This book addresses an unmet need in the care of adolescents and young adults with lung disease. The increasing survival of young adults with childhood-onset pulmonary conditions is a testament to major advances in treatments and health care delivery. With the increase in survival of children with chronic respiratory conditions, there is a need for formalized transition programs to integrate adolescents and young adults into the adult model of care. This book helps fill gaps in knowledge to best achieve that initiative. This book takes a comprehensive approach to transition care in pulmonary medicine by satisfying the following objectives: 1) Understand the barriers and developmental challenges in the transition from pediatric to adult care for patients with chronic childhood-onset pulmonary disease; 2) Learn about successful evidence based transition models in pulmonary disease populations, focusing on key process and outcome measures for success; and 3) Develop knowledge to design, implement, and measure a transition program based on evidence and expert opinion. In the first section, the book outlines general principles of transition care that are applicable to all patients regardless of underlying disease process and describe best practices for performing necessary research in transition care. In the second section, the book explores psychosocial factors known to play a role in affecting transition outcomes, including parental support, psychological development, and socioeconomic factors. In the final section, transition outcomes and best practices in specific respiratory diseases are outlined. With a focus on populations with chronic pulmonary disease, this book highlights the challenges and barriers of transition, reviews model systems to understand the essential components of a transition program, and provides evidence-based information to navigate these barriers and achieve successful outcomes during transition to adulthood. This is an ideal guide for pediatric and adult pulmonary providers caring for patients who are transition age, as well as multidisciplinary care team members who work with these providers in care models on transition projects to improve the transition process.

This book provides comprehensive coverage of all aspects related to pediatric sleep and its associated disorders. It addresses the ontogeny and maturational aspects of physiological sleep and circadian rhythms, as well as the effects of sleep on the various organ systems as a function of development. Organized into nine sections, the book begins with a basic introduction to sleep, and proceeds into an extensive coverage of normative sleep and functional homeostasis. Part three then concisely examines the humoral and developmental aspects of sleep, namely the emerging role of metabolic tissue and the intestinal microbiota in regulation. Parts four, five, and six discuss diagnoses methods, techniques in sleep measurement, and specific aspects of pharmacotherapy and ventilator support for the pediatric patient. Various sleep disorders are explored in part seven, followed by an in-depth analysis of obstructive sleep apnea in part eight. The book concludes with discussions on the presence of sleep issues in other disorders such as Down syndrome, obesity, cystic fibrosis, and asthma. Written by recognized leaders in the field, Pediatric Sleep Medicine facilitates an extensive learning experience for practicing physicians who encounter specific sleep-related issues in their practice.

This detailed book serves as a laboratory manual containing vital protocols and in-depth discussion involving commonly used experimental approaches for the characterization of several aspects of lung tumor biology. Beginning with an extensive section on biomarker detection, the volume continues with chapters on the genetic and molecular characterization of lung cancer biological samples as well as protocols for the generation of research tools and pre-clinical lung cancer models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Lung Cancer: Methods and Protocols provides a global perspective of research efforts related to lung cancer, while allowing researchers to experimentally probe the different aspects of lung cancer research, including the experimentally relevant tests used in the establishment of lung cancer diagnosis and prognosis, in their laboratories.

This book covers relevant concepts in nuclear cardiology, combining imaging techniques and clinical data to do so. Today, nuclear cardiology is a worldwide discipline connected to the broader field of cardiovascular imaging. The combination of clinical aspects (symptoms, medications, previous cardiac procedures), ancillary exams and nuclear images is key to decision-making in clinical practice. Thus, a book on this topic is essential to provide better outcomes for cardiology patients. The chapters cover a comprehensive range of topics in current cardiology practice, such as ambulatory patients, patients in emergency settings, patients after complex cardiac procedures, and patients during and after the use of cancer therapies that are potentially toxic for the heart (cardio-oncology). As such, multiple clinical scenarios are also presented: patients with suspected coronary disease, patients with heart failure of unknown origin, patients with acute chest pain in the emergency department, patients with suspected pulmonary embolism, patients with complications of the left ventricular assist device, etc. Furthermore, the book describes nuclear cardiology procedures and techniques, discusses the main clinical indications and scenarios for each procedure, presents new technological advances in the field (machine learning and artificial intelligence tools), and mentions the coronavirus disease 2019 (COVID-19) pandemic. Given its scope, the book offers a valuable guide and videos for various medical professionals, especially cardiologists and nuclear physicians.

