This issue of Immunology and Allergy Clinics, devoted to Obesity and Asthma, is edited by Dr. Anurag Agrawal. Articles in this issue include: Clinical Implications of the Obese Asthma Phenotypes; Childhood Obesity and the Risk of Allergy; Metabolic Asthma: Is there a link between obesity, asthma, and diabetes?; Role of Weight Management in Obese-Asthma Control; Obesity and Airway Disease: A Bioenergetic Problem?; Nutrition, Obesity, and Asthma: Exploring Epigenetic Programming; Obesity and Asthma: The Role of Environmental Pollutants; Novel Therapeutic Strategies for Adult Obese Asthmatics; and From ADMA to Asthma.

This volume covers data describing the role of free radicals and antioxidants in respiratory disorders, including the data that deal with clinical and pre-clinical trials. Chapters describe the relationship of oxidative stress to a number of respiratory and pulmonary conditions from a basic science and clinical perspective, including chronic obstructive pulmonary disease, asthma, acute lung injury, pulmonary hypertension, toxicity and fibrosis, cancer and asbestosis. The book also discusses the use of conventional biomarkers of oxidative stress and breath condensates as adjuncts to classical laboratory testing, the effect of antioxidants on cellular protection, as well as the development of novel antioxidant modalities.

This issue of Thoracic Surgery Clinics is devoted to "Clinical Management of Neuroendocrine Tumors of the Lung" and is edited by Dr. Pier Luigi Filosso. Articles in this outstanding issue include: Pathology of neuroendocrine tumors, Clinical and radiological presentation of neuroendocrine tumors of the lung, Neuroendocrine tumors and endocrine syndromes, The significance of histology: typical and atypical bronchial carcinoids, Surgical management of well-differentiated lung neuroendocrine tumors, Surgical management of large cell neuroendocrine carcinoma (LCNC) of the lung, The role of surgery in small cell carcinoma, Management of thymic neuroendocrine tumors, Medical treatment of advanced thoracic neuroendocrine tumors, Radiometabolic treatment of advanced neuroendocrine tumors, Biological and clinical prognostic factors in thoracic neuroendocrine tumors, and more!

The Year Book of Pulmonary Disease brings you abstracts of the articles that reported the year's breakthrough developments in pulmonary disease carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Asthma and Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Lung Cancer, Community-Acquired Pneumonia, Lung Transplantation, Sleep Disorders, and Critical Care Medicine are represented highlighting the most current and relevant articles in the field.

Drs. Nici and ZuWallack have assembled an expert team of authors covering topics such as: The history of pulmonary rehabilitation, The systemic nature of chronic lung disease, Evidence-based outcomes from pulmonary rehabilitation in the COPD patient, Location, duration and timing of pulmonary rehabilitation, Exercise training in pulmonary rehabilitation, Strategies to enhance the benefits of exercise training in the respiratory patient, Collaborative self management and behavior change, Approaches to outcome assessment in pulmonary rehabilitation, and more!

Acute respiratory infections are responsible for an estimated 4 million deaths annually worldwide, and are the leading cause of death in children younger than 5 years. Over 1 million people in the United States are hospitalized each year with pneumonia. Mycobacterium tuberculosis infects one third of world's population. There are more than 1 million tuberculosis-related deaths worldwide each year. Emerging resistance to multiple available antimicrobial agents has hampered the ability to treat tuberculosis and hospital-acquired respiratory infections. The laboratory diagnosis of respiratory infections is an important part of patient management and treatment. In addition to culture isolation of pathogens, advances have been made in a number of non-culture methods. This issue of Clinics in Laboratory Medicinee reviews state-of-the-art laboratory diagnosis of respiratory infections, as well as the testing of susceptibility to antibiotics and antiviral agents. Among some of the respiratory infections covered are: Cystic fibrosis infections; Pertussis; Pharyngitis; Fungal infections. Among the diagnostic tests are: Interferon gamma release assays; Molecuar diagnosis of TB; Urine antigen tests and discussion of Antibiotic resistance in nosocomial respiratory infections.

