Nunn's Applied Respiratory Physiology, Ninth Edition, is your concise, one-stop guide to all aspects of respiratory physiology in health, disease, and in the many physiologically challenging situations and environments into which humans take themselves - coverage is from basic science to clinical applications. Trusted for over 50 years, this most comprehensive single volume on respiratory physiology will prove invaluable to those in training or preparing for examinations in anaesthesia, intensive care, respiratory medicine or thoracic surgery - as well as an essential quick reference for physiologists and the range of practitioners requiring ready access to current knowledge in this field. Now fully revised and updated, this ninth edition includes a larger page format for improved clarity, as well as full access to the complete, downloadable eBook version. This incorporates BONUS chapters, handy topic summaries, interactive self-assessment material and a NEW series of expert lectures on key topics. The result is a more flexible, engaging and complete resource than ever before. Enhancements to this edition include: A new dedicated chapter on obesity - covering the effects of this global challenge on the physiology of the respiratory system in health and disease, in both adults and children Expanded coverage of the adverse effects of hyperoxia - including the physiology of the now popular technique of high-flow nasal therapy A revised section on air pollution - reflecting the growing importance and understanding of the impact of pollution on the lungs and other body systems, along with the latest worldwide guidelines Detailed coverage of artificial ventilation during general anaesthesia - covering post-operative respiratory complications and the physiological basis of current best-practice for optimizing ventilation Print comes with enhanced eBook - includes access to the complete, fully searchable text, PLUS: bonus chapters handy chapter summaries interactive self-assessment material a NEW series of 25 expert lectures focusing on the most essential topics in respiratory physiology

Pervasive Cardiac and Respiratory Monitoring Devices: Model-Based Design is the first book to combine biomedical instrumentation and model-based design. As the scope is limited to cardiac and respiratory devices only, this book offers more depth of information on these devices; focusing in on signals used for home monitoring and offering additional analysis of these devices. The author offers an insight into new industry and research trends, including advances in contactless monitoring of breathing and heart rate. Each chapter presents a section on current trends. As instrumentation as a field is becoming increasingly smart, basic signal processing is also discussed. Real case-studies for each modelling approach are used, primarily covering blood pressure, ECG and radar-based devices. This title is ideal for teaching and supporting learning as it is written in an accessible style and a solutions manual for the problem sets is provided. It will be useful to 4th year undergraduate students, graduate/masters/PhD students, early career researchers and professionals working on an interdisciplinary project; as it introduces the field and provides real world applications. For engineers this book solves the problem of how to assess and calibrate a medical device to ensure the data collected is trustworthy. For students, this book allows for trying concepts and circuits via simulations and learning modeling techniques. Students will learn concepts from this book and be ready to design bioinstrumentations devices based on specifications/requirements.

First volume in state-of-the-art radiologic text-atlas series details anatomy of the lungs, mediastinum, and heart Normal imaging anatomy and variants, including both diagnostic and surgical anatomy, are the cornerstones of radiologic knowledge. Imaging Anatomy: Text and Atlas Volume 1, Lungs, Mediastinum, and Heart is the first in a series of four richly illustrated radiologic references edited by distinguished radiologist Farhood Saremi and coedited by Damian Sanchez-Quintana, Hiro Kiyosue, Francesco F. Faletra, Meng Law, Dakshesh Patel, and Shane Tubbs, with contributions from an impressive cadre of international authors. The exquisitely crafted atlas provides high-quality multiplanar and volumetric color-coded imaging techniques utilizing CT, MRI, or angiography, supplemented by cadaveric presentations and color drawings that best elucidate each specific anatomic region. Twenty-one chapters with concise text encompass thoracic wall, mediastinum, lung, vascular, and cardiac anatomy, providing readers with a virtual dissection experience. Many anatomical variants along with pathological examples are presented. Key Highlights More than 600 illustrations enhance understanding of impacted regions Lung anatomy including the pleura, pulmonary arteries, pulmonary veins, and lymphatics Discussion of the tracheobronchial system, mediastinum and thymus, thoracic aorta and major branches, systemic veins, lymphatics and nerves of the thorax, diaphragm, and breast Heart anatomy including the atrioventricular septal region; aortic, pulmonary, mitral and tricuspid valves; coronary arteries and myocardial perfusion; coronary veins; and pericardium This superb resource is essential reading for medical students, radiology residents and veteran radiologists, cardiologists, as well as cardiovascular and thoracic surgeons. It provides an excellent desk reference and practical guide for differentiating normal versus pathologic anatomy. This book includes complimentary access to a digital copy on https://medone.thieme.com.

