We proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system. The first chapters introduce basic notions of purinergic pharmacology and metabolism, which allows readers from all scientific backgrounds to fully grasp the importance of these signaling networks for airway defenses, including mucociliary clearance and inflammatory responses. Then, chapters are devoted to the groundbreaking discovery that chronic respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD), present specific aberrances in purinergic signaling which essentially drive lung complications. The last chapters describe the animal models used to investigate purinergic signaling in respiratory diseases, and the therapeutic applications developed by the pharmaceutical industry based on receptor agonists/antagonists and metabolic correctors. This highly comprehensive manuscript constitutes an invaluable tool for beginners and experts to follow the rapidly evolving research field of purinergic signaling. Furthermore, the critical analysis of past clinical protocols should facilitate the identification of potent therapeutic targets, and provide a better understanding of the data acquired in current clinical trials.

Discusses three major classes of asthma therapies-bronchodilators, antiinflammatories, and antiallergics-as well as potential new therapeutic approaches
This comprehensive volume addresses the latest treatment strategies for asthma, keying in on the genetics and molecular biology of asthma and pointing the way toward new, commercially viable therapies.
Presents the most up-to-date information available on the genetics, epidemiology, pathology, pharmacology, and pulmonology of asthma.
Written by more than 20 leading international experts, New and Exploratory Therapeutic Agents for Asthma
explores asthma both as incidence of dysfunctional airway smooth muscle and as a disorder of the immune system
examines the role of monoclonal antibodies in allergy and asthma
describes functions and pharmacokinetic profiles of bronchodilator 2 agonists, anticholinergics, and inhaled glucocorticosteroids
investigates the controversy of different types of asthma
illustrates the connections between clinical symptoms and the immunopathology of eosinophilic inflammation
assesses prospects for the development of a successful oral anti-inflammatory therapy, an immunomodulator that lowers antigen-specific IgE, an anticytokine compound, and an agent that safely combines bronchospasmolytic and anti-inflammatory properties
reviews the impact of the recent introduction of antileukotriene agents, clinical findings with PAF antagonists, and selective antimuscarinics
evaluates the relationship between improvements in laboratory results and clinical effectiveness
and more
Containing over 2000 bibliographic citations and a concise introduction for each chapter, New and Exploratory Therapeutic Agents for Asthma is indispensable for pulmonologists, pediatricians, physiologists, immunologists, allergists, pharmaceutical industry scientists, primary care physicians, and medical school students in these disciplines.

This book provides a unique frame work for examining acute lung syndromes that arise from hematologic disorders or is defined by a hematologic abnormality as a key feature. Acute lung processes arising from hematologic disorders can present as life-threatening conditions, and as such, the pulmonary physician or critical care physician are often directly involved in care or called upon to provide expertise. Chapters are organized into three sections, each with an emphasis on pathogenesis and current understanding of mechanisms. The text begins with the central theme of the lungs as the direct interface between the external environment and blood, description of individual components of the hematopoietic system, their function and relevance to the lungs. The second section outlines both benign and malignant primary hematologic disorders that can lead to acute pulmonary manifestations. The final section focuses on acute lung syndromes stemming from complications of transfusion and treatment. Chapters are presented in an easy-to-access format, providing information on diagnosis, management, and outcomes. This is a valuable resource for pulmonary fellows in training, pulmonologists, critical care physicians, and physicians involved in caring for patients in the ICU.

