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Airway Wall Remodelling in Asthma (Hardcover, New)
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Airway Wall Remodelling in Asthma (Hardcover, New)
Series: Handbooks in Pharmacology and Toxicology
Expected to ship within 12 - 17 working days
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Asthma is a disease of high prevalence that has shown a trend
toward increasing incidence, morbidity, and mortality over the last
three decades despite apparently effective drug treatments and
increasing awareness of the need for better disease management.
Often the inflammatory component of asthma is studied; however, the
tissue remodelling process is a significant process that should not
be overlooked. This valuable reference synthesizes current data and
concepts developed to determine the relationship between airway
wall remodelling and the pathogenesis of asthma. It discusses
evidence for structural changes in asthmatic airway, the
relationship between airway thickening and hyperresponsiveness, the
relationship between cytokine production and tissue remodelling and
inflammation, the significance of epithelial changes and the
extracellular matrix, and in vivo and in vitro experimental
approaches to the assessment of remodelling. Pharmacological and
biochemical mechanisms that control cell proliferation are also
examined. The consequences of airway wall remodelling for airway
hyperresponsiveness is the unique focus of this volume, offering a
fresh perspective of advances in asthma research.
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