The Respiratory System chart presents a visual overview of the structures of breathing, from nasal passages to the bronchi. Additional imagery illustrates the paranasl sinuses and views of the larynx. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).

Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a clinically important driver alteration affecting approximately one-third of lung cancer patients. Treatments for EGFR-exon 19 deletion and exon 21 L858R NSCLC have evolved over the last decade from first-generation reversible tyrosine kinase inhibitors (TKI) to third-generation irreversible TKIs, of which osimertinib has been the widely accepted as first-line therapy. Despite survival improvement seen with osimertinib and its efficacy against acquired T790M mutation, resistance through on-target and off-target pathways eventually develop. This Element describes the structural biology and pathophysiology of EGFR-mutant NSCLC and discusses past, current, and future treatment options in the metastatic, neoadjuvant, and adjuvant settings. It describes the biology and recently approved treatment for EGFR-exon 20 insertion mutation and the treatment for the uncommon exon 18 (G719X), 20 (S768I), and 21 (L861Q) mutations. It also outlines the promising clinical applications of circulating tumor DNA (ctDNA).

This book discriminates and emphasizes approaches that are likely to be productive in terms of understanding the causation and mechanisms of occupational lung diseases. It benefits research academicians in the field of lung diseases, and government and public health authorities.

This book provides a current and integrated approach to the subject of genetic determinants of pulmonary disease with emphasis on physiologic derangements and genetic mechanisms. It describes the epidemiologic-genetic approach to chronic pulmonary disease.

Key Features * Sets the standard for training and competency of this emerging, yet scientifically approved non-invasive technique of ultrasound with all the essential information on how to perform ultrasound and interpret the images obtained. * Features clear and didactic images demonstrating echo findings in various situations along with videos of diaphragmatic ultrasound offering a unique "window" on mechanically ventilated patients, allowing to take important clinical decisions on ventilatory modes and assistance by pulmonologists, critical care specialists, thoracic surgeons, emergency medicine specialists as well as trainees. * Includes a chapter on pediatric ultrasound along with ultrasound of other respiratory muscles (i.e., intercostal and abdominal) which is emerging as a useful complementary tool.

Molecular Aspects of Aging: Understanding Lung Aging covers recent research in the mechanisms that contribute to cellular senescence. Covering universal themes in aging, such as the exhaustion of stem cells and subsequent loss of the regenerative refueling of organs as well as immunosenescence, this text illuminates new directions for research not yet explored in the still poorly investigated area of molecular mechanisms of lung aging. The molecular nature of general aging processes is explored with targeted coverage on how to analyze lung aging through experimental approaches.

With the high prevalence of chronic pulmonary diseases, including asthma, COPD, and interstitial lung disease, physicians need to recognize the cause of dyspnea and know how to treat it so that patients can cope effectively with this distressing symptom. Detailing recent developments and treatment methods, this revised and updated third edition of Dyspnea: Mechanisms, Measurement, and Management includes new chapters on gender-based differences in dyspnea and explores guidelines for treating the condition in challenging special populations, including in the aged, in pregnancy and obesity, and in palliative care settings. With three sections spanning the mechanisms of dyspnea, measurement and assessment strategies, and management techniques, this book provides pulmonologists and other healthcare professionals the vital information needed to understand this complex symptom.

This volume contains the Proceedings of the XVIIth ISAC Meeting held in Valladolid, Spain, July 1-5, 2008. As such, it contains the most permanent records of the combined efforts of all attendants. The meeting was held at the School of Medicine of Valladolid, that had the privilege of a recent celebration. The celeb- tion was none other than its 600th anniversary, implying that all participants were surrounded by historical landmarks, from the historical building of the University, to the Museum of polychrome sculpture of Valladolid, to the Monastery of Clarisas in Tordesillas, to the beauty and charm of Salamanca. In this ambience we had three days of intense work, distributed in several oral sessions, preceded by plenary lectures given by our invited speakers who were kind enough to provide us with the latestprogressintheirspeci c elds. We also hadtimeallottedtoposterviewing. As regularattendantsto the XVIIth ISACMeeting, we want to expressourappreciation forthevaluablediscussionssurroundingeachposter,theenthusiasticpresentationof data, the comments of colleagues with suggestions for improvement, and the plans for collaborations that emerged from these discussions. Needless to say that XVIIth ISAC Meeting was the fruit of many collabo- tive efforts. The Local Organizing Committee pro ted from the advice of several colleagues from around the world, namely, Prof. Chris Peers from Leeds, UK, Prof. Prem Kumar from Birmingham, UK, Prof. Nanduri Prabhakar from Chicago, USA, Prof. Colin Nurse from Hamilton, Canada, and Prof. Rodrigo Iturriaga from Santiago, Chile.