The Respiratory System at a Glance The market-leading at a Glance series is popular among healthcare students and newly qualified practitioners for its concise, simple approach and excellent illustrations. Each bite-sized chapter is covered in a double-page spread with clear, easy-to-follow diagrams, supported by succinct explanatory text. Covering a wide range of topics, books in the at a Glance series are ideal as introductory texts for teaching, learning and revision, and are useful throughout university and beyond. Everything you need to know about The Respiratory System... at a Glance! Highly-illustrated overview of the structure and function of the lungs and airways, with sections on history, examination, pathophysiology, treatment and management Respiratory System at a Glance is a comprehensive guide to normal lung structure and function and associated pathophysiology, featuring key information on all major respiratory disorders. As per the familiar, easy-to-use 'at a Glance' format, each topic is presented as a double-page spread, with key facts accompanied by clear diagrams that encapsulate essential knowledge. This 'one-stop' resource has been revised and updated for this 5thedition to include recent advances in our understanding and/or treatment of asthma, COPD, pulmonary vasculitis, sarcoidosis, cystic fibrosis, respiratory infections (including COVID-19), and the most recent national clinical management guidelines. The accompanying website includes self-assessment case studies, flashcards and MCQs to support learning or for review. Respiratory System at a Glance also provides information on: Structure and function of the respiratory system, the thoracic cage and respiratory muscles, gas laws, diffusion, and elastic forces Acid-base balance and disorders, control of breathing through chemical and neural mechanisms, and pulmonary circulation and ventilation-perfusion matching Exercise, altitude, and diving, complications of development and congenital disease, lung defense mechanisms, and immunology of the lungs Public health and smoking, respiratory failure, and the pathophysiology and management of asthma, chronic obstructive pulmonary disease and other respiratory disorders With accompanying self-assessment clinical cases and multiple-choice questions, The Respiratory System at a Glance is the ideal companion for anyone about to start a respiratory module or rotation, and will appeal to medical students and junior doctors, as well as nurses, dentists, physiotherapists, technicians, and biomedical scientists. For more information on the complete range of Wiley nursing and health publishing, please visit: www.wiley.com To receive automatic updates on Wiley books and journals, join our email list. Sign up today at www.wiley.com/email All content reviewed by students for students Wiley Medical Education books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind. If you would like to be one of our student reviewers, go to www.reviewmedicalbooks.com to find out more. This new edition is also available as an e-book. For more details, please see www.wiley.com

Achieving Quality in Brachytherapy addresses the main issues that often prevent correct delivery of brachytherapy treatment. The book explains how to set up a functional quality assurance program in brachytherapy and covers all the steps needed to undertake particular treatment plans, from the initial planning required to the detailed specification. It highlights the importance of planning as a means of controlling and dealing with errors during the treatment process and advises on what to check and how to check during treatment to ensure effective quality assurance. This comprehensive reference is ideal for professionals working in brachytherapy, physics, and radiation oncology, and serves as an introduction for trainees with an undergraduate degree in medical physics or clinical radiation oncology.

An up-to-the-minute reference guide for health professionals confronting pulmonary disorders in children, Pediatric Asthma offers the latest findings on this classification-defying disease and related conditions. Written by more than 20 international experts in the field, the book focuses on drug administration-issues of compliance, aerosol delivery, and pharmacokinetic differences among children-with a view toward developing new and more efficacious therapies.
Provides cutting-edge analysis for more effective diagnosis of children with asthma and improved monitoring and treatment for chronic patients
With a firm theoretical grounding and reflecting the state of the art in pharmacological research and development, Pediatric Asthma
reviews the prevalence, causes, and demographics of childhood asthma worldwide
explores determinants of the disorder in various populations-gender, age and severity of onset, atopic status, family history, and smoking
elucidates physiological factors such as airway remodeling, airway hyperresponsiveness, and persistent inflammation
describes in vivo and in vitro testing for asthma-associated allergy and the pros and cons of allergen immunotherapy
delineates the dynamics of the lung in terms of phenomena such as peak expiratory flow (PEF), forced vital capacity (FVC), and bronchial hyperresponsiveness (BHR)
highlights the importance of patient education and self-management
investigates the role that developmental psychopathologies and neurobehavioral dysfunctions may play in pediatric asthma
discusses inflammatory mediators such as cytokines, chemokines, leukotrienes, and prostaglandins
evaluates intravenous and inhaled 2 agonists for the bronchodilating treatment of acute severe asthma
and more
Featuring over 2100 references, more than 60 user-friendly tables, and a handy Appendix on clinical monitoring of childhood asthma and recommended drug dosages for its treatment, Pediatric Asthma is an indispensable resource for pediatricians, pediatric pulmonologists, and pediatric pharmacists; clinical allergists and immunologists; general and family practitioners; and graduate and medical school students in these disciplines.

