The 2nd edition of this book describes the recent techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill, defined as those who have acute failure of at least one organ, due to either a pathological condition or a medical intervention, and require intensive care treatment. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as noninvasive mechanical ventilation, protective ventilation, prone positioning, intravenous salbutamol in ARDS, high-frequency oscillatory ventilation, mild hypothermia after cardiac arrest, daily interruption of sedatives, tranexamic acid, diaspirin cross-linked hemoglobin, albumin, growth hormone, glutamine supplementation, tight glucose control, supranormal oxygen delivery, and hydroxyethyl starch in sepsis. The topics selection was performed with the help of hundreds of specialists from dozens of countries; they expressed via web if they agreed or not with these topics and if they used them in their daily clinical practice. The clear text is supported by "how to do" sections and "key point" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in Critically Ill Patients is of interest for a wide variety of specialists, including intensivists, emergency doctors, and anesthesiologists.

This book discusses all aspects of pulmonary pathology, including different bacterial, viral, fungal, mycoplasma and protozoan pathogens, accompanied by illustrations that show macro- and histopathological changes. It also presents microbiological, epidemiological and clinical data, with a particular focus on pneumonias of different bacterial aetiologies, influenza, and other viral infections. Further, the book explores the importance of mixed infections, including those in the late stages of HIV infections and virus-bacterial pneumonias, as well as pathological changes in modern tuberculosis, lung granuloma, and respiratory tract inflammation in different age groups.

The third edition of a classic work originally published by Lippincott Raven. Tuberous Sclerosis is a genetic disease characterized by lesions of the skin and central nervous system, seizures, and sometimes severe mental retardation. This revised edition will include biological analysis of underlying genetic causes.

The book describes how changes in respiration can affect the heart and circulation, with particular reference to the control of the two systems by small organs, known as chemoreceptors, which are situated in the neck and chest. These are stimulated when the body is partly deprived of an oxygen supply. Apart from a detailed description of the mechanisms by which the respiratory and circulatory systems are integrated the book also contains chapters which would appeal to those interested in the historical, morphological, medico-legal and clinical aspects of the subject.

This book addresses an unmet need in the care of adolescents and young adults with lung disease. The increasing survival of young adults with childhood-onset pulmonary conditions is a testament to major advances in treatments and health care delivery. With the increase in survival of children with chronic respiratory conditions, there is a need for formalized transition programs to integrate adolescents and young adults into the adult model of care. This book helps fill gaps in knowledge to best achieve that initiative. This book takes a comprehensive approach to transition care in pulmonary medicine by satisfying the following objectives: 1) Understand the barriers and developmental challenges in the transition from pediatric to adult care for patients with chronic childhood-onset pulmonary disease; 2) Learn about successful evidence based transition models in pulmonary disease populations, focusing on key process and outcome measures for success; and 3) Develop knowledge to design, implement, and measure a transition program based on evidence and expert opinion. In the first section, the book outlines general principles of transition care that are applicable to all patients regardless of underlying disease process and describe best practices for performing necessary research in transition care. In the second section, the book explores psychosocial factors known to play a role in affecting transition outcomes, including parental support, psychological development, and socioeconomic factors. In the final section, transition outcomes and best practices in specific respiratory diseases are outlined. With a focus on populations with chronic pulmonary disease, this book highlights the challenges and barriers of transition, reviews model systems to understand the essential components of a transition program, and provides evidence-based information to navigate these barriers and achieve successful outcomes during transition to adulthood. This is an ideal guide for pediatric and adult pulmonary providers caring for patients who are transition age, as well as multidisciplinary care team members who work with these providers in care models on transition projects to improve the transition process.

How does it feel to confront a pandemic from the inside, one patient at a time? To bridge the gulf between a perilously unwell patient in quarantine and their distraught family outside? To be uncertain whether the protective equipment you wear fits the science or the size of the government stockpile? To strive your utmost to maintain your humanity even while barricaded behind visors and masks? Rachel is a palliative care doctor who looked after the most gravely unwell patients on the Covid-19 wards of her hospital. Amid the tensions, fatigue and rising death toll, she witnessed the courage of patients and NHS staff alike in conditions of unprecedented adversity. For all the bleakness and fear, she found that moments that could stop you in your tracks abounded. People who rose to their best, upon facing the worst, as a microbe laid waste to the population. Her new book, Breathtaking, is an unflinching insider's account of medicine in the time of coronavirus. Drawing on testimony from nursing, acute and intensive care colleagues - as well as, crucially, her patients - Clarke argue that this age of contagion has inspired a profound attentiveness to - and gratitude for - what matters most in life.