This book covers the complete field of pleura and mediastinum pathology - from acquired multilocular thymic cyst to well-differentiated papillary mesothelioma. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

Maximum oxygen uptake during exercise is one of the best predictors of operative mortality and of prognosis in chronic cardiac or respiratory disease. Cardiopulmonary exercise tests (CPET) are therefore an increasingly common component of pre-operative assessment and the management of patients with chronic cardiopulmonary problems. Part of the Oxford Respiratory Medicine Library (ORML) series, A Practical Guide to the Interpretation of Cardiopulmonary Exercise Tests, Second Edition provides readers with a practical, concise, and accessible approach to all aspects of cardiopulmonary exercise tests (CPET). CPET is often perceived as being incredibly complex to evaluate so this book breaks down interpretation to simple steps, allowing readers to rapidly understand the key points underpinning the application and interpretation of CPET. The text is focused and with the use of a substantial number of figures, learning points, and self-test questions helps readers to build confidence in undertaking and interpreting CPET. The second edition has been extended and extensively revised in line with the latest international guidelines and evidence, and includes 16 fully updated chapters, 4 new chapters, and a new section of worked examples has been added.

Mustard Lung: Diagnosis and Treatment of Respiratory Disorders in Sulfur-Mustard Injured Patients brings together the details regarding pathophysiology, medication, and protective issues to provide a comprehensive look at health problems associated with sulfur mustard injury. It provides a bench-to-bedside look at the long term complications of vesicant exposure in humans as well as how mustard gas exposure affects lung function. By providing guidelines and approaches for the diagnosis, pathogenesis, and treatment of SM injury cases, this book is helpful for a wide range of medical researchers and clinicians. For decades, chemical respiratory disorders were diagnosed and managed traditionally similar to other chronic respiratory diseases. However, the exact nature of chemical respiratory disorders is different and needs to be treated as such.

Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.

Chronic obstructive pulmonary disease (COPD) is a major cause of disability and is the fourth leading cause of death throughout the world. Although cigarette smoking is the major and best studied causative factor of COPD, there is consistent evidence that a substantial proportion of COPD cases cannot be explained by smoking. Other noxious particles and gases, such as workplace dusts, vapours, fumes or gases, indoor air pollution from burning biomass fuels during cooking foods and heating spaces, and air pollution in urban areas are important risk factors of COPD. According to collected data, 15-20% of COPD cases are likely to be caused or made worse by work; around 4,000 COPD deaths every year are related to workplace exposures, and 40% of COPD patients are below the retirement age. The development of COPD as a consequence of workplace exposure is a matter of growing interest and importance. There is no doubt that certain workplace exposures enhance the risk of COPD and may do so independently of or in concordance with cigarette smoking. The evidence is most coherent for work that entails exposure to coal, silica, welding fumes, cadmium fumes, cotton dust, farming dusts, grain dust and/or wood dust. The research found consistent associations between workplace exposures and COPD across a wide range of sectors, describing a nearly uniform pattern of exposure-response relationships. Based on the research, affected occupations include miners, construction workers, road workers, tunnel workers, welders, glass workers, metal workers, foundry workers, textile workers, farm laborers, wood workers, chemical workers, and rubber workers; in other words, a working population including millions and millions workers worldwide have been affected. It seems that occupational risk for COPD, although variable, is smaller compared with that of cigarette smoking. However, it affects a large proportion of the population and its contribution to the total burden of COPD cannot not be neglected. In addition, existing evidence indicates that workplace exposure may influence the course of COPD as factors with significant impacts on the progression and severity of the disease. As in the case of the workplace agents being causative factors of COPD, the mechanisms underlying this effect still are not fully understood. This monograph contains seven chapters which cover the most important aspects of this issue. It summarizes results of the studies performed in this area of research and conclusions based on them. This monograph also presents the author's view regarding the influence of workplace exposures on the development and progression of COPD. In addition, it may be a basis for further research for better understanding of the association between COPD and workplace exposures.