The spectrum of systemic rheumatologic disease (often termed connective tissue disease) is characterized by autoimmune-mediated organ dysfunction and the lungs are a frequent target. There are numerous pulmonary manifestations--with varied incidence and prevalence--associated with connective tissue diseases and all patients with rheumatologic disease are at risk of developing associated lung disease. It is not known why specific connective tissue diseases are more likely to be associated with certain types of lung disease and there is still much to learn about the natural history of this connection. Largely due to the interplay concerning the diverse nature of the connective tissue diseases and the frequently heterogeneous forms of lung involvement encountered, the arena of rheumatologic lung disease poses major challenges to practicing clinicians. Moreover, the assessment and management of rheumatologic lung disease requires a multi-disciplinary approach and is optimized by active engagement by rheumatologists working closely with pulmonologists and other specialists.Pulmonary Manifestations of Rheumatic Disease offers a practical and comprehensive overview of lung disease encountered in patients with systemic rheumatic diseases. The book helps practicing clinicians in the ongoing assessment, management, and understanding of rheumatologic lung disease. While providing chapters on the science and pathophysiology underlying rheumatologic lung diseases, the text has a case-based approach and is more significantly weighted towards the clinical aspects and implications of the diseases. The first text of its kind specifically dedicated to describe diverse, commonplace, and challenging aspects of rheumatologic lung diseases, Pulmonary Manifestations of Rheumatic Disease serves as an invaluable tool for the practicing clinician.

"Analyzes the role of peptides in promoting or suppressing inflammation. Thoroughly examines the therapeutic potential of key peptides, analogs, agonists, and antagonists that influence cell injury and repair."

Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become "the" reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field.
Key Features
* Comprehensive coverage of both basic science and clinical aspects of asthma
* Extensively referenced throughout

This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for the further development of safe and efficient gene delivery systems.

Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma is studied; however, the tissue remodelling process is a significant process that should not be overlooked. This valuable reference synthesizes current data and concepts developed to determine the relationship between airway wall remodelling and the pathogenesis of asthma. It discusses evidence for structural changes in asthmatic airway, the relationship between airway thickening and hyperresponsiveness, the relationship between cytokine production and tissue remodelling and inflammation, the significance of epithelial changes and the extracellular matrix, and in vivo and in vitro experimental approaches to the assessment of remodelling. Pharmacological and biochemical mechanisms that control cell proliferation are also examined. The consequences of airway wall remodelling for airway hyperresponsiveness is the unique focus of this volume, offering a fresh perspective of advances in asthma research.

This book proposes an introduction to the mathematical modeling of the respiratory system. A detailed introduction on the physiological aspects makes it accessible to a large audience without any prior knowledge on the lung. Different levels of description are proposed, from the lumped models with a small number of parameters (Ordinary Differential Equations), up to infinite dimensional models based on Partial Differential Equations. Besides these two types of differential equations, two chapters are dedicated to resistive networks, and to the way they can be used to investigate the dependence of the resistance of the lung upon geometrical characteristics. The theoretical analysis of the various models is provided, together with state-of-the-art techniques to compute approximate solutions, allowing comparisons with experimental measurements. The book contains several exercises, most of which are accessible to advanced undergraduate students.

Contents:
An introduction to inhalation toxicology; Inhalation exposure systems; Generation and characterization of gases and vapours; Generation and characterization of test atmospheres: particles and droplets; Morphology of the respiratory tract; Lung biochemistry and intermediary metabolism; Metabolic characteristics of the respiratory tract; Deposition and clearance of inhaled particles; Pulmonary retention of particles and fibres: biokinetics and effects of exposure concentrations; Regional deposition of inhaled reactive gases; Factors modifying the disposition of inhaled organic compounds; Carcinogenic responses of the respiratory tract to inhaled toxicants; Assessment of pulmonary function and the effects of inhaled toxicants; Immunological responses of respiratory tract to inhaled materials; Biological markers in the respiratory tract; Role of cytocines in pulmonary inflammation and fibrosis; Applications of behavioural measures to inhalation toxicology; Non-carcinogenic responses of the respiratory tract to inhaled toxicants; Risk assessment for inhaled toxicants.