Highly Commended, BMA Medical Book Awards 2013 Oncology research and practice in lung cancer continues to develop rapidly. This latest edition of an acclaimed reference briefs the oncology community with a review of the recent literature, emphasizing the most significant therapeutic advances. The expert contributions of Lung Cancer Therapy Annual 7 offer an update of the impact that this information will have on the day-to-day management of the lung cancer patient. New to the seventh edition are four new chapters on the treatment of non-small cell lung cancer (NSCLC) and a new chapter on thymoma. Additional topics include: Oncogenic driver mutations First line therapy of advanced non-small cell lung cancer without activating EGFR mutation Second line therapy of non-small cell lung cancer Adjunct and neoadjunct therapy of non-small cell lung cancer Advances in surgery of lung cancer; advances in radiotherapy of lung cancer Mesothelioma Thymic tumors

Highly Commended, BMA Medical Book Awards 2013 Sarcoidosis represents a major challenge for physicians-not just in respiratory medicine, but across a range of specialties. This book, with a multidisciplinary authorship of the highest standard, presents the most up-to-date thinking on all aspects of the condition, from epidemiology to clinical manifestations and treatment options. Full coverage is given to both respiratory and non-respiratory aspects. The basic science that underlies the disease and its progression is evaluated in detail, and placed into its correct clinical context. Possible future advances are covered in a concluding section. The editors-all leading figures in the field with international reputations-have compiled the definitive work on the subject in a single volume. The book is fully comprehensive and evidence based and will be an essential addition to the bookshelves of all whose practice involves the care and treatment of patients with sarcoidosis.

Sleep apnea is a common chronic condition affecting millions of people. Written by a multidisciplinary team including sleep medicine specialists, pulmonologists, scientists, psychiatrists, otorhinolaryngologists, and more, this text provides essential scientific and clinical information for those treating and researching the condition. Since the previous edition published, sleep medicine has become a fully formed medical speciality. This second edition has been expanded to contain more clinically relevant information regarding diagnosis and treatment, and includes: New developments regarding the cardiovascular effects of sleep apnea New developments regarding the role of sleep apnea in insulin resistance Developing research on intermittent hypoxia in the disorder Latest pharmacotherapeutic trials, addressed in the last chapter Organized into sections and subsections to make the book easier for the reader to use, this essential text also examines sleep apnea in special populations, such as children, older adults or pregnant women, and takes into account gender differences in the disorder.

Whatever affects one part of the respiratory system may affect all other parts. It's common for an allergy that festers to lead to sinusitis and then to asthma. But all these conditions involve your whole body. That's why you need to learn how to engage the healing attributes of your entire body to cure the full range of respiratory problems. As a longtime, highly regarded practitioner, Dr. Grossan has adopted a holistic methodology for allergy and sinus health in addition to conventional medical practices. He advocates what he calls the "Whole Body Approach" (WBA) that includes "tools needed to take charge of your own healing." For instance, to promote natural healing in the nose, Dr. Grossan recommends humming, because "the vibration of the sound stimulates your nasal cilia [tiny hairs] to move faster" which "breaks up thick mucus that may impede cilia movement" following an allergy season. Humming loudly and in a low frequency - such as ooommmm - doesn't allow harmful bacteria to build up which can produce the toxins that cause sinus disease. Dr. Grossan, also, recommends using pulse-wave nasal irrigation and drinking hot lemon/lime drinks or teas with honey for positive cilia movement and allergy relief. Dr. Grossan bases his WBA on new discoveries about how the body heals, particularly psychoneuroimmunology, the study of the interaction between psychological processes and the nervous and immune systems. Relaxation, smiling, humour, biofeedback and five-sensory visualisation are in this tool kit. Some WBA activities he suggests are common-sense practices. For instance, when dealing with a seasonal allergy, avoid getting chilled and get good sleep. While Dr. Grossan discusses sound, time-tested medical practices for everything from sinus headaches to postnasal drip, chronic obstructive pulmonary disease, pollution-induced bronchial inflammation, asthma, snoring, loss of smell or taste, surgery and paediatric issues, he raises WBA for every issue. Lacing the text with humorous examples of how unconventional healing techniques cured people, Dr. Grossan has written a comprehensive review of the latest treatments, both holistic and medical, for the full range of respiratory ailments.

