With cutting-edge and clinically relevant information, MECHANICAL VENTILATION, 2nd Edition takes a practical, clinical approach to the principles and practice of mechanical ventilation. This informative resource explains mechanical ventilation decisions and procedures in real-world terms so information is easy to understand and apply. This thoroughly updated edition includes one new chapter, four completely updated chapters, and a wealth of new user-friendly features. Detailed, clinically focused coverage of the application of mechanical ventilation to the most common respiratory diseases, provides practical answers to real life problems. UNIQUE! Sections of chapters on Special Techniques and Future Therapies include information on the newest techniques for treating patients in respiratory distress. A separate appendix of case studies helps you apply what you've learned to realistic situations. Well-known and respected authors, Neil MacIntyre and Rich Branson, share their vast expertise and accurate, cutting-edge information. Chapter Objectives, Key Point Summaries, and Assessment Questions reinforce basic concepts from each chapter. New chapter on Unique Patient Populations highlights the mechanical ventilation issues of traumatic brain injury, neuromuscular disease, lung transplantation, burn injury, and perioperative patient populations. Expanded glossary includes relevant terminology and key terms to help you easily find unfamiliar terminology.

Respiratory system and artificial ventilation are key topics when considering the main aspects of Anaesthesiology and Critical Care Medicine: assisted ventilation techniques are essential to preserve the patient s life, but just as any other treatments they can be also extremely pernicious.

Scientific research and clinical evidences are equally fundamental in investigating the best methods to provide effective support and increase positive outcomes. It is obviously desirable that this knowledge and know-how are widely shared among scientists and practitioners.

With this purpose, the book includes contributions by an international panel of authors and gathers their varied and valuable expertise up to illustrate principles, study results and case experiences on respiratory physiopathology, respiratory mechanics, respiratory functions monitoring, artificial ventilation and diagnostic radiology in respiratory dysfunction failure.

We trust it can represent a precious reference for professionals in their ongoing self-improvement process to increase skilfulness. Furthermore, we hope that this book can serve as a useful learning tool for medical students and can contribute to the education of future anaesthesiologists and intensivists."

This book discusses a wide range of investigations and practice-oriented advances in pulmonary medicine and critical care. Pulmonary diseases are a major cause of hospitalization and mortality, affecting millions of people worldwide. Addressing a range of topics, including chronic obstructive pulmonary disease, sleep apnea, and lung cancer, the book offers insights into the disease mechanisms and risk factors, along with practical aspects concerning the maintenance of quality of life, adherence to therapy, and palliative treatment and care. Further, it explores diagnostic and treatment approaches to respiratory dysfunction and respiratory failure, highlighting the beneficial effects of good sleep quality in chronic pulmonary conditions and lung transplant patients. The book also presents novel experimental research on the cellular voltage-gated sodium channels in the mechanism of pathological cough, which is particularly relevant for future targeted antitussive therapy. Lastly, it addresses the epidemiological aspects of pulmonary infections. As such, this book is a valuable resource for medical scholars, clinicians, family physicians, and other professionals seeking to improve the management of respiratory diseases.

Dedicated to dealing with a challenging disease, previously thought to be incurable, but with the advent of new drugs, now amenable to management and a much improved prognosis for patients.

- Latest publication in a fast-moving area of keen clinical interest
- Authored by leading international authorities
- Builds on success of a respected first edition
- Incorporates new data on latest imaging technologies and therapies
- Covers both the science and clinical aspects, including presentation, surgical intervention and drug therapy
- Includes coverage of both Pulmonary Embolism and Deep Vein Thrombosis

A concise review of the epidemiology, pathogenesis, and management of common respiratory conditions seen in a primary care setting. Using an illuminating case-based approach, Dr. Mintz assesses the key clinical questions that a primary care physician would ask and applies the most up-to-date research and guidelines to offer the practitioner evidence-based solutions. The author covers the range of knowledge needed to provide excellent care for patients with respiratory disease, from the basics of pulmonary function testing to understanding and caring for common respiratory illnesses, including chronic obstructive pulmonary disease, asthma, allergic rhinitis, and pneumonia. For each disorder, Dr. Mintz explains the key points regarding the epidemiology of the disease, its pathophysiology, the differential diagnosis and diagnosis, and its recommended treatment. A special PDA version of Disorders of the Respiratory Tract: Common Challenges in Primary Care is also available.

