This easy yet comprehensive reference guide covers the mechanisms of respiratory diseases, explaining the main respiratory conditions for clinicians and postgraduate trainees. It discusses their aetiology as well as the basic concepts required to effectively evaluate and treat them. Applied Respiratory Pathophysiology is the first book to bring together detailed, clinically-relevant explanation of respiratory physiological processes and pathophysiological processes in one text. It is essential reading for anyone diagnosing and treating specific clinical conditions of the lungs.

When the SARS virus broke out in China in January 2003, Karl Taro Greenfeld was the editor of Time Asia in Hong Kong, just a few miles from the epicenter of the outbreak. After vague, initial reports of terrified Chinese boiling vinegar to "purify" the air, Greenfeld and his staff soon found themselves immersed in the story of a lifetime.

Deftly tracking a mysterious viral killer from the bedside of one of the first victims to China's overwhelmed hospital wards--from cutting-edge labs where researchers struggle to identify the virus to the war rooms at the World Health Organization headquarters in Geneva--"China Syndrome" takes readers on a gripping ride that blows through the Chinese government's effort to cover up the disease . . . and sounds a clarion call warning of a catastrophe to come: a great viral storm potentially more deadly than any respiratory disease since the influenza of 1918.

Respiratory problems are the most common cause of acute admission to hospital. A variety of diagnostic investigations are required, both for acute and clinic assessment. Making Sense of Lung Function Tests, Second Edition familiarises both trainees and more experienced clinicians with the interpretation of a range of respiratory parameters. It places lung function in a clinical context using real-life examples and provides invaluable hands-on guidance. For this second edition Consultant Respiratory Physician Jonathan Dakin and Consultant Anaesthetist Elena Kourteli are joined by Mark Mottershaw, Chief Respiratory Physiologist from Queen Alexandra Hospital, Portsmouth, all contributing a broad range of expertise and perspectives. Together they have updated the book throughout and added new chapters including an algorithm for interpretation of pulmonary function tests, exhaled nitric oxide (FENO) and cardiopulmonary exercise testing. The text offers a clear explanation of the concepts which students find difficult, including: The basis of obstructive and restrictive defects Pattern recognition of the flow volume loop Differences between TLCO and KCO Assessment of oxygenation using PO2 and SO2 The basis of Type 1 and type 2 respiratory failure Distinguishing respiratory and metabolic acidosis The relationship between sleep and respiratory failure The information is presented in an accessible way, suitable for those seeking a basic grounding in spirometry or blood gases, but also sufficiently comprehensive for readers completing specialist training in general or respiratory medicine.

Concise, current, and evidence-based, Practical Guide to Interventional Pulmonology provides authoritative guidance on basic and advanced interventional pulmonology (IP) procedures and state-of-the-art technologies. Leading IP experts offer detailed, practical tips on everything from, how to start an IP practice, patient selection, and pre-procedural decision making to practical approaches and alternate therapies such as surgery or radiation. This one-stop manual covers all the latest IP procedures and their efficacy, precautions, safety aspects, complications, and step-by-step illustrated techniques and tips in one convenient volume. Covers all the latest interventional pulmonology procedures, including advanced diagnostic studies, endobronchial ultrasound (EBUS), navigational bronchoscopy, rigid bronchoscopy, use of airway ablation therapy, debulking of tumors, cryotherapy, and insertion of airway stents. Uses a consistent, easy-to-follow format for procedures: Definition, Pre-procedural preparation, Procedural techniques, Precautions and caveats, Complications, Evidence, and Summary. Provides superb visual guidance on IP procedures with step-by-step photos, anatomic drawings, imaging studies and videos for selected procedures. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Most postgraduate examinations now include radiographic interpretation. This may be presented as a slide show of as a film-viewing session. Radiographs and other imaging modalities are also used ubiquitously in the viva' section of most such examinations including those of the American Boards and professional societies and universities worldwide. This series of Clinical Film Viewing will assist candidates to prepare for this process. Each book examines a particular system or technique followed by profusely illustrated cases typical of those presented in postgraduate examinations.

This book covers several aspects of inhalation toxicology ranging from inhalation drug abuse to battlefield chemical inhalation lung injury, and emphasizes pathophysiology and therapy.

