This book provides an overview of pulmonary hypertensive diseases, the current understanding of their pathobiology, and a contemporary approach to diagnosis and treatment. It discusses the definition and classification of these disorders and the epidemiology of pulmonary arterial hypertension (PAH); explores the approach to diagnosis and evaluation via methods such as echocardiography, right heart catheterization, and cardiopulmonary exercise testing; describes the major drug classes used to treat PAH and the cell signaling pathways that they target as well as adjunct and investigative therapies; and highlights special situations that are particularly challenging in the management of PAH. Written by experts in their respective fields, Diagnosis and Management of Pulmonary Hypertension is a valuable resource for pulmonologists, cardiologists, and practitioners in internal medicine and critical care.

Learn basics about how to read a blood gas report. What are the principle components, how they are derived and what is their significance? This includes pH, PaCO2, PCO2, PaO2, PAO2, FiO2, CaO2, A-a gradient, SaO2, HCO3, Pulse oximetry, Carbon-monoxide poisoning, Hyperbaric Chamber. This is section I of the book. Section II of the book is a work book approach where the doctor learns to interpret blood gases from the given report (emphasis is not to use the graph) in a step by step manner. One learns to interpret simple and mixed disorders including Respiratory Acidosis, Metabolic Acidosis, Anion gap and Non Anion Gap Acidosis, Respiratory Alkalosis, Metabolic Alkalosis, Chloride Responsive and Non-Responsive Alkalosis, Mixed Disorders and common mistakes made while interpreting a blood gas report and how to avoid them. Each disorder is separately explained. Section III further challenges the resident with over 200 exercises on blood gases. Section IV is the summary of the book.

Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment.

This issue of Clinics in Chest Medicine, guest-edited by Dr. M. Patricia Rivera, is the first of two issues focused on Lung Cancer. Topics discussed in this issue include but are not limited to: Lung Cancer in the 21st Century; Epidemiology, Etiology, and Prevention; Lung Cancer in Women: A Modern Epidemic; Primary Prevention of Lung Cancer: Tobacco Treatment; The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment; Pathology of Lung Cancer; Lung Cancer Screening: Patient Selection and Implementation; The Approach to the Subsolid Nodule; Bronchoscopic Diagnostic Procedures Available to the Pulmonologist; Bronchoscopic Therapeutic Procedures Available to the Pulmonologist; and Biomarkers in Lung Cancer.

More than 50 million Americans, one out of five, suffer from hay fever, asthma, and other allergic diseases. Many of these conditions are caused by exposure to allergens in indoor environments such as the house, work, and school--where we spend as much as 98 percent of our time.
Developed by medical, public health, and engineering professionals working together, this unique volume summarizes what is known about indoor allergens, how they affect human health, the magnitude of their effect on various populations, and how they can be controlled. The book addresses controversies, recommends research directions, and suggests how to assist and educate allergy patients, as well as professionals.
Indoor Allergens presents a wealth of information about common indoor allergens and their varying effects, from significant hay fever to life-threatening asthma. The volume discusses sources of allergens, from fungi and dust mites to allergenic chemicals, plants, and animals, and examines practical measures for their control.
Indoor Allergens discusses how the human airway and immune system respond to inhaled allergens and assesses patient testing methods, covering the importance of the patient's medical history and outlining procedures and approaches to interpretation for skin tests, "in vitro" diagnostic tests, and tests of patients' pulmonary function.
This comprehensive and practical volume will be important to allergists and other health care providers; public health professionals; specialists in building design, construction, and maintenance; faculty and students in public health; and interested allergy patients.

This is a set of 2 DVDs. About the DVDs: DVD 1 - "Essentials of ABG": with the help of this DVD, you can understand in simple language various parameters of the blood gas report including the SaO2, PaO2, PB, PiO2, FiO2, PaCO2, A-a DO2, pH and much more. You can also understand how and why normal and abnormal values are achieved and what their clinical significance is. This DVD is at least equivalent to 10 hours of reading. DVD 2 - "Details of ABG": this DVD explains step-by-step as to how to interpret the blood gas report without using a paper, pen or calculator. It discusses simple and then mixed acid base disorders. Common conditions like metabolic acidosis, metabolic alkalosis, Respiratory Acidosis are explained in more details. This DVD is equivalent to at least 20 hours of reading and trains the reader for a life time in less than an hour. Approximate running time of this title is 110 minutes.