A fully updated edition of a widely respected classic on the diagnosis and management of asthma in a variety of patient subpopulations. Though this fifth edition continues to emphasize the definition, medications, and use of asthma treatment plans, it also focuses on the special needs patient, including the pediatric patient, the pregnant patient, and the patient undergoing surgery, as well as on the perennial issues of exercise and asthma, pulmonary aspergillosis, occupation, recreational drug use, and psychological/social considerations. Highlights for the fifth edition include a liberal use of tables and charts to make the book more practical and user-friendly, updates on the many new pharmaceuticals used to treat asthma, and first-time sections on food sensitivity and the diagnosis of asthma.

The development of new therapeutic strategies and the minimization of both direct and indirect costs represent crucial goals in the management of chronic diseases, particularly when these are characterized by a high degree of disability.

Chronic respiratory insufficiency (CRI) represents an example of a persistent disease worldwide, for which home management (i.e., daily nursing and treatment) was introduced more than two decades ago according to traditional operating protocols. "Home long-term oxygen treatment" (H-LTOT) was expected to produce significant clinical improvements, together with a substantial drop in CRI social costs (e.g., hospital admissions, number of exacerbations, pharmaceutical costs, and patienta (TM)s reduced productivity).

The present volume describes the evolution in the home management of severe CRI over the last two decades in Italy. It reviews a range of topics including the epidemiological aspects, complicating events, current systems for oxygen delivery with the most convenient interfaces, changing approaches to the patient--caregiver relationship, and the economic burden. Particular attention is paid to the new trends in telemedicine, which is regarded as the future step in respiratory medicine for home-assisted and home-ventilated patients. Data concerning the new role of nursing, the patienta (TM)s expectation of life, and the patienta (TM)s, family's, and doctora (TM)s perspective are also reported, together with an update on the economic impact of telemedicine and the continuing improvements in the quality of telematic H-OTLT.

Many international experts collaborated in creating this groundbreaking work, a principal-coding system, and in developing reference films and imaging parameters for the" "International Classification of HRCT for Occupational and Environmental Respiratory Diseases. The book is an authoritative guide to the recognition of dust diseases of the lung, using radiological imaging techniques, with special emphasis on high-resolution computerized tomography (CT). The classification is a powerful, essential tool for recording patient data on CT in a globally standardized semiquantitative way. The system is also applicable to surveillance and screening for occupational and environmental respiratory diseases. The book is a valuable resource not only for radiologists but for all who work in occupational medicine and public health.

-SARS has received much attention and coverage by the media and has a high impact on the public making this a hot research topic for scientists.

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Respiratory failure is a complex disease process whereby the underlying disease and therapeutic measures interact. The patienta (TM)s outcome is determined by a variety of factors including how we use therapeutic maneuvers such as mechanical ventilation for prevention of complications, e.g., ventilator associated pneumonia. This book is a comprehensive review of all aspects of acute respiratory failure, providing critical reviews of various topics related to respiratory failure and discussing the clinical evidence available for the diagnoses and management of patients with respiratory failure.

This book contains an extensive bibliographic review, focusing on preventive and therapeutic studies, that was methodologically standardized, with authors assessing and classifying studies according to statutes of evidence-based medicine. It considers epidemiology and outcome of mechanical ventilation; addresses ventilator modes and utility of pulmonary mechanics monitoring for treatment; analyzes physiologic effect and patient-outcomes of pulmonary recruitment and lung protective ventilation procedures; describes complications that can be present in these patients such as ventilator associated pneumonia and useful methods to prevent respiratory infections; covers the impact of bronchodilators, corticosteroids, and antibiotics in acute exacerbation of chronic obstructive pulmonary disease; discusses how, when, and in whom to do tracheostomy; and evaluates the use of sedation and neuromuscular blockade, as well as current clinical trials in acute lung injury.