Using a unique, case-based approach, Pleural Diseases: Clinical Cases and Real-World Discussions brings you up to date with the latest advances in this fast-moving subspecialty. A wide variety of real-world challenges are presented along with multiple perspectives from expert pulmonologists who discuss and analyze each case collaboratively, replicating actual patient experiences and outcomes. This first-of-its-kind resource is ideal for practicing pulmonologists and fellows, interventional pulmonologists, critical care physicians, and others who are interested in an interactive approach to everyday clinical problems related to pleural disease. Provides a unique, interactive approach to understanding the nuances and complexities of patient cases for both invasive and non-invasive therapies, drawing from real clinical cases and accompanying case discussions. Describes the approach taken by experts for each case, presenting the clinical reasoning on the most appropriate approaches and the possible therapies. Offers easy-to-read, templated information for every case: onset of symptoms, the entire diagnostic-therapeutic path including clinical and laboratory findings, and discussions on the clinical choices made in accordance with evidence-based medical procedures. Includes both positive and negative outcomes for a broader experience. Features more than 200 illustrations including x-rays, procedural photos, ultrasound, CT scans, and histopathology specimens, as well as video procedures for thoracentesis, chest tube placing, medical thoracoscopy, and insertion of indwelling pleural catheter. Addresses other common clinical issues such as the management of multimorbid elderly patients, the optimization of fluid balance, and the need to discontinue antiplatelet or anticoagulant therapy before invasive procedures. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This book discriminates and emphasizes approaches that are likely to be productive in terms of understanding the causation and mechanisms of occupational lung diseases. It benefits research academicians in the field of lung diseases, and government and public health authorities.

Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available. This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled ?2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.

This book provides a current and integrated approach to the subject of genetic determinants of pulmonary disease with emphasis on physiologic derangements and genetic mechanisms. It describes the epidemiologic-genetic approach to chronic pulmonary disease.

Respiratory Medicine Lecture Notes covers everything from the basics of anatomy and physiology, through to the aetiology, epidemiology, symptoms and management of a full range of respiratory diseases, providing a comprehensive yet easy-to-read overview of all the essentials of respiratory medicine. Key features of this new, full-colour edition include: Updated and expanded material on chest X-rays and radiology Self-assessment exercises for each chapter A range of clinical images and scans showing the key features of each disease Fully supported by a companion website at www.lecturenoteseries.com/respiratory featuring figures, key points, web links, and interactive self-assessment questions Ideal for learning the basics of the respiratory system, starting a placement, or as a quick-reference revision guide, Respiratory Medicine Lecture Notes is an invaluable resource for medical students, respiratory nurses and junior doctors.

'Excellent . . . analyses clearly and authoritatively how the coronavirus pandemic played out, what governments should have done, and what we need to do when it happens again - as it undoubtedly will' Financial Times 'You could not hope for a better guide to the pandemic world order than Debora MacKenzie, who's been on this story from the start. This is an authoritative yet readable explanation of how this catastrophe happened - and more important, how it will happen again if we don't change' Tim Harford, author of The Undercover Economist, Adapt and Messy 'This definitely deserves a read - the first of the post mortems by a writer who knows what she's talking about' Laura Spinney, author of Pale Rider: The Spanish Flu of 1918 and How It Changed the World In a gripping, accessible narrative, a veteran science journalist lays out the shocking story of how the COVID-19 coronavirus pandemic happened and how to make sure this never happens again Over the last 30 years of epidemics and pandemics, we learned every lesson needed to stop this coronavirus outbreak in its tracks. We heeded almost none of them. The result is a pandemic on a scale never before seen in our lifetimes. In this captivating, authoritative, and eye-opening book, science journalist Debora MacKenzie lays out the full story of how and why it happened: the previous viruses that should have prepared us, the shocking public health failures that paved the way, the failure to contain the outbreak, and most importantly, what we must do to prevent future pandemics. Debora MacKenzie has been reporting on emerging diseases for more than three decades, and she draws on that experience to explain how COVID-19 went from a potentially manageable outbreak to a global pandemic. Offering a compelling history of the most significant recent outbreaks, including SARS, MERS, H1N1, Zika, and Ebola, she gives a crash course in Epidemiology 101--how viruses spread and how pandemics end--and outlines the lessons we failed to learn from each past crisis. In vivid detail, she takes us through the arrival and spread of COVID-19, making clear the steps that governments knew they could have taken to prevent or at least prepare for this. Looking forward, MacKenzie makes a bold, optimistic argument: this pandemic might finally galvanize the world to take viruses seriously. Fighting this pandemic and preventing the next one will take political action of all kinds, globally, from governments, the scientific community, and individuals--but it is possible. No one has yet brought together our knowledge of COVID-19 in a comprehensive, informative, and accessible way. But that story can already be told, and Debora MacKenzie's urgent telling is required reading for these times and beyond. It is too early to say where the COVID-19 pandemic will go, but it is past time to talk about what went wrong and how we can do better.