Understanding Lung Cancer, Second Edition, defines lung cancer and describes the two main types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Fully up to date with current guidelines, the chart describes how lung cancer is diagnosed and staged and lists risk factors, signs and symptoms, and treatment options. The main lung image shows the left upper lobe and left lower lobe with metastasis to paratracheal lymph nodes, metastasis to carinal lymph nodes, and a close-up, inset image of a tumor projecting into bronchi. The chart also describes how lung cancer can be prevented, includes a graphic showing how to calculate number of "pack years" along with an image of a cigarette in ashtray and the statistic that approximately 90 percent of lung cancer deaths are related to smoking. Featured sections: Risk Factors Signs and Symptoms Risk Factors Diagnosis and Staging Treatment Options How Can Lung Cancer Be Prevented? What's a Pack Year? 20" x 26" heavy paper laminated with grommets at top corners

"Extracorporeal Membrane Oxygenation : An Interdisciplinary Problem-Based Learning Approach" provides an overview of the latest techniques, management strategies and technology surrounding the clinical use of ECMO. This interdisciplinary book reviews the most common scenarios of ECMO in 62 chapters exploring the conditions and problems arising in ECMO practice. Each chapter begins with a stem case, followed by open questions to encourage critical thinking and enable the reader to follow the management strategies of the authors, who are world leaders in the field. Followed by an evidence-based discussion, each chapter concludes with multiple-choice questions for self-assessment. This book is current in its knowledge of organ systems and management and keeps pace with new ECMO technology and surgical techniques coupled with current guidelines for management. Starting with the history of ECMO to technical aspects, circuit biocompatibility and interaction with blood, drugs and flow physics, the volume continues into pediatric and adult sections, focussing on both respiratory and cardiovascular support, followed by a section on trauma. The volume then concludes with a section on neurologic complications and ethics, as well as rehabilitation and ambulation of ECMO patients. In addition, to reflect the current global health situation, this book also includes a chapter on ECMO management in patients suffering with COVID-19, to cover the most urgent and pressing questions around ECMO during the ongoing pandemic. This is the first ECMO book on the market to utilise a problem-based learning approach and as such is an important unprecedented project on ECMO education.

This detailed book serves as a laboratory manual containing vital protocols and in-depth discussion involving commonly used experimental approaches for the characterization of several aspects of lung tumor biology. Beginning with an extensive section on biomarker detection, the volume continues with chapters on the genetic and molecular characterization of lung cancer biological samples as well as protocols for the generation of research tools and pre-clinical lung cancer models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Lung Cancer: Methods and Protocols provides a global perspective of research efforts related to lung cancer, while allowing researchers to experimentally probe the different aspects of lung cancer research, including the experimentally relevant tests used in the establishment of lung cancer diagnosis and prognosis, in their laboratories.

This book provides comprehensive coverage of all aspects related to pediatric sleep and its associated disorders. It addresses the ontogeny and maturational aspects of physiological sleep and circadian rhythms, as well as the effects of sleep on the various organ systems as a function of development. Organized into nine sections, the book begins with a basic introduction to sleep, and proceeds into an extensive coverage of normative sleep and functional homeostasis. Part three then concisely examines the humoral and developmental aspects of sleep, namely the emerging role of metabolic tissue and the intestinal microbiota in regulation. Parts four, five, and six discuss diagnoses methods, techniques in sleep measurement, and specific aspects of pharmacotherapy and ventilator support for the pediatric patient. Various sleep disorders are explored in part seven, followed by an in-depth analysis of obstructive sleep apnea in part eight. The book concludes with discussions on the presence of sleep issues in other disorders such as Down syndrome, obesity, cystic fibrosis, and asthma. Written by recognized leaders in the field, Pediatric Sleep Medicine facilitates an extensive learning experience for practicing physicians who encounter specific sleep-related issues in their practice.

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Gain a solid understanding of neonatal and pediatric diseases as you explore real-world patient experiences with this unique resource.