In summary, this book on the Evidence-based Management of Patients with Respiratory Failure provides important information toimprove patient outcome by clearly identifying the research evidence that we can apply in daily clinical practice.

The Methods in Molecular Medicine series is intended as a resource for both novice and experienced investigators attempting to diversify their tech- logical base in research. Lung Cancer: Volume 1: Molecular Pathology Me- ods and Reviews presents an overview of the current status of assays employed to detect and characterize the multitude of pathologies that contribute to the development of this deadly disease. As with all volumes in the Methods in Molecular Medicine series, the reader should find that each methods-based chapter provides clear instructions for the performance of various protocols, supplemented by additional technical notes that provide valuable insight. These notes are designed to enable the reader to acquire the techniques described with a proficiency not easily achieved by re- ing standard method formats. No volume can exhaustively cover every aspect of biological research and there will be gaps in this endeavor that one or another research group will id- tify. Each section herein could readily be expanded into a book in its own right. However, I have sought to include a spectrum of techniques that should allow for the acquisition of key skills in each area covered.

This work, Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews, in the Methods in Molecular Medicine series presents an overview of the current status of those methods useful in the diagnosis and tre- ment of lung cancer-both as it exists in the clinic and as it is being revoluti- ized in the laboratory. The book is intended to serve as a resource for researchers wishing to increase their knowledge of current and cutting edge technologies, in order that their investigations into neoplasms of the lung may benefit from this enriched diversity of techniques and approaches. Owing to the complex nature of the disease and the variety of methods available to analyze and attack it, no volume attempting to define diagnostic and therapeutic approaches to lung cancer can ever be complete. The sheer number of investigators involved in lung cancer research guarantees that some aspect will be inadvertently excluded. However, I hope that the range of techniques included herein will serve to open up new avenues of investigation for both the novice and experienced researcher.

Lung cancer remains the leading cause of cancer-related death in men, and in women, it has surpassed even breast cancer. According to the American Cancer Society, in 2001, there will be about 169,500 new cases of lung cancer in the United States: 90,700 among men and 78,800 among women. LUNG CANCER is the second installment in the M. D. Anderson Cancer Care Series, featuring the current standard approach to lung cancer care from the experts at M. D. Anderson Cancer Center. Designed for the practicing oncologist, this clinical guidebook allows for quick, authoritative access to the latest and best multimodality therapies. Topics covered in this volume include the clinical examination of patients with suspected lung cancer, thoracic imaging techniques for non-small cell and small cell lung cancer, pathology of lung cancer, treatment and management of non-small and small-cell lung cancer, including the role of guidelines and clinical pathways, molecular events in lung cancer and implications for prevention and therapy, palliation, and much more. Each of the 15 chapters ends with an up-to-date list of suggested readings, as well as "key practice points" highlighting the most important principles and practices of each chapter for at-a-glance reference. Over 50 illustrations and 40 tables round out the text. This thorough, practical volume is the essential clinical guide for oncologists, surgeons, and all physicians involved in the care of patients with lung cancer.

Mechanical ventilation and weaning is one of the most common procedures carried out in critically ill patients. Appropriate management of these patients is of paramount importance to improve the outcome in terms of both morbidity and mortality. This book offers the physiological and clinical basis required to improve the care delivered to patients undergoing mechanical ventilation.

