This book has become the standard reference text on respiratory diseases in children. It has been extensively revised and updated to encompass the latest developments, and there are now specific chapters on obstructive sleep apnoea and the lung in HIV infection. The biggest revisions to existing chapters are in those on growth and development, respiratory noises, cough and pulmonary consequences of inhalation. The clinical approach in this book is strongly based on an understanding of epidemiology, pathophysiology and increasingly, molecular biology. This fourth edtition brings a stronger theoretical basis to the clinical practice that has been one of the strengths of previous edtitions.

Extracorporeal membrane oxygenation (ECMO) has been in clinical use for some 40 years, but it is only in the past decade that its application in the treatment of life-threatening circulatory and respiratory failure has truly flourished. This book presents a comprehensive overview of both pathophysiological and practical aspects of circulatory and respiratory extracorporeal support. The basics of ECMO, including its history, the "ECMO team," cannulation, materials, and blood- surface interactions, are first discussed. The various indications for and particular characteristics of circulatory and respiratory extracorporeal life support are then described in detail in the main part of the book. Patient care during ECMO and monitoring of the ECMO patient are also carefully covered, with explanation of the management of technical and clinical complications and transport-related problems. Further topics include long-term therapy options beyond ECMO, such as ventricular assist devices and transplants, outcome, the new frontiers of ECMO for organ procurement and future challenges. The authors are well-known experts in the field whose authoritative contributions and attention to practical aspects will be invaluable for novices and experienced practitioners alike.

This issue of Thoracic Surgery Clinics of North America focuses on Pulmonary Metastasectomy. Articles will include: Biology of Pulmonary Metastases; Preoperative Evaluations and Indications for Metastasectomy; Open Approaches to Pulmonary Metastases: Thoracotomy and Sternotomy; Ablative Approaches for Pulmonary Metastases: RFA, microwave, SBRT; Role of Lymphadenectomy with Pulmonary Metastasectomy; Results of Pulmonary Resection: Colorectal Carcinoma; Results of Pulmonary Resection: Sarcoma and Germ Cell Tumors; Isolated Lung Perfusion; Immunotherapy; Medical Management of Pulmonary Metastases: Is There a Role for Surgery?; Thoracoscopic Management of Pulmonary Metastases; Results of Pulmonary Resection: Other Epithelial Malignancies; Thoracoscopic Lung Suffusion; and more!

This encyclopedia presents important research on lung cancer. Some of the topics discussed herein include therapeutic antibodies in non-small cell lung cancer; radiation therapy; epigenetics; paraneoplastic syndromes associated with lung cancer; palliative radiotherapy treatments; bone and lung metastases; and asymptomatic presentation of lung and bone metastases in patients with breast cancer.

Reflecting recent major advances in the field of artificial intelligence, Developing the Digital Lung, From First Lung CT to Clinical AI, by Dr. John Newell, is your go-to reference for all aspects of applied artificial intelligence in lung disease development, including application to clinical medicine. It provides a unique overview of the field, beginning with a review of the origins of artificial intelligence in the mid-1970s and progressing to its application to clinical medicine in the early 2020s. Organized based on the four stages of development, this practical, easy-to-use resource helps you effectively apply artificial intelligences to lung imaging. Traces the development of precise quantitative CT of diffuse lung disease through the use of applied AI, leading to faster effective diagnosis of patients with lung disease. Reviews CT manufacturers, models and scanning protocol used to produce the 3D digital maps of the lungs. Discusses how the data processed by AI algorithms can produce measures of emphysema, air trapping, and airway wall thickening in subjects with COPD and measures of pulmonary fibrosis and traction bronchiectasis in idiopathic pulmonary fibrosis (IPF). Demonstrates the differences between reactive machine AI and limited memory AI methods. Includes comprehensive case studies and current information on cloud computing. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Pleural diseases are very common and of increasing prevalence. This brand new title in the ABC series covers a wide range of conditions including pneumothorax, pleural effusions, pleural infections, chylothorax and mesothelioma.

Written by a team of specialists this overview of pleural diseases is a practical guide for the management of pleural diseases including general practitioners, junior doctors, specialist nurses, radiologists and all healthcare professionals working within chest medicine.