The definitive guide to the use of mechanical ventilation in critically ill patients - now in full color and updated to reflect the latest advances

"Principles & Practice of Mechanical Ventilation, 3e" provides comprehensive, authoritative coverage of all the clinical, pharmacological, and technical issues surrounding the use of mechanical ventilation.

Editor Martin J. Tobin - past editor-in-chief of the "American Journal of Respiratory and Critical Care Medicine" - has enlisted more than 100 authors, all of whom are at the forefront of research in their chosen subfield in order to provide the most authoritative and up-to-date information possible. No other text so thoroughly and comprehensively explores the myriad advances in modes and methodologies that have occurred in this ever-changing field as this cornerstone text.

Features Each chapter has been extensively revised to reflect the latest research A strong focus on the biomedical principles that govern ventilator management Expert insights from contributors in critical care, pulmonary medicine, anesthesiology, surgery, basic science, provide a unique multidisciplinary approach 68 chapters that explore every important aspect of mechanical ventilation, including: Conventional and unconventional methods of ventilator support; Noninvasive methods of ventilator support; Unconventional methods of ventilator support; Physiologic effect of mechanical ventilation; Complications in ventilator supported patients; Weaning of ventilator-support; Management of the ventilator-supported patient; Adjunctive therapy, including fluid management, inhaled antibiotic therapy, and bronchodilator therapy; Ethics and economics

"Principles & Practice of Mechanical Ventilation, 3e" comprehensively covers the principles and practice of keeping patients alive through the use of mechanical ventilation, along with related pharmacological and technical issues.

Reinforce your understanding of the concepts and skills described in Egan's Fundamentals of Respiratory Care, 12th Edition! With chapters corresponding to the chapters in Egan's market-leading textbook, this workbook prepares you to succeed on certification exams with NBRC-style, case study application, and analysis-style questions. This edition includes two new chapters plus a wide range of activities and exercises to guide you through difficult concepts. Word Wizard helps you remember the terminology used in respiratory care. Key points identify the main concepts to remember in each chapter. Meet the Objectives lets you assess your understanding of the key content in each chapter. Case studies let you apply assessment and intervention strategies, and help you practice critical thinking. What Does the NBRC Say? summarizes the expectations of the NBRC (National Board for Respiratory Care) and provides a sampling of NBRC-style, multiple-choice questions to help students prepare for the certification exam. Food for Thought provides thought-provoking questions related to respiratory care topics. Exercises in each chapter offer hands-on learning with a wide range of activities. NEW Heart Failure chapter reinforces the content in this new chapter of the textbook, challenging you to use recall and critical thinking skills. NEW Ethics and End-of-Life Care chapter helps you understand this issue and how to help patients and their families.

This issue of Medical Clinics of North America, guest edited by Dr. Otto Costantini, is devoted to Cardiac Arrhythmias. Articles in this important issue include: Basic principles of cardiac electrophysiology; The electrocardiogram: Still a useful tool in the primary care office; Palpitation: Extended electrocardiogram monitoring: Which tests to use and when; Inherited cardiac arrhythmias/channelopathies; Antiarrhythmic drugs: Benefits and risks; Stroke prevention in atrial fibrillation: Anticoagulants and/or devices; Pharmacologic and non-pharmacologic management of atrial fibrillation; Supraventricular tachycardia; Ventricular tachycardia with and without structural heart disease; Cardiac Devices: Pacemakers, Defibrillators and Biventricular Devices; Brady-arrhythmias; When is syncope arrhythmic?; Sudden Cardiac Death: Who is at risk?; and Arrhythmias and Congenital Heart Disease. A CME program is also available for this title.

This issue of Clinics in Chest Medicine, edited by Dr. Denis O'Donnell and Dr. Alberto Neder, focuses on Clinical Respiratory Physiology. Articles include: The Pathophysiology of Obstructive Sleep Apnea; The Physiology of Mechanical Ventilation; Exercise Pathophysiology in Congestive Heart Failure; Control of Breathing; Breathing at Extremes; Exercise Pathophysiology in Interstitial Lung Disease; Importance of Physiology in Clinical Decision-Making in the ICU; Pulmonary Hypertension and Exercise; Physiologic Effects of Oxygen Supplementation During Exercise in COPD; Benefits and Pitfalls of DLCO measurements in Clinical Practice; Cardio-pulmonary Interactions in COPD-CHF; Exercise Physiology in COPD; Dyspnea of Unknown Origin: The Role of Exercise Testing; Assessment of Ventilatory Limitation During Exercise; Respiratory Muscle Assessment in Clinical Practice; Exertional Periodic Breathing in Heart Failure; and Strategies to Increase Physical Activity in Chronic Respiratory Diseases.

