Discusses new treatment strategies for malignant mesothelioma, pulmonary edema, fibrosis, asthma, emphysema, and bronchiectasis.
Proteoglycans in Lung Disease considers
glycosaminoglycans as novel therapeutic agents or targets in lung disease
the role of proteoglycans in determining mechanical behavior of lung tissue
hyaluronan and its receptors in wound healing, inflammation, vasculogenesis, and angiogenesis
the impact of small proteoglycans on matrix assembly
versican as a modulator of cell adhesion, migration, and proliferation
antiproliferative activity of heparin and its derivatives on pulmonary artery smooth muscle cells
the effects of mechanical strain on proteoglycans
the functions of proteoglycans in the vascular wall
the effect of hypoxia on glycosaminoglycans in the lung
Comprised of more than 1940 references, Proteoglycans in Lung Disease

Many patients with pulmonary complaints fail to improve despite physicians' best efforts. Sometimes, we ascribe this failure to lack of adherence with therapy, or to the severity of the condition. What we often fail to appreciate, however, is that sometimes the lack of improvement can be explained by the patients' psychological states. The first section of Functional Respiratory Disorders: When Respiratory Symptoms Do Not Respond to Pulmonary Treatment will help clinicians recognize functional respiratory symptoms that can arise as a result of both organic and psychological causes. The second section of this book provides detailed discussions of such disorders, links to video examples of laryngoscopic evaluation of patients with vocal cord issues, case studies and quizzes. Examples and exercises that should strengthen the clinician's confidence in identifying and treating these functional conditions are also provided. Finally, the third section of the book will help the clinician differentiate the patients for whom referral to a mental health provider is mandatory from those for whom other approaches may be useful. For the latter group, the book teaches clinicians to empower themselves by learning how to incorporate various therapies for functional disorders into their practice, including biofeedback, breathing techniques, basic cognitive behavioral therapy techniques, and hypnosis. Links are provided to instructive video examples of biofeedback, hypnosis, and speech therapy. Practical strategies for obtaining training in these modalities are provided in the appendix. Functional Respiratory Disorders: When Respiratory Symptoms Do Not Respond to Pulmonary Treatment is an important new book that will help clinicians consider the possible impact of functional contributions to the clinical presentation of every patient with respiratory symptoms and identified respiratory disease.

Starting with patient assessment, the authors explain the physiological basis of all major cardiopulmonary problems before describing the physiotherapy interventions possible - this ensures the reader understands why the problems occur and not just how to treat them. The book concludes with a detailed glossary, an appendix describing all the treatment methods required, and a final section provides case studies to enhance problem-based learning. The unique combination of physiology, the latest evidence, and detailed methodologies and case studies, ensures that Cardiopulmonary Physiotherapy is an essential purchase for all undergraduates. Postgraduate students in their first years of training will also benefit from quick access to the core information they need on a daily basis.

This book sums up the mechanistic basis, current status, and future prospects of steroid inhalation as the cornerstone of prophylactic asthma therapy, identifying its kinetic basis-especially the essential airway selectivity-and including a historical account of inhaled glucocorticoid development. Makes connections among the underlying pharmacology, impact of new simulation models, newly recognized molecular targets, and therapeutic outcomes of short- and long-term steroid inhalation therapy! Containing more than 1600 works cited, drawings, tables, equations, and micrographs, Inhaled Steroids in Asthma -describes the developmental history of inhaled steroids and provides general models for lung selectivity -considers the best way to select inhaled steroids -clarifies local metabolism, airway and lung uptake and retention, and other determinants of once-daily usage -addresses variations in lung deposition and total bioavailability among available steroids and formulations -surveys the dynamics of receptor gene-mediated processes -analyzes the role of chemokines in airway allergic inflammatory diseases -discusses the effects of inhaled steroids in vivo on cell progenitors in asthma and rhinitis -details measuring airway inflammation as a guide for treatment decisions -outlines the clinical relevancy of exhaled nitric oxide in asthma -covers optimal trial design for judging antiasthmatic potency and efficacy -evaluates the safety of inhaled steroids Written by more than 40 of the world's leading authorities and investigators, Inhaled Steroids in Asthma is an authoritative reference for pulmonologists and pulmonary disease specialists; physiologists; allergists; immunologists; molecular, cell, and lung biologists; pediatricians; pharmaceutical scientists and pharmacologists; and medical school and upper-level undergraduate, graduate, and medical school students in these disciplines.

This book provides an up-to-date perspective on the inflammatory cells, mediators, and molecular pathology of Chronic obstructive pulmonary disease (COPD), emphasizing the urgent need to clearly understand the underlying cellular and molecular mechanisms involved in COPD.