This book is a comprehensive reference on diffuse cystic lung diseases (DCLDs). DCLDs are a group of pathophysiologically heterogenous processes that are characterized by the presence of multiple spherical or irregularly shaped, thin-walled, air-filled spaces within the pulmonary parenchyma. In recent years, tremendous advancements have been made in these diseases leading to improved understanding of the underlying pathophysiology, and improved outcomes with targeted therapies. The authors, who are leading experts in the field, delineate DCLDs as a separate category distinct from other interstitial lung diseases, and have created this textbook specifically dedicated to this disease group. This book begins with a chapter introducing the definition and classification of DCLDs. Subsequent chapters address the pathogenic mechanisms underlying pulmonary cyst formation and provide a detailed overview of the radiological and pathological features of DCLDs. The common as well as uncommon causes of DCLDs are comprehensively reviewed in individual chapters, as are the varied clinical presentations and extrapulmonary manifestations, and approaches to management and treatment. The book culminates in a final chapter that presents a practical algorithmic approach to diagnosis that progresses from least invasive to most invasive approaches. This textbook provides a one-stop, comprehensive and integrated, clinical, radiologic, and pathologic overview of DCLDs that will be as useful to the practicing clinician as it is to the clinical investigator.

The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg's Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition. Integrates basic science into individual cancer chapters for more efficient reference Features quarterly updates that include late-breaking developments in oncology such as new drugs and clinical trials, as well as new case studies and interactive algorithms Offers balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist Provides updated content on immunotherapy and genetics throughout Includes important related topics such as cancer screening and prevention, palliative care, supportive oncology, and quality of life issues Now available in a convenient single volume, or a seven-multivolume option for portability and ease of use Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Asthma is a chronic airway disease affecting over 300 million people worldwide with an expected increase of an additional 100 million by 2025. Past decade has observed a notable increase in asthma prevalence on both national and global levels with highest rates observed in western countries (about 30%). Over the past 40 years, a drastic increase in global prevalence, morbidity, mortality, and economic burden have been observed due to asthma especially in children. The rising numbers of hospital admissions for asthma, especially young children, reflect an increase in severe asthma, poverty and lack of proper disease management. Worldwide, approximately 180,000 deaths annually are caused due to this condition. The financial burden on a single asthma patient per year in different western countries ranges from US$300-1,300. Asthma is an intricate respiratory disorder with differences in its severity, natural history and hence treatment response. These differences in intensities of various presentations such as bronchial hyper-responsiveness, airway inflammation, mucus production, airflow obstruction make asthma a heterogeneous disease. The mainstay of current therapies for asthma includes inhaled corticosteroids, phosphodiesterase inhibitors, leukotriene modifiers and 2-adrenoceptor agonists. Some of the currently available drugs are efficient in one or more aspects. However the associated side effects or heterogeneity of the disease limit their usefulness and efficacy, thereby putting a demand on development of new drugs and therapies. On the other hand, asthma has also been treated/managed via herbal medications. These approaches have been described in Unani, Ayurvedic or Chinese system of medicine since antiquity. In fact, several anti-asthmatic drugs were developed from herbs commonly utilized in the non-Western system of medicine. This book focuses on the pathophysiology of asthma, its medication (both herbal and modern), limitations and their future prospects.

The fifth edition of this seminal textbook continues to provide those who are studying or are in practice with comprehensive evidence-based coverage of all the main aspects of respiratory and cardiac physiotherapy throughout the whole lifespan - neonates, infants, children, adolescents and adults - with the patient at centre and advocating a problem-based approach. For the new edition, Jennifer Pryor and Ammani Prasad hand the baton of editorship and their lasting legacy over to Eleanor Main and Linda Denehy. With a team of over 60 international expert authors, the new editors have incorporated major changes reflecting current cardiorespiratory physiotherapy education and practice. These changes are heralded by a new title - Cardiorespiratory Physiotherapy: Adults and Paediatrics (formerly Physiotherapy for Respiratory and Cardiac Problems: Adults and Paediatrics) - and a significant restructure of the content with a new set of chapters. A new key chapter on anatomy and physiology of the respiratory system lays the foundation which is then followed by a chapter on clinical assessment of adults, infants and children, and acutely ill or deteriorating patients. Additional new content includes a chapter on outcome measurement in practice and a large chapter describing rehabilitation in acute and chronic conditions in special populations including spinal cord injury, oncology, trauma and paediatrics. The chapter on therapeutic interventions is comprehensive and reflective of evidence based practice. Integrates evidence with clinical practice Case studies used to facilitate problem solving Boxes throughout highlighting key issues and points Emphasizes the need for a holistic approach to patient care Bank of 350 images on Evolve Resources. Log on to https://evolve.elsevier.com/Main/cardiorespiratory and register to access. Newly appointed editors - Eleanor Main (UK) and Linda Denehy (Australia) Content restructure and overhaul with contributions from over 60 world leading experts Chapters on: Anatomy and physiology of the respiratory system Clinical assessment of the adult, infant/child and the acutely ill/deteriorating patient Outcome measurement in practice Therapeutic interventions Managing special populations Over 180 new figures including additional full-colour photographs