This book focuses on World clinics Pulmonary & Critical Care Medicine: Pneumonia. Pneumonia has overwhelming importance in clinical medicine and affects all age groups from neonates to the elderly. It leads on to serious consequences such as sepsis, respiratory failure and death. This book consists of 14 chapters, which include epidemiology and risk factors of pneumonia, etiological diagnosis of pneumonia, role of imaging in respiratory infections, severity assessment of pneumonia, management of

The fifth edition of this seminal textbook continues to provide those who are studying or are in practice with comprehensive evidence-based coverage of all the main aspects of respiratory and cardiac physiotherapy throughout the whole lifespan - neonates, infants, children, adolescents and adults - with the patient at centre and advocating a problem-based approach. For the new edition, Jennifer Pryor and Ammani Prasad hand the baton of editorship and their lasting legacy over to Eleanor Main and Linda Denehy. With a team of over 60 international expert authors, the new editors have incorporated major changes reflecting current cardiorespiratory physiotherapy education and practice. These changes are heralded by a new title - Cardiorespiratory Physiotherapy: Adults and Paediatrics (formerly Physiotherapy for Respiratory and Cardiac Problems: Adults and Paediatrics) - and a significant restructure of the content with a new set of chapters. A new key chapter on anatomy and physiology of the respiratory system lays the foundation which is then followed by a chapter on clinical assessment of adults, infants and children, and acutely ill or deteriorating patients. Additional new content includes a chapter on outcome measurement in practice and a large chapter describing rehabilitation in acute and chronic conditions in special populations including spinal cord injury, oncology, trauma and paediatrics. The chapter on therapeutic interventions is comprehensive and reflective of evidence based practice. Integrates evidence with clinical practice Case studies used to facilitate problem solving Boxes throughout highlighting key issues and points Emphasizes the need for a holistic approach to patient care Bank of 350 images on Evolve Resources. Log on to https://evolve.elsevier.com/Main/cardiorespiratory and register to access. Newly appointed editors - Eleanor Main (UK) and Linda Denehy (Australia) Content restructure and overhaul with contributions from over 60 world leading experts Chapters on: Anatomy and physiology of the respiratory system Clinical assessment of the adult, infant/child and the acutely ill/deteriorating patient Outcome measurement in practice Therapeutic interventions Managing special populations Over 180 new figures including additional full-colour photographs

This issue of Sleep Medicine Clinics focuses on Dental Sleep Medicine and includes topics on: Clinical Evaluation for Oral Appliance Therapy; Bruxism and Obstructive Sleep Apnea; Obstructive Sleep Apnea's Connections with Clinical Dentistry; Avoiding and Managing with Oral Appliance Therapy Side Effects; Predicting outcomes with Oral Appliance Therapy; Oral Appliance Therapy and Temporomandibular Disordres; Dental Sleep Medicine in the Military; and Pediatric Considerations in Dental Sleep Medicine

This issue of Clinics in Chest Medicine, edited by Dr. Michael Niederman, focuses on Pneumonia, with topics including: Inflammation and Pneumonia; The Lung Microbiome's Role in Pneumonia; Biomarkers for the Management of Pneumonia; Influenza and Viral Pneumonia; Guidelines to Manage Community-Acquired Pneumonia (CAP); Vaccines to Prevent CAP; Adjunctive Therapies for CAP; Healthcare Associated Pneumonia; Rapid Diagnostic Methods for Pneumonia; Airway Devices in VAP Pathogenesis and Prevention; Management of VAP; Distinguishing Ventilator-Associated Tracheobronchitis from VAP; Practical Approaches to VAP Prevention; Optimizing Antibiotic Administration for Pneumonia; New Antibiotics for Pneumonia; and Personalized Approach to Pneumonia Management.

Get a quick, expert overview of the many key facets of lung cancer evaluation and management with this concise, practical resource by Drs. Lynn T. Tanoue and Frank Detterbeck. This easy-to-read reference presents a summary of today's best evidence-based approaches to diagnosis and management in this critical area.