Der endobronchiale Ultraschall (EBUS) ist eine aufregende Diagnosetechnik. Das Verfahren wird immer weiterentwickelt und hat die Diagnose und das Staging von Lungenkrebs und anderen Thoraxerkrankungen erheblich vereinfacht. Einer der Pioniere der Methode ist Mitautor dieses Fachbuchs, das das notwendige Wissen vermittelt, um endobronchiale Ultraschalluntersuchungen zur Diagnose und zum Staging von Lungenkrebs und anderer Tumoren in der Brusthoehle durchzufuhren. Die 2. Auflage von Endobronchial Ultrasonography behandelt alle Standardverfahren sowie die neuesten Entwicklungen und Richtlinien in dem Fachgebiet. Dabei werden zwei gangige Verfahren, Bronchoskopie und Echtzeit-Sonografie, kombiniert. So erhalten Mediziner prazise Biopsien der Lymphknoten und der Organe in der Brusthoehle.

From frontline experts on the topic-everything you need to know about COVID-19 and how it affects the heart COVID-19's effect on the cardiovascular system continues to drive increases in morbidity and mortality. Building a solid understanding of the disease spectrum is critical for accurately diagnosing, treating, and managing patients with heart issues in the time of COVID. Written by a team of experts who worked on the frontlines in New York City throughout the worst of the pandemic, COVID-19 and the Heart: A Cased-Based Pocket Guide is a one-of-a-kind resource for providing safe, effective care for COVID-19-related heart conditions. Designed for quick and easy learning and on-the-spot clinical decision making, this practical guide is organized into chapters based on genuine clinical cases and provides the best approach for each one. The authors highlight key points throughout the clinical content for easy review, and provide up-to-date information on clinical trials/vaccines, diagnostic and treatment algorithms, therapeutics, monitoring, and patient education. Ideal for healthcare workers actively engaged in the ongoing pandemic and students seeking to build their expertise, COVID-19 and the Heart is the go-to guide to making the right clinical judgments with respect to the cardiac manifestations of COVID-19. COVID-19 and the Heart starts with the physiology of COVID-related heart disease, and walks you through COVID's effect on: ACS Valvular heart disease Arrythmia Pericardial disease Heart failure Shock Thromboembolism Hypertension

Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel's Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases. Included with your print purchase is the Expert Consult eBook version, which offers content updates, videos, review questions, and Thoracic Imaging Cases (TICs), all of which are easily navigable on any device for access on rounds or in the clinic. The embedded videos cover thoracoscopy, therapeutic bronchoscopy, volumetric chest CT scans, and more, while brand-new audio files highlight normal and abnormal breath sounds and the separate components of cough. Full-color design enhances teaching points and highlights challenging concepts. Understand clinical applications and the scientific principles of respiratory medicine. Detailed explanations of each disease entity allow you to work through differential diagnoses. Expert Consult eBook version included with purchase. This enhanced eBook experience offers content updates, videos, review questions, and Thoracic Imaging Cases (TICs), all of which are easily navigable on any device for access on rounds or in the clinic. Includes more than 1,000 figures and over 200 videos and audio files. Key Points and Key Reading sections highlight the most useful references and resources for each chapter. An expanded sleep section now covers four chapters and includes control of breathing, consequences of sleep disruption, as well as obstructive and central apnea. New chapters in the Critical Care section cover Noninvasive Ventilation (NIV) and Extracorporeal Support of Gas Exchange (ECMO). New chapters focusing on diagnostic techniques now include Invasive Diagnostic Imaging and Image-Guided Interventions and Positron Emission Tomography, and a new chapter on Therapeutic Bronchoscopy highlights the interventional role of pulmonologists. Embedded videos feature thoracoscopy, therapeutic bronchoscopy, volumetric chest CT scans, and more. Brand-new audio files highlight normal and abnormal breath sounds and the separate components of cough.

Ultrasound scanners are available in an increasing number of clinical areas. They are excellent for identifying the presence of a pleural effusion and the optimal site for aspration. The National Patient Safety Agency recommends their use prior to insertion of chest drains for pleural effusions. This book is for clinicians who want to start using portable ultrasound scanners to look at the chest. It will teach you some basic physics and how to adjust the controls on the scanner. Then you will learn how to recognise a pleural effusion. When you are proficient at identifying pleural effusions, you can start to look for some of the other clinical conditions which are shown in the many illustrations in this book. There are examples of the artefacts which may catch you out, with diagrams to explain how they are caused. Once you have started to use ultrasound at the bedside, you will not want to undertake "blind" pleural aspirations ever again. Competency in this technique is becoming the norm for those involved in managing patients with disease of the chest; this book will help you along that road

Practising regular breathing exercises helps to develop healthy breathing patterns, which can lessen the effects of breathing difficulties caused by COPD (Chronic Obstructive Pulmonary Disease). This is a short, practical guide to using new therapeutic breathing exercises which focus on techniques to reduce breathlessness and control coughing to help you to get the most out of every breath. The exercises are simple, easy to follow, and designed to work alongside usual medical care. No special equipment is necessary, you can practise in your own home at your own pace, and this illustrated guide contains all the information you need to get started. This handbook will be perfect for anyone with COPD who wants to help manage their breathing difficulties, coughing and fatigue with simple and effective techniques. Professionals working with COPD sufferers, such as physiotherapists, physical therapists and carers, will also find the book of interest.

