ideal reading for practicing physicians, nurses, perfusion specialists, therapists and critical care trainees who are considering whether to refer their patients for ECLS or are already providing ECLS and are seeking a practical reference to best practices and updated information.

In a gripping, accessible narrative, a veteran science journalist lays out the shocking story of how the COVID-19 coronavirus pandemic happened and how to make sure this never happens again

Over the last 30 years of epidemics and pandemics, we learned every lesson needed to stop this coronavirus outbreak in its tracks. We heeded almost none of them. The result is a pandemic on a scale never before seen in our lifetimes. In this captivating, authoritative, and eye-opening book, science journalist Debora MacKenzie lays out the full story of how and why it happened: the previous viruses that should have prepared us, the shocking public health failures that paved the way, the failure to contain the outbreak, and most importantly, what we must do to prevent future pandemics.

Debora MacKenzie has been reporting on emerging diseases for more than three decades, and she draws on that experience to explain how COVID-19 went from a potentially manageable outbreak to a global pandemic. Offering a compelling history of the most significant recent outbreaks, including SARS, MERS, H1N1, Zika, and Ebola, she gives a crash course in Epidemiology 101--how viruses spread and how pandemics end--and outlines the lessons we failed to learn from each past crisis. In vivid detail, she takes us through the arrival and spread of COVID-19, making clear the steps that governments knew they could have taken to prevent or at least prepare for this. Looking forward, MacKenzie makes a bold, optimistic argument: this pandemic might finally galvanize the world to take viruses seriously. Fighting this pandemic and preventing the next one will take political action of all kinds, globally, from governments, the scientific community, and individuals--but it is possible.

No one has yet brought together our knowledge of COVID-19 in a comprehensive, informative, and accessible way. But that story can already be told, and Debora MacKenzie's urgent telling is required reading for these times and beyond. It is too early to say where the COVID-19 pandemic will go, but it is past time to talk about what went wrong and how we can do better.

This book thoroughly covers each subfield of respiratory mechanics: pulmonary mechanics, the respiratory pump, and flow. It presents the current understanding of the field and serves as a guide to the scientific literature from the golden age of respiratory mechanics, 1960 - 2010. Specific topics covered include the contributions of surface tension and tissue forces to lung recoil, the gravitational deformation of the lung, and the interdependence forces that act on pulmonary airways and blood vessels. The geometry and kinematics of the ribs is also covered in detail, as well as the respiratory action of the external and internal intercostal muscles, the mechanics of the diaphragm, and the quantitative compartmental models of the chest wall is also described. Additionally, flow in the airways is covered thoroughly, including the wave-speed and viscous expiratory flow-limiting mechanisms; convection, diffusion and the stationary front; and the distribution of ventilation. This is an ideal book for respiratory physiologists, pneumologists, exercise physiologists, and critical care physicians. This book also: Maximizes reader insights into current and landmark respiratory mechanics researchConcisely yet thoroughly explores the current research on pulmonary mechanics, the respiratory pump, and flow Serves as an invaluable guide for those entering the field, or those seeking to expand their knowledge of it