Inside, you'll find everything you need to know about perinatal lung diseases - common neonatal complications - congenital diseases - pediatric pulmonary and upper airway diseases - and neuromuscular disorders. A streamlined presentation helps you easily grasp the background, pathophysiology, clinical manifestations, management and treatment, and the course and prognosis of each disease. In every chapter, unfolding case studies with full-color illustrations and photographs enhance your critical-thinking skills, making it easy to connect theory with practice. Plus, multiple-choice review questions help you assess your progress. Explore MORE online at DavisPlus Access your complete text online with the Davis Digital Version and gain additional practice with Student Questions and Interactive Case Studies. Redeem the Plus Code, inside new, printed texts, to access these DavisPlus Premium Resources.

This book covers relevant concepts in nuclear cardiology, combining imaging techniques and clinical data to do so. Today, nuclear cardiology is a worldwide discipline connected to the broader field of cardiovascular imaging. The combination of clinical aspects (symptoms, medications, previous cardiac procedures), ancillary exams and nuclear images is key to decision-making in clinical practice. Thus, a book on this topic is essential to provide better outcomes for cardiology patients. The chapters cover a comprehensive range of topics in current cardiology practice, such as ambulatory patients, patients in emergency settings, patients after complex cardiac procedures, and patients during and after the use of cancer therapies that are potentially toxic for the heart (cardio-oncology). As such, multiple clinical scenarios are also presented: patients with suspected coronary disease, patients with heart failure of unknown origin, patients with acute chest pain in the emergency department, patients with suspected pulmonary embolism, patients with complications of the left ventricular assist device, etc. Furthermore, the book describes nuclear cardiology procedures and techniques, discusses the main clinical indications and scenarios for each procedure, presents new technological advances in the field (machine learning and artificial intelligence tools), and mentions the coronavirus disease 2019 (COVID-19) pandemic. Given its scope, the book offers a valuable guide and videos for various medical professionals, especially cardiologists and nuclear physicians.

Selected as a Doody's Core Title for 2022! Practical and clinically relevant, Hyatt's Interpretation of Pulmonary Function Tests provides user-friendly coverage of all types of pulmonary function testing as it applies to a wide range of disease conditions. In this revised 5th Edition, Dr. Paul D. Scanlon expands upon the tradition of excellence begun by renowned pulmonary physiologist and father of the flow-volume curve, Dr. Robert E. Hyatt. A new two-color design, new and reorganized cases, and revised and expanded content keep you up to date with all that's new in the field. Provides a solid basis for administering and interpreting pulmonary function tests, making it an ideal resource for pulmonologists, fellows, and other healthcare practitioners who have a basic knowledge of pulmonary physiology. Offers valuable guidance for day-to-day clinical work, featuring chapters such as "When to Test and What to Order" and "Approaches to Interpreting Pulmonary Function Tests." Features a new section on the interpretation of complex tests, including the nonspecific pattern, mixed obstruction with restriction, and the complex restrictive pattern. Includes more than 40 illustrative cases for self-testing and reinforcing the principles discussed in the text, as well as clear illustrations that demonstrate dozens of PFT patterns. Contains expert "pearls" regarding performance and interpretation of key tests. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This book is a comprehensive reference on diffuse cystic lung diseases (DCLDs). DCLDs are a group of pathophysiologically heterogenous processes that are characterized by the presence of multiple spherical or irregularly shaped, thin-walled, air-filled spaces within the pulmonary parenchyma. In recent years, tremendous advancements have been made in these diseases leading to improved understanding of the underlying pathophysiology, and improved outcomes with targeted therapies. The authors, who are leading experts in the field, delineate DCLDs as a separate category distinct from other interstitial lung diseases, and have created this textbook specifically dedicated to this disease group. This book begins with a chapter introducing the definition and classification of DCLDs. Subsequent chapters address the pathogenic mechanisms underlying pulmonary cyst formation and provide a detailed overview of the radiological and pathological features of DCLDs. The common as well as uncommon causes of DCLDs are comprehensively reviewed in individual chapters, as are the varied clinical presentations and extrapulmonary manifestations, and approaches to management and treatment. The book culminates in a final chapter that presents a practical algorithmic approach to diagnosis that progresses from least invasive to most invasive approaches. This textbook provides a one-stop, comprehensive and integrated, clinical, radiologic, and pathologic overview of DCLDs that will be as useful to the practicing clinician as it is to the clinical investigator.

