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Mitochondrial Function in Lung Health and Disease (Hardcover, 2014 ed.)
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Mitochondrial Function in Lung Health and Disease (Hardcover, 2014 ed.)
Series: Respiratory Medicine
Expected to ship within 12 - 17 working days
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Mitochondria, often referred to as the "powerhouses" of the cell,
generate adenosine triphosphate (ATP) by oxidative phosphorylation
or OXPHOS, and maintain cellular homeostasis. In addition to
generating ATP, mitochondria are involved in regulation of cell
cycle, proliferation, free radical production, innate immune
responses and apoptosis. Mitochondrial Function in Lung Health and
Disease fills the current gap in the literature and outlines the
growing clinical relevance of mitochondrial dysfunction. Currently,
there is no overview on the role of mitochondria in pulmonary
diseases and this volume focuses on the mitochondrial metabolism,
redox signaling, and mechanisms of mitochondrial pathways in lung
injury, inflammation, repair and remodeling. Furthermore, in
addition to their well-recognized role in cellular energy
production and apoptosis, mitochondria appear to play a role in
many respiratory diseases and lung cancer. Chapters are written by
top notch researchers and clinicians and outline the evidence for
mitochondrial biogenesis in inhalational lung injury, COPD and
asthma.
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