This book provides essential information on recent advances in molecular genetics, epidemiology, translational research, and the latest results of clinical trials on mesothelioma. Significant progress has been made in understanding mesothelioma biology, and in developing new therapies for this refractory tumor, malignant pleural mesothelioma (MPM). Not only does this volume summarize the latest research-based data on the disease; it also shares insights into future research directions. The book consists of 5 themed sections on: epidemiology, pathogenesis, screening and early detection, molecular genetics, and clinical aspects and management. Several chapters focus on new trends in the field, e.g. immune therapy and identification of biomarkers, molecular oncogenesis including genetic susceptibility, and molecular diagnostic pathology. The book also highlights new cancer treatment approaches, such as immunotherapy based on immune checkpoint inhibitors, which has meant a paradigm shift in other types of cancer, and given some hope to MPM patients. In turn, it discusses recent molecular pathological studies on mesothelioma, which claim to offer more accurate classifications than traditional morphology and immunohistochemistry-based approaches. All of these cutting-edge analyses provide the basis for a closing discussion on future developments and research directions. Malignant Pleural Mesothelioma - Advances in Pathogenesis, Diagnosis, and Treatments has been edited and authored by respected researchers and will be of interest to medical, surgical and radiation oncologists; pulmonologists; pathologists and basic researchers alike. Since the disease represents a significant diagnostic and therapeutic challenge, scientists and clinicians from learners to experts, as well as fellows in training in these subspecialties, will value this book.

Non-invasive ventilation (NIV) involves the use of a mask to assist breathing for patients who can't breathe for themselves, providing an alternative to invasive ventilation, which involves the insertion of a tracheal tube into the throat of an unconscious patient. The procedure can be used for many problems involving breathing difficulties, such as lung disease and sleep apnea. This book provides a clear practical guide to medical practitioners on how to make use of NIV under various conditions - an approach that is easily applied. New additions to this second edition include chapters on cough-assist devices and non-invasive ventilation at home, along with an expansion of the chapters on long-term ventilation and physiotherapy. [Subject: Medicine]

As an adjunct to the text, this workbook helps reinforce essential respiratory care A&P concepts learned in the main text. Various learning activities encourage you to use recall, application, and analysis to develop the necessary critical thinking skills. Exercises include listing, matching, and labeling activities; critical thinking questions; case studies; and key concept questions that provide review and practice for the NBRC credentialing exam. Direct correlation with the 3rd edition of Respiratory Care Anatomy and Physiology makes it easy to parallel workbook activities with content from the main text. A variety of learning activities include fill-in-the-blank, matching, and labeling exercises to help you assess your knowledge of text content. Open-ended critical thinking questions ask you to apply your understanding of text material with a written response. Case studies place key subject matter in a clinical context to help you connect theory with practice. Key concept questions are NBRC-style multiple choice questions that require recall, application, and analysis. ALL NEW! Content is divided into easy-to-follow sections that progress in difficulty from recall exercises to application exercises.

This book addresses the manifestation of lung disease in patients with rheumatoid arthritis (RA). Lung disease in RA is common and often associated with significant morbidity and mortality. This stems partially from the nature of RA and partially from the many therapies used to manage RA that are associated with pneumotoxicity. Despite the severity and commonality of this comorbidity, little has been written on the topic. This book thus takes a multidisciplinary approach to provide: a concise overview of RA and why lung disease so commonly coincides with it; overviews of the specific lung diseases, including interstitial lung disease, and their epidemiology, associated imaging, histopathology, biomarkers, and management; a presentation of risk factors for these diseases; and specifics on what still needs to be uncovered about these pulmonary manifestations. Lung Disease in Rheumatoid Arthritis is a comprehensive and practical resource for clinicians and clinician scientists in pulmonology, rheumatology, pathology, and primary care.