As the prevalence of allergic diseases and asthma has increased in recent years, scientists have intensified research efforts to understand the pathogenesis of these sometimes debilitating conditions. Indeed, researchers have provided key insights-and new concepts-that have changed therapeutic strategies. Moreover, allergic inflammation has served as something of a model in furthering our understanding of regulatory mechanisms of inflammation in general. Presented in an encyclopedic format, the CRC Desk Reference for Allergy and Asthma provides the latest scientific information on allergic diseases and asthma. It combines knowledge from clinical immunology with basic immunology, pharmacology, biochemistry, and molecular biology to examine new treatment strategies for allergic diseases and asthma. Highlights of the CRC Desk Reference for Allergy and Asthma include: oEASE OF USE. This desk reference presents topics in alphabetical order so that they are easy to find. oCROSS-REFERENCING. Utilizes cross-referencing to aid in the rapid switch between basic and clinical science. oUNIFIED NOMENCLATURE. Greatly assists those readers who are new in the field. oHIGHLIGHTS VITAL INFORMATION. Vital information is highlighted in boxes, allowing rapid identification of key concepts. Written by leading authorities in the field, the CRC Desk Reference for Allergy and Asthma serves as a timely reference for anyone interested in this area of research. Not only does it present information in an easy-to-use format, but it addresses many hot topics and views that will have sustaining value for years to come.

From frontline experts on the topic-everything you need to know about COVID-19 and how it affects the heart COVID-19's effect on the cardiovascular system continues to drive increases in morbidity and mortality. Building a solid understanding of the disease spectrum is critical for accurately diagnosing, treating, and managing patients with heart issues in the time of COVID. Written by a team of experts who worked on the frontlines in New York City throughout the worst of the pandemic, COVID-19 and the Heart: A Cased-Based Pocket Guide is a one-of-a-kind resource for providing safe, effective care for COVID-19-related heart conditions. Designed for quick and easy learning and on-the-spot clinical decision making, this practical guide is organized into chapters based on genuine clinical cases and provides the best approach for each one. The authors highlight key points throughout the clinical content for easy review, and provide up-to-date information on clinical trials/vaccines, diagnostic and treatment algorithms, therapeutics, monitoring, and patient education. Ideal for healthcare workers actively engaged in the ongoing pandemic and students seeking to build their expertise, COVID-19 and the Heart is the go-to guide to making the right clinical judgments with respect to the cardiac manifestations of COVID-19. COVID-19 and the Heart starts with the physiology of COVID-related heart disease, and walks you through COVID's effect on: ACS Valvular heart disease Arrythmia Pericardial disease Heart failure Shock Thromboembolism Hypertension

This book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections. It discusses the pharmacological, cellular and molecular factors involved in the pathogenies of respiratory diseases and their modulation by plant-derived compounds. Additionally, it underlines the growing relevance of medicinal plant-based advanced drug delivery systems for treating lung diseases providing maximal therapeutic efficacy with better patient compliance. Overall, this comprehensive book is a blend of translational, biological, chemical and drug delivery aspects of medicinal plants employed in targeting respiratory diseases and attracts a range of audiences including physiochemist, translational and clinical researchers working in the field of respiratory diseases.

This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies.
Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma
describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis
reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages
considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations
presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis
and more
Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.

Written by world authorities, this reference explores the utilization and advancement of state-of-the-art imaging modalities for the analysis of pulmonary function-providing an up-to-date and global perspective of imaging applications with detailed contributions from experts in Europe, North America, Japan, and Australia.

This book aims to help the reader confused by a multiplicity of diseases responsible for similar symptoms in different patients. Consequently, the chapters are noticeably sign-oriented rather than disease-oriented, each dealing with one of the four cardinal modalities of HRCT presentation, namely the reticular, nodular, alveolar and cystic patterns. Each chapter is introduced by a list of diseases, immediately followed by a detailed description of each disease. All the chapters are thoroughly illustrated with high-quality, enlarged images which, like a counterpoint, provide the rhythm to the written text.

When dealing with the diseases within each pattern, only the pertinent manifestations are taken into account. This is a feature unique to this book, which sees the same disease being introduced more than once. This distinction is not artificial, since different phases in the progression of a process not only have different clinical features, but also dissimilar pathological findings, and therefore different radiological aspects.

Often, clinical presentation, history and HRCT are sufficient for making a diagnosis and defining disease management; in other cases, further investigation is required to obtain a more confident diagnosis or to determine the activity of the disease more precisely. Consequently, the contributions of other techniques involved in diagnostic refinement are also highlighted (bronchoalveolar lavage, bronchoscopic or thoracovideoscopic biopsy, open chest surgery).

This timely Second Edition of a landmark reference furnishes in-depth examinations of the latest developments in the physiology, pathophysiology, and clinical relevance of the respiratory muscles and chest wall-reflecting the explosion of information that has occurred since the publication of the previous edition.

Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine.

A fully updated edition of a widely respected classic on the diagnosis and management of asthma in a variety of patient subpopulations. Though this fifth edition continues to emphasize the definition, medications, and use of asthma treatment plans, it also focuses on the special needs patient, including the pediatric patient, the pregnant patient, and the patient undergoing surgery, as well as on the perennial issues of exercise and asthma, pulmonary aspergillosis, occupation, recreational drug use, and psychological/social considerations. Highlights for the fifth edition include a liberal use of tables and charts to make the book more practical and user-friendly, updates on the many new pharmaceuticals used to treat asthma, and first-time sections on food sensitivity and the diagnosis of asthma.