Cystic fibrosis is a disease that affects the entire body. It tends to be thought of as primarily a pulmonary disease since pulmonary decline is the main factor in early mortality. Because of the multi-system nature of the disease, a better understanding of cystic fibrosis expands the family physician's understanding of subjects ranging from genetics to pulmonary function to nutrition to colon transport to hydration to electrolyte management. The primary care philosophy is unique in that it always considers how a narrow problem can affect an individual globally. Cystic Fibrosis care can often feel fractured to patients as they are sent to multiple specialists to deal with problems outside of the comfort level of a prior or current specialist. With a broad medical philosophy, care is more inclusive as clinicians can manage topics such as diabetes and preventive care without multiple referrals and additional appointments. Family physicians are well-positioned and well-qualified to competently meet many of the care needs of those with cystic fibrosis. This book is edited by a family medicine physician who has specialist level experience with the disease. It opens with a background on cystic fibrosis foundations and centers to familiarize the reader. The next chapter gives a basic overview of the disease. Each of the subsequent chapters provide a comprehensive look at how cystic fibrosis affects other areas of the body that the primary care physician should be familiar with. Major components of cystic fibrosis such as physiology, spirometry, inflammation, airway clearance, chronic infection, cystic fibrosis related diabetes and pancreatic insufficiency, among others, are thoroughly explained. Written by experts in the field, Cystic Fibrosis in Primary Care appeals to all family physicians as well as specialists, residents, medical students physician assistants and nurse practitioners alike.

This issue of Chest Medicine Clinics focuses on Respiratory Manifestations of Neuromuscular and Chest Wall Disease, with topics including: Respiratory Pathophysiology of CW; Respiratory Pathophysiology of NMDiseases; Sleep Disordered breathing in NMDs and CW; PFT Measurements in NMD and CW disorders; Assessing diaphragm function in chest wall and neuromuscular disease; Disorders of the Diaphragm; Disorders of the CW; Muscular Dystrophies; Respiratory Issues in Amyotrophic Lateral Sclerosis; Metabolic myopathies and the Respiratory System; Respiratory complications of SCI; Obesity hypoventilation syndrome; NIV in NMD and CW; Swallowing and Secretion Management Issues in Neuromuscular Disease; Advances in Cell and Molecular Biology in NMD; and Diaphragm Pacing.

Normal and Pathological Bronchial Semiology: A Visual Approach provides normal endobronchial aspects, including variations, anomalies and abnormal findings. Comprehensive coverage includes preoperative airway assessment in lung surgeries, airways after surgery, including complications, process and management, and airway complications in lung transplantation patients. It is a full reference that is perfect for pulmonary researchers, chest physicians, bronchoscopists, pulmonologists and cardiothoracic surgeons.

This issue of Clinics in Chest Medicine focuses on Current Perspectives on the Diagnosis and Treatment of Fungal Chest Infections.Editors Andrew Limper and Eva Carmona have assembled an expert team of authors on topics such as: When to consider the possibility of a fungal infection: an overview of clinical diagnosis and laboratory approaches; Overview of treatment approaches for fungal infections; Clinical perspectives in the diagnosis and management of histoplasmosis; Presentation and management of coccidiodomycosis in immune competent and immunosuppressed patients; Clinical manifestations and treatment of blastomycosis; Update on the epidemiology, diagnosis, and treatment of cryptococcal infections; Approach to fungal infections in HIV-infected individuals: Pneumocystis and beyond; Fungal infections in immunocompromised patients with malignancies: practical approaches to prevention, diagnosis, and treatment; Candidemia in the intensive care unit; Fungal infections following lung transplantation; Noninvasive aspergillus infections and syndromes; Contemporary laboratory modalities for the diagnosis of fungal infections; Emergence of the molds other than Aspergillus in immunocompromised patients.

This issue of Clinics in Chest Medicine focuses on Viral and Atypical Pneumonia. Editors Charles Dela Cruz and Richard Wunderlink have assembled an expert team of authors on topics such as: Epidemiology of Viral Pneumonia; Diagnostic Testing for Viral and Atypical Infections;Lung Microbiome: Atypical Infections and Viruses; RSV Pneumonia in the Young and Old;Viral infections in Chronic Lung Diseases; Viral Pneumonia and ARDS;Viruses in the Immunocompromised; Atypical Bacterial Pneumonia; Other Community Respiratory Viruses; Pandemic Viruses; Epidemic and Emerging Coronaviruses; Post-Viral Complications; Antiviral Treatments; and Vaccines in the Prevention of Viral Pneumonia.