With the high prevalence of chronic pulmonary diseases, including asthma, COPD, and interstitial lung disease, physicians need to recognize the cause of dyspnea and know how to treat it so that patients can cope effectively with this distressing symptom. Detailing recent developments and treatment methods, this revised and updated third edition of Dyspnea: Mechanisms, Measurement, and Management includes new chapters on gender-based differences in dyspnea and explores guidelines for treating the condition in challenging special populations, including in the aged, in pregnancy and obesity, and in palliative care settings. With three sections spanning the mechanisms of dyspnea, measurement and assessment strategies, and management techniques, this book provides pulmonologists and other healthcare professionals the vital information needed to understand this complex symptom.

Bundled with Lippincott® Connect, The Vascular System is more informative and approachable than ever. By using multimedia content and customizable assignments, this edition strengthens comprehension and prepares you for success in your course. Part of the highly regarded Diagnostic Medical Sonography series, Ann Marie Kupinski’s The Vascular System, 3rd Edition, thoroughly covers the core content students need to master in today’s rigorous sonography programs. Careful, collaborative editing ensures consistency across all three titles in this series: The Vascular System, Abdomen and Superficial Structures, and Obstetrics and Gynecology, providing the right content at the right level for both students and instructors.  Features up-to-date sonograms and relevant content throughout, including new coverage of ergonomics  Reflects today’s best practices with up-to-date coverage of diagnostic criteria  Provides key terms for quick reference, pathology boxes with tables of relevant pathologies, a complete glossary to help students master vocabulary of the sonography profession, and updated references that reflect the latest research in the field    Student ancillaries include: self-assessment questions • videos • internet resources  Instructor ancillaries include: eBook  • PowerPoint presentations • image bank • syllabus conversion guide    Also available: Workbook for Diagnostic Medical Sonography-The Vascular System, 3rd Edition, ISBN 978-1-9751-7707-2  This hands-on, full-color workbook (available separately for each series title) provides a variety of custom-designed exercises to help students master each objective and get the most out of their study time. Diagnostic Medical Sonography: The Vascular System, 3rd Edition, is now available with Lippincott® Connect! Lippincott® Connect enables you to personalize your teaching and enhance your students’ course experience in a customizable, all-in-one learning solution combining assessment, multimedia content, and an interactive eBook. Instructors can create assignments, assess students’ knowledge, and track their progress. Students maximize efficiency through valuable feedback and remediation. Key performance insights are reported in a user-friendly dashboard that allows instructors and students to tailor their teaching and learning experiences.  If you would like to use Diagnostic Medical Sonography: The Vascular System, 3rd Edition, in your course, please contact [email protected].    Enrich Your eBook Reading Experience  Read directly on your preferred device(s), such as computer, tablet, or smartphone.  Easily convert to audiobook, powering your content with natural language text-to-speech.  Lippincott® Connect enhances your student experience in an all-in-one learning solution combining an interactive eBook, multimedia content, and assessment. Instructors can customize the course, create assignments, and track your progress. Students maximize efficiency through valuable feedback and remediation. Key performance insights are reported in a user-friendly dashboard that allows you to tailor your learning experiences.

This volume contains the Proceedings of the XVIIth ISAC Meeting held in Valladolid, Spain, July 1-5, 2008. As such, it contains the most permanent records of the combined efforts of all attendants. The meeting was held at the School of Medicine of Valladolid, that had the privilege of a recent celebration. The celeb- tion was none other than its 600th anniversary, implying that all participants were surrounded by historical landmarks, from the historical building of the University, to the Museum of polychrome sculpture of Valladolid, to the Monastery of Clarisas in Tordesillas, to the beauty and charm of Salamanca. In this ambience we had three days of intense work, distributed in several oral sessions, preceded by plenary lectures given by our invited speakers who were kind enough to provide us with the latestprogressintheirspeci c elds. We also hadtimeallottedtoposterviewing. As regularattendantsto the XVIIth ISACMeeting, we want to expressourappreciation forthevaluablediscussionssurroundingeachposter,theenthusiasticpresentationof data, the comments of colleagues with suggestions for improvement, and the plans for collaborations that emerged from these discussions. Needless to say that XVIIth ISAC Meeting was the fruit of many collabo- tive efforts. The Local Organizing Committee pro ted from the advice of several colleagues from around the world, namely, Prof. Chris Peers from Leeds, UK, Prof. Prem Kumar from Birmingham, UK, Prof. Nanduri Prabhakar from Chicago, USA, Prof. Colin Nurse from Hamilton, Canada, and Prof. Rodrigo Iturriaga from Santiago, Chile.