For some years, international guidelines on the management of asthma have stressed the importance of early intervention with anti-inflammatory drugs to prevent acute asthma exacerbations and to avert chronic inflammatory damage to the airway. Introduced by a broad survey of the targets for anti-inflammatory drugs, this book proceeds to bring together the most recent research into the mechanisms and clinical benefits of presently available anti-inflammatory treatments including corticosteroids, cromones, and theophylline. For the first time, these drugs are discussed alongside the newly introduced leukotriene modifier drugs, and in the context of frontline research into anti-inflammatory drugs of the future. Leading authorities in their fields evaluate the prospects of novel anti-IgE agents and cytokine antagonists, and examine recent developments in immunosuppressant compounds, protease inhibitors, and selective phosphodiesterase inhibitors. This book is an up-to-date and authoritative survey which will be invaluable to university and pharmaceutical company researchers working on anti-asthma and anti-allergy drugs and to respiratory physicians keeping abreast of developments in their specialty.

The latest in a series of books from the International Hypoxia Symposia, this volume spans reviews on key topics in hypoxia, and abstracts from poster and oral presentations. The biannual International Hypoxia Symposia are dedicated to hosting the best basic scientific and clinical minds to focus on the integrative and translational biology of hypoxia. Long before 'translational medicine' was a catchphrase, the founders of the International Hypoxia Symposia brought together basic scientists, clinicians and physiologists to live, eat, ski, innovate and collaborate in the Canadian Rockies. This collection of reviews and abstracts is divided into six sections, each covering new and important work relevant to a broad range of researchers interested in how humans adjust to hypoxia, whether on the top of Mt. Everest or in the pulmonary or cardiology clinic at low altitude. The sections include: Epigenetic Variations in Hypoxia High Altitude Adaptation Hypoxia and Sleep Hypoxia and the Brain Molecular Oxygen Sensing Physiological Responses to Hypoxia

This issue of Clinics in Chest Medicine is Guest Edited by Peter J. Barnes FRS, FMedSci from Imperial College London and will fosus on COPD. Article topics include epidemiology, pathophysiology, cellular and molecular mechanisms and comorbidities of COPD, diagnosis and phenotype of COPD, pulmonary rehabilitation, asthma and COPD, biomarkers, bronchodilators, non invasive ventialtion, and new drug therapies.

The Year Book of Pulmonary Disease brings you abstracts of the articles that reported the year's breakthrough developments in pulmonary disease carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Asthma and Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Lung Cancer, Community-Acquired Pneumonia, Lung Transplantation, Sleep Disorders, and Critical Care Medicine are represented highlighting the most current and relevant articles in the field.

Guest editor Terence K. Trow has assembled an expert team of authors on the topic of Pulmonary Arterial Hypertension. Articles include: Epidemiology of Pulmonary Arterial Hypertension, Pathology of Pulmonary Hypertension, Genetics of Pulmonary Arterial Hypertension, Diagnosis of Pulmonary Arterial Hypertension, Pulmonary Hypertension Owing to Left Heart Disease, Pulmonary Hypertension due to Lung Disease and/or Hypoxia, Pulmonary Arterial Hypertension Associated with Congenital Heart Disease, World Health Organization Group 5 Pulmonary Hypertension, and more!

This new edition is a practical guide to respiratory medicine for postgraduate and undergraduate medical students. Beginning with an overview of anatomy of the respiratory system, the following sections discuss history taking, symptoms, examination and common investigations. The next chapters offer detailed guidance on the reading of, and interpretation of chest X-Rays, and management of pulmonary emergencies. The book concludes with a selection of common viva voce and bedside questions that students may encounter in examinations. The second edition has been fully revised to provide the latest advances in the field. The comprehensive text is further enhanced by clinical photographs illustrating clinical signs to assist learning. Key points Practical guide to respiratory medicine for postgraduate and undergraduate medical students Fully revised, second edition detailing latest advances in the field Features viva voce and bedside questions to assist revision Previous edition (9789386261779) published in 2017

Guest edited by Sandra Anderson this issue of Immunology and Allergy Clinics covers all aspects of exercise-induced bronchospasm, including treatment through pharmacologic agents, patient assessments, and biomarkers.