This volume covers advances in the field of respiratory diseases, reflecting the recent and dramatic expansion of knowledge regarding the determinants of respiratory health, screening tests for early pulmonary lesions, therapeutic interventions for respiratory infections and strategies for prevention. It examines indoor and outdoor environmental sources of respiratory diseases, including levels of pollutants, air conditioning, indoor air quality and airborne allergens. Exploring ways to promote the respiratory health of both the individual and the community, Prevention of Respiratory Diseases covers areas including: the role of most of the known extrinsic and potentially preventable determinants in respiratory diseases; developments in epidemiology and children's respiratory health; the relationship between respiratory diseases and occupations; individual sensitivity or susceptibility to the effects of air pollutants; genetic, epidemiological and immunological markers, markers for bronchial cancer and the protease-antiprotease system; and the connection between tobacco smoke and respiratory diseases.;This resource is intended for pulmonologists, clinical immunologists and allergists, oncologists, physiologists, infectious disease specialists, respiratory therapists and graduate and medical school students in these disciplines.

Known for its clear readability, thorough coverage, and expert authorship, Murray & Nadel's Textbook of Respiratory Medicine has long been the gold standard text in the fast-changing field of pulmonary medicine. The new 7th Edition brings you fully up to date with newly expanded content, numerous new chapters, and extensive updates throughout. It covers the entire spectrum of pulmonology in one authoritative point-of-care reference, making it an ideal resource for pulmonary physicians, fellows, and other pulmonary practitioners. Offers definitive, full-color coverage of basic science, diagnosis, evaluation, and treatment of the full range of respiratory diseases. Provides detailed explanations of each disease entity and differential diagnoses with state-of-the-art, evidence-based content by global leaders in the field. Contains a newly expanded section on common presentations of respiratory disease, plus new chapters on COVID-19, asthma and obesity, airplane travel, lung cancer screening, noninvasive support of oxygenation, lung microbiome, thoracic surgery, inhaled substances, treatment of lung cancer, and more. Covers hot topics such as vaping; advanced ultrasound applications and procedures; interventional pulmonology; immunotherapy; lung cancer targeted therapy; outbreaks, pandemics and bioterrorism; point-of-care ultrasound; use of high-flow oxygen, and more. Includes extensively reorganized sections on basic science, pleural disease, and sleep, with new chapters and approaches to the topics. Features more than 1,450 anatomic, algorithmic, and radiologic images (400 are new!) including CT, PET, MR, and HRCT, plus extensive online-only content: 200 procedural and conceptual videos plus audio clips of lung sounds. Brings you up to date with the latest respiratory drugs, mechanisms of action, indications, precautions, adverse effects, and recommendations, with increased emphasis on algorithms to illustrate decision making. Enhanced eBook version included with purchase. Your enhanced eBook allows you access to all of the text, figures, reporting templates, and references from the book on a variety of devices.

Gastroesophageal Reflux and the Lung provides a comprehensive review of current knowledge concerning normal deglutition and foregut digestive processes and examines how abnormalities of swallowing or excessive/abnormal GER can lead to respiratory tract dysfunction and lung disease. In-depth Chapters deliver a concise review of the prevalence of GER in patients with lung disease and synthesize the current evidence regarding its diagnosis and management. Each chapter includes key points and a summary. In addition to outlining the current state of knowledge, each chapter provides a summary of ongoing research in the field and identifies the need for future research. Written by an international group of authors who are experts in their respective fields, Gastroesophageal Reflux and the Lung is a valuable resource for practicing clinicians, internists, pulmonologists and primary care personnel.

Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art techniques and methods and relevance to human disease. Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are interested in experimental model systems for insight into ARDS pathogenesis and treatment strategies.

Over the past 20 years, diagnostic tests for pediatric pulmonologists have revolutionized care of children afflicted with respiratory disorders. These tests have been used to not only help in diagnosis, but also in the management and treatment of these children. Bronchoscopic, imaging and physiologic advances have improved clinical care of these children and have been used as outcome measures in research trials. Diagnostic Tests in Pediatric Pulmonology: Applications and Interpretation describes the various diagnostic modalities (especially the newer ones) that are available for the evaluation of pediatric respiratory disorders. It also provides an understanding of the advantages and limitations of each test so that the clinician may choose the most appropriate ones. An internationally renowned group of authors describe how best to interpret the key findings in a variety of tests as well as the possible pitfalls in incorrect interpretation. This volume focuses on the main diagnostic modalities used in the evaluation of pediatric patients with respiratory disorders and presents up-to-date information on the advantages and limitations of each test for a variety of conditions encountered in the practice of pediatric pulmonology. Clinical utility of these tests is also highlighted. This valuable resource is well suited to practicing clinicians, including pediatric pulmonologists, pediatricians and primary care practitioners, as well as trainees, respiratory therapists and clinical researchers.