Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene (Paperback, 2015 ed.)

Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

General

Imprint:	Springer Verlag, Singapore
Country of origin:	Singapore
Series:	SpringerBriefs in Applied Sciences and Technology
Release date:	September 2014
First published:	2015
Authors:	Amita Kashyap • D. Bujamma • Naresh Babu M
Dimensions:	235 x 155 x 4mm (L x W x T)
Format:	Paperback
Pages:	72
Edition:	2015 ed.
ISBN-13:	978-981-4585-07-1
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > Clinical & internal medicine > Respiratory medicine Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General Promotions
LSN:	981-4585-07-6
Barcode:	9789814585071

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