This book provides an unbiased and evidence-based guide to the potential role of interventional pulmonology as an alternative to thoracic surgery. Interventional pulmonology is a new and quickly growing sub-specialty in pulmonary medicine and increasingly more pulmonologists are turning to interventional therapies over the more costly and invasive surgical options. The text thoroughly presents detailed coverage of and diagnostic methods for many diseases and conditions that pulmonologists encounter daily, including: diffuse lung infiltrates, solitary lung nodule, undiagnosed exudative pleural effusion, pneumothorax, hemoptysis, and airway foreign body. Experts then detail treatment options, from both a surgical and interventional perspective, with guidance on: when each procedure is most appropriate, what can be performed by a pulmonologist (with guidelines on how those procedures are done) versus what needs to be referred to a thoracic surgeon or an intervention pulmonologist, and the benefits and disadvantages involved with each option. This is an ideal guide for pulmonologists, trainees, and students to better understand the full scope of possible treatment options for their patients and to make the best informed decision about patient care.

The goal of the first edition of Interventional Critical Care: A Manual for Advanced Care Practitioners was to fill a knowledge gap of the advanced practice provider (APP) specifically regarding the skills and understanding of critical care procedures in response to the rapidly expanding participation of APPs in critical care. Written by experts in the field, this successor edition adds to the content of the first by expanding upon ultrasonography areas to include more direct hemodynamic evaluations as well as the newer "e"FAST. It also explores the specialty of Urology to include more complex interventions. As billing and coding are necessary, the authors added appropriate CPT codes for each of the appropriate chapters. Most chapters have been completely re-written and updated from the first edition and have different authors - thereby a different perspective and experience level. Interventional Critical Care 2nd Edition serves as a valuable reference for physicians and advanced practice providers in daily practice in the ICU, OR and/or ED setting.

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient's genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

This volume provides protocols that expand on the latest alpha-1-antitrypsin (AAT) research. The chapters in this book are divided in to three sections: Part I is dedicated to patient-oriented research; part II discusses animal models; and Part III focuses on in vitro studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Alpha-1 Antitrypsin Deficiency: Methods and Protocols is a valuable resource for researchers, students, and clinican-scientists interested in AAT deficiency, as well as anyone working in the fields of pulmonology and hepatology.

Cystic fibrosis (CF) is one of the most common autosomal recessive disorders in the Caucasian population with an estimated incidence of 1 in 2,500 childbirths. While this disease affects several organ systems of the body, morbidity and mortality is chiefly related to the extent of pulmonary involvement. Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial disease of the lung of unknown etiology with a median survival time of about 3 years. IPF occurs mainly in men older than 60 years who have comorbidities such as pulmonary hypertension, COPD, lung cancer, gastro-esophageal reflux, ischemic heart disease and obstructive sleep apnoea. This book provides current research on risk factors of CF and IPF, as well as management options and long-term health outcomes of the disorders.

The present volume is supposed to be a major reference resource for chest physicians and those involved in the development of novel pharmaceutical entities for these diseases. Internationally recognized authorities review the most important new information on the advances in our understanding of the pathogenesis and treatment of these diseases, including the substantial advances in the topical delivery of inhaled medicines. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of respiratory medicine.

With cutting-edge and clinically relevant information, MECHANICAL VENTILATION, 2nd Edition takes a practical, clinical approach to the principles and practice of mechanical ventilation. This informative resource explains mechanical ventilation decisions and procedures in real-world terms so information is easy to understand and apply. This thoroughly updated edition includes one new chapter, four completely updated chapters, and a wealth of new user-friendly features. Detailed, clinically focused coverage of the application of mechanical ventilation to the most common respiratory diseases, provides practical answers to real life problems. UNIQUE! Sections of chapters on Special Techniques and Future Therapies include information on the newest techniques for treating patients in respiratory distress. A separate appendix of case studies helps you apply what you've learned to realistic situations. Well-known and respected authors, Neil MacIntyre and Rich Branson, share their vast expertise and accurate, cutting-edge information. Chapter Objectives, Key Point Summaries, and Assessment Questions reinforce basic concepts from each chapter. New chapter on Unique Patient Populations highlights the mechanical ventilation issues of traumatic brain injury, neuromuscular disease, lung transplantation, burn injury, and perioperative patient populations. Expanded glossary includes relevant terminology and key terms to help you easily find unfamiliar terminology.

This concise and practical book provides an overview of neuromuscular disorders in clinical practice. Diagnostic approaches are covered along with patient management strategies in an easy-to-understand and introductory framework. Filling a significant gap in the literature, this resource delivers essential information for neurology trainees and practitioners, as well as anyone interested in learning the fundamentals of this important medical subspecialty.