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Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene (Paperback, 2015 ed.)
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Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene (Paperback, 2015 ed.)
Series: SpringerBriefs in Applied Sciences and Technology
Expected to ship within 10 - 15 working days
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Cancer is initiated by activation of oncogenes or inactivation of
tumor suppressor genes. Mutations in the K-ras proto-oncogene are
responsible for 10-30% of adenocarcinomas. Clinical Findings point
to a wide variety of other cancers contributing to lung cancer
incidence. Such a scenario makes identification of lung cancer
difficult and thus identifying its mechanisms can contribute to the
society. Identifying unique conserved patterns common to
contributing proto-oncogenes may further be a boon to
Pharmacogenomics and pharmacoinformatics. This calls for ab
initio/de novo drug discovery that in turn will require a
comprehensive in silico approach of Sequence, Domain, Phylogenetic
and Structural analysis of the receptors, ligand screening and
optimization and detailed Docking studies. This brief involves
extensive role of the RAS subfamily that includes a set of
proteins, which cause an over expression of cancer-causing genes
like M-ras and initiate tumour formation in lungs. SNP Studies and
Structure based drug discovery will also be undertaken.
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