Alan B. Weitberg, MD, and a panel of internationally recognized basic scientists and clinicians present a comprehensive discussion of lung cancer, including a practice-oriented review of its diagnosis, evaluation, and treatment. The contributors offer not only an understandable description of its molecular origins-an essential key to developing future therapies and preventive measures-but also rigorously discuss well-tested approaches, as well as those that are currently being evaluated for future use in both the laboratory and clinic. The book also elucidates the creation and effective deployment of treatment guidelines introduced by third party payers to improve clinical outcomes, even while lowering healthcare costs.

This book provides practising clinicians with the relevant information for the diagnosis and management of COPD patients. Chronic obstructive pulmonary disease (or chronic bronchitis and emphysema) is a common cause of lost work days and ranks high in the list of causes of death. This volume covers all aspects of the disease. After discussing basic science, the emphasis is on the clinical management of these patients. It discusses specific problems, such as sleep problems, and includes recent trends, future perspectives and new developments in therapeutics.

Chronic Obstructive Pulmonary Disease (COPD) Diagnosis using Electromyography (EMG) presents a new and innovative method of COPD diagnosis using EMG to analyze sternomastoid muscle activity using features extraction and classification. The book describes the methodology of EMG analysis, the slope-based onset detection algorithm and SEMG analysis in time, frequency and time frequency domain analyses. It also explores the identification of frequencies for single frequency Continuous Wavelet Transform (CWT) analysis and feature extraction and selection for successful classification COPD into its severity grades. The book provides a compilation of all techniques used in the literatures and emphasizes newly proposed techniques for the early detection of COPD. Fully comprehensive, the book includes discussion of limitations of existing methods for COPD diagnosis and introduces new efficient methods for COPD identification, classification and early diagnosis.

This title contains a book & DVD. About the DVD: The best-selling book "Arterial Blood Gas Analysis Made Easy" discussion and excerpts are now also available in a DVD movie format. Watch this 55 minute presentation by Dr Anup, MD and learn complex topics like ABG Report, Sa02, Pulse Oximetry, Pa02, PACO2, PaCO2, Fi02, Sp02, A-a Gradient, Ca02, pH, BE and much more. Understand these parameters and common pitfalls while interpreting them. The presentation narrative uses very simple, easy-to-understand language. The viewer will find that the difficult to understand topic of ABGs becomes interesting and easy. This DVD is a must for any new resident in Internal Medicine, Casualty and intensive care units (ICU) and will further facilitate and expedite learning of the blood gas report analysis. Approximate running time: 55 minutes. About the Book: Learn basics about how to read a blood gas report. What are the principle components, how they are derived and what is their significance? This includes pH, PaCO2, PCO2, PaO2, PAO2, FiO2, CaO2, A-a gradient, SaO2, HCO3, Pulse oximetry, Carbon-monoxide poisoning, Hyperbaric Chamber. This is section I of the book. Section II of the book is a work book approach where the doctor learns to interpret blood gases from the given report (emphasis is not to use the graph) in a step by step manner. One learns to interpret simple and mixed disorders including Respiratory Acidosis, Metabolic Acidosis, Anion gap and Non Anion Gap Acidosis, Respiratory Alkalosis, Metabolic Alkalosis, Chloride Responsive and Non-Responsive Alkalosis, Mixed Disorders and common mistakes made while interpreting a blood gas report and how to avoid them. Each disorder is separately explained. Section III further challenges the resident with over 200 exercises on blood gases. Section IV is the summary of the book.

Chlamydia pneumoniae is now recognized as an important human pathogen. Chlamydia pneumoniae is involved in 5%-15% of community acquired pneumonias, and recent data indicate its relevance in severe pneumonia and as a respiratory pathogen in immunocompromised subjects. A causal role for Chlamydia pneumoniae in the initiation, exacerbations and promotion of asthma has been suggested. Approximately 5% of chronic bronchitis exacerbations have been attributed to Chlamydia pneumoniae infections, and chronic infection may facilitate access of other pathogens to the lower respiratory tract. Another field of potential great social impact is the possible involvement of Chlamydia pneumoniae in the pathogenesis of atherosclerosis and related cardiovascular diseases. This book presents the current state-of-the-art knowledge on Chlamydia pneumoniae infection and highlights future lines of research.