Clinics Collections: Chronic Obstructive Pulmonary Disease draws from Elsevier's robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, pulmonologists, sleep specialists, radiologists,and critical care nurses, with practical clinical advice and insights on this highly prevalent condition and its comorbidities. Clinics Collections: Chronic Obstructive Pulmonary Disease guides readers on how to apply current primary research findings on lipid disorders to everyday practice to help overcome challenges and complications, keep up with new and improved treatment methods, and improve patient outcomes. . Areas of focus include pathogenesis, COPD and secondary disorders, clinical considerations and complications, treatment and pharmacotherapy, and special considerations. . Each article begins with keywords and key points for immediate access to the most critical information. . Articles are presented in an easy-to-digest and concisely worded format. Elsevier's Clinics Collections provide concise reviews of today's most prevalent conditions and significant medical developments. Other Clinics Collections titles available include Type II Diabetes Mellitus, Asthma, Obesity, Pain Management, and Lipid Disorders.

Sarcoidosis is a multisystem granulomatous disease of unknown etiology. It can occur at all ages, with the incidence peaking at 20 to 40 years. This book reviews the epidemiology, etiology, pathology, clinical manifestations, diagnosis and management strategies of sarcoidosis, while highlighting recent studies that have provided new insights into this unique and debilitating disease. The authors also specifically point out the urological manifestations of sarcoidosis to avoid misdiagnoses and to provide early intervention.

Clinics Collections: Asthma draws from Elsevier's robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, pulmonologists, otolaryngologists, allergists, pediatricians, and other healthcare professionals, with practical clinical advice and insights on this highly prevalent disease and its comorbidities. Clinics Collections: Asthma guides readers on how to apply current primary research findings on asthma to everyday practice to help overcome challenges and complications, keep up with new and improved treatment methods, and improve patient outcomes. Areas of focus include pathogenesis, treatment and management of adult asthma, management of pediatric asthma, and special considerations. Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format. Elsevier Clinics Collections provide concise reviews of today's most prevalent conditions and significant medical developments.

This issue of Thoracic Surgery Clinics is devoted to "Advanced Lung Cancer: Radical Surgical Therapy" and is edited by Dr. Raja M. Flores. Articles in this outstanding issue include: Surgical Resection of Lung Cancer in the Elderly; Extended Chest Wall Resection and Reconstruction in the Setting of Lung Cancer; The Management of Non-Small Cell Lung Cancer with Oligometastases; Lung Resection in Patients with Marginal Pulmonary Function; Surgery for Small Cell Lung Cancer; Bronchial and Arterial Sleeve Resection after Induction Therapy for Lung Cancer; Advanced Lung Cancer: Aggressive Surgical Therapy Vertebral Body Involvement; Pulmonary Resection after Pneumonectomy; Superior Vena Caval Resection in Lung Cancer; Surgical Resection of Non-Small Cell Lung Cancer with N2 Disease; Lung Transplantation for Multifocal Lung Adenocarcinoma; Extended Resections of Non-Small Cell Lung Cancers Invading the Aorta, Pulmonary Artery, Left Atrium or Esophagus: Can They Be Justified?; VATS Lobectomy after Induction Therapy; Extrapleural Pneumonectomy for Pleural Disease; Carinal Resection, and more!

Comparative Biology of the Normal Lung, Second Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung.

Pulmonary arterial hypertension (PAH) is a progressive, fatal syndrome characterised by increased vascular resistance that leads to right-ventricular hypertrophy and heart failure, eventually leading to death. The chapters of this book describe the molecular mechanisms and cellular events regulating vascular remodelling in PAH; the various animal models and drugs currently being used in various laboratories to study mechanisms leading to pulmonary arterial hypertension; and nifedipine, its pharmacology and its role in the management of pulmonary hypertension and some of the drawbacks concerning its use. The authors also discuss drug delivery systems that can lead to different crystallisation forms of the immobilised drug which can lead to better solubility and bioavailability.

This book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections. It discusses the pharmacological, cellular and molecular factors involved in the pathogenies of respiratory diseases and their modulation by plant-derived compounds. Additionally, it underlines the growing relevance of medicinal plant-based advanced drug delivery systems for treating lung diseases providing maximal therapeutic efficacy with better patient compliance. Overall, this comprehensive book is a blend of translational, biological, chemical and drug delivery aspects of medicinal plants employed in targeting respiratory diseases and attracts a range of audiences including physiochemist, translational and clinical researchers working in the field of respiratory diseases.