At the present time, 430 drugs are known to cause respiratory injury. This represents an increase of almost 200 in the last ten years, and the number is still increasing. This comprehensive, definitive reference work, with an outstanding range of international expert contributors and two of the world's leading editors, provides an essential reference for the practising respiratory physician. Key features: The text builds upon basics with a review of basic sciences. The book covers imaging, varied drug-induced interstitial lung disease including pulmonary edema and diffuse alveolar hemorrhage, acute respiratory failure, pleural involvement and upper to lower airway disease A wide range of diseases are detailed from chemotherapy and radiation to biologic-induced lung disease, drug misuse, and special groups such as recipients of stem cell and solid organ transplants. A range of world class contributions from key opinion leaders. This book provides essential information for recognizing and managing drug-induced respiratory disease for all pulmonologists and respiratory care physicians. It will be of great interest to: critical care medicine specialists, hematologists, oncologists, cardiologists, allergists, rheumatologists, neurologists, internists, blood-bank specialists, pathologists and primary care physicians.

An annual death toll of 2 million, coupled with rising drug resistance, highlights the need for the development of new drugs, better diagnostics, and a tuberculosis (TB) vaccine. Addressing these key issues, A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, students, scientists, and doctors working, learning, and teaching in the field of TB. It contains 100 color photographs and illustrations that bring clarity to the information presented. The atlas takes the unusual approach of covering multiple species histopathology, arguably the first and quite possibly the only resource to do so. It provides a simple, annotated, and visual presentation of the comparative histopathology of TB in human and animal models. The editors have compiled information that helps TB scientists to distinguish between the features of all major animal models available and to use them with their strengths and limitations in mind. The book provides guidance for selecting the best animal model(s) to answer specific questions and to test the efficacy of drug candidates.

The aim of this book is to present articles that are stimulating to read and inform readers with the most up-to-date clinical research. The articles incorporate the latest developments on a variety of topics in pulmonary medicine, therapy, and related mutlisystem disorders with varied manifestations. Emphasis is given to air quality and lung health, therapeutic management of airway reactivity and cough sensitivity linked to mucous clearance ability, ventilatory and cellular effects of hypoxia, influenza epidemics and persistently dismal vaccination coverage rate, disorders of mixed provenance and genetic background affecting lung parenchyma such as cystic fibrosis or Langerhans cell histiocytosis, and others. New diagnostic strategies and therapeutic management will hopefully serve to enhance the way patient care is delivered and thus clinical outcomes. Being a blend of medical research and practice the book addresses the needs of respiratory scientists and physicians, and allied health professionals.

The burden of chronic obstructive pulmonary disease (COPD) is enormous and is increasing, but early, accurate diagnosis in a primary care setting can have a crucial impact on managing the condition. New NICE guidelines and the GMS Contract with incentives give GPs and practice nurses the opportunity to diagnose COPD patients and manage them in a structured fashion. This book brings together clear and concise information for GPs and primary healthcare teams on how this can be achieved accurately and effectively. This book sets out a very practical approach to caring for one group who can demonstrably benefit from access to the very best that primary care can offer: patients living with COPD. This book is for busy primary care physicians and nurses committed to improving diagnosis, enabling self-management, ensuring rapid treatment, and providing truly patient-centred care. Written by an experienced, practising general practitioner, it provides a timely contribution to the high-quality primary care services needed now and in the future.A " - from the Foreword by Gail Richards Anita Sharma is to be congratulated on producing a clear, concise and practical book on COPD which will educate, give confidence to, and encourage primary care physicians to manage this important disease effectively and at an early stage.A" - from the Foreword by Joyce Barclay

This book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections. It discusses the pharmacological, cellular and molecular factors involved in the pathogenies of respiratory diseases and their modulation by plant-derived compounds. Additionally, it underlines the growing relevance of medicinal plant-based advanced drug delivery systems for treating lung diseases providing maximal therapeutic efficacy with better patient compliance. Overall, this comprehensive book is a blend of translational, biological, chemical and drug delivery aspects of medicinal plants employed in targeting respiratory diseases and attracts a range of audiences including physiochemist, translational and clinical researchers working in the field of respiratory diseases.