An updated edition of the essential guide to dealing with common respiratory illness, featuring a new chapter offering practical strategies on how to prevent, treat, and recover from Covid-19. From cold and flu to pneumonia and bronchitis; from tonsillitis and sinusitis to SARS, eminent pulmonologist Neil Schachter, M.D., explains how to treat and prevent common respiratory illnesses and protect yourself from Covid-19. The Good Doctor's Guide to Colds and Flu shows how to avoid illness, boost immunity, and combat congestion, fever, and discomfort when cold, flu, and other infections strike. Dr. Schachter provides the latest and most effective information and advice to help you protect your health including: Six prevention and treatment plans for the six most common respiratory infections: colds, influenza, sinusitis, bronchitis, tonsillitis, and pneumonia The four stages of a cold, and one of the best ways to avoid catching one Conflicting research on well-known cold remedies such as Vitamin C, Zinc, and Echinacea The four major types of pneumonias, and the prevention technique that can eliminate more than 80 organisms that cause it Why humming five seconds a day can reduce risk of sinus problems The surprising reason why women catch more colds The five best ways to conquer a cough Three symptoms that signal it's time to call a doctor And much more

This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases. The lungs of humans and animals are under constant threat from oxidants from either endogenous (e.g. in situ metabolic reactions) or exogenous sources (e.g. air pollutants). Further, oxidative stress causes the oxidation of proteins, DNA and lipids, which in turn generates secondary metabolic products. The book consists of sections, each focusing on different aspects of oxidant-mediated lung diseases. As such it is a unique reference resource for postgraduate students, biomedical researchers and also for the clinicians who are interested in studying and understanding oxidant-mediated lung diseases. The second volume will incorporate other aspects of oxidant-mediated lung diseases, including prevention and therapeutics.

This book discusses a wide range of investigations and practice-oriented advances in pulmonary medicine and critical care. Pulmonary diseases are a major cause of hospitalization and mortality, affecting millions of people worldwide. Addressing a range of topics, including chronic obstructive pulmonary disease, sleep apnea, and lung cancer, the book offers insights into the disease mechanisms and risk factors, along with practical aspects concerning the maintenance of quality of life, adherence to therapy, and palliative treatment and care. Further, it explores diagnostic and treatment approaches to respiratory dysfunction and respiratory failure, highlighting the beneficial effects of good sleep quality in chronic pulmonary conditions and lung transplant patients. The book also presents novel experimental research on the cellular voltage-gated sodium channels in the mechanism of pathological cough, which is particularly relevant for future targeted antitussive therapy. Lastly, it addresses the epidemiological aspects of pulmonary infections. As such, this book is a valuable resource for medical scholars, clinicians, family physicians, and other professionals seeking to improve the management of respiratory diseases.

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient's genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

This is the second volume of the comprehensive, two-volume work on oxidative stress in lung diseases. Adopting a multidisciplinary approach, it demonstrates the cellular and molecular mechanisms associated with ROS (reactive oxygen species)-induced initiation and progression of a variety of lung diseases, such as COPD, emphysema, asthma, cystic fibrosis, occupational pulmonary diseases and pulmonary hypertension and discusses points for therapeutic intervention. The book also covers translational research and the latest research on prevention and therapeutics. Each chapter includes in-depth insights into the mechanisms associated with lung diseases and into identifying targets for drug development. Bridging the gap between fundamental and translational research, and examining applications in the biomedical and pharmaceutical industry, it is a thought- provoking read for basic and applied scientists engaged in biomedical research.