This edition has been extensively rewritten in order to reflect the changes in clinical practice and learning methods which have taken place since the 5th edition was published. The seventeen chapters are divided into three sections: normal voice, descriptions of the various types of voice disorders, and the methods of treating abnormal voice.

A profile summary of each voice disorder is provided for easy reference and comparison, and tables are used throughout the text. New laryngeal images and electroglottographic interpretations have also been included.

The current emphasis on evidence-based practice is addressed in the review and descriptions of intervention strategies used in voice therapy.

The Year Book of Pulmonary Disease brings you abstracts of the articles that reported the year's breakthrough developments in pulmonary disease carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Asthma and Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Lung Cancer, Community-Acquired Pneumonia, Lung Transplantation, Sleep Disorders, and Critical Care Medicine are represented highlighting the most current and relevant articles in the field.

This is a book for clinician educators. It offers modern, evidence-based practices to use in teaching learners at a range of levels, with an emphasis on concrete strategies that teachers can implement in their own clinical practices as well as in small and large group settings. Medical education is rapidly changing with emerging evidence on best practices and a proliferation of new technologies. As strategies for effectively teaching medical learners evolve, it is important to understand the implications for Pulmonary, Critical Care, and Sleep Medicine (PCCM). This text is structured to allow easy access to the reader. Chapters are organized around level of learner (e.g., medical student to PCCM fellow to practicing physicians) as well as the location of teaching. Given the variety of clinical settings in which PCCM physicians teach, specific consideration of best practices, broad changes in curricular design and pedagogy are considered in different clinical contexts. Each chapter begins with a focus on why the topic is important for clinician educators. A review of the available evidence and relevant medical education theory about the topic follows, with examples from specific studies that provide insight into best practices regarding the concepts and topics discussed in the chapter. For chapters focusing on learners, different environments are considered and similarly, if the focus is on the learning environment, attention is paid to the approach to different learners. Each chapter ends with a summary of the primary points from the chapter and concrete examples of how clinician teachers can put the concepts discussed in the chapter into practice. This is an ideal guide for educators in pulmonary, critical care, and sleep medicine.

3D Lung Models for Regenerating Lung Tissue is a comprehensive summary on the current state of art 3D lung models and novel techniques that can be used to regenerate lung tissue. Written by experts in the field, readers can expect to learn more about 3D lung models, novel techniques including bioprinting and advanced imaging techniques, as well as important knowledge about the complexity of the lung and its extracellular matrix composition. Structured into 15 different chapters, the book spans from the original 2D cell culture model on plastic, to advanced 3D lung models such as using human extracellular matrix protein. In addition, the last chapters cover new techniques including 3D printing, bioprinting, and artificial intelligence that can be used to drive the field forward and some future perspectives. This highly topical book with chapters on everything from the complexity of the lung and its microenvironment to cutting-edge 3D lung models, represents an exciting body of work that can be used by researchers during study design, grant writing, as teaching material, or to stay updated with the progression of the field.

This book presents the state of the art in high-flow nasal cannula (HFNC), an oxygen therapy technique that has recently proven to be a very promising approach to supporting respiratory function in several medical fields.In the opening part of the book, readers will learn the differences between high-flow and low-flow techniques and gain an overview of HFNC's technical aspects and physiological effects. The book subsequently describes the pathophysiological mechanisms involved in different respiratory diseases, analyzing how this technique positively impacts patients' respiratory status. The authors highlight clinical applications of HFNC, both in adults and in children, in various clinical settings - e.g. intensive care and semi-intensive care unit, emergencies, rehabilitation etc. - and present tips, tricks and pitfalls, as well as up-to-date reports on technical issues. The book is intended for pneumologists, intensivists, anesthesiologists, ED doctors, rehabilitation therapists, internists and oncologists, as well as fellows and nurses in these fields.

This issue provides fully updated information on respiratory infections, including healthcare associated pneumonia, new diagnostic tests for pneumonia, epidemic viral pneumonia and other emerging pathogens, biomarkers to optimize antibiotic therapy for pneumonia, pharmacokinetics and pharmacodynamics to improve management of penumonia.? Nosocomial tracheobronchitis and bronchiectasis are also discussed.? Articles on CAP and VAP, including an examination of the impact of guidelines on outcomes, de-escalation therapy, inhaled antibiotic therapy and prevention of VAP are also included.

Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

PET imaging has been used for the assessment of lung cancer for several years for diagnosis, staging, and post-treatment follow up.? Expanded applications are now being used and explored in the imaging of the heart, thoracic vascular disease, and chest wall disorders.? This issue provides an up-to-date review of the uses of PET for oncologic and nononcologic diseases of the thorax.

