This issue, Guest Edited by Drs. Shyam Mohapatra and Gary Hellermann, will include topics such as: Virus-induced airway injury and asthma inception; Pediatric infectious diseases and asthma; Rhinoviruses and inception or exacerbation of asthma; Respiratory syncytial virus infections in the adult asthmatic-role of viral subversion and host susceptibility in RSV infection; New rhinovirus clades and their significance in asthma exacerbation and airway remodeling; Metapneumovirus and asthma.

Respiratory infections are among the most common causes of morbidity and mortality worldwide.? These infections present a special challenge to physicians for several reasons, including of the recent disasters caused by severe acute respiratory syndrome (SARS) and bird and swine influenza, the increase in viral and bacterial resistance to currently available anti-microbial drugs, the increased frequency of new viral lung infections in clinical practice, and the worldwide emergence of deadly drug-resistant forms of TB.? For these reasons, it is important for infectious disease specialists to have an overview of emerging respiratory infections.

A realistic look at treating respiratory diseases! Clinical Manifestations and Assessment of Respiratory Disease, 9th Edition gives you the fundamental knowledge and understanding required to successfully assess and treat patients with respiratory diseases. This foundation helps you learn how to systematically gather relevant clinical data; make an objective evaluation; identify the desired outcome and formulate an assessment; design a safe, appropriate, and effective treatment plan; and document all the steps involved. With this knowledge, you will understand the effectiveness of performing therapies and when to adjust therapy to a desired outcome. UNIQUE! Emphasis on clinical scenarios and critical thinking skills prepares you for real-world practice. UNIQUE! Focus on assessment and Therapist Driven Protocols (TDPs). UNIQUE! Overview boxes highlight the clinical manifestations for each disease. Logically organized content is written at a user-friendly, approachable reading level for ease of use and understanding. Case studies provide realistic examples of the respiratory therapy practitioner's role in successful patient care. End-of-chapter self-assessment questions and answer key are available on the companion Evolve website. NEW! Clinical Connection boxes provide real-world clinical case studies in relevant chapters. NEW! An updated design and additional tables, boxes, and figures draw attention to key information. UPDATED! Content includes the latest developments related to SARS and COVID-19. UPDATED! Information on ventilators, usage, and protocols reflects current practice. NEW! QR codes in most chapters direct to additional outside content to enhance the chapter, including audio sounds and animations.

Long-term oxygen therapy (LTOT) usually represents the final step in the management of severe chronic respiratory diseases: a large proportion of patients suffering from these conditions is involved and the corresponding impact for the Health Institutions and the Society is dramatically increasing. Although LTOT is well known and widely used since long ago in most modern countries, it still represents a challenging topic due to the huge amount of variables which can affect both its efficacy and effectiveness. Unfortunately, patients, doctors, care-givers, together with health institutions and political decision makers frequently have different visions on LTOT, thus highly contributing to obtain uneven results and changing outcomes. The focus of this volume is on new insights and novel perspectives of LTOT. Starting from consolidated experiences, it's aim is also to emphasize the strategic value of developing technologies and innovative organizational models uniquely to find out even more opportunities and advantages for the management of chronic respiratory patients needing long-term oxygen treatment.

This issue offers a valuable update in the fast-moving specialty of sleep medicine.? Topics covered include: The Neurobiology of Sleep; Adult Obstructive Sleep Apnea; Central Sleep Apnea (including complex sleep apnea and ASV); Pediatric Sleep-Related Breathing Disorders; Hypoventilation Syndromes; Metabolism in OSA; Cardiovascular Consequences of Sleep Apnea; Home Sleep Apnea Testing; Insomnia; Excessive Sleepiness; Narcolepsy; Restless Leg Syndrome and Movement Disorders; Parasomnia; Circadian Rhythm Sleep Disorders; Medication Effects on Sleep; and Polysomnography.