The importance of accurately diagnosing nosocomial infections and providing appropriate therapies, including antimicrobial therapy effective against the identified agents of infection, have been shown to be important determinants of patient outcome. Critical care practitioners are in a unique position to deal with infectious diseases, as they are often the initial providers of care to seriously ill patients with infections. Additionally, they have a responsibility to insure that nosocomial infections are prevented and that antimicrobial resistance is minimised by employing antibiotic agents prudently. It is our hope that this textbook will provide clinicians practising in the intensive care unit with a reference to help guide their care of infected patients. To that end we have brought together a group of international authors to address important topics related to infectious diseases for the critical care practitioner. Critical Care Infectious Diseases should become an advanced standard reference work in the field of infectious diseases and intensive care medicine. The content is original and the first of its kind in this area.It is a reference work for those physicians who care daily for critically ill patients suffering from infectious complications. Residents and other specialists interested in focused problems will benefit from the wide spectrum of information provided in this book. Infectious control practitioners and nurses will also benefit from this collection by recognised experts who work with specific aspects of infectious disease problems in the critically ill patient. Critical Care Infectious Diseases includes seven sections addressing the following topics: specific microbiologic and pharmacologic considerations, epidemiology/infection control in the ICU, anti-infective therapy in the critically ill patient, severe respiratory infections, intra-abdominal infections, severe skin/soft tissue infections, catheter-related infections, and other infectious syndromes frequently seen in the intensive care unit.

Find critical respiratory care information fast! Comprehensive and precise, this portable guide provides rapid access to vital respiratory procedures, facts, and formulas with an emphasis on critical care. It fits easily into your pocket, and the spiral binding allows it to lie flat on any given page. Whether you use it as a clinical resource, a study tool, or a quick refresher, this full-color resource offers quick access to just the right amount of practical, must-know information - essential for boosting your confidence at the point of care. A quick-reference format provides all of the key information you need with fast-access to respiratory care guidelines, including assessment, arterial blood gases, EKGs, medications, and PFTs. You'll also find essential information on pulmonary diseases, equipment disinfection, and neonatal and pediatric care. Waterproof and stain-resistant pages keep your PDQ reference guide performing like new in any clinical setting. Color coded tabs feature a table of contents with page references, making it easy to quickly locate key information within each section. Full color design includes illustrations and clarifies important facts to help you easily find what you need. Commonly used and updated clinical information, including tables, formulas, equations, algorithms, and lab values - all necessary to deliver safe and efficient care. AARC Clinical Practice Guidelines content has been redesigned into easy-to-use, compact algorithms. The latest asthma guidelines Increased coverage of neonatal and pediatric care Expanded BLS and ACLS protocols; updated medications, therapies, and therapeutic devices; and updated ventilator modes More formulas and facts than in the previous edition

This issue of Radiologic Clinics of North America focuses on Diffuse Lung Disease, and is edited by Dr. Jeffrey Kanne. Articles will include: Idiopathic Interstitial Pneumonias: An Update; Collagen-Vascular Diseases; Hypersensitivity Pneumonitis; Acute Lung Injury; Occupational Lung Diseases; Pulmonary Vasculitis; Eosinophilic Lung Diseases; Large Airways Diseases; Small Airways Diseases; Smoking Related Lung Diseases; Pulmonary Hypertension; and more!

This issue of Surgical Oncology Clinics of North America, guest edited by Dr. Mark Krasna, is devoted to Lung Cancer. Dr. Krasna has assembled expert authors to review the following topics: Epidemiology for Lung Cancer; Screening for Lung Cancer; Pathology for Lung Cancer; Treatment of Patients with Oligometastatic Disease for NSCLC; SBRT/Ablative Therapies for NSCLC; Mediastinal Staging for Lung Cancer; VATS Lobectomy for NSCLC; Robotic Lung Resection for NSCLC; Pneumonectomy for NSCLC; Bronchoscopy-Diagnostic and Therapeutic for NSCLC; Neoadjuvant Therapy for Lung Cancer; Molecular/Targeted Therapy for Lung Cancer; Adjuvant Therapy for Stage 1and 2 NSCLC, and more!