A must have resource for clinicians and investigators interested in pulmonary embolism and deep venous thrombosis * Highly illustrated with numerous tables and graphs alongside clear concise text * Includes chapters addressing pulmonary embolism (PE) and deep venous thrombosis (DVT) in relation to diseases and disorders such as; chronic heart failure, cancer, diabetes, stroke, chronic obstructive pulmonary disease (COPD) and many more * Discusses the role the different tools offered in imaging for PE, including echocardiography, multidetector computed tomography (CT), single photon emission computed tomography (SPECT), ventilation-perfusion (V-Q) imaging, dual energy CT, and magnetic resonance angiography * Contains 29 new chapters and includes new content on epidemiology of deep venous thrombosis; use of the new anticoagulants (dabigatran, rivaroxaban, and apixaban) for DVT and PE; indications and results with thrombolytic therapy and with vena cava filters; and information and indications for invasive mechanical thrombectomy and thrombolysis * Written by an internationally recognized and respected expert in the field

This timely Second Edition of a landmark reference furnishes in-depth examinations of the latest developments in the physiology, pathophysiology, and clinical relevance of the respiratory muscles and chest wall-reflecting the explosion of information that has occurred since the publication of the previous edition.

This easy yet comprehensive reference guide covers the mechanisms of respiratory diseases, explaining the main respiratory conditions for clinicians and postgraduate trainees. It discusses their aetiology as well as the basic concepts required to effectively evaluate and treat them. Applied Respiratory Pathophysiology is the first book to bring together detailed, clinically-relevant explanation of respiratory physiological processes and pathophysiological processes in one text. It is essential reading for anyone diagnosing and treating specific clinical conditions of the lungs.

This book presents the current trends and state of the art solutions addressing various issues related to pulmonary disorders. Diagnostic and therapeutic challenges are tackled, starting with the noncommunicable diseases of sarcoidosis and granulomatosis with polyangiitis. Pulmonary involvement, practically unavoidable, runs an insidious course, and is often occulted by systemic symptoms. The establishment of a firm diagnosis, with a precision no one could oppugn, is difficult. Other issues pertain to quality of life, disease preventive measures, and the move toward personal health care in chronic sufferers from multiple conditions in later life. There is also an update on the prevalence and diagnostic and treatment challenges of extrapulmonary tuberculosis. In addition, the place of neuroproteomics in modern clinical practice is presented. The practical insights emphasize the role of science in advancing biomedical knowledge and care. The book is addressed to researchers and practitioners, and allied health care professionals engaged in effective patient care and therapy.

This book contains the refereed contributions from the 43rd annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. ISOTT conferences are a place where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The proceedings include sessions covered various research topics including Multi-Modal Imaging/Spectroscopy & Instrumentation; Cancer Metabolism; Cellular Hypoxia and Mitochondrial Function; Brain Oxygenation and Function; Other Organ Function and Metabolism; Oxygen Transport in Sports, Diseases and Clinical Care; Acupuncture, Meridians, and Primo Vascular System; EPR, MRS and MRI.

This work, Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews, in the Methods in Molecular Medicine series presents an overview of the current status of those methods useful in the diagnosis and tre- ment of lung cancer-both as it exists in the clinic and as it is being revoluti- ized in the laboratory. The book is intended to serve as a resource for researchers wishing to increase their knowledge of current and cutting edge technologies, in order that their investigations into neoplasms of the lung may benefit from this enriched diversity of techniques and approaches. Owing to the complex nature of the disease and the variety of methods available to analyze and attack it, no volume attempting to define diagnostic and therapeutic approaches to lung cancer can ever be complete. The sheer number of investigators involved in lung cancer research guarantees that some aspect will be inadvertently excluded. However, I hope that the range of techniques included herein will serve to open up new avenues of investigation for both the novice and experienced researcher.

"This outstanding resource offers comprehensive presentations of the latest basic knowledge and the most advanced research on neuropeptides of the respiratory tract covering the structure, receptors, molecular biology, and function of each important neuropeptide and examining how they relate to disease. Demonstrates the utility of immunohistochemistry, autoradiography, molecular biology, smooth muscle contraction, and glandular secretion for the study of neural function both in vitro and in vivo "

Chronic obstructive airways disease (COAD: bronchitis, emphysema and chronic asthma) is a major medical, psychological, social and economic problem. Breathlessness is one of the most distressing and disabling symptoms of COAD, and it has long been apparent that the condition results in impaired quality of life. Drawing upon sociological and psychological sources, and his own detailed research in this area, Simon Williams sesitively portrays the meaning, experience and impact of COAD. Sufferers' and their families' own accounts are used to portray the various stages and aspects of COAD, ranging from the experience of symptoms and the management of medical regimens, to the practical problems it creates in daily life and the more diffuse and intangible ways in which it impinges on social and family life. He also provides a comprehensive review of the psychosocial literature and concludes by discussing some of the policy implications for health care professionals.