Topics include: Bronchoscopy of the past and the Future, Flexible Bronchoscopes of the 21st Century, Electromagnetic Navigation, Airway Stents, Early Diagnosis of Lung Cancer, Endoscopic Staging of Bronchogenic Carcinoma, Role of Bronchoscopy in the evaluation of Solitary Pulmonary Nodule, Endoscopic Management of Emphysema, Bronchoscopic Thermoplasty, Radiofrequency Ablation of the Peripheral Lung Lesions, Role of Bronchoscopy in Lung Transplantation, Virtual Mapping, Current Status of Pleuroscopy.

In this book is found the information essential to diagnosing, managing and treating the lung complications of connective tissue diseases. This is a notoriously difficult area, which continues to puzzle clinicians, despite the fact that these disorders are increasingly frequent (as a result of longer survival in connective tissue disease).
In separate chapters, the major connective tissue diseases are reviewed, with detailed discussion of a variety of lung abnormalities, including pleural disease, parenchymal lung disease and pulmonary vascular disease. There are also invaluable overviews of lung histological and CT appearances in these disorders, and a deeply insightful chapter on drug-induced lung disease in connective tissue disease. The emphasis in this book is on accuracy of evaluation and the construction of a logical management plan, based on disease severity and intrinsic progressiveness.

This issue, guest edited by Alimuddin Zumla and H. Simon Schaaf, focuses on the topic of Tuberculosis. Articles include: Global Burden and Epidemiology of Tuberculosis; Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis in the West. Europe and the United States: Epidemiology, Surveillance, and Control; Multidrug- and Extensively Drug-resistant Tuberculosis in Africa and South America: Epidemiology, Diagnosis and Management in Adults and Children; Antiretroviral Therapy for Control of the HIV-associated Tuberculosis Epidemic in Resource-Limited Settings; Novel and Improved Technologies for Tuberculosis Diagnosis: Progress and Challenges; Advances in Imaging Chest Tuberculosis: Blurring of Differences Between Children and Adults; Update on Tuberculosis of the Central Nervous System: Pathogenesis, Diagnosis, and Treatment; Advances in Immunotherapy for Tuberculosis Treatment, and more!

This issue will focus on treatments for Chronic Rhinosinusitis. Dr. Wyste Fokkens guest edits topics such as: "Inflammatory mechanisms in chronic rhinosinusitis with or without nasal polyposis," "European versus Asian Chronic rhinosinusitis. What did it teach us and what do we want to know," "Epithelium, cilia and mucus, their importance in chronic rhinosinusitis Noam Cohen Noam," "Aspirin intolerance: does desensitization alter the course of the disease," "Anti-inflammatory effects of macrolides: applications in CRS," and more!

Topics include: The History of Polysomnography and Sleep Technology, Generating a Signal: Biopotentials, Amplifiers and Filters, Recording sleep; Electrodes, 10/20 Recording system and sleep system specifications, Staging sleep, Respiratory monitoring equipment and detection of respiratory events, Differentiating Nocturnal Movements; Leg movements, Parasomnias and Seizures, Cardiac monitoring during sleep, Determination of Sleepiness - MWT & MSLT, Pediatric Polysomnography, PSG features of medical and psychiatric disorders and their treatments, Artifacts and Troubleshooting, Portable Monitoring, PAP titration, The Future of Sleep and Circadian Testing

This issue of Clinics in Laboratory Medicine, entitled Respiratory Viruses in Pediatric and adult Populations, is Guest Edited by Alexander J. McAdam MD, PhD, and includes: Developments in Specimen Collection and Tissue Culture for Respiratory Viruses; Nucleic acid amplification assays for respiratory viruses; Emerging molecular assays for respiratory viruses; Drug Resistance in Influenza Virus; Quantitative assays for adenovirus; RSV vaccine development; Human Metapneumovirus; and Recently discovered coronaviruses.