Molecular Aspects of Aging: Understanding Lung Aging covers recent research in the mechanisms that contribute to cellular senescence. Covering universal themes in aging, such as the exhaustion of stem cells and subsequent loss of the regenerative refueling of organs as well as immunosenescence, this text illuminates new directions for research not yet explored in the still poorly investigated area of molecular mechanisms of lung aging. The molecular nature of general aging processes is explored with targeted coverage on how to analyze lung aging through experimental approaches.

When a patient presents to the emergency department, in the GP practice, or in the outpatient clinic with a range of clinical signs, the chest x-ray is one of the most valuable diagnostic tools available to the attending physician. Accurate interpretation and understanding of the chest x-ray is therefore a crucial skill that all medical students and junior doctors must acquire to formulate quickly an appropriate management plan. Making Sense of the Chest X-ray is here to help. The second edition of this well-received pocket guide remains the perfect introduction to the subject. Written from a problem-oriented approach, the author shares his extensive experience of teaching this subject, with "real life" scenarios interspersed throughout the text. Making Sense of the Chest X-ray offers: * Advice on when to seek additional/expert opinion * Suggestions on how to deal with particularly difficult areas * An emphasis on the link between radiographic appearance and clinical finding

Highly Commended, BMA Medical Book Awards 2013 Oncology research and practice in lung cancer continues to develop rapidly. This latest edition of an acclaimed reference briefs the oncology community with a review of the recent literature, emphasizing the most significant therapeutic advances. The expert contributions of Lung Cancer Therapy Annual 7 offer an update of the impact that this information will have on the day-to-day management of the lung cancer patient. New to the seventh edition are four new chapters on the treatment of non-small cell lung cancer (NSCLC) and a new chapter on thymoma. Additional topics include: Oncogenic driver mutations First line therapy of advanced non-small cell lung cancer without activating EGFR mutation Second line therapy of non-small cell lung cancer Adjunct and neoadjunct therapy of non-small cell lung cancer Advances in surgery of lung cancer; advances in radiotherapy of lung cancer Mesothelioma Thymic tumors

Highly Commended, BMA Medical Book Awards 2013 Sarcoidosis represents a major challenge for physicians-not just in respiratory medicine, but across a range of specialties. This book, with a multidisciplinary authorship of the highest standard, presents the most up-to-date thinking on all aspects of the condition, from epidemiology to clinical manifestations and treatment options. Full coverage is given to both respiratory and non-respiratory aspects. The basic science that underlies the disease and its progression is evaluated in detail, and placed into its correct clinical context. Possible future advances are covered in a concluding section. The editors-all leading figures in the field with international reputations-have compiled the definitive work on the subject in a single volume. The book is fully comprehensive and evidence based and will be an essential addition to the bookshelves of all whose practice involves the care and treatment of patients with sarcoidosis.

Lung cancer remains the leading cause of cancer-related deaths worldwide. Early diagnosis can improve the effectiveness of treatment and increase a patient's chances of survival. Thus, there is an urgent need for new technology to diagnose small, malignant lung nodules early as well as large nodules located away from large diameter airways because the current technology-namely, needle biopsy and bronchoscopy-fail to diagnose those cases. However, the analysis of small, indeterminate lung masses is fraught with many technical difficulties. Often patients must be followed for years with serial CT scans in order to establish a diagnosis, but inter-scan variability, slice selection artifacts, differences in degree of inspiration, and scan angles can make comparing serial scans unreliable. Lung Imaging and Computer Aided Diagnosis brings together researchers in pulmonary image analysis to present state-of-the-art image processing techniques for detecting and diagnosing lung cancer at an early stage. The book addresses variables and discrepancies in scans and proposes ways of evaluating small lung masses more consistently to allow for more accurate measurement of growth rates and analysis of shape and appearance of the detected lung nodules. Dealing with all aspects of image analysis of the data, this book examines: Lung segmentation Nodule segmentation Vessels segmentation Airways segmentation Lung registration Detection of lung nodules Diagnosis of detected lung nodules Shape and appearance analysis of lung nodules Contributors also explore the effective use of these methodologies for diagnosis and therapy in clinical applications. Arguably the first book of its kind to address and evaluate image-based diagnostic approaches for the early diagnosis of lung cancer, Lung Imaging and Computer Aided Diagnosis constitutes a valuable resource for biomedical engineers, researchers, and clinicians in lung disease imaging.