A must-have reference for the entire NICU, Goldsmith's Assisted Ventilation of the Neonate, 7th Edition, is the only fully comprehensive, evidence-based guide to all aspects of this fast-changing field. Easy to use and multidisciplinary in scope, this trusted reference provides authoritative guidance on contemporary management of neonatal respiratory diseases, with an emphasis on evidence-based pharmacologic and technologic advances that improve outcomes and quality of life in newborns. It's an outstanding resource for neonatologists and NICU professionals to acquire new knowledge and techniques in this critical area of neonatal care. Covers all aspects of both basic and advanced respiratory management of neonates: general principles and concepts; assessment, diagnosis and monitoring methods; therapeutic respiratory interventions; adjunctive interventions; and special situations and outcomes. Provides updated content on rapidly changing technology and guidelines for assisted ventilation, with up-to-date descriptions of bedside methodologies and the rationale for providing all types of ventilator care in infants. Contains new chapters on respiratory gas conditioning, diagnosis and management of PPHN, care of the infant with CDH, gaps in knowledge, and future directions. Includes significant updates on cardiovascular assessment and management, as well as complications of respiratory support. Provides extensive, full-color visual support with photographs, drawings, charts and diagrams, and radiographic images throughout. Features more than 30 appendices that help you quickly find normal values, assessment charts, ICU flow charts, procedure steps and other useful, printable forms. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Asthma is a chronic airway disease affecting over 300 million people worldwide with an expected increase of an additional 100 million by 2025. Past decade has observed a notable increase in asthma prevalence on both national and global levels with highest rates observed in western countries (about 30%). Over the past 40 years, a drastic increase in global prevalence, morbidity, mortality, and economic burden have been observed due to asthma especially in children. The rising numbers of hospital admissions for asthma, especially young children, reflect an increase in severe asthma, poverty and lack of proper disease management. Worldwide, approximately 180,000 deaths annually are caused due to this condition. The financial burden on a single asthma patient per year in different western countries ranges from US$300-1,300. Asthma is an intricate respiratory disorder with differences in its severity, natural history and hence treatment response. These differences in intensities of various presentations such as bronchial hyper-responsiveness, airway inflammation, mucus production, airflow obstruction make asthma a heterogeneous disease. The mainstay of current therapies for asthma includes inhaled corticosteroids, phosphodiesterase inhibitors, leukotriene modifiers and 2-adrenoceptor agonists. Some of the currently available drugs are efficient in one or more aspects. However the associated side effects or heterogeneity of the disease limit their usefulness and efficacy, thereby putting a demand on development of new drugs and therapies. On the other hand, asthma has also been treated/managed via herbal medications. These approaches have been described in Unani, Ayurvedic or Chinese system of medicine since antiquity. In fact, several anti-asthmatic drugs were developed from herbs commonly utilized in the non-Western system of medicine. This book focuses on the pathophysiology of asthma, its medication (both herbal and modern), limitations and their future prospects.

An updated edition of the essential guide to dealing with common respiratory illness, featuring a new chapter offering practical strategies on how to prevent, treat, and recover from Covid-19. From cold and flu to pneumonia and bronchitis; from tonsillitis and sinusitis to SARS, eminent pulmonologist Neil Schachter, M.D., explains how to treat and prevent common respiratory illnesses and protect yourself from Covid-19. The Good Doctor's Guide to Colds and Flu shows how to avoid illness, boost immunity, and combat congestion, fever, and discomfort when cold, flu, and other infections strike. Dr. Schachter provides the latest and most effective information and advice to help you protect your health including: Six prevention and treatment plans for the six most common respiratory infections: colds, influenza, sinusitis, bronchitis, tonsillitis, and pneumonia The four stages of a cold, and one of the best ways to avoid catching one Conflicting research on well-known cold remedies such as Vitamin C, Zinc, and Echinacea The four major types of pneumonias, and the prevention technique that can eliminate more than 80 organisms that cause it Why humming five seconds a day can reduce risk of sinus problems The surprising reason why women catch more colds The five best ways to conquer a cough Three symptoms that signal it's time to call a doctor And much more