This book gives an up-to-date analysis of the epidemiology of asthma i n children and adults, the role of steroids in asthma management and n ew and novel asthma therapies. Specific chapters deal with the epidem iology of asthma mortality and of childhood asthma, others discuss the advantages and drawbacks of the use of b2-adenoreceptor agonists, cor ticosteroids, theophylline and new generation phosphodiesterase inhibi tors in the treatment of asthma. A new non-invasive method to assess a irway inflammation is also presented as well as steroid-sparing therap ies in asthma. The book addresses clinicians and basic scientists wit h an interest in asthma epidemiology, steroids and future therapies. I t is also of interest to clinical and no-clinical teachers in academic disciplines relating to respiratory disease.

Topics include: The Obesity Epidemic, Altered Resting and Exercise Respiratory Physiology in Obesity, Association of Asthma and Other Obstructive Lung Diseases and Obesity, Role of Obesity in Obstructive Sleep Apnea, The Pickwickian Syndrome - Obesity Hypoventilation Syndrome, Obesity and Thromboembolic Disease, Medical Therapy of Obesity, Obesity and Bariatric Surgery, Airway Management of Patients with Obesity, Anesthetic Management of Patients with Obesity, Obesity and Acute Lung Injury, Obese Patients in the Intensive Care Units, Obesity Cardiomyopathy, Obesity and Respiratory Diseases in Childhood, Obesity and Respiratory Diseases in the Aging Population.

Interstitial lung disease (ILD) is a broad category of lung diseases that includes more than 150 disorders characterized by scarring or fibrosis of the lungs. In Pulmonary Arterial Hypertension and Interstitial Lung Disease: A Clinical Guide, renowned experts provide a state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. Divided into two sections, the first part provides and update on general issues and introduces both interstitial lung disease and associated pulmonary hypertension. A detailed analysis of the pathology of the various interstitial lung diseases is also provided. The second part addresses specific categories of disease. Bronchiolitis, hypersensitivity pneumonitis, and other conditions are covered, and the use of inspiratory and expiratory high resolution CT scan is discussed as well. This important new text is an invaluable resource for the practicing physician who must be aware of the broad and troubling manifestations of interstitial lung disease.

This issue provides an update on some of the most common conditions that a pulmonologist sees in the ICU. Topics covered include intraabdominal hypertension, liver failure, intracranial catastrophes, critical issues in Nephrology, Heart failure, adrenal insufficiency and septic shock, obstetrical emergencies in critical care, hematologic issues in the ICU, ICU cognitive outcomes, end-of-life issues, sepsis, sedation and analgesia, measurement of quality and assurance of safety, and critical care of the hematopoetic transplant recipient.

In this imporatant update, the guest editors have brought together experts in fungal disease to discuss some of the most important topics in this area: histoplasmosis, blastomycosis, coccidioidomycosis, PCP, cryptococcosis, fungal infections in the era of biologics, Candida in the ICU, Aspergillus pulmonary syndromes, fungal disease in BMT and SOT, fungal complications of lung transplantation, Moulds, serology and Ag testing, role of BAL in rapid diagnosis, molecular testing, and overview of antifungal agents.

This issue of Pediatric Clinics, guest edited by Dr. Anne Chang, reviews the topic of Common Respiratory Disorders of Childhood. The articles in this issue approach the topic from an evidence-based management perspective. The first half of the issue offers symptom-based articles addressing respiratory noises, cough, exercise intolerance/dyspnoea, chest pain and chest wall deformity, and recurrent upper and lower respiratory infections. The second half of the issue offers disease-based articles on topics including upper respiratory tract infections and ear infections, asthma, bronchiolitis and croup, congenital airway lesions and lung disease, bronchiectasis and cystic fibrosis, aspiration lung disease, pneumonia and other respiratory infections, sleep disorders, neuromuscular disease and other chronic respiratory failure, and children on ambulatory oxygen.