This book presents original articles that report on new approaches and developments involving pulmonary disorders. Pulmonary health attracts public concern as lungs are the first line of defense of the organism against various contagions and are directly influenced by all too often unhealthy constituents of ambient air, which make them vulnerable to diseases. The articles deal with the pathogenic background and most relevant practical aspects of the widespread pulmonary disorders. Topics include the mechanisms and treatment options of sleep apnea syndrome, occupational exposure to carbon dioxide, and the research on prognostic factors in lung cancer. Another theme tackles quality of life in chronic pathologies and the psychosocial factors, often underestimated, having influence on lung function already in adolescence, and thus liable to shape adult pulmonary morbidity. Reports on the course of recent influenza outbreaks and a rather dismal state of anti-influenza measures top off the content. The volume is addressed to clinicians and researchers, pulmonary doctors, and other professionals engaged in patient care and therapy.

This book addresses several burning issues concerning diseases involving the lungs and respiratory tract. It discusses the epidemiology, mechanisms, prevention, and diagnosis of chest conditions such as chronic obstructive pulmonary disease, sleep apnea and respiratory infections. Further, it examines the intertwined connection between oxidative stress, cardiovascular disorders such as hypertension, and the occurrence and course of obstructive sleep apnea. It also provides pulmonologists with valuable information on the diagnosis and treatment of patients with severe airway obstruction or respiratory tract infections. Other topics covered include viral infections of the airways, such as influenza, particularly in high-risk groups like pediatric populations, as well as psychosocial aspects, e.g., quality of life in lung cancer patients. Combining basic science and clinical practice, the articles provide key insights and highlight the areas of still limited understanding of disease processes. Stimulating new directions in clinical practice, this collection of articles is intended for respiratory physicians, clinical experts, family practitioners, and all allied healthcare professionals.

The purpose of this book is to disseminate and deliberate on the latest knowledge concerning immunity and its role in protection and fight against microorganism invasion. The articles tackle both humoral and cellular immunity, and their interconnectivity. The former involves B cells that recognize invading pathogens and create the antibody-mediated response, which when memorized provides future immunity. The latter involves mostly T cells, exemplified by cytotoxic or killer cell destroying the pathogens, or helper cells stimulating B cells to produce antibodies to bind and neutralize the pathogens. T cells act through release of cytokines, interleukins, and other bioactive mediators. Neutrophils play a key role in innate immunity against bacterial infections. The process of NETosis is a recently unraveled sophisticated defense mechanism, consisting of the formation of neutrophil extracellular traps that catch, immobilize, and remove pathogens from the body. Dysfunction of immunity is indisputably conducive to the propensity for infections, particularly respiratory tract infections, as the airways are the first line of defense against invading pathogens. Pathogens can rapidly evolve and adapt to avoid detection by the immune system. The case in point is the influenza virus. The articles report on the epidemiology, diagnostics, serology, complications, and the process of acquired immunity due to vaccination against influenza and influenza-like infections in recent epidemic seasons. The book is a blend of medical research and practice. It is intended for academic scientists, research scholars, clinicians, family doctors, and healthcare professionals.

A must-have reference for the entire NICU, Goldsmith's Assisted Ventilation of the Neonate, 7th Edition, is the only fully comprehensive, evidence-based guide to all aspects of this fast-changing field. Easy to use and multidisciplinary in scope, this trusted reference provides authoritative guidance on contemporary management of neonatal respiratory diseases, with an emphasis on evidence-based pharmacologic and technologic advances that improve outcomes and quality of life in newborns. It's an outstanding resource for neonatologists and NICU professionals to acquire new knowledge and techniques in this critical area of neonatal care. Covers all aspects of both basic and advanced respiratory management of neonates: general principles and concepts; assessment, diagnosis and monitoring methods; therapeutic respiratory interventions; adjunctive interventions; and special situations and outcomes. Provides updated content on rapidly changing technology and guidelines for assisted ventilation, with up-to-date descriptions of bedside methodologies and the rationale for providing all types of ventilator care in infants. Contains new chapters on respiratory gas conditioning, diagnosis and management of PPHN, care of the infant with CDH, gaps in knowledge, and future directions. Includes significant updates on cardiovascular assessment and management, as well as complications of respiratory support. Provides extensive, full-color visual support with photographs, drawings, charts and diagrams, and radiographic images throughout. Features more than 30 appendices that help you quickly find normal values, assessment charts, ICU flow charts, procedure steps and other useful, printable forms. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This atlas is designed as an easy-to-use reference guide that identifies and illustrates the key patterns of diffuse lung diseases observed on high-resolution computed tomography (HRCT) and then documents in more detail the characteristics and appearances of the individual diseases, grouped on the basis of their prevalent pattern. A further feature of the book is its interdisciplinary nature: contributions from experts in various specialties are tightly interwoven throughout and many pathologic correlations are included. Less experienced readers will find that this atlas, with its wealth of figures and helpful color coding, steers them towards correct interpretation when confronted by the multiplicity and complexity of these diseases; those who are already experts, on the other hand, will benefit from the detailed coverage of individual diseases, which will deepen their understanding. At the end of the book, a graphically appealing and practice-oriented illustrated glossary with tips and tricks offers a further highly effective educational tool. Given the clinical spectrum of diseases covered, this atlas will prove invaluable for a wide range of healthcare workers, especially radiologists, pulmonologists, and pathologists.