Sleep apnea is a common chronic condition affecting millions of people. Written by a multidisciplinary team including sleep medicine specialists, pulmonologists, scientists, psychiatrists, otorhinolaryngologists, and more, this text provides essential scientific and clinical information for those treating and researching the condition. Since the previous edition published, sleep medicine has become a fully formed medical speciality. This second edition has been expanded to contain more clinically relevant information regarding diagnosis and treatment, and includes: New developments regarding the cardiovascular effects of sleep apnea New developments regarding the role of sleep apnea in insulin resistance Developing research on intermittent hypoxia in the disorder Latest pharmacotherapeutic trials, addressed in the last chapter Organized into sections and subsections to make the book easier for the reader to use, this essential text also examines sleep apnea in special populations, such as children, older adults or pregnant women, and takes into account gender differences in the disorder.

An annual death toll of 2 million, coupled with rising drug resistance, highlights the need for the development of new drugs, better diagnostics, and a tuberculosis (TB) vaccine. Addressing these key issues, A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, students, scientists, and doctors working, learning, and teaching in the field of TB. It contains 100 color photographs and illustrations that bring clarity to the information presented. The atlas takes the unusual approach of covering multiple species histopathology, arguably the first and quite possibly the only resource to do so. It provides a simple, annotated, and visual presentation of the comparative histopathology of TB in human and animal models. The editors have compiled information that helps TB scientists to distinguish between the features of all major animal models available and to use them with their strengths and limitations in mind. The book provides guidance for selecting the best animal model(s) to answer specific questions and to test the efficacy of drug candidates.

At the present time, 430 drugs are known to cause respiratory injury. This represents an increase of almost 200 in the last ten years, and the number is still increasing. This comprehensive, definitive reference work, with an outstanding range of international expert contributors and two of the world's leading editors, provides an essential reference for the practising respiratory physician. Key features: The text builds upon basics with a review of basic sciences. The book covers imaging, varied drug-induced interstitial lung disease including pulmonary edema and diffuse alveolar hemorrhage, acute respiratory failure, pleural involvement and upper to lower airway disease A wide range of diseases are detailed from chemotherapy and radiation to biologic-induced lung disease, drug misuse, and special groups such as recipients of stem cell and solid organ transplants. A range of world class contributions from key opinion leaders. This book provides essential information for recognizing and managing drug-induced respiratory disease for all pulmonologists and respiratory care physicians. It will be of great interest to: critical care medicine specialists, hematologists, oncologists, cardiologists, allergists, rheumatologists, neurologists, internists, blood-bank specialists, pathologists and primary care physicians.

The burden of chronic obstructive pulmonary disease (COPD) is enormous and is increasing, but early, accurate diagnosis in a primary care setting can have a crucial impact on managing the condition. New NICE guidelines and the GMS Contract with incentives give GPs and practice nurses the opportunity to diagnose COPD patients and manage them in a structured fashion. This book brings together clear and concise information for GPs and primary healthcare teams on how this can be achieved accurately and effectively. This book sets out a very practical approach to caring for one group who can demonstrably benefit from access to the very best that primary care can offer: patients living with COPD. This book is for busy primary care physicians and nurses committed to improving diagnosis, enabling self-management, ensuring rapid treatment, and providing truly patient-centred care. Written by an experienced, practising general practitioner, it provides a timely contribution to the high-quality primary care services needed now and in the future.A " - from the Foreword by Gail Richards Anita Sharma is to be congratulated on producing a clear, concise and practical book on COPD which will educate, give confidence to, and encourage primary care physicians to manage this important disease effectively and at an early stage.A" - from the Foreword by Joyce Barclay

Chronic obstructive pulmonary disease (COPD) is the most common respiratory disorder of adults in the developed world and is the fourth main cause of death in the USA. It is also associated with high morbidity, and poses an enormous burden of suffering and expense. Despite this, the disease has received little attention compared with other respiratory conditions such as asthma and lung cancer.
Current treatment can offer some marginal symptomatic relief but does not address the underlying disease process. Indeed, smoking cessation is the only intervention known to alter the rate of disease progression. There is clearly great need, and potential, for the development of superior therapies for symptomatic relief and disease modification. This book brings together leading researchers and physicians to discuss the most recent advances in our understanding of COPD, and draws together basic and clinical aspects relevant to the topic. Coverage includes the basic pathology, current and potential therapies, and detailed consideration of the major theories for the pathogenesis of COPD.