Integrative Therapies in Lung Health and Sleep provides an overview of integrative therapies to assist clinicians caring for patients with acute or chronic lung diseases and sleep disorders-- emphasizing the scientific bases for these therapies; and their implementation into clinical practice. This volume focuses on complementary and alternative medicine (CAM) treatments, modalities, and practices that are integrated with conventional medical treatment and for which there is some evidence of safety and efficacy. Whole Medical Systems, with a specific focus on Traditional Chinese Medicine, are also addressed. Individual chapters are devoted to specific health conditions or illnesses, addressing the current state of the science in the four organizing CAM domains, including available information regarding benefits, risks, or safety considerations. Unique aspects of this volume are the chapters related to evaluation of the evidence base for integrative therapies; new animal model research with herbal preparations focused on the serious problem of sepsis in the ICU; guidance for counseling patients with chronic lung illnesses who may be desperate for a cure; and palliative and end-of-life care for patients with chronic lung conditions. Clinicians in various health care settings will find Integrative Therapies in Lung Health and Sleep beneficial in their practice, particularly as the use of integrative therapies becomes more widespread.

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.
* Each chapter considers Asthma and COPD in side-by-side contrast and comparison not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management
* Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD
* Most extensive reference to primary literature on both Asthma and COPD in one source.
* Easy-to-read summaries of the latest advances alongside clear illustrations

1. Application of Transgenic and Gene-Targeted Mice to Dissect Mechanisms of Lung Disease.- Emphysema.- 2. Models of Genetic Emphysema: The C57B1/6J Mice and their Mutants: Tight-Skin, Pallid and Beige Giuseppe Lungarella, Eleonora Cavarra and.- 3. ?1-Antitrypsin Deficiency.- 4. Recombinant SLPI: Emphysema and Asthma.- 5. Elastase Inhibitors in the Lung: Expression and Functional Relationships.- 6. Regulation of Neutrophil Proteinases.- 7. Control of Connective Tissue Genes.- Infection.- 8. Genetic Models of Bacterial Lung Infection.- 9. Genetics of Bacteria: Role in Pathogenesis of Infection of the Respiratory Tract.- 10. Polymerase Chain Reaction in the Diagnosis of Respiratory Tract Infections.- 11. Cystic Fibrosis.- 12. Respiratory Bacterial Infections in Patients with Cystic Fibrosis: Pathogenicity and Implications for Serine Proteinase Inhibitor Therapy.

The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.

Presenting topics from the basic application of molecular genetics to more complex gene expression analysis using different models of study, this detailed volume explores asthma through the lens of genetics, considered to play an essential role in the etiopathogenesis of the disease. Since asthma is a complex disease, this book is designed to provide a review of the most useful techniques with examples of their applications in specific laboratory protocols. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Molecular Genetics of Asthma serves as an ideal guide to researchers investigating this vital field of study.

In this state-of-the-art exploration of a hugely dynamic and fast-evolving field of research, leading researchers share their collective wisdom on the role that stem cells could play in the context of physiological stress and lung injury. The text focuses on reviewing the most relevant-and recent-ideas on using local, endogenous, and exogenous progenitor/stem cells in preventing and treating injury to the lung. The lungs are one of the most complex organs in the human body, with a mature adult lung boasting at least 40 morphologically differentiated cell lineages. Our entire blood supply passes through the lung's alveolar units during oxygenation. This interaction with the outside world, along with the intricacies of its structure, makes the lung a highly susceptible organ that is vulnerable to numerous types of injury and infection. This means that the mechanisms of lung repair are in themselves correspondingly complex. Because of their multipotentiality, as well as the fact of the lung's relatively rapid cell turnover, stem cells are thought to be an important alternative cell-base therapy in lung injury. Despite the controversial nature of stem cell research, there has been growing interest in both local and endogenous stem cells in the lung. This highly topical book with chapters on everything from using mesenchymal stem cells in lung repair to the effect of physical activity on the mobilization of stem and progenitor cells, represents an exciting body of work by outstanding investigators and will be required reading for those with an interest in the subject.

Covering all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism, this book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.