Respiratory problems are the most common cause of acute admission to hospital. A variety of diagnostic investigations are required, both for acute and clinic assessment. Making Sense of Lung Function Tests, Second Edition familiarises both trainees and more experienced clinicians with the interpretation of a range of respiratory parameters. It places lung function in a clinical context using real-life examples and provides invaluable hands-on guidance. For this second edition Consultant Respiratory Physician Jonathan Dakin and Consultant Anaesthetist Elena Kourteli are joined by Mark Mottershaw, Chief Respiratory Physiologist from Queen Alexandra Hospital, Portsmouth, all contributing a broad range of expertise and perspectives. Together they have updated the book throughout and added new chapters including an algorithm for interpretation of pulmonary function tests, exhaled nitric oxide (FENO) and cardiopulmonary exercise testing. The text offers a clear explanation of the concepts which students find difficult, including: The basis of obstructive and restrictive defects Pattern recognition of the flow volume loop Differences between TLCO and KCO Assessment of oxygenation using PO2 and SO2 The basis of Type 1 and type 2 respiratory failure Distinguishing respiratory and metabolic acidosis The relationship between sleep and respiratory failure The information is presented in an accessible way, suitable for those seeking a basic grounding in spirometry or blood gases, but also sufficiently comprehensive for readers completing specialist training in general or respiratory medicine.

This volume covers advances in the field of respiratory diseases, reflecting the recent and dramatic expansion of knowledge regarding the determinants of respiratory health, screening tests for early pulmonary lesions, therapeutic interventions for respiratory infections and strategies for prevention. It examines indoor and outdoor environmental sources of respiratory diseases, including levels of pollutants, air conditioning, indoor air quality and airborne allergens. Exploring ways to promote the respiratory health of both the individual and the community, Prevention of Respiratory Diseases covers areas including: the role of most of the known extrinsic and potentially preventable determinants in respiratory diseases; developments in epidemiology and children's respiratory health; the relationship between respiratory diseases and occupations; individual sensitivity or susceptibility to the effects of air pollutants; genetic, epidemiological and immunological markers, markers for bronchial cancer and the protease-antiprotease system; and the connection between tobacco smoke and respiratory diseases.;This resource is intended for pulmonologists, clinical immunologists and allergists, oncologists, physiologists, infectious disease specialists, respiratory therapists and graduate and medical school students in these disciplines.

Learn the latest in respiratory care for newborns and children from COMPREHENSIVE PERINATAL AND PEDIATRIC RESPIRATORY CARE, 4E. This newly updated book is clear, consistent, and easy for you to follow. Comprehensive coverage of fetal development of the cardiopulmonary system, is followed by respiratory care of neonatal and pediatric patients, and progresses into causes and care of respiratory illnesses. It provides discussion of the ventilation and oxygenation needs of neonatal and pediatric patients including information on both conventional and special techniques. Topics unique to this book, such as care of parents and home care, are discussed in detail. COMPREHENSIVE PERINATAL AND PEDIATRIC RESPIRATORY CARE, 4E provides you with the theory and clinical expertise necessary to embark on your career and meet the challenges presented in a rapidly changing health care environment.

Focusing on all the major cytokine families, this reference book provides coverage of cytokine regulatory processes in the lung and other tissues and comprehensive descriptions of cytokine functions specific to the lung.;Discussing the diverse cytokine-binding proteins and the role of cytokines in tissue injury and repair processes and extracellular matrix regulations, the book supplies information on amino acid structure and gene regulatory sequences, examines the receptor biology of individual cytokines, illustrates cytokine interactions with their cognate receptors and surveys the phenotypic effects of individual cytokines on target cells. With over 2700 literature citations and figures, this book is a resource for pulmonologists, physiologists, immunologists, cell and molecular biologists, environmental toxicologists, oncologists, and graduate-level and medical school students in these disciplines.