The field of interventional bronchoscopy is rapidly expanding and has emerged as a new and exciting subspecialty in pulmonary medicine. To date, the impact of interventional bronchoscopy procedures has been felt in diagnosis, staging, and management of lung cancer, the most lethal cancer worldwide. Interventional Bronchoscopy: A Clinical Guide provides a state-of-the art description of interventional bronchoscopy procedures, addressing the scientific basis, indications, techniques, results, complications, and cost issues. Chapters address the current status, the advantages of new techniques and, most importantly, when to choose new techniques over the existing techniques. Each chapter will discuss the future of these procedures. Interventional Bronchoscopy: A Clinical Guide is an essential resource for a successful interventional pulmonology service and will be useful for the bronchoscopist, anesthesiologist, radiologist, thoracic surgeon and oncologist as well as practicing pulmonologists who do not perform these procedures but have to make decisions regarding appropriate referral of their patients to advanced airway centers.

This issue focuses on three disease sections: Diabetes, Hematology and Coagulation, and covers diagnostic and management issues during pregnancy of selected topics in each section. The chapters cover new concepts, evolving management and important impacts on the mother and unborn child.

This issue of Clinics in Chest Medicine is Guest Edited by Kristina Crothers, MD from the University of Washington and will focus on HIV and Respiratory Disease. Article topics include Abnormalities in Host Defense, Antiretroviral Therapy and Lung Immunology, HIV associated Pneumonia, HIV associated Tuberculosis, HIV associated lung malignancies, and HIV associated COPD.

This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens (Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens (Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future. It is a valuable resource for students, scientists and clinicians, providing up-to-date information on this emerging research topic.

This issue of Thoracic Surgery Clinics covers the screening for and diagnosis and staging of lung cancer. Expert authors review the most current information available about fluorescence and navigational bronchoscopy, integrated PET/CT for mediastinal nodal staging, contraindications to pulmonary resection, approach to patients with multiple lung nodules, and more. Keep up-to-the-minute with the latest developments in this important aspect of thoracic surgery practice.

This issue of Clinics in Chest Medicine is Guest Edited by Jon Puchalski, MD, from Yale and will focus on Pleural Disease. Article topics include Obtaining Pleural Fluid, Analyzing Pleural Fluid, Pleural Interventions and Genetic Therapy and Biomarkers.

This issue of Immunology and Allergy Clinics provides the latest essential updates in interstitial lung diseases and autoimmune lung diseases. This comprehensive issue covers causes, symptoms, diagnosis, and treatment.

The Must-Have Guide for Navigating the ICU. The House Officer's Guide to ICU Care is an eminently practical handbook for junior house officers, medical students, PAs, and nurses that offers nuts-and-bolts guidelines for optimal management of medical and surgical patients in the ICU setting. Using clear, straightforward language, the authors methodically guide clinicians through the decision-making process, first by outlining the pathophysiology of abnormalities seen in the ICU and then by explaining the principles underlying today's therapeutic measures and describing how these agents and devices are used to ensure safe patient recovery. While the text focuses on the postoperative cardiothoracic surgery patient, the principles and therapies covered are broadly relevant to all medical and general surgery ICU patients. This third edition has been thoroughly updated to include the newest diagnostic and treatment technologies, procedures, and practices, and covers everything the house officer needs to know to deliver safe, effective, front-line care - especially during those times when senior staff are not there to rely on. Updated references, self-assessment tools, and an Emergency Response Sheet of essential paradigms, drugs, and doses will ensure confident decision-making when it counts the most. For the house officer, this book gives you everything you need to know, and not a word more. Especially useful for: house officers and medical students embarking on ICU responsibilities,intensive care nurses and nurses in training physicians' assistants,and respiratory therapists.

This issue of Clinics in Chest Medicine, Guest Edited by Carrie A. Redlich, MD, MPH, Paul Blanc, MD, MSPH, Mridu Gulati, MD, and Ware Kuschner, MD, will focus on Occupational and Environmental Lung Diseases, with article topics including: asthma, hypersensitivity pneumonitis, and other immune-mediated lung disease; Work-exacerbated asthma; Occupational COPD; Indoor fuel exposure and the lung in both the developed and developing worlds; New (and newly recognized) occupational and environmental causes of selected chronic parenchymal and terminal airway diseases; Occupational rhinitis and other work-related upper respiratory tract conditions; Military service and lung disease; Ambient air pollution; Protecting the lungs from microbes, particles and other inhalational exposures; and Exhaled breath and induce sputum analysis in assessing the effects of occupational and environmental exposures.