In the 15 years of the acquired immunodeficiency syndrome (AIDS) pandemic much has been learnt about its natural history and complications. It is clear that the lung is a major target organ both for the human immunodeficiency virus (HIV), and a wide array of infectious and non-infectious pulmonary complications. A great deal of information on the epidemiology, microbiology, immunology, clinical features, diagnosis and management of these pulmonary complications has accumulated during the past 15 years. Given the enormous explosion in information, it is now timely to bring together this knowledge in this 25-chapter volume on AIDS and respiratory medicine. The contributors to this volume are prominent epidemiologists, doctors, microbiologists and scientists from Europe, USA and Africa. Professors Chretien and Enarson give a masterful account of the epidemiology of lung complications of HIV. Drs Zumla, Rowland Jones and Professor McMichael give a detailed summary of the lung immune responses to HIV. They outline normal lung defenses and discuss the consequences of HIV infection on them. The pulmonary radiological features of HIV and its complications as seen in the USA and Europe are illustrated by Professors Armstrong and Dee and this is compared and contrasted by Professor Tshibwabwa-Tumba who brings together his vast experience of chest X-rays in AIDS patients from Central Africa. Drs O'Doherty and Miller deal with the uses, and potential applications, of nuclear medicine in imaging of the chest in AIDS patients."

This text provides a practical introduction to peak flow measurement, its indications, uses and benefits, and associated problems.;Asthma is a very common condition affecting at least 12 per cent of schoolchildren and 5 per cent of adults. Recent guidelines proposed by the British Thoracic Society for the management of chronic and acute asthma recommend the domiciliary use of the peak flow meter to assist doctors in the management of the condition, as well as helping the patient manage his or her own asthma flow. This illustrated guide gives the doctor instructions on the correct use of the meter as well as providing information on the benefits and limitations of the test. Worked case histories and "real" examples of classical peak flow histories can be found throughout the text. It should be of use to respiratory physicians, general practitioners, practice nurses, physiotherapists and other health professionals involved in the day-to-day care of asthma patients.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

This issue of Clinics in Chest Medicine, guest-edited by Dr. Margaret Pisani, is focused on Gender and Respiratory Disease. Topics discussed in this issue include but are not limited to: What are sex and gender and how can we study their impact in respiratory disease?, Sex differences in respiratory physiology, Impact of gender on social determinants of health, Gender differences in obstructive sleep apnea, Impact of gender on sleep disorders across the lifespan, Differences between men and women with COPD, Women and Lung Cancer, Pulmonary considerations in pregnant women and Asthma in women-gender specific considerations.

Great progress has been made since the first description of the acute respiratory distress syndrome by the Denver group in 1967 (Lancet). Although we introduced the term 'adult respiratory distress syndrome' in our second and more detailed description of the syndrome (ehest, 1971), this was probably amistake for the simple reason that children also suffer the same syndrome fo11owing acute lung insults. Today, the syndrome of acute respiratory distress in adults (ARDS) is recognized as a worldwide problem, but the prevalence of disease varies in different parts of the world. A huge amount of research has focused on the mechanisms of acute lung injury and yet the exact sequence of events and media tors in inflammatory cascade, which result in acute respiratory failure from ARDS, is not known but many possibilities exist. The definition of ARDS has been gradua11y modified in recent years and investigators around the world are now co11aborating in order to establish more uniform concepts in identification, risk factors and mechanisms of lung injury, which someday will result in improved approaches to management. Already, at least some centers are showing improved outcomes in ARDS, achieving an approximate 60% survival rate. In the past, most large series documented only about a 40% survivability taking a11 causes of ARDS. This apparent progress is likely attributable to more meticulous and disciplined care than any specific pharmacologic attack on the basic mechanism resulting in ARDS.