- Coming Soon - The long-awaited update of The Netter Collection of Medical Illustrations is now becoming a reality! Master artist-physician, Carlos Machado, and other top medical illustrators have teamed-up with medical experts to make the classic Netter "green books" a reliable effective current-day reference. The first three volumes to be released will be: The Reproductive System The Endocrine System The Respiratory System See www.NetterReference.com/greenbooks for more information. Pre-order your copies today! Access rare illustrations in one convenient source from the only Netter work devoted specifically to the respiratory system. Get a complete overview of the respiratory system through multidisciplinary coverage from physiology and biochemistry to adult and pediatric medicine and surgery. Gain a quick understanding of complex topics from a concise text-atlas format that provides a context bridge between primary and specialized medicine. Grasp the nuances of the pathophysiology of today's major respiratory conditions-including pulmonary hypertension, COPD, asthma, environmental lung disease, sleep disorders, infections of the immunocompromised, neonatal breathing disorders, and drug-resistant TB, and modern endoscopic and surgical techniques-through advances in molecular biology and radiologic imaging. Benefit from the expertise of the new editor, David Kaminsky, MD, who contributes significant experience in asthma and general pulmonary and critical care medicine, and his team of world class contributors. Clearly see the connection between basic and clinical sciences with an integrated overview of normal structure and function as it relates to pathologic conditions. Apply a visual approach-with the classic Netter art, updated illustrations, and modern imaging-to normal and abnormal body function and the clinical presentation of the patient. Tap into the perspectives of an international advisory board for content that reflects the current global consensus. A reliable and effective reference on the respiratory system with the visual support of Netter

This first of the three-volume tuberculosis book series provides a comprehensive overview of molecular biological and biochemical aspects of tuberculosis. Edited by the undisputed world leader in the field, this is the most comprehensive book on the topic available, and the first in recent years to focus on both basic research and clinical aspects of TB.

Does your heart rate increase when you are paged to the emergency department or ICU for emergency airway management? Would you know how to handle the unexpected arrival of a patient with a gunshot wound to the neck and worsening airway compromise? This guide to critical airway emergencies will prepare you to safely manage these high-pressure situations. Case-based discussions focus on specific scenarios and provide background on the relevant medical issues along with practical guidance and algorithms. This systematic approach gives quick access to vital clinical information. Multidisciplinary in approach and written by experts from a variety of specialties, the content covers both pediatric and adult patients, encompassing many of the challenging airway situations you could be faced with. Every healthcare practitioner involved with emergency airway management will benefit from this book.

This authoritative text is written by leaders in pulmonary rehabilitation. It is clearly written, logically organized, well referenced, and emphasizes evidence-based practice and a contemporary multidisciplinary approach. Offering unrivaled depth, this edition updates coverage of the benefits of pulmonary rehabilitation, therapeutic interventions, smoking cessation, exercise training, and much more as well as important research such as the Global Initiative for Chronic Obstructive Lung Disease (GOLD) report. This text prepares students for the Certified Respiratory Therapist (CRT) exam and the written registry and clinical simulations portions of the Registered Respiratory Therapist (RRT) exams. Information on existing techniques and procedures is expanded and updated in chapters on lung transplantation, functional performance assessment and training, and the management of pulmonary rehabilitation services. Illustrations, photographs, tables, and boxes address new and important information, reinforcing and simplifying the material. A hard cover and portable size offer durability and convenience. Reader-friendly features in each chapter include an outline, professional skills objectives, and a summary, allowing easy access to content and highlighting important concepts and ideas. New chapters covering new advances and discoveries in respiratory care: Systemic Effects of Chronic Obstructive Pulmonary Disorders Complementary Alternative Medicine for Patients with Chronic Lung Disease Pulmonary Rehabilitation and Lung Volume Reduction Surgery Management of and Reimbursement for Pulmonary Rehabilitation Services Exercise and Pulmonary Hypertension New and revised illustrations and photographs. Expanded coverage of patients with respiratory diseases other than COPD as well as pediatric pulmonary patients. New and revised pedagogy including chapter outlines and updated objectives Enhanced chapters Addresses the latest research and reports including The Global Initiative for Chronic Obstructive Lung Disease (GOLD) report recommending pulmonary rehabilitation.