This book discusses normal sex-related differences in lung structure and function and the role these differences play in lung disease. New research on the effects of sex hormone signaling on specific cell types of the lung has begun to reveal how these hormones may drive or prevent lung disease. Expertly written chapters examine the effects of sex hormones on normal pulmonary structure and function, hormone signaling in lung health, and specific diseases such as chronic obstructive pulmonary disease, asthma, pulmonary hypertension, and lung cancer. Gender, Sex Hormones, and Respiratory Disease: A Comprehensive Guide focuses on our current understanding and the gaps in research, with suggestions for future directions and implications for therapy. This book is a useful reference for pulmonologists and researchers and will prompt further inquiry aimed at improving overall lung health.

Clinical investigation plays an essential role in the differential diagnosis, biomarker development, and therapy and cure of diseases. The book presents a bench-to-bed approach, with broad empirical coverage by experienced practitioners. The articles include topics like cytokine receptors in lung cancer, conduciveness of oxidative stress to carcinogenesis, safety and effectiveness of surgical correction of deformed chest, diagnostic and treatment regimens in inflammation-ridden obstructive lung conditions, alterations in growth hormone secretion leading to disorders of growth and metabolism, microbiota transplantation in pediatric patients, and the promising markers of renal epithelial injury. Yet another issue concerns the restructuring of chronic pain management by establishing the community-based specialized pain clinics. The book aims to disseminate and deliberate on the latest interdisciplinary medical knowledge to enhance clinical outcomes. Being a blend of clinical investigation and practice the book is addressed to physicians, scientists, and allied health care professionals.

This concise and practical book provides an overview of neuromuscular disorders in clinical practice. Diagnostic approaches are covered along with patient management strategies in an easy-to-understand and introductory framework. Filling a significant gap in the literature, this resource delivers essential information for neurology trainees and practitioners, as well as anyone interested in learning the fundamentals of this important medical subspecialty.

This book presents the current trends and state of the art solutions addressing various issues related to pulmonary disorders. Diagnostic and therapeutic challenges are tackled, starting with the noncommunicable diseases of sarcoidosis and granulomatosis with polyangiitis. Pulmonary involvement, practically unavoidable, runs an insidious course, and is often occulted by systemic symptoms. The establishment of a firm diagnosis, with a precision no one could oppugn, is difficult. Other issues pertain to quality of life, disease preventive measures, and the move toward personal health care in chronic sufferers from multiple conditions in later life. There is also an update on the prevalence and diagnostic and treatment challenges of extrapulmonary tuberculosis. In addition, the place of neuroproteomics in modern clinical practice is presented. The practical insights emphasize the role of science in advancing biomedical knowledge and care. The book is addressed to researchers and practitioners, and allied health care professionals engaged in effective patient care and therapy.

This book is a comprehensive guide to our current understanding of idiopathic pulmonary fibrosis (IPF), its disease pathogenesis, genetic underpinnings, diagnosis, and management. Since the first edition, many new developments have occurred in the understanding and management of this serious disease, revising our understanding of how it presents, manifests, and reacts to certain treatments. This second edition is fully updated with six new chapters by our team of international, expert authors. New topics include: classification of interstitial lung disease, pulmonary function tests in IPF, biomarkers, clinical phenotypes, mimics, and a discussion of clinical trials. Each chapter additionally includes a brief summary of ongoing research and potential future directions. Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide, Second Edition is an invaluable resource for clinicians who desire a deeper understanding of IPF in order to better help their patients.