Mechanical ventilators have long been an integral part of the care of patients with acute and chronic respiratory failure, and the recent COVID-19 pandemic has further underscored the need for greater understanding of the basic principles of their use in today’s ICU. Mechanical Ventilation for Respiratory Failure: Demystifying the Box in the Corner of the Room, by Drs. Richard M. Schwartzstein, Jeremy B. Richards, and Elias N. Baedorf-Kassis, is an easy-to-read, accessible text covering must-know information in this essential area—from basic and core principles to advanced topics in the field.  Outlines the core physiological principles critical for understanding the use of mechanical ventilators as life-saving treatment for respiratory failure, and describes how to apply those principles to basic modes of ventilation  Explains how to use mechanical ventilation for common diseases that cause acute respiratory failure  Addresses special topics such as esophageal balloons, advanced modes of ventilation, ventilator asynchrony, and more  An ideal reference for residents on ICU rotations; critical care nurses, practitioners, and fellows; and respiratory therapists    Enrich Your eBook Reading Experience  Read directly on your preferred device(s), such as computer, tablet, or smartphone.  Easily convert to audiobook, powering your content with natural language text-to-speech. 

This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases. The lungs of humans and animals are under constant threat from oxidants from either endogenous (e.g. in situ metabolic reactions) or exogenous sources (e.g. air pollutants). Further, oxidative stress causes the oxidation of proteins, DNA and lipids, which in turn generates secondary metabolic products. The book consists of sections, each focusing on different aspects of oxidant-mediated lung diseases. As such it is a unique reference resource for postgraduate students, biomedical researchers and also for the clinicians who are interested in studying and understanding oxidant-mediated lung diseases. The second volume will incorporate other aspects of oxidant-mediated lung diseases, including prevention and therapeutics.

This book discusses a wide range of investigations and practice-oriented advances in pulmonary medicine and critical care. Pulmonary diseases are a major cause of hospitalization and mortality, affecting millions of people worldwide. Addressing a range of topics, including chronic obstructive pulmonary disease, sleep apnea, and lung cancer, the book offers insights into the disease mechanisms and risk factors, along with practical aspects concerning the maintenance of quality of life, adherence to therapy, and palliative treatment and care. Further, it explores diagnostic and treatment approaches to respiratory dysfunction and respiratory failure, highlighting the beneficial effects of good sleep quality in chronic pulmonary conditions and lung transplant patients. The book also presents novel experimental research on the cellular voltage-gated sodium channels in the mechanism of pathological cough, which is particularly relevant for future targeted antitussive therapy. Lastly, it addresses the epidemiological aspects of pulmonary infections. As such, this book is a valuable resource for medical scholars, clinicians, family physicians, and other professionals seeking to improve the management of respiratory diseases.

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient's genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

This is the second volume of the comprehensive, two-volume work on oxidative stress in lung diseases. Adopting a multidisciplinary approach, it demonstrates the cellular and molecular mechanisms associated with ROS (reactive oxygen species)-induced initiation and progression of a variety of lung diseases, such as COPD, emphysema, asthma, cystic fibrosis, occupational pulmonary diseases and pulmonary hypertension and discusses points for therapeutic intervention. The book also covers translational research and the latest research on prevention and therapeutics. Each chapter includes in-depth insights into the mechanisms associated with lung diseases and into identifying targets for drug development. Bridging the gap between fundamental and translational research, and examining applications in the biomedical and pharmaceutical industry, it is a thought- provoking read for basic and applied scientists engaged in biomedical research.

This book presents original articles that report on new approaches and developments involving pulmonary disorders. Pulmonary health attracts public concern as lungs are the first line of defense of the organism against various contagions and are directly influenced by all too often unhealthy constituents of ambient air, which make them vulnerable to diseases. The articles deal with the pathogenic background and most relevant practical aspects of the widespread pulmonary disorders. Topics include the mechanisms and treatment options of sleep apnea syndrome, occupational exposure to carbon dioxide, and the research on prognostic factors in lung cancer. Another theme tackles quality of life in chronic pathologies and the psychosocial factors, often underestimated, having influence on lung function already in adolescence, and thus liable to shape adult pulmonary morbidity. Reports on the course of recent influenza outbreaks and a rather dismal state of anti-influenza measures top off the content. The volume is addressed to clinicians and researchers, pulmonary doctors, and other professionals engaged in patient care and therapy.