Tuberculosis (TB), a deadly airborne disease caused by the bacterium Mycobacterium tuberculosis, takes the lives of almost 2 million people each year and is considered to be the most common infectious disease in the world. However, thanks to the efforts of researchers such as the volumes' lead editor, Dr. Stefan H. E. Kaufmann, there have been several recent advances in fighting the disease. Dr. Stefan Kaufmann, the Founding Director of the Max Planck Institute for Infection Biology in Berlin and Professor of Microbiology and Immunology at the Charite at the Humboldt University, Berlin, has published more than 600 scientific articles and currently serves as President of the European Federation of Immunological Societies and Chair of the Immunology Division of the American Society of Microbiology. Dr. Kaufmann is considered the world's leading expert in the field of tuberculosis. The Handbook of Tuberculosis, which explores the causes and available treatments of the widespread infection as well as current research into vaccination, is divided into three separate volumes covering different areas of study. Each volume provides an essential resource to molecular and cell biologists, bacteriologists, immunologists, pathologists and pathophysiologists, clinicians and those working in the pharmaceutical industry and interested in world health. Volume 1: Molecular Biology and Biochemistry highlights the molecular mechanisms of tuberculosis. Volume 2: Immunology and Cell Biology presents the pre-eminent resource for all aspects of cell biology and immunology of tuberculosis, including vaccine development. Volume 3: Clinics, Diagnostics, Therapy and Epidemiology introduces a comprehensive overview of clinical aspects of tuberculosis, including drug resistance, epidemiological aspects and clinical trials. It is co-edited by Dr. Paul van Helden, Professor of Medical Biochemistry at Stellenbosch University, South Africa, Director of Laboratory Research for the Desmond Tutu Tuberculosis Centre and former President of the South African Society of Biochemistry and Molecular Biology.

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

Removing the guesswork associated with Interstitial Lung Disorders (ILDs) and bronchiolar disorders, Interstitial Pulmonary and Bronchiolar Disorders addresses the issues faced by pulmonologists in treating these disorders. Divided into sections based on the disease type (granulomatous, pneumonias, bronchiolar disorders, vasculitis, and orphan lung disease), each disorder is covered from epidemiological, pathogenic, clinical, and radiographic perspectives.

The only text on the market today that deals with the entire spectrum of ILDs, this handy, one-stop reference includes:

• a special focus on treatment and the proper use of treatment options, including in depth coverage of the most common and potentially dangerous means of treatment
• emerging concepts in patient care
• discussion of lung diseases affecting the survivors of 9/11

"Textbook of Lung Cancer, 2nd edition, " published in association with the European Society of Medical Oncology, is a comprehensive and multidisciplinary text, which examines all aspects of this disease, with contributions from a multinational team of authors on etiology, epidemiology, molecular biology, pathology, smoking, detection and management, clinical features, staging and prognostic factors, surgery, radiotherapy and chemotherapy. It provides essential information and guidance for specialist trainees in oncology, and for the many physicians and specialists involved in the field of lung cancer.

Infants and children spend one- to two-thirds of their life asleep. Despite this, very little attention has been paid to understanding both normal sleep and sleep-related abnormalities during child development. This volume is devoted to breathing during sleep, its changes with development (from the fetus onwards), and the pathophysiology of sleep-related breathing disorders. Sleep and Breathing in Children: investigates breathing during sleep from the fetus onwards examines the effects of sleep on upper airway resistance, ventilatory drive, and respiratory muscle tone compares differences between childhood and adult obstructive sleep apnea, and the profound changes in breathing and sleep during growth and maturation discusses the current research within the field of pediatric sleep disorders reviews the history of childhood obstructive sleep apnea syndrome, and outlines a future framework for the study of childhood sleep-disordered breathing

Lung diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma. Each year, tens of millions of people develop and can die from lung infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for some patients. Current treatment options for lung